Can a Community-Based Football Program Benefit Motor Ability in Children with Autism Spectrum Disorder? A Pilot Evaluation Considering the Role of Social Impairments / K. HOWELLS in Journal of Autism and Developmental Disorders, 52-1 (January 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.402-413 Titre : Can a Community-Based Football Program Benefit Motor Ability in Children with Autism Spectrum Disorder? A Pilot Evaluation Considering the Role of Social Impairments Type de document : texte imprimé Auteurs : K. HOWELLS, Auteur ; Carmel SIVARATNAM, Auteur ; Ebony LINDOR, Auteur ; Jason HE, Auteur ; Carly HYDE, Auteur ; Jane MCGILLIVRAY, Auteur ; Rujuta B. WILSON, Auteur ; Nicole J. RINEHART, Auteur Article en page(s) : p.402-413 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Football  Humans  Motor Skills  Pilot Projects  Soccer  Autism spectrum disorders  Community-based  Motor ability  Organised physical activity  Social skills Index. décimale : PER Périodiques Résumé : This non-randomised pilot study evaluated the impact of a community football program on motor ability in children aged 5-12 years with autism spectrum disorder. Sixteen children were evaluated at baseline-and-post attendance in a football program for a varied number of weeks and compared to 19 children engaging in treatment-as-usual. Primary analyses indicated a statistically significant increase in total MABC-2, aiming and catching, and balance scores for the intervention group, with no changes in scores in the comparison group. There were no changes in manual dexterity across either group. At a between group level, the changes in aiming and catching scores were significantly greater for the intervention group. Further analyses highlighted the potential importance of social impairments regarding aiming and catching. En ligne : http://dx.doi.org/10.1007/s10803-021-04933-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Can a Community-Based Football Program Benefit Motor Ability in Children with Autism Spectrum Disorder? A Pilot Evaluation Considering the Role of Social Impairments [texte imprimé] / K. HOWELLS, Auteur ; Carmel SIVARATNAM, Auteur ; Ebony LINDOR, Auteur ; Jason HE, Auteur ; Carly HYDE, Auteur ; Jane MCGILLIVRAY, Auteur ; Rujuta B. WILSON, Auteur ; Nicole J. RINEHART, Auteur . - p.402-413. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.402-413 Mots-clés : Autism Spectrum Disorder  Child  Football  Humans  Motor Skills  Pilot Projects  Soccer  Autism spectrum disorders  Community-based  Motor ability  Organised physical activity  Social skills Index. décimale : PER Périodiques Résumé : This non-randomised pilot study evaluated the impact of a community football program on motor ability in children aged 5-12 years with autism spectrum disorder. Sixteen children were evaluated at baseline-and-post attendance in a football program for a varied number of weeks and compared to 19 children engaging in treatment-as-usual. Primary analyses indicated a statistically significant increase in total MABC-2, aiming and catching, and balance scores for the intervention group, with no changes in scores in the comparison group. There were no changes in manual dexterity across either group. At a between group level, the changes in aiming and catching scores were significantly greater for the intervention group. Further analyses highlighted the potential importance of social impairments regarding aiming and catching. En ligne : http://dx.doi.org/10.1007/s10803-021-04933-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Clinical determinants of psychiatric care in genetic neurodevelopmental disorders: a cross-sectional analysis / David J. ADAMS in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Clinical determinants of psychiatric care in genetic neurodevelopmental disorders: a cross-sectional analysis Type de document : texte imprimé Auteurs : David J. ADAMS, Auteur ; Alexandra M. KLOMHAUS, Auteur ; Nicole R. WONG, Auteur ; Benjamin N. SCHNEIDER, Auteur ; Charlotte DISTEFANO, Auteur ; Sunil MEHTA, Auteur ; Rujuta B. WILSON, Auteur ; Julian A. MARTINEZ-AGOSTO, Auteur ; Shafali S. JESTE, Auteur ; Aaron D. BESTERMAN, Auteur Langues : Anglais (eng) Mots-clés : Genetic testing  Multidisciplinary care  Neurodevelopmental disorders  Neuropsychiatry  Precision medicine  granted by the UCLA Medical Institutional Review Board 3. One-hundred-ten  patients and/or their legal guardians provided informed consent for prospective  collection of clinical data (UCLA IRB#: 14-001908). With an IRB-approved waiver  of consent, the charts of an additional 206 patients were retrospectively  reviewed (UCLA IRB#: 19–000121). Consent for publication: Not applicable.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: This study aims to identify clinical and developmental factors associated with psychotropic medication exposure and subspecialty psychiatric service utilization among patients with genetic neurodevelopmental disorders (GNDDs). METHODS: We conducted a retrospective analysis of 316 patients from the Care and Research in Neurogenetics (CARING) Clinic at the University of California, Los Angeles (UCLA). We assessed the association between neurodevelopmental and psychiatric diagnoses, behavioral histories, family history, and service utilization with two outcomes: (1) the number of psychotropic medication classes trialed before clinic intake and (2) whether the patient was evaluated by a CARING psychiatrist. Poisson and logistic regression models were used to evaluate associations while adjusting for demographic and clinical covariates. RESULTS: Individuals with more severe behavioral disturbances had higher psychiatric service needs, while intellectual disability was associated with greater psychotropic medication exposure but not increased psychiatric consultation, possibly due to prior community-based care. The presence of a pathogenic/likely pathogenic genetic variant was not associated with either outcome, suggesting that genetic diagnosis alone does not predict psychiatric needs. Instead, behavioral comorbidities, not genetic status, were the primary drivers of psychotropic use and psychiatric referrals. A history of developmental delay was negatively associated with psychiatric consultation, and mediation analyses indicated that early intervention services partly explained this relationship. Additionally, patients receiving behavioral therapies had higher psychotropic exposure, reflecting greater clinical complexity and frequent use of multimodal treatment strategies. CONCLUSIONS: Our findings suggest that psychiatric needs in GNDDs are more closely tied to behavioral comorbidities than to genetic diagnosis status, reinforcing the importance of symptom-driven psychiatric evaluation. The observed relationship between early developmental interventions and psychiatric service utilization warrants further longitudinal investigation. These results highlight opportunities to optimize psychiatric care pathways through early screening, integrated behavioral and pharmacologic interventions, and targeted resource allocation for individuals with neurodevelopmental disorders. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-025-09654-0. En ligne : https://dx.doi.org/10.1186/s11689-025-09654-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Clinical determinants of psychiatric care in genetic neurodevelopmental disorders: a cross-sectional analysis [texte imprimé] / David J. ADAMS, Auteur ; Alexandra M. KLOMHAUS, Auteur ; Nicole R. WONG, Auteur ; Benjamin N. SCHNEIDER, Auteur ; Charlotte DISTEFANO, Auteur ; Sunil MEHTA, Auteur ; Rujuta B. WILSON, Auteur ; Julian A. MARTINEZ-AGOSTO, Auteur ; Shafali S. JESTE, Auteur ; Aaron D. BESTERMAN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Genetic testing  Multidisciplinary care  Neurodevelopmental disorders  Neuropsychiatry  Precision medicine  granted by the UCLA Medical Institutional Review Board 3. One-hundred-ten  patients and/or their legal guardians provided informed consent for prospective  collection of clinical data (UCLA IRB#: 14-001908). With an IRB-approved waiver  of consent, the charts of an additional 206 patients were retrospectively  reviewed (UCLA IRB#: 19–000121). Consent for publication: Not applicable.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: This study aims to identify clinical and developmental factors associated with psychotropic medication exposure and subspecialty psychiatric service utilization among patients with genetic neurodevelopmental disorders (GNDDs). METHODS: We conducted a retrospective analysis of 316 patients from the Care and Research in Neurogenetics (CARING) Clinic at the University of California, Los Angeles (UCLA). We assessed the association between neurodevelopmental and psychiatric diagnoses, behavioral histories, family history, and service utilization with two outcomes: (1) the number of psychotropic medication classes trialed before clinic intake and (2) whether the patient was evaluated by a CARING psychiatrist. Poisson and logistic regression models were used to evaluate associations while adjusting for demographic and clinical covariates. RESULTS: Individuals with more severe behavioral disturbances had higher psychiatric service needs, while intellectual disability was associated with greater psychotropic medication exposure but not increased psychiatric consultation, possibly due to prior community-based care. The presence of a pathogenic/likely pathogenic genetic variant was not associated with either outcome, suggesting that genetic diagnosis alone does not predict psychiatric needs. Instead, behavioral comorbidities, not genetic status, were the primary drivers of psychotropic use and psychiatric referrals. A history of developmental delay was negatively associated with psychiatric consultation, and mediation analyses indicated that early intervention services partly explained this relationship. Additionally, patients receiving behavioral therapies had higher psychotropic exposure, reflecting greater clinical complexity and frequent use of multimodal treatment strategies. CONCLUSIONS: Our findings suggest that psychiatric needs in GNDDs are more closely tied to behavioral comorbidities than to genetic diagnosis status, reinforcing the importance of symptom-driven psychiatric evaluation. The observed relationship between early developmental interventions and psychiatric service utilization warrants further longitudinal investigation. These results highlight opportunities to optimize psychiatric care pathways through early screening, integrated behavioral and pharmacologic interventions, and targeted resource allocation for individuals with neurodevelopmental disorders. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-025-09654-0. En ligne : https://dx.doi.org/10.1186/s11689-025-09654-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Quantitative Gait Analysis in Duplication 15q Syndrome and Nonsyndromic ASD / Rujuta B. WILSON in Autism Research, 13-7 (July 2020)  

Public ISBD [article]  inAutism Research > 13-7 (July 2020) . - p.1102-1110 Titre : Quantitative Gait Analysis in Duplication 15q Syndrome and Nonsyndromic ASD Type de document : texte imprimé Auteurs : Rujuta B. WILSON, Auteur ; David ELASHOFF, Auteur ; Arnaud GOUELLE, Auteur ; Beth A. SMITH, Auteur ; Andrew M. WILSON, Auteur ; Abigail DICKINSON, Auteur ; Tabitha SAFARI, Auteur ; Carly HYDE, Auteur ; Shafali S. JESTE, Auteur Article en page(s) : p.1102-1110 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  duplication 15q syndrome  gait function  genetic syndrome  motor impairments  quantitative gait analysis Index. décimale : PER Périodiques Résumé : Motor impairments occur frequently in genetic syndromes highly penetrant for autism spectrum disorder (syndromic ASD) and in individuals with ASD without a genetic diagnosis (nonsyndromic ASD). In particular, abnormalities in gait in ASD have been linked to language delay, ASD severity, and likelihood of having a genetic disorder. Quantitative measures of motor function can improve our ability to evaluate motor differences in individuals with syndromic and nonsyndromic ASD with varying levels of intellectual disability and adaptive skills. To evaluate this methodology, we chose to use quantitative gait analysis to study duplication 15q syndrome (dup15q syndrome), a genetic disorder highly penetrant for motor delays, intellectual disability, and ASD. We evaluated quantitative gait variables in individuals with dup15q syndrome (n = 39) and nonsyndromic ASD (n = 21) and compared these data to a reference typically developing cohort. We found a gait pattern of slow pace, poor postural control, and large gait variability in dup15q syndrome. Our findings improve characterization of motor function in dup15q syndrome and nonsyndromic ASD. Quantitative gait analysis can be used as a translational method and can improve our identification of clinical endpoints to be used in treatment trials for these syndromes. Autism Res 2020, 13: 1102-1110. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Motor impairments, particularly abnormalities in walking, occur frequently in genetic syndromes highly penetrant for autism spectrum disorder (syndromic ASD). Here, using quantitative gait analysis, we find that individuals with duplication 15q syndrome have an atypical gait pattern that differentiates them from typically developing and nonsyndromic ASD individuals. Our findings improve motor characterization in dup15q syndrome and nonsyndromic ASD. En ligne : http://dx.doi.org/10.1002/aur.2298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Quantitative Gait Analysis in Duplication 15q Syndrome and Nonsyndromic ASD [texte imprimé] / Rujuta B. WILSON, Auteur ; David ELASHOFF, Auteur ; Arnaud GOUELLE, Auteur ; Beth A. SMITH, Auteur ; Andrew M. WILSON, Auteur ; Abigail DICKINSON, Auteur ; Tabitha SAFARI, Auteur ; Carly HYDE, Auteur ; Shafali S. JESTE, Auteur . - p.1102-1110. Langues : Anglais (eng) in Autism Research > 13-7 (July 2020) . - p.1102-1110 Mots-clés : autism spectrum disorder  duplication 15q syndrome  gait function  genetic syndrome  motor impairments  quantitative gait analysis Index. décimale : PER Périodiques Résumé : Motor impairments occur frequently in genetic syndromes highly penetrant for autism spectrum disorder (syndromic ASD) and in individuals with ASD without a genetic diagnosis (nonsyndromic ASD). In particular, abnormalities in gait in ASD have been linked to language delay, ASD severity, and likelihood of having a genetic disorder. Quantitative measures of motor function can improve our ability to evaluate motor differences in individuals with syndromic and nonsyndromic ASD with varying levels of intellectual disability and adaptive skills. To evaluate this methodology, we chose to use quantitative gait analysis to study duplication 15q syndrome (dup15q syndrome), a genetic disorder highly penetrant for motor delays, intellectual disability, and ASD. We evaluated quantitative gait variables in individuals with dup15q syndrome (n = 39) and nonsyndromic ASD (n = 21) and compared these data to a reference typically developing cohort. We found a gait pattern of slow pace, poor postural control, and large gait variability in dup15q syndrome. Our findings improve characterization of motor function in dup15q syndrome and nonsyndromic ASD. Quantitative gait analysis can be used as a translational method and can improve our identification of clinical endpoints to be used in treatment trials for these syndromes. Autism Res 2020, 13: 1102-1110. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Motor impairments, particularly abnormalities in walking, occur frequently in genetic syndromes highly penetrant for autism spectrum disorder (syndromic ASD). Here, using quantitative gait analysis, we find that individuals with duplication 15q syndrome have an atypical gait pattern that differentiates them from typically developing and nonsyndromic ASD individuals. Our findings improve motor characterization in dup15q syndrome and nonsyndromic ASD. En ligne : http://dx.doi.org/10.1002/aur.2298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

What's missing in autism spectrum disorder motor assessments? / Rujuta B. WILSON in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 33 p. Titre : What's missing in autism spectrum disorder motor assessments? Type de document : texte imprimé Auteurs : Rujuta B. WILSON, Auteur ; James T. MCCRACKEN, Auteur ; Nicole J. RINEHART, Auteur ; Shafali S. JESTE, Auteur Année de publication : 2018 Article en page(s) : 33 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Motor assessments  Motor function  Quantitative motor measures Index. décimale : PER Périodiques Résumé : BACKGROUND: Motor delays and impairments in autism spectrum disorders (ASD) are extremely common and often herald the emergence of pervasive atypical development. Clinical accounts of ASD and standardized measures of motor function have identified deficits in multiple motor domains. However, literature describing frequently used standardized motor assessments in children with ASD, their test properties, and their limitations are sparse. METHODS: We systematically reviewed the literature to identify the most frequently used standardized motor assessments used to evaluate children with ASD from infancy to early childhood. All assessments included were required to possess reference norms, evaluate more than one motor domain, and have undergone some degree of validation. RESULTS: We identified six frequently used standardized measures of motor function per our inclusion and exclusion criteria. We investigated and described in detail the psychometric properties of these assessments, their utility for use with children with ASD, and their individual and overall strengths and limitations. The global strengths of these assessments are the ability to identify early development delays and differences in fine and gross motor function in children with ASD. Global limitations of these studies are lack of validation in individuals with ASD and scoring systems that often miss specific and subtle abnormalities. CONCLUSIONS: Standardized assessments of motor function have provided valuable information on motor impairments in ASD. However, significant limitations remain in the use of these measures in children with ASD. Moving forward, it is imperative that standardized measures of motor function receive greater validation testing in children with ASD to assess their potential application given the clinical heterogeneity of this condition. In addition, utilizing quantitative measures of motor function should allow for evaluation and comparison of individuals with ASD across the lifespan with varying cognitive and behavioral abilities. En ligne : http://dx.doi.org/10.1186/s11689-018-9257-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] What's missing in autism spectrum disorder motor assessments? [texte imprimé] / Rujuta B. WILSON, Auteur ; James T. MCCRACKEN, Auteur ; Nicole J. RINEHART, Auteur ; Shafali S. JESTE, Auteur . - 2018 . - 33 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 33 p. Mots-clés : Autism spectrum disorder  Motor assessments  Motor function  Quantitative motor measures Index. décimale : PER Périodiques Résumé : BACKGROUND: Motor delays and impairments in autism spectrum disorders (ASD) are extremely common and often herald the emergence of pervasive atypical development. Clinical accounts of ASD and standardized measures of motor function have identified deficits in multiple motor domains. However, literature describing frequently used standardized motor assessments in children with ASD, their test properties, and their limitations are sparse. METHODS: We systematically reviewed the literature to identify the most frequently used standardized motor assessments used to evaluate children with ASD from infancy to early childhood. All assessments included were required to possess reference norms, evaluate more than one motor domain, and have undergone some degree of validation. RESULTS: We identified six frequently used standardized measures of motor function per our inclusion and exclusion criteria. We investigated and described in detail the psychometric properties of these assessments, their utility for use with children with ASD, and their individual and overall strengths and limitations. The global strengths of these assessments are the ability to identify early development delays and differences in fine and gross motor function in children with ASD. Global limitations of these studies are lack of validation in individuals with ASD and scoring systems that often miss specific and subtle abnormalities. CONCLUSIONS: Standardized assessments of motor function have provided valuable information on motor impairments in ASD. However, significant limitations remain in the use of these measures in children with ASD. Moving forward, it is imperative that standardized measures of motor function receive greater validation testing in children with ASD to assess their potential application given the clinical heterogeneity of this condition. In addition, utilizing quantitative measures of motor function should allow for evaluation and comparison of individuals with ASD across the lifespan with varying cognitive and behavioral abilities. En ligne : http://dx.doi.org/10.1186/s11689-018-9257-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

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