Correction to: Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR) / Anouck AMESTOY in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 4p. Titre : Correction to: Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR) Type de document : Texte imprimé et/ou numérique Auteurs : Anouck AMESTOY, Auteur ; E. GUILLAUD, Auteur ; G. BUCCHIONI, Auteur ; T. ZALLA, Auteur ; D. UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; L. MURTAGH, Auteur ; J. HOUENOU, Auteur ; R. DELORME, Auteur ; M. L. MOAL, Auteur ; M. LEBOYER, Auteur ; Manuel P. BOUVARD, Auteur ; J. R. CAZALETS, Auteur Article en page(s) : 4p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-021-00479-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Correction to: Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR) [Texte imprimé et/ou numérique] / Anouck AMESTOY, Auteur ; E. GUILLAUD, Auteur ; G. BUCCHIONI, Auteur ; T. ZALLA, Auteur ; D. UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; L. MURTAGH, Auteur ; J. HOUENOU, Auteur ; R. DELORME, Auteur ; M. L. MOAL, Auteur ; M. LEBOYER, Auteur ; Manuel P. BOUVARD, Auteur ; J. R. CAZALETS, Auteur . - 4p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 4p. Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-021-00479-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism / C. LAIDI in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409 Titre : Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism Type de document : Texte imprimé et/ou numérique Auteurs : C. LAIDI, Auteur ; J. BOISGONTIER, Auteur ; A. DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; S. HOTIER, Auteur ; M. A. D'ALBIS, Auteur ; R. DELORME, Auteur ; Federico BOLOGNANI, Auteur ; C. CZECH, Auteur ; C. BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; J. PETIT, Auteur ; S. HOLIGA, Auteur ; J. DUKART, Auteur ; A. GAMAN, Auteur ; E. TOLEDANO, Auteur ; M. LY-LE MOAL, Auteur ; Isabelle SCHEID, Auteur ; M. LEBOYER, Auteur ; J. HOUENOU, Auteur Article en page(s) : p.1402-1409 Langues : Anglais (eng) Mots-clés : Adults  Anterior cingulate cortex  Autism  Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism [Texte imprimé et/ou numérique] / C. LAIDI, Auteur ; J. BOISGONTIER, Auteur ; A. DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; S. HOTIER, Auteur ; M. A. D'ALBIS, Auteur ; R. DELORME, Auteur ; Federico BOLOGNANI, Auteur ; C. CZECH, Auteur ; C. BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; J. PETIT, Auteur ; S. HOLIGA, Auteur ; J. DUKART, Auteur ; A. GAMAN, Auteur ; E. TOLEDANO, Auteur ; M. LY-LE MOAL, Auteur ; Isabelle SCHEID, Auteur ; M. LEBOYER, Auteur ; J. HOUENOU, Auteur . - p.1402-1409. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409 Mots-clés : Adults  Anterior cingulate cortex  Autism  Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands / A. LEFEBVRE in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2373-2382 Titre : Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands Type de document : Texte imprimé et/ou numérique Auteurs : A. LEFEBVRE, Auteur ; A. COHEN, Auteur ; A. MARUANI, Auteur ; Frédérique AMSELLEM, Auteur ; Anita BEGGIATO, Auteur ; Anouck AMESTOY, Auteur ; M. L. MOAL, Auteur ; D. UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; L. MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; M. LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; R. DELORME, Auteur Article en page(s) : p.2373-2382 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/genetics  Cognition  Humans  Obsessive-Compulsive Disorder/genetics  habits  heritability  neurodevelopment  phenotype Index. décimale : PER Périodiques Résumé : Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p? En ligne : http://dx.doi.org/10.1002/aur.2570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands [Texte imprimé et/ou numérique] / A. LEFEBVRE, Auteur ; A. COHEN, Auteur ; A. MARUANI, Auteur ; Frédérique AMSELLEM, Auteur ; Anita BEGGIATO, Auteur ; Anouck AMESTOY, Auteur ; M. L. MOAL, Auteur ; D. UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; L. MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; M. LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; R. DELORME, Auteur . - p.2373-2382. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2373-2382 Mots-clés : Autism Spectrum Disorder/complications/genetics  Cognition  Humans  Obsessive-Compulsive Disorder/genetics  habits  heritability  neurodevelopment  phenotype Index. décimale : PER Périodiques Résumé : Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p? En ligne : http://dx.doi.org/10.1002/aur.2570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? / M. BENNABI in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 22p. Titre : Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? Type de document : Texte imprimé et/ou numérique Auteurs : M. BENNABI, Auteur ; N. TARANTINO, Auteur ; A. GAMAN, Auteur ; Isabelle SCHEID, Auteur ; R. KRISHNAMOORTHY, Auteur ; P. DEBRE, Auteur ; A. BOULEAU, Auteur ; M. CARALP, Auteur ; S. GUEGUEN, Auteur ; M. L. LE-MOAL, Auteur ; Manuel P. BOUVARD, Auteur ; Anouck AMESTOY, Auteur ; R. DELORME, Auteur ; M. LEBOYER, Auteur ; R. TAMOUZA, Auteur ; V. VIEILLARD, Auteur Article en page(s) : 22p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  High-functioning autism  Natural killer cells  Pathogens Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD. Methods: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up period for four patients. The phenotype and polyfunctional capacities of NK cells were explored according to infectious stigma and clinical parameters (IQ, social, and communication scores). Results: As compared to HC, NK cells from patients with hf-ASD showed a high level of cell activation (p < 0.0001), spontaneous degranulation (p < 0.0001), and interferon-gamma production (p = 0.0004), whereas they were exhausted after in vitro stimulations (p = 0.0006). These data yielded a specific HLA-DR(+)KIR2DL1(+)NKG2C(+) NK-cell signature. Significant overexpression of NKG2C in hf-ASD patients (p = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (r = - 0.67; p < 0.0001), regardless of the IgG status of tested pathogens. Multivariate linear regression analysis also revealed that expression of the late-activating HLA-DR marker was both associated with structural language (r = 0.48; p = 0.007) and social awareness (r = 0.60; p = 0.0007) scores in adult patients with hf-ASD, while KIR2DL1 expression correlated with IQ scores (p = 0.0083). Conclusions: This study demonstrates that adults with hf-ASD have specific NK-cell profile. Presence of NKG2C overexpression together with high-level activation of NK cells suggest an association with underlying pathogens, a hypothesis warranting further exploration in future studies. En ligne : http://dx.doi.org/10.1186/s13229-019-0269-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? [Texte imprimé et/ou numérique] / M. BENNABI, Auteur ; N. TARANTINO, Auteur ; A. GAMAN, Auteur ; Isabelle SCHEID, Auteur ; R. KRISHNAMOORTHY, Auteur ; P. DEBRE, Auteur ; A. BOULEAU, Auteur ; M. CARALP, Auteur ; S. GUEGUEN, Auteur ; M. L. LE-MOAL, Auteur ; Manuel P. BOUVARD, Auteur ; Anouck AMESTOY, Auteur ; R. DELORME, Auteur ; M. LEBOYER, Auteur ; R. TAMOUZA, Auteur ; V. VIEILLARD, Auteur . - 22p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 22p. Mots-clés : Autism spectrum disorders  High-functioning autism  Natural killer cells  Pathogens Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD. Methods: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up period for four patients. The phenotype and polyfunctional capacities of NK cells were explored according to infectious stigma and clinical parameters (IQ, social, and communication scores). Results: As compared to HC, NK cells from patients with hf-ASD showed a high level of cell activation (p < 0.0001), spontaneous degranulation (p < 0.0001), and interferon-gamma production (p = 0.0004), whereas they were exhausted after in vitro stimulations (p = 0.0006). These data yielded a specific HLA-DR(+)KIR2DL1(+)NKG2C(+) NK-cell signature. Significant overexpression of NKG2C in hf-ASD patients (p = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (r = - 0.67; p < 0.0001), regardless of the IgG status of tested pathogens. Multivariate linear regression analysis also revealed that expression of the late-activating HLA-DR marker was both associated with structural language (r = 0.48; p = 0.007) and social awareness (r = 0.60; p = 0.0007) scores in adult patients with hf-ASD, while KIR2DL1 expression correlated with IQ scores (p = 0.0083). Conclusions: This study demonstrates that adults with hf-ASD have specific NK-cell profile. Presence of NKG2C overexpression together with high-level activation of NK cells suggest an association with underlying pathogens, a hypothesis warranting further exploration in future studies. En ligne : http://dx.doi.org/10.1186/s13229-019-0269-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Temporal preparation in adults with autistic spectrum disorder: The variable foreperiod effect / G. GIRARDI in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2393-2404 Titre : Temporal preparation in adults with autistic spectrum disorder: The variable foreperiod effect Type de document : Texte imprimé et/ou numérique Auteurs : G. GIRARDI, Auteur ; L. G. FERNANDEZ, Auteur ; M. LEBOYER, Auteur ; A. LATIMIER, Auteur ; S. CHOKRON, Auteur ; T. ZALLA, Auteur Article en page(s) : p.2393-2404 Langues : Anglais (eng) Mots-clés : Adult  Attention  Autism Spectrum Disorder  Cognition  Humans  Reaction Time  Time Perception  arousal  conditional probability  foreperiod  implicit temporal preparation  timing Index. décimale : PER Périodiques Résumé : Research suggested the possibility that temporal cognition may be different in autistic spectrum disorder (ASD). Although there are some empirical studies examining timing ability in these individuals, to our knowledge, no one directly assessed the ability to predict when an event will occur. Here, we report a study on implicit temporal preparation in individuals with ASD as indexed by the variable foreperiod (FP) effect. We compared a group of adult ASD participants to a group of typically-developed (TD) controls, for their respective abilities to utilize implicit temporal information in a simple detection task with three different preparatory intervals (FP, short, middle and long). Participants were given a warning tone to signal an imminent stimulus, and asked to press a key as quickly as they could upon detection of the stimulus. Both groups were able to use implicit temporal information, as revealed by both the variable-FP effect (i.e., faster response for targets appearing after a long FP) and asymmetric sequential effects (i.e., slower response in short-FP trials following a previous long-FP trial). The TD group exhibited a faster response in a long-FP trial that was preceded by short-FP one, whereas the ASD group did not, as reflected in their higher percentage of response omissions for a target that appeared later than in the previous trial. The reduced ability of ASD participants to modulate their responses under these conditions might reflect a difficulty in time-based monitoring of stimulus occurrence. LAY SUMMARY: Time-processing may be different in autistic spectrum disorder (ASD). This study addressed the ability to anticipate a relevant stimulus's onset according to predictable interstimulus intervals comparing adults with ASD and typically developed controls. We found that ASD participants did not benefit from temporal preparation when stimulus appeared later than previously attended. This suggests a reduced ability in detecting implicit temporal regularities between events. En ligne : http://dx.doi.org/10.1002/aur.2573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Temporal preparation in adults with autistic spectrum disorder: The variable foreperiod effect [Texte imprimé et/ou numérique] / G. GIRARDI, Auteur ; L. G. FERNANDEZ, Auteur ; M. LEBOYER, Auteur ; A. LATIMIER, Auteur ; S. CHOKRON, Auteur ; T. ZALLA, Auteur . - p.2393-2404. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2393-2404 Mots-clés : Adult  Attention  Autism Spectrum Disorder  Cognition  Humans  Reaction Time  Time Perception  arousal  conditional probability  foreperiod  implicit temporal preparation  timing Index. décimale : PER Périodiques Résumé : Research suggested the possibility that temporal cognition may be different in autistic spectrum disorder (ASD). Although there are some empirical studies examining timing ability in these individuals, to our knowledge, no one directly assessed the ability to predict when an event will occur. Here, we report a study on implicit temporal preparation in individuals with ASD as indexed by the variable foreperiod (FP) effect. We compared a group of adult ASD participants to a group of typically-developed (TD) controls, for their respective abilities to utilize implicit temporal information in a simple detection task with three different preparatory intervals (FP, short, middle and long). Participants were given a warning tone to signal an imminent stimulus, and asked to press a key as quickly as they could upon detection of the stimulus. Both groups were able to use implicit temporal information, as revealed by both the variable-FP effect (i.e., faster response for targets appearing after a long FP) and asymmetric sequential effects (i.e., slower response in short-FP trials following a previous long-FP trial). The TD group exhibited a faster response in a long-FP trial that was preceded by short-FP one, whereas the ASD group did not, as reflected in their higher percentage of response omissions for a target that appeared later than in the previous trial. The reduced ability of ASD participants to modulate their responses under these conditions might reflect a difficulty in time-based monitoring of stimulus occurrence. LAY SUMMARY: Time-processing may be different in autistic spectrum disorder (ASD). This study addressed the ability to anticipate a relevant stimulus's onset according to predictable interstimulus intervals comparing adults with ASD and typically developed controls. We found that ASD participants did not benefit from temporal preparation when stimulus appeared later than previously attended. This suggests a reduced ability in detecting implicit temporal regularities between events. En ligne : http://dx.doi.org/10.1002/aur.2573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Trustworthiness and Dominance Personality Traits' Judgments in Adults with Autism Spectrum Disorder / A. LATIMIER in Journal of Autism and Developmental Disorders, 49-11 (November 2019)  

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Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR) / Anouck AMESTOY in Molecular Autism, 12 (2021)  

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