Mapping the Relationship between Dysmorphology and Cognitive, Behavioral, and Developmental Outcomes in Children with Autism Spectrum Disorder / Lin H. TIAN in Autism Research, 13-7 (July 2020)  

Public ISBD [article]  inAutism Research > 13-7 (July 2020) . - p.1227-1238 Titre : Mapping the Relationship between Dysmorphology and Cognitive, Behavioral, and Developmental Outcomes in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lin H. TIAN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Patricia M. DIETZ, Auteur ; Arthur S. AYLSWORTH, Auteur ; Ellen R. ELIAS, Auteur ; Julie E. HOOVER-FONG, Auteur ; Naomi J. L. MEEKS, Auteur ; Margaret C. SOUDERS, Auteur ; Anne C. H. TSAI, Auteur ; Elaine H. ZACKAI, Auteur ; Aimee A. ALEXANDER, Auteur ; Nicole F. DOWLING, Auteur ; Stuart K. SHAPIRA, Auteur Article en page(s) : p.1227-1238 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  dysmorphic features  dysmorphology severity  intellectual disability  neurodevelopment Index. décimale : PER Périodiques Résumé : Previous studies investigating the association between dysmorphology and cognitive, behavioral, and developmental outcomes among individuals with autism spectrum disorder (ASD) have been limited by the binary classification of dysmorphology and lack of comparison groups. We assessed the association using a continuous measure of dysmorphology severity (DS) in preschool children aged 2-5?years (322 with ASD and intellectual disability [ID], 188 with ASD without ID, and 371 without ASD from the general population [POP]). In bivariate analyses, an inverse association between DS and expressive language, receptive language, fine motor, and visual reception skills was observed in children with ASD and ID. An inverse association of DS with fine motor and visual reception skills, but not expressive language and receptive language, was found in children with ASD without ID. No associations were observed in POP children. These results persisted after exclusion of children with known genetic syndromes or major morphologic anomalies. Quantile regression models showed that the inverse relationships remained significant after adjustment for sex, race/ethnicity, maternal education, family income, study site, and preterm birth. DS was not associated with autistic traits or autism symptom severity, behaviors, or regression among children with ASD with or without ID. Thus, DS was associated with a global impairment of cognitive functioning in children with ASD and ID, but only with fine motor and visual reception deficits in children with ASD without ID. A better understanding is needed for mechanisms that explain the association between DS and cognitive impairment in children with different disorders. Autism Res 2020, 13: 1227-1238. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We examined whether having more dysmorphic features (DFs) was related to developmental problems among children with autism spectrum disorder (ASD) with or without intellectual disability (ID), and children without ASD from the general population (POP). Children with ASD and ID had more language, movement, and learning issues as the number of DFs increased. Children with ASD without ID had more movement and learning issues as the number of DFs increased. These relationships were not observed in the POP group. Implications are discussed. En ligne : http://dx.doi.org/10.1002/aur.2314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Mapping the Relationship between Dysmorphology and Cognitive, Behavioral, and Developmental Outcomes in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lin H. TIAN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Patricia M. DIETZ, Auteur ; Arthur S. AYLSWORTH, Auteur ; Ellen R. ELIAS, Auteur ; Julie E. HOOVER-FONG, Auteur ; Naomi J. L. MEEKS, Auteur ; Margaret C. SOUDERS, Auteur ; Anne C. H. TSAI, Auteur ; Elaine H. ZACKAI, Auteur ; Aimee A. ALEXANDER, Auteur ; Nicole F. DOWLING, Auteur ; Stuart K. SHAPIRA, Auteur . - p.1227-1238. Langues : Anglais (eng) in Autism Research > 13-7 (July 2020) . - p.1227-1238 Mots-clés : autism spectrum disorder  dysmorphic features  dysmorphology severity  intellectual disability  neurodevelopment Index. décimale : PER Périodiques Résumé : Previous studies investigating the association between dysmorphology and cognitive, behavioral, and developmental outcomes among individuals with autism spectrum disorder (ASD) have been limited by the binary classification of dysmorphology and lack of comparison groups. We assessed the association using a continuous measure of dysmorphology severity (DS) in preschool children aged 2-5?years (322 with ASD and intellectual disability [ID], 188 with ASD without ID, and 371 without ASD from the general population [POP]). In bivariate analyses, an inverse association between DS and expressive language, receptive language, fine motor, and visual reception skills was observed in children with ASD and ID. An inverse association of DS with fine motor and visual reception skills, but not expressive language and receptive language, was found in children with ASD without ID. No associations were observed in POP children. These results persisted after exclusion of children with known genetic syndromes or major morphologic anomalies. Quantile regression models showed that the inverse relationships remained significant after adjustment for sex, race/ethnicity, maternal education, family income, study site, and preterm birth. DS was not associated with autistic traits or autism symptom severity, behaviors, or regression among children with ASD with or without ID. Thus, DS was associated with a global impairment of cognitive functioning in children with ASD and ID, but only with fine motor and visual reception deficits in children with ASD without ID. A better understanding is needed for mechanisms that explain the association between DS and cognitive impairment in children with different disorders. Autism Res 2020, 13: 1227-1238. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We examined whether having more dysmorphic features (DFs) was related to developmental problems among children with autism spectrum disorder (ASD) with or without intellectual disability (ID), and children without ASD from the general population (POP). Children with ASD and ID had more language, movement, and learning issues as the number of DFs increased. Children with ASD without ID had more movement and learning issues as the number of DFs increased. These relationships were not observed in the POP group. Implications are discussed. En ligne : http://dx.doi.org/10.1002/aur.2314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

The Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network / Diana SCHENDEL in Journal of Autism and Developmental Disorders, 42-10 (October 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2121-2140 Titre : The Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network Type de document : Texte imprimé et/ou numérique Auteurs : Diana SCHENDEL, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Phil REED, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa D. WIGGINS, Auteur ; Julie L. DANIELS, Auteur ; Judith K. GRETHER, Auteur ; Susan E. LEVY, Auteur ; Lisa MILLER, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; Cordelia ROBINSON, Auteur ; Gayle C. WINDHAM, Auteur ; Aimee A. ALEXANDER, Auteur ; Arthur S. AYLSWORTH, Auteur ; Pilar BERNAL, Auteur ; Joseph D. BONNER, Auteur ; Lisa BLASKEY, Auteur ; Chyrise BRADLEY, Auteur ; Jack COLLINS, Auteur ; Casara J. FERRETTI, Auteur ; Homayoon FARZADEGAN, Auteur ; Ellen GIARELLI, Auteur ; Marques HARVEY, Auteur ; Susan HEPBURN, Auteur ; Matthew HERR, Auteur ; Kristina KAPARICH, Auteur ; Rebecca LANDA, Auteur ; Li-Ching LEE, Auteur ; Brooke LEVENSELLER, Auteur ; Stacey MEYERER, Auteur ; Mohammad Hossein RAHBAR, Auteur ; Andria RATCHFORD, Auteur ; Ann REYNOLDS, Auteur ; Steven ROSENBERG, Auteur ; Julie RUSYNIAK, Auteur ; Stuart K. SHAPIRA, Auteur ; Karen S. SMITH, Auteur ; Margaret SOUDERS, Auteur ; Patrick Aaron THOMPSON, Auteur ; Lisa YOUNG, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur Année de publication : 2012 Article en page(s) : p.2121-2140 Langues : Anglais (eng) Mots-clés : Autism  Epidemiology  Study methods  Risk factors  Phenotype Index. décimale : PER Périodiques Résumé : The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to: (1) characterize the autism behavioral phenotype and associated developmental, medical, and behavioral conditions and (2) investigate genetic and environmental risks with emphasis on immunologic, hormonal, gastrointestinal, and sociodemographic characteristics. SEED uses a case–control design with population-based ascertainment of children aged 2–5 years with an autism spectrum disorder (ASD) and children in two control groups—one from the general population and one with non-ASD developmental problems. Data from parent-completed questionnaires, interviews, clinical evaluations, biospecimen sampling, and medical record abstraction focus on the prenatal and early postnatal periods. SEED is a valuable resource for testing hypotheses regarding ASD characteristics and causes. En ligne : http://dx.doi.org/10.1007/s10803-012-1461-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 [article] The Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network [Texte imprimé et/ou numérique] / Diana SCHENDEL, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Phil REED, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa D. WIGGINS, Auteur ; Julie L. DANIELS, Auteur ; Judith K. GRETHER, Auteur ; Susan E. LEVY, Auteur ; Lisa MILLER, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; Cordelia ROBINSON, Auteur ; Gayle C. WINDHAM, Auteur ; Aimee A. ALEXANDER, Auteur ; Arthur S. AYLSWORTH, Auteur ; Pilar BERNAL, Auteur ; Joseph D. BONNER, Auteur ; Lisa BLASKEY, Auteur ; Chyrise BRADLEY, Auteur ; Jack COLLINS, Auteur ; Casara J. FERRETTI, Auteur ; Homayoon FARZADEGAN, Auteur ; Ellen GIARELLI, Auteur ; Marques HARVEY, Auteur ; Susan HEPBURN, Auteur ; Matthew HERR, Auteur ; Kristina KAPARICH, Auteur ; Rebecca LANDA, Auteur ; Li-Ching LEE, Auteur ; Brooke LEVENSELLER, Auteur ; Stacey MEYERER, Auteur ; Mohammad Hossein RAHBAR, Auteur ; Andria RATCHFORD, Auteur ; Ann REYNOLDS, Auteur ; Steven ROSENBERG, Auteur ; Julie RUSYNIAK, Auteur ; Stuart K. SHAPIRA, Auteur ; Karen S. SMITH, Auteur ; Margaret SOUDERS, Auteur ; Patrick Aaron THOMPSON, Auteur ; Lisa YOUNG, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur . - 2012 . - p.2121-2140. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2121-2140 Mots-clés : Autism  Epidemiology  Study methods  Risk factors  Phenotype Index. décimale : PER Périodiques Résumé : The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to: (1) characterize the autism behavioral phenotype and associated developmental, medical, and behavioral conditions and (2) investigate genetic and environmental risks with emphasis on immunologic, hormonal, gastrointestinal, and sociodemographic characteristics. SEED uses a case–control design with population-based ascertainment of children aged 2–5 years with an autism spectrum disorder (ASD) and children in two control groups—one from the general population and one with non-ASD developmental problems. Data from parent-completed questionnaires, interviews, clinical evaluations, biospecimen sampling, and medical record abstraction focus on the prenatal and early postnatal periods. SEED is a valuable resource for testing hypotheses regarding ASD characteristics and causes. En ligne : http://dx.doi.org/10.1007/s10803-012-1461-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180

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