Cognitive correlates of autism spectrum disorder symptoms / C. N. JOHNSON in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2405-2411 Titre : Cognitive correlates of autism spectrum disorder symptoms Type de document : Texte imprimé et/ou numérique Auteurs : C. N. JOHNSON, Auteur ; B. RAMPHAL, Auteur ; E. KOE, Auteur ; A. RAUDALES, Auteur ; J. GOLDSMITH, Auteur ; A. E. MARGOLIS, Auteur Article en page(s) : p.2405-2411 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/complications  Brain  Child  Cognition  Humans  Intelligence  Intelligence Tests  adult  autism spectrum disorder  child  cognition  communication  intelligence  intelligence tests Index. décimale : PER Périodiques Résumé : Due to the diverse behavioral presentation of autism spectrum disorder (ASD), identifying ASD subtypes using patterns of cognitive abilities has become an important point of research. Some previous studies on cognitive profiles in ASD suggest that the discrepancy between verbal intelligence quotient (VIQ) and performance IQ (PIQ) is associated with ASD symptoms, while others have pointed to VIQ as the critical predictor. Given that VIQ is a component of the VIQ-PIQ discrepancy, it was unclear which was most driving these associations. This study tested whether VIQ, PIQ, or the VIQ-PIQ discrepancy was most associated with ASD symptoms in children and adults with ASD (N = 527). Using data from the Autism Brain Imaging Data Exchange (ABIDE), we tested the independent contribution of each IQ index and their discrepancy to ASD symptom severity using multiple linear regressions predicting ASD symptoms. VIQ was most associated with lower symptom severity as measured by the Autism Diagnostic Observation Schedule (ADOS) total score, and when VIQ was included in models predicting ASD symptoms, associations with PIQ and IQ discrepancy were not significant. An association between VIQ and ASD communication symptoms drove the association with ASD symptom severity. These results suggest that associations between ASD communication symptoms and IQ discrepancy or PIQ reported in prior studies likely resulted from variance shared with VIQ. Subtyping ASD on the basis of VIQ should be a point of future research, as it may allow for the development of more personalized approaches to intervention. LAY SUMMARY: Previous research on links between autism severity and verbal and nonverbal intelligence has produced mixed results. Our study examined whether verbal intelligence, nonverbal intelligence, or the discrepancy between the two was most related to autism symptoms. We found that higher verbal intelligence was most associated with less severe autism communication symptoms. Given the relevance of verbal intelligence in predicting autism symptom severity, subtyping autism on the basis of verbal intelligence could lead to more personalized treatments. En ligne : http://dx.doi.org/10.1002/aur.2577 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Cognitive correlates of autism spectrum disorder symptoms [Texte imprimé et/ou numérique] / C. N. JOHNSON, Auteur ; B. RAMPHAL, Auteur ; E. KOE, Auteur ; A. RAUDALES, Auteur ; J. GOLDSMITH, Auteur ; A. E. MARGOLIS, Auteur . - p.2405-2411. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2405-2411 Mots-clés : Adult  Autism Spectrum Disorder/complications  Brain  Child  Cognition  Humans  Intelligence  Intelligence Tests  adult  autism spectrum disorder  child  cognition  communication  intelligence  intelligence tests Index. décimale : PER Périodiques Résumé : Due to the diverse behavioral presentation of autism spectrum disorder (ASD), identifying ASD subtypes using patterns of cognitive abilities has become an important point of research. Some previous studies on cognitive profiles in ASD suggest that the discrepancy between verbal intelligence quotient (VIQ) and performance IQ (PIQ) is associated with ASD symptoms, while others have pointed to VIQ as the critical predictor. Given that VIQ is a component of the VIQ-PIQ discrepancy, it was unclear which was most driving these associations. This study tested whether VIQ, PIQ, or the VIQ-PIQ discrepancy was most associated with ASD symptoms in children and adults with ASD (N = 527). Using data from the Autism Brain Imaging Data Exchange (ABIDE), we tested the independent contribution of each IQ index and their discrepancy to ASD symptom severity using multiple linear regressions predicting ASD symptoms. VIQ was most associated with lower symptom severity as measured by the Autism Diagnostic Observation Schedule (ADOS) total score, and when VIQ was included in models predicting ASD symptoms, associations with PIQ and IQ discrepancy were not significant. An association between VIQ and ASD communication symptoms drove the association with ASD symptom severity. These results suggest that associations between ASD communication symptoms and IQ discrepancy or PIQ reported in prior studies likely resulted from variance shared with VIQ. Subtyping ASD on the basis of VIQ should be a point of future research, as it may allow for the development of more personalized approaches to intervention. LAY SUMMARY: Previous research on links between autism severity and verbal and nonverbal intelligence has produced mixed results. Our study examined whether verbal intelligence, nonverbal intelligence, or the discrepancy between the two was most related to autism symptoms. We found that higher verbal intelligence was most associated with less severe autism communication symptoms. Given the relevance of verbal intelligence in predicting autism symptom severity, subtyping autism on the basis of verbal intelligence could lead to more personalized treatments. En ligne : http://dx.doi.org/10.1002/aur.2577 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood / E. DE WATER in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.1010-1020 Titre : A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood Type de document : Texte imprimé et/ou numérique Auteurs : E. DE WATER, Auteur ; P. CURTIN, Auteur ; A. ZILVERSTAND, Auteur ; A. SJODIN, Auteur ; A. BONILLA, Auteur ; J. B. HERBSTMAN, Auteur ; J. RAMIREZ, Auteur ; A. E. MARGOLIS, Auteur ; R. BANSAL, Auteur ; R. M. WHYATT, Auteur ; B. S. PETERSON, Auteur ; P. FACTOR-LITVAK, Auteur ; M. K. HORTON, Auteur Article en page(s) : p.1010-1020 Langues : Anglais (eng) Mots-clés : Children  executive functioning  flame retardants  pregnancy  resting state fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The prenatal period is a period of vulnerability during which neurotoxic exposures exert persistent changes in brain development and behavior. Polybrominated diphenyl ethers (PBDEs), used as flame retardants in commercial products, are known to be developmental neurotoxicants. PBDEs were phased out of use in the United States a decade ago, but exposure remains widespread due to their release from existing products and biopersistence. Despite consistent animal and epidemiological evidence of developmental neurotoxicity, the neural substrates linking prenatal PBDE serum concentrations to impaired neurodevelopment are poorly understood. METHODS: In the present study, we used resting state functional magnetic resonance imaging (fMRI) to examine associations between prenatal PBDE concentrations measured in maternal serum and intrinsic functional network organization (i.e., global and local efficiency; estimated using a graph-theoretical approach) in 5-year-old children (n = 34). We explored whether PBDE serum concentrations were associated with executive functioning (EF) assessed using a parent-report questionnaire (BRIEF-P) (n = 106) and whether changes in intrinsic functional network organization linked the association between prenatal PBDE serum concentrations and EF problems. RESULTS: Children with higher prenatal PBDE serum concentrations showed: (a) increased global efficiency of brain areas involved in visual attention (e.g., inferior occipital gyrus) (beta's = .01, FDR-corrected p's En ligne : http://dx.doi.org/10.1111/jcpp.13040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood [Texte imprimé et/ou numérique] / E. DE WATER, Auteur ; P. CURTIN, Auteur ; A. ZILVERSTAND, Auteur ; A. SJODIN, Auteur ; A. BONILLA, Auteur ; J. B. HERBSTMAN, Auteur ; J. RAMIREZ, Auteur ; A. E. MARGOLIS, Auteur ; R. BANSAL, Auteur ; R. M. WHYATT, Auteur ; B. S. PETERSON, Auteur ; P. FACTOR-LITVAK, Auteur ; M. K. HORTON, Auteur . - p.1010-1020. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.1010-1020 Mots-clés : Children  executive functioning  flame retardants  pregnancy  resting state fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The prenatal period is a period of vulnerability during which neurotoxic exposures exert persistent changes in brain development and behavior. Polybrominated diphenyl ethers (PBDEs), used as flame retardants in commercial products, are known to be developmental neurotoxicants. PBDEs were phased out of use in the United States a decade ago, but exposure remains widespread due to their release from existing products and biopersistence. Despite consistent animal and epidemiological evidence of developmental neurotoxicity, the neural substrates linking prenatal PBDE serum concentrations to impaired neurodevelopment are poorly understood. METHODS: In the present study, we used resting state functional magnetic resonance imaging (fMRI) to examine associations between prenatal PBDE concentrations measured in maternal serum and intrinsic functional network organization (i.e., global and local efficiency; estimated using a graph-theoretical approach) in 5-year-old children (n = 34). We explored whether PBDE serum concentrations were associated with executive functioning (EF) assessed using a parent-report questionnaire (BRIEF-P) (n = 106) and whether changes in intrinsic functional network organization linked the association between prenatal PBDE serum concentrations and EF problems. RESULTS: Children with higher prenatal PBDE serum concentrations showed: (a) increased global efficiency of brain areas involved in visual attention (e.g., inferior occipital gyrus) (beta's = .01, FDR-corrected p's En ligne : http://dx.doi.org/10.1111/jcpp.13040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

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