Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder / Yumi UMESAWA in Journal of Autism and Developmental Disorders, 50-8 (August 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2710-2722 Titre : Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Yumi UMESAWA, Auteur ; Kanae MATSUSHIMA, Auteur ; Takeshi ATSUMI, Auteur ; Toshihiro KATO, Auteur ; Reiko FUKATSU, Auteur ; Makoto WADA, Auteur ; Masakazu IDE, Auteur Article en page(s) : p.2710-2722 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Developmental coordination disorder  Gamma-aminobutyric acid  Magnetic resonance spectroscopy  Primary motor area  Supplementary motor area Index. décimale : PER Périodiques Résumé : Several motor disabilities accompanied with autism spectrum disorder (ASD) are widely known despite limited reports of underlying neural mechanisms. Gamma-aminobutyric acid (GABA) levels in the motor-related cortical areas modulate several motor performances in healthy participants. We hypothesized that abnormal GABA concentrations in the primary motor area (M1) and supplementary motor area (SMA) associate with different motor difficulties for ASD adolescents/adults. We found that increased GABA concentrations in M1 measured using (1)H-magnetic resonance spectroscopy exhibited lower motor performance in tasks requiring increased muscle strength while lower GABA concentrations in SMA were associated with lower scores in tests measuring body coordination. The degrees of neural inhibition in the M1 and SMA regions would contribute to different dimensions of motor disabilities in autism. En ligne : http://dx.doi.org/10.1007/s10803-020-04382-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428 [article] Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder [texte imprimé] / Yumi UMESAWA, Auteur ; Kanae MATSUSHIMA, Auteur ; Takeshi ATSUMI, Auteur ; Toshihiro KATO, Auteur ; Reiko FUKATSU, Auteur ; Makoto WADA, Auteur ; Masakazu IDE, Auteur . - p.2710-2722. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2710-2722 Mots-clés : Autism spectrum disorder  Developmental coordination disorder  Gamma-aminobutyric acid  Magnetic resonance spectroscopy  Primary motor area  Supplementary motor area Index. décimale : PER Périodiques Résumé : Several motor disabilities accompanied with autism spectrum disorder (ASD) are widely known despite limited reports of underlying neural mechanisms. Gamma-aminobutyric acid (GABA) levels in the motor-related cortical areas modulate several motor performances in healthy participants. We hypothesized that abnormal GABA concentrations in the primary motor area (M1) and supplementary motor area (SMA) associate with different motor difficulties for ASD adolescents/adults. We found that increased GABA concentrations in M1 measured using (1)H-magnetic resonance spectroscopy exhibited lower motor performance in tasks requiring increased muscle strength while lower GABA concentrations in SMA were associated with lower scores in tests measuring body coordination. The degrees of neural inhibition in the M1 and SMA regions would contribute to different dimensions of motor disabilities in autism. En ligne : http://dx.doi.org/10.1007/s10803-020-04382-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428

Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review / Fumi MASUDA in Autism, 23-7 (October 2019)  

Public ISBD [article]  inAutism > 23-7 (October 2019) . - p.1614-1629 Titre : Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review Type de document : texte imprimé Auteurs : Fumi MASUDA, Auteur ; Shinichiro NAKAJIMA, Auteur ; Takahiro MIYAZAKI, Auteur ; Ryosuke TARUMI, Auteur ; Kamiyu OGYU, Auteur ; Makoto WADA, Auteur ; Sakiko TSUGAWA, Auteur ; P.E. CROARKIN, Auteur ; Masaru MIMURA, Auteur ; Yoshihiro NODA, Auteur Article en page(s) : p.1614-1629 Langues : Anglais (eng) Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  children and adolescents  neurodevelopmental disorders  repetitive transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders, including autism spectrum disorder, are common in children and adolescents, but treatment strategies remain limited. Although repetitive transcranial magnetic stimulation has been studied for neurodevelopmental disorders, there is no clear consensus on its therapeutic effects. This systematic review examined literature on repetitive transcranial magnetic stimulation for children and adolescents with neurodevelopmental disorders published up to 2018 using the PubMed database. The search identified 264 articles and 14 articles met eligibility criteria. Twelve of these studies used conventional repetitive transcranial magnetic stimulation and two studies used theta burst stimulation. No severe adverse effects were reported in these studies. In patients with autism spectrum disorder, low-frequency repetitive transcranial magnetic stimulation and intermittent theta burst stimulation applied to the dorsolateral prefrontal cortex may have therapeutic effects on social functioning and repetitive behaviors. In patients with attention deficit/hyperactivity disorder, low-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex and high-frequency repetitive transcranial magnetic stimulation applied to the right dorsolateral prefrontal cortex may target inattention, hyperactivity, and impulsivity. In patients with tic disorders, low-frequency repetitive transcranial magnetic stimulation applied to the bilateral supplementary motor area improved tic symptom severity. This systematic review suggests that repetitive transcranial magnetic stimulation may be a promising intervention for children and adolescents with neurodevelopmental disorders. The results warrant further large randomized controlled trials of repetitive transcranial magnetic stimulation in children with neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1177/1362361318822502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review [texte imprimé] / Fumi MASUDA, Auteur ; Shinichiro NAKAJIMA, Auteur ; Takahiro MIYAZAKI, Auteur ; Ryosuke TARUMI, Auteur ; Kamiyu OGYU, Auteur ; Makoto WADA, Auteur ; Sakiko TSUGAWA, Auteur ; P.E. CROARKIN, Auteur ; Masaru MIMURA, Auteur ; Yoshihiro NODA, Auteur . - p.1614-1629. Langues : Anglais (eng) in Autism > 23-7 (October 2019) . - p.1614-1629 Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  children and adolescents  neurodevelopmental disorders  repetitive transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders, including autism spectrum disorder, are common in children and adolescents, but treatment strategies remain limited. Although repetitive transcranial magnetic stimulation has been studied for neurodevelopmental disorders, there is no clear consensus on its therapeutic effects. This systematic review examined literature on repetitive transcranial magnetic stimulation for children and adolescents with neurodevelopmental disorders published up to 2018 using the PubMed database. The search identified 264 articles and 14 articles met eligibility criteria. Twelve of these studies used conventional repetitive transcranial magnetic stimulation and two studies used theta burst stimulation. No severe adverse effects were reported in these studies. In patients with autism spectrum disorder, low-frequency repetitive transcranial magnetic stimulation and intermittent theta burst stimulation applied to the dorsolateral prefrontal cortex may have therapeutic effects on social functioning and repetitive behaviors. In patients with attention deficit/hyperactivity disorder, low-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex and high-frequency repetitive transcranial magnetic stimulation applied to the right dorsolateral prefrontal cortex may target inattention, hyperactivity, and impulsivity. In patients with tic disorders, low-frequency repetitive transcranial magnetic stimulation applied to the bilateral supplementary motor area improved tic symptom severity. This systematic review suggests that repetitive transcranial magnetic stimulation may be a promising intervention for children and adolescents with neurodevelopmental disorders. The results warrant further large randomized controlled trials of repetitive transcranial magnetic stimulation in children with neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1177/1362361318822502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Higher Tactile Temporal Resolution as a Basis of Hypersensitivity in Individuals with Autism Spectrum Disorder / Masayuki IDE in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.44-53 Titre : Higher Tactile Temporal Resolution as a Basis of Hypersensitivity in Individuals with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Masayuki IDE, Auteur ; Ayako YAGUCHI, Auteur ; Misako SANO, Auteur ; Reiko FUKATSU, Auteur ; Makoto WADA, Auteur Article en page(s) : p.44-53 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Detection threshold/sensitivity  E/I imbalance  Hypersensitivity  Tactile  Temporal order judgment Index. décimale : PER Périodiques Résumé : Many individuals with autism spectrum disorder (ASD) have symptoms of sensory hypersensitivity. Several studies have shown high individual variations in temporal processing of tactile stimuli. We hypothesized that these individual differences are linked to differences in hyper-reactivity among individuals with ASD. Participants performed two tasks as to vibrotactile stimuli: One is a temporal order judgement task, and another is a detection task. We found that individuals with ASD with higher temporal resolution tended to have more severe hypersensitivity symptoms. In contrast, the tactile detection threshold/sensitivity were related to the severities of stereotyped behaviour and restricted interests, rather than to hypersensitivity. Our findings demonstrate that higher temporal resolution to sensory stimuli may contribute to sensory hypersensitivity in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3677-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] Higher Tactile Temporal Resolution as a Basis of Hypersensitivity in Individuals with Autism Spectrum Disorder [texte imprimé] / Masayuki IDE, Auteur ; Ayako YAGUCHI, Auteur ; Misako SANO, Auteur ; Reiko FUKATSU, Auteur ; Makoto WADA, Auteur . - p.44-53. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.44-53 Mots-clés : Autism spectrum disorder  Detection threshold/sensitivity  E/I imbalance  Hypersensitivity  Tactile  Temporal order judgment Index. décimale : PER Périodiques Résumé : Many individuals with autism spectrum disorder (ASD) have symptoms of sensory hypersensitivity. Several studies have shown high individual variations in temporal processing of tactile stimuli. We hypothesized that these individual differences are linked to differences in hyper-reactivity among individuals with ASD. Participants performed two tasks as to vibrotactile stimuli: One is a temporal order judgement task, and another is a detection task. We found that individuals with ASD with higher temporal resolution tended to have more severe hypersensitivity symptoms. In contrast, the tactile detection threshold/sensitivity were related to the severities of stereotyped behaviour and restricted interests, rather than to hypersensitivity. Our findings demonstrate that higher temporal resolution to sensory stimuli may contribute to sensory hypersensitivity in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3677-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

No differences in implicit hand maps among different degrees of autistic traits / Souta HIDAKA in Autism Research, 16-9 (September 2023)  

Public ISBD [article]  inAutism Research > 16-9 (September 2023) . - p.1750-1764 Titre : No differences in implicit hand maps among different degrees of autistic traits Type de document : texte imprimé Auteurs : Souta HIDAKA, Auteur ; Na CHEN, Auteur ; Naomi ISHII, Auteur ; Risa IKETANI, Auteur ; Kirino SUZUKI, Auteur ; Matthew R. LONGO, Auteur ; Makoto WADA, Auteur Article en page(s) : p.1750-1764 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract People with autism spectrum disorder (ASD) or higher levels of autistic traits have atypical characteristics in sensory processing. Atypicalities have been reported for proprioceptive judgments, which are tightly related to internal bodily representations underlying position sense. However, no research has directly investigated whether self-bodily representations are different in individuals with ASD. Implicit hand maps, estimated based on participants' proprioceptive sensations without sight of their hand, are known to be distorted such that the shape is stretched along the medio-lateral hand axis even for neurotypical participants. Here, with the view of ASD as falling on a continuous distribution among the general population, we explored differences in implicit body representations along with autistic traits by focusing on relationships between autistic traits and the magnitudes of the distortions in implicit hand maps (N?~ 100). We estimated the magnitudes of distortions in implicit hand maps both for fingers and hand surfaces on the dorsal and palmar sides of the hand. Autistic traits were measured by questionnaires (Autism Spectrum [AQ] and Empathy/Systemizing [EQ-SQ] Quotients). The distortions in implicit hand maps were replicated in our experimental situations. However, there were no significant relationships between autistic traits and the magnitudes of the distortions as well as within-individual variabilities in the maps and localization performances. Consistent results were observed from comparisons between IQ-matched samples of people with and without a diagnosis of ASD. Our findings suggest that there exist perceptual and neural processes for implicit body representations underlying position sense consistent across levels of autistic traits. En ligne : https://doi.org/10.1002/aur.2979 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] No differences in implicit hand maps among different degrees of autistic traits [texte imprimé] / Souta HIDAKA, Auteur ; Na CHEN, Auteur ; Naomi ISHII, Auteur ; Risa IKETANI, Auteur ; Kirino SUZUKI, Auteur ; Matthew R. LONGO, Auteur ; Makoto WADA, Auteur . - p.1750-1764. Langues : Anglais (eng) in Autism Research > 16-9 (September 2023) . - p.1750-1764 Index. décimale : PER Périodiques Résumé : Abstract People with autism spectrum disorder (ASD) or higher levels of autistic traits have atypical characteristics in sensory processing. Atypicalities have been reported for proprioceptive judgments, which are tightly related to internal bodily representations underlying position sense. However, no research has directly investigated whether self-bodily representations are different in individuals with ASD. Implicit hand maps, estimated based on participants' proprioceptive sensations without sight of their hand, are known to be distorted such that the shape is stretched along the medio-lateral hand axis even for neurotypical participants. Here, with the view of ASD as falling on a continuous distribution among the general population, we explored differences in implicit body representations along with autistic traits by focusing on relationships between autistic traits and the magnitudes of the distortions in implicit hand maps (N?~ 100). We estimated the magnitudes of distortions in implicit hand maps both for fingers and hand surfaces on the dorsal and palmar sides of the hand. Autistic traits were measured by questionnaires (Autism Spectrum [AQ] and Empathy/Systemizing [EQ-SQ] Quotients). The distortions in implicit hand maps were replicated in our experimental situations. However, there were no significant relationships between autistic traits and the magnitudes of the distortions as well as within-individual variabilities in the maps and localization performances. Consistent results were observed from comparisons between IQ-matched samples of people with and without a diagnosis of ASD. Our findings suggest that there exist perceptual and neural processes for implicit body representations underlying position sense consistent across levels of autistic traits. En ligne : https://doi.org/10.1002/aur.2979 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Weakened Bayesian Calibration for Tactile Temporal Order Judgment in Individuals with Higher Autistic Traits / Makoto WADA in Journal of Autism and Developmental Disorders, 53-1 (January 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-1 (January 2023) . - p.378-389 Titre : Weakened Bayesian Calibration for Tactile Temporal Order Judgment in Individuals with Higher Autistic Traits Type de document : texte imprimé Auteurs : Makoto WADA, Auteur ; Yumi UMESAWA, Auteur ; Misako SANO, Auteur ; Seiki TAJIMA, Auteur ; Shinichiro KUMAGAYA, Auteur ; Makoto MIYAZAKI, Auteur Article en page(s) : p.378-389 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous psychophysical studies reported a positive aftereffect in tactile temporal order judgments, which can be explained by the Bayesian estimation model ( ËœBayesian calibration’). We investigated the relationship between Bayesian calibration and autistic traits in participants with typical development (TD) and autism spectrum disorder (ASD). Bayesian calibration was weakened in TD participants with high autistic traits, consistent with the Ëœhypo-priors’ hypothesis for autistic perceptions. The results from the ASD group were generally observed as a continuation of those from the TD groups. Meanwhile, two ASD participants showed irregularly large positive or negative aftereffects. We discussed the mechanisms behind the general results among TD and ASD participants and two particular results among ASD participants based on the Bayesian estimation model. En ligne : https://doi.org/10.1007/s10803-022-05442-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Weakened Bayesian Calibration for Tactile Temporal Order Judgment in Individuals with Higher Autistic Traits [texte imprimé] / Makoto WADA, Auteur ; Yumi UMESAWA, Auteur ; Misako SANO, Auteur ; Seiki TAJIMA, Auteur ; Shinichiro KUMAGAYA, Auteur ; Makoto MIYAZAKI, Auteur . - p.378-389. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-1 (January 2023) . - p.378-389 Index. décimale : PER Périodiques Résumé : Previous psychophysical studies reported a positive aftereffect in tactile temporal order judgments, which can be explained by the Bayesian estimation model ( ËœBayesian calibration’). We investigated the relationship between Bayesian calibration and autistic traits in participants with typical development (TD) and autism spectrum disorder (ASD). Bayesian calibration was weakened in TD participants with high autistic traits, consistent with the Ëœhypo-priors’ hypothesis for autistic perceptions. The results from the ASD group were generally observed as a continuation of those from the TD groups. Meanwhile, two ASD participants showed irregularly large positive or negative aftereffects. We discussed the mechanisms behind the general results among TD and ASD participants and two particular results among ASD participants based on the Bayesian estimation model. En ligne : https://doi.org/10.1007/s10803-022-05442-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

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