Caregiver sensitivity predicts infant language use, and infant language complexity predicts caregiver language complexity, in the context of possible emerging autism / Jodie SMITH in Autism Research, 16-4 (April 2023)  

Public ISBD [article]  inAutism Research > 16-4 (April 2023) . - p.745-756 Titre : Caregiver sensitivity predicts infant language use, and infant language complexity predicts caregiver language complexity, in the context of possible emerging autism Type de document : Texte imprimé et/ou numérique Auteurs : Jodie SMITH, Auteur ; Lacey CHETCUTI, Auteur ; Lyndel KENNEDY, Auteur ; Kandice J. VARCIN, Auteur ; Vicky SLONIMS, Auteur ; Catherine A. BENT, Auteur ; Jonathan GREEN, Auteur ; Teresa IACONO, Auteur ; Sarah PILLAR, Auteur ; Carol TAYLOR, Auteur ; Ming Wai WAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur ; the AICES TEAM, Auteur Article en page(s) : p.745-756 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract While theory supports bidirectional effects between caregiver sensitivity and language use, and infant language acquisition-both caregiver-to-infant and also infant-to-caregiver effects-empirical research has chiefly explored the former unidirectional path. In the context of infants showing early signs of autism, we investigated prospective bidirectional associations with 6-min free-play interaction samples collected for 103 caregivers and their infants (mean age 12-months; and followed up 6-months later). We anticipated that measures of caregiver sensitivity/language input and infant language would show within-domain temporal stability/continuity, but also that there would be predictive associations from earlier caregiver input to subsequent child language, and vice versa. Caregiver sensitive responsiveness (from the Manchester Assessment of Caregiver-Infant interaction [MACI]) predicted subsequent infant word tokens (i.e., amount of language, coded following the Systematic Analysis of Language Transcripts [SALT]). Further, earlier infant Mean Length of Utterance (MLU; reflecting language complexity, also derived from SALT coding) predicted later caregiver MLU, even when controlling for variability in infant ages and clear within-domain temporal stability/continuity in key measures (i.e., caregiver sensitive responsiveness and infant word tokens; and infant and caregiver MLU). These data add empirical support to theorization on how caregiver input can be both supportive of, and potentially influenced by, infant capacities, when infants have social-communication differences and/or communication/language delays suggestive of possible emerging autism. En ligne : https://doi.org/10.1002/aur.2879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Caregiver sensitivity predicts infant language use, and infant language complexity predicts caregiver language complexity, in the context of possible emerging autism [Texte imprimé et/ou numérique] / Jodie SMITH, Auteur ; Lacey CHETCUTI, Auteur ; Lyndel KENNEDY, Auteur ; Kandice J. VARCIN, Auteur ; Vicky SLONIMS, Auteur ; Catherine A. BENT, Auteur ; Jonathan GREEN, Auteur ; Teresa IACONO, Auteur ; Sarah PILLAR, Auteur ; Carol TAYLOR, Auteur ; Ming Wai WAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur ; the AICES TEAM, Auteur . - p.745-756. Langues : Anglais (eng) in Autism Research > 16-4 (April 2023) . - p.745-756 Index. décimale : PER Périodiques Résumé : Abstract While theory supports bidirectional effects between caregiver sensitivity and language use, and infant language acquisition-both caregiver-to-infant and also infant-to-caregiver effects-empirical research has chiefly explored the former unidirectional path. In the context of infants showing early signs of autism, we investigated prospective bidirectional associations with 6-min free-play interaction samples collected for 103 caregivers and their infants (mean age 12-months; and followed up 6-months later). We anticipated that measures of caregiver sensitivity/language input and infant language would show within-domain temporal stability/continuity, but also that there would be predictive associations from earlier caregiver input to subsequent child language, and vice versa. Caregiver sensitive responsiveness (from the Manchester Assessment of Caregiver-Infant interaction [MACI]) predicted subsequent infant word tokens (i.e., amount of language, coded following the Systematic Analysis of Language Transcripts [SALT]). Further, earlier infant Mean Length of Utterance (MLU; reflecting language complexity, also derived from SALT coding) predicted later caregiver MLU, even when controlling for variability in infant ages and clear within-domain temporal stability/continuity in key measures (i.e., caregiver sensitive responsiveness and infant word tokens; and infant and caregiver MLU). These data add empirical support to theorization on how caregiver input can be both supportive of, and potentially influenced by, infant capacities, when infants have social-communication differences and/or communication/language delays suggestive of possible emerging autism. En ligne : https://doi.org/10.1002/aur.2879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits / Lacey CHETCUTI in Autism Research, 16-3 (March 2023)  

Public ISBD [article]  inAutism Research > 16-3 (March 2023) . - p.591-604 Titre : Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits Type de document : Texte imprimé et/ou numérique Auteurs : Lacey CHETCUTI, Auteur ; Mirko ULJAREVI?, Auteur ; Kandice J. VARCIN, Auteur ; Maryam BOUTRUS, Auteur ; Stefanie DIMOV, Auteur ; Sarah PILLAR, Auteur ; Josephine BARBARO, Auteur ; Cheryl DISSANAYAKE, Auteur ; Jonathan GREEN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur ; the AICES TEAM, Auteur Article en page(s) : p.591-604 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Our previous cross-sectional investigation (Chetcuti et al., 2020) showed that infants with autism traits could be divided into distinct subgroups based on temperament. This longitudinal study builds on this existing work by exploring the continuity of temperament subgroup classifications and their associations with behavioral/clinical phenotypic features from infancy to toddlerhood. 103 infants (68% male) showing early signs of autism were referred to the study by community healthcare professionals and seen for assessments when aged around 12-months (Time 1), 18-months (Time 2), and 24-months (Time 3). Latent profile analysis revealed inhibited/low positive, active/negative reactive, and sociable/well-regulated subgroups at each timepoint, and a unique reactive/regulated subgroup at Time 3. Cross-tabulations indicated a significant likelihood of children having a recurrent subgroup classification from one timepoint to the next, and no apparent patterns to the movement of children who did change from one subgroup to another over time. Temperament subgroups were associated with concurrent child social-emotional functioning and autism traits, but unrelated to child age, sex, or developmental level. These findings suggest that temperament subgroup classifications might represent a reliable and very early indicator of autism characteristics and social-emotional functioning among infants/toddlers with autism traits. En ligne : https://doi.org/10.1002/aur.2874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 [article] Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits [Texte imprimé et/ou numérique] / Lacey CHETCUTI, Auteur ; Mirko ULJAREVI?, Auteur ; Kandice J. VARCIN, Auteur ; Maryam BOUTRUS, Auteur ; Stefanie DIMOV, Auteur ; Sarah PILLAR, Auteur ; Josephine BARBARO, Auteur ; Cheryl DISSANAYAKE, Auteur ; Jonathan GREEN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur ; the AICES TEAM, Auteur . - p.591-604. Langues : Anglais (eng) in Autism Research > 16-3 (March 2023) . - p.591-604 Index. décimale : PER Périodiques Résumé : Abstract Our previous cross-sectional investigation (Chetcuti et al., 2020) showed that infants with autism traits could be divided into distinct subgroups based on temperament. This longitudinal study builds on this existing work by exploring the continuity of temperament subgroup classifications and their associations with behavioral/clinical phenotypic features from infancy to toddlerhood. 103 infants (68% male) showing early signs of autism were referred to the study by community healthcare professionals and seen for assessments when aged around 12-months (Time 1), 18-months (Time 2), and 24-months (Time 3). Latent profile analysis revealed inhibited/low positive, active/negative reactive, and sociable/well-regulated subgroups at each timepoint, and a unique reactive/regulated subgroup at Time 3. Cross-tabulations indicated a significant likelihood of children having a recurrent subgroup classification from one timepoint to the next, and no apparent patterns to the movement of children who did change from one subgroup to another over time. Temperament subgroups were associated with concurrent child social-emotional functioning and autism traits, but unrelated to child age, sex, or developmental level. These findings suggest that temperament subgroup classifications might represent a reliable and very early indicator of autism characteristics and social-emotional functioning among infants/toddlers with autism traits. En ligne : https://doi.org/10.1002/aur.2874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498

Deconstructing the repetitive behaviour phenotype in autism spectrum disorder through a large population-based analysis / Mirko ULJAREVIC in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1030-1042 Titre : Deconstructing the repetitive behaviour phenotype in autism spectrum disorder through a large population-based analysis Type de document : Texte imprimé et/ou numérique Auteurs : Mirko ULJAREVIC, Auteur ; Matthew N. COOPER, Auteur ; Keely BEBBINGTON, Auteur ; Emma J. GLASSON, Auteur ; Murray T. MAYBERY, Auteur ; Kandice J. VARCIN, Auteur ; Gail A. ALVARES, Auteur ; John WRAY, Auteur ; Susan R LEEKAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.1030-1042 Langues : Anglais (eng) Mots-clés : Repetitive behaviours  autism  social and communication impairments Index. décimale : PER Périodiques Résumé : OBJECTIVE: Restricted and repetitive pattern of behaviours and interests (RRB) are a cardinal feature of autism spectrum disorder (ASD), but there remains uncertainty about how these diverse behaviours vary according to individual characteristics. This study provided the largest exploration to date of the relationship between Repetitive Motor Behaviours, Rigidity/Insistence on Sameness and Circumscribed Interests with other individual characteristics in newly diagnosed individuals with ASD. METHOD: Participants (N = 3,647; 17.7% females; Mage = 6.6 years [SD = 4.7]) were part of the Western Australian (WA) Register for ASD, an independent, prospective collection of demographic and diagnostic data of newly diagnosed cases of ASD in WA. Diagnosticians rated each of the DSM-IV-TR criteria on a 4-point Likert severity scale, and here we focused on the Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests symptoms. RESULTS: The associations between RRB domains, indexed by Kendall's Tau, were weak, ranging from non-significant for both Circumscribed Interests and Repetitive Motor Behaviours to significant (.20) for Insistence on Sameness and Repetitive Motor Behaviours. Older age at diagnosis was significantly associated with lower Circumscribed Interests and significantly associated with higher Insistence on Sameness and Repetitive Motor Behaviours. Male sex was significantly associated with higher Repetitive Motor Behaviours but not Insistence on Sameness or Circumscribed Interests. CONCLUSIONS: The pattern of associations identified in this study provides suggestive evidence for the distinctiveness of Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests, highlighting the potential utility of RRB domains for stratifying the larger ASD population into smaller, more phenotypically homogeneous subgroups that can help to facilitate efforts to understand diverse ASD aetiology and inform design of future interventions. En ligne : http://dx.doi.org/10.1111/jcpp.13203 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Deconstructing the repetitive behaviour phenotype in autism spectrum disorder through a large population-based analysis [Texte imprimé et/ou numérique] / Mirko ULJAREVIC, Auteur ; Matthew N. COOPER, Auteur ; Keely BEBBINGTON, Auteur ; Emma J. GLASSON, Auteur ; Murray T. MAYBERY, Auteur ; Kandice J. VARCIN, Auteur ; Gail A. ALVARES, Auteur ; John WRAY, Auteur ; Susan R LEEKAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.1030-1042. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1030-1042 Mots-clés : Repetitive behaviours  autism  social and communication impairments Index. décimale : PER Périodiques Résumé : OBJECTIVE: Restricted and repetitive pattern of behaviours and interests (RRB) are a cardinal feature of autism spectrum disorder (ASD), but there remains uncertainty about how these diverse behaviours vary according to individual characteristics. This study provided the largest exploration to date of the relationship between Repetitive Motor Behaviours, Rigidity/Insistence on Sameness and Circumscribed Interests with other individual characteristics in newly diagnosed individuals with ASD. METHOD: Participants (N = 3,647; 17.7% females; Mage = 6.6 years [SD = 4.7]) were part of the Western Australian (WA) Register for ASD, an independent, prospective collection of demographic and diagnostic data of newly diagnosed cases of ASD in WA. Diagnosticians rated each of the DSM-IV-TR criteria on a 4-point Likert severity scale, and here we focused on the Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests symptoms. RESULTS: The associations between RRB domains, indexed by Kendall's Tau, were weak, ranging from non-significant for both Circumscribed Interests and Repetitive Motor Behaviours to significant (.20) for Insistence on Sameness and Repetitive Motor Behaviours. Older age at diagnosis was significantly associated with lower Circumscribed Interests and significantly associated with higher Insistence on Sameness and Repetitive Motor Behaviours. Male sex was significantly associated with higher Repetitive Motor Behaviours but not Insistence on Sameness or Circumscribed Interests. CONCLUSIONS: The pattern of associations identified in this study provides suggestive evidence for the distinctiveness of Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests, highlighting the potential utility of RRB domains for stratifying the larger ASD population into smaller, more phenotypically homogeneous subgroups that can help to facilitate efforts to understand diverse ASD aetiology and inform design of future interventions. En ligne : http://dx.doi.org/10.1111/jcpp.13203 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Early autism symptoms in infants with tuberous sclerosis complex / Nicole M. MCDONALD in Autism Research, 10-12 (December 2017)  

Public ISBD [article]  inAutism Research > 10-12 (December 2017) . - p.1981-1990 Titre : Early autism symptoms in infants with tuberous sclerosis complex Type de document : Texte imprimé et/ou numérique Auteurs : Nicole M. MCDONALD, Auteur ; Kandice J. VARCIN, Auteur ; Rujuta BHATT, Auteur ; Joyce Y. WU, Auteur ; Mustafa SAHIN, Auteur ; Charles A. NELSON, Auteur ; Shafali S. JESTE, Auteur Article en page(s) : p.1981-1990 Langues : Anglais (eng) Mots-clés : tuberous sclerosis complex  autism spectrum disorder  Autism Observation Scale for Infants  high-risk infants  early risk markers Index. décimale : PER Périodiques Résumé : Tuberous sclerosis complex (TSC) is a rare, autosomal dominant genetic syndrome that confers significantly increased risk for autism spectrum disorder (ASD), with 50–60% of infants with TSC meeting criteria for ASD by 3 years of age. In a previous study of the current longitudinal cohort, we found that infants with TSC who develop ASD (TSC/ASD) evidence decreased cognitive abilities that diverge from infants with TSC and no ASD (TSC/no ASD). We extended this work by asking whether TSC/ASD infants (n?=?13) differed from TSC/no ASD infants (n?=?10) and infants with low developmental risk and no ASD (LR; n?=?21) in their social communication functioning during the first year of life. We measured early ASD symptoms with the Autism Observation Scale for Infants (AOSI) at 9 and 12 months of age. At both ages, infants in the TSC/ASD group had significantly higher AOSI total scores than infants in the TSC/no ASD and LR groups, which were not fully explained by differences in cognitive abilities. Several items on the AOSI at both ages were predictive of ASD outcome, particularly those representing core social communication deficits (e.g., social referencing). Our findings signal the need for further study of this population within the first year and provide strong justification for early identification and early intervention targeting social communication skills in infants with TSC. Autism Res 2017, 10: 1981–1990. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We examined early signs of autism spectrum disorder (ASD) in infants with tuberous sclerosis complex (TSC), approximately 50% of whom will meet criteria for ASD by age 3. Infants with TSC and ASD showed deficits in social communication behaviors by 9 months of age that were clearly distinguishable from behaviors in infants with TSC who do not develop ASD and low risk infants. Results support the importance of early ASD screening and intervention for infants with TSC. En ligne : http://dx.doi.org/10.1002/aur.1846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Early autism symptoms in infants with tuberous sclerosis complex [Texte imprimé et/ou numérique] / Nicole M. MCDONALD, Auteur ; Kandice J. VARCIN, Auteur ; Rujuta BHATT, Auteur ; Joyce Y. WU, Auteur ; Mustafa SAHIN, Auteur ; Charles A. NELSON, Auteur ; Shafali S. JESTE, Auteur . - p.1981-1990. Langues : Anglais (eng) in Autism Research > 10-12 (December 2017) . - p.1981-1990 Mots-clés : tuberous sclerosis complex  autism spectrum disorder  Autism Observation Scale for Infants  high-risk infants  early risk markers Index. décimale : PER Périodiques Résumé : Tuberous sclerosis complex (TSC) is a rare, autosomal dominant genetic syndrome that confers significantly increased risk for autism spectrum disorder (ASD), with 50–60% of infants with TSC meeting criteria for ASD by 3 years of age. In a previous study of the current longitudinal cohort, we found that infants with TSC who develop ASD (TSC/ASD) evidence decreased cognitive abilities that diverge from infants with TSC and no ASD (TSC/no ASD). We extended this work by asking whether TSC/ASD infants (n?=?13) differed from TSC/no ASD infants (n?=?10) and infants with low developmental risk and no ASD (LR; n?=?21) in their social communication functioning during the first year of life. We measured early ASD symptoms with the Autism Observation Scale for Infants (AOSI) at 9 and 12 months of age. At both ages, infants in the TSC/ASD group had significantly higher AOSI total scores than infants in the TSC/no ASD and LR groups, which were not fully explained by differences in cognitive abilities. Several items on the AOSI at both ages were predictive of ASD outcome, particularly those representing core social communication deficits (e.g., social referencing). Our findings signal the need for further study of this population within the first year and provide strong justification for early identification and early intervention targeting social communication skills in infants with TSC. Autism Res 2017, 10: 1981–1990. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We examined early signs of autism spectrum disorder (ASD) in infants with tuberous sclerosis complex (TSC), approximately 50% of whom will meet criteria for ASD by age 3. Infants with TSC and ASD showed deficits in social communication behaviors by 9 months of age that were clearly distinguishable from behaviors in infants with TSC who do not develop ASD and low risk infants. Results support the importance of early ASD screening and intervention for infants with TSC. En ligne : http://dx.doi.org/10.1002/aur.1846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Early patterns of functional brain development associated with autism spectrum disorder in tuberous sclerosis complex / A. DICKINSON in Autism Research, 12-12 (December)  

Public ISBD [article]  inAutism Research > 12-12 (December) . - p.1758-1773 Titre : Early patterns of functional brain development associated with autism spectrum disorder in tuberous sclerosis complex Type de document : Texte imprimé et/ou numérique Auteurs : A. DICKINSON, Auteur ; Kandice J. VARCIN, Auteur ; M. SAHIN, Auteur ; C. A. NELSON, Auteur ; S. S. JESTE, Auteur Année de publication : 2019 Article en page(s) : p.1758-1773 Langues : Anglais (eng) Mots-clés : alpha oscillations  autism spectrum disorder  cognitive function  electroencephalography  functional connectivity  infancy  tuberous sclerosis complex Index. décimale : PER Périodiques Résumé : Tuberous sclerosis complex (TSC) is a rare genetic disorder that confers a high risk for autism spectrum disorders (ASD), with behavioral predictors of ASD emerging early in life. Deviations in structural and functional neural connectivity are highly implicated in both TSC and ASD. For the first time, we explore whether electroencephalographic (EEG) measures of neural network function precede or predict the emergence of ASD in TSC. We determine whether altered brain function (a) is present in infancy in TSC, (b) differentiates infants with TSC based on ASD diagnostic status, and (c) is associated with later cognitive function. We studied 35 infants with TSC (N = 35), and a group of typically developing infants (N = 20) at 12 and 24 months of age. Infants with TSC were later subdivided into ASD and non-ASD groups based on clinical evaluation. We measured features of spontaneous alpha oscillations (6-12 Hz) that are closely associated with neural network development: alpha power, alpha phase coherence (APC), and peak alpha frequency (PAF). Infants with TSC demonstrated reduced interhemispheric APC compared to controls at 12 months of age, and these differences were found to be most pronounced at 24 months in the infants who later developed ASD. Across all infants, PAF at 24 months was associated with verbal and nonverbal cognition at 36 months. Associations between early network function and later neurodevelopmental and cognitive outcomes highlight the potential utility of early scalable EEG markers to identify infants with TSC requiring additional targeted intervention initiated very early in life. Autism Res 2019, 12: 1758-1773. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Approximately half of infants with tuberous sclerosis complex (TSC) develop autism. Here, using EEG, we find that there is a reduction in communication between brain regions during infancy in TSC, and that the infants who show the largest reductions are those who later develop autism. Being able to identify infants who show early signs of disrupted brain development may improve the timing of early prediction and interventions in TSC, and also help us to understand how early brain changes lead to autism. En ligne : http://dx.doi.org/10.1002/aur.2193 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 [article] Early patterns of functional brain development associated with autism spectrum disorder in tuberous sclerosis complex [Texte imprimé et/ou numérique] / A. DICKINSON, Auteur ; Kandice J. VARCIN, Auteur ; M. SAHIN, Auteur ; C. A. NELSON, Auteur ; S. S. JESTE, Auteur . - 2019 . - p.1758-1773. Langues : Anglais (eng) in Autism Research > 12-12 (December) . - p.1758-1773 Mots-clés : alpha oscillations  autism spectrum disorder  cognitive function  electroencephalography  functional connectivity  infancy  tuberous sclerosis complex Index. décimale : PER Périodiques Résumé : Tuberous sclerosis complex (TSC) is a rare genetic disorder that confers a high risk for autism spectrum disorders (ASD), with behavioral predictors of ASD emerging early in life. Deviations in structural and functional neural connectivity are highly implicated in both TSC and ASD. For the first time, we explore whether electroencephalographic (EEG) measures of neural network function precede or predict the emergence of ASD in TSC. We determine whether altered brain function (a) is present in infancy in TSC, (b) differentiates infants with TSC based on ASD diagnostic status, and (c) is associated with later cognitive function. We studied 35 infants with TSC (N = 35), and a group of typically developing infants (N = 20) at 12 and 24 months of age. Infants with TSC were later subdivided into ASD and non-ASD groups based on clinical evaluation. We measured features of spontaneous alpha oscillations (6-12 Hz) that are closely associated with neural network development: alpha power, alpha phase coherence (APC), and peak alpha frequency (PAF). Infants with TSC demonstrated reduced interhemispheric APC compared to controls at 12 months of age, and these differences were found to be most pronounced at 24 months in the infants who later developed ASD. Across all infants, PAF at 24 months was associated with verbal and nonverbal cognition at 36 months. Associations between early network function and later neurodevelopmental and cognitive outcomes highlight the potential utility of early scalable EEG markers to identify infants with TSC requiring additional targeted intervention initiated very early in life. Autism Res 2019, 12: 1758-1773. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Approximately half of infants with tuberous sclerosis complex (TSC) develop autism. Here, using EEG, we find that there is a reduction in communication between brain regions during infancy in TSC, and that the infants who show the largest reductions are those who later develop autism. Being able to identify infants who show early signs of disrupted brain development may improve the timing of early prediction and interventions in TSC, and also help us to understand how early brain changes lead to autism. En ligne : http://dx.doi.org/10.1002/aur.2193 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413

EEG power at 3 months in infants at high familial risk for autism / A. R. LEVIN in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

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Investigating associations between birth order and autism diagnostic phenotypes / Gail A. ALVARES in Journal of Child Psychology and Psychiatry, 62-8 (August 2021)  

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Investigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach / Maryam BOUTRUS in Autism Research, 10-12 (December 2017)  

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Maternal pre-pregnancy weight and autistic-like traits among offspring in the general population / Kandice J. VARCIN in Autism Research, 12-1 (January 2019)  

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Non-pharmacological interventions for autistic children: An umbrella review / David TREMBATH in Autism, 27-2 (February 2023)  

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Parent-Child Interactions May Help to Explain Relations Between Parent Characteristics and Clinically Observed Child Autistic Behaviours / Murray T. MAYBERY ; Josephine BARBARO ; Cheryl DISSANAYAKE ; Jonathan GREEN ; Kristelle HUDRY ; Teresa IACONO ; Vicky SLONIMS ; Kandice J. VARCIN ; Ming Wai WAN ; John WRAY ; Andrew J. O. WHITEHOUSE in Journal of Autism and Developmental Disorders, 54-7 (July 2024)  

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Performance of the Autism Observation Scale for Infants with community-ascertained infants showing early signs of autism / Kristelle HUDRY in Autism, 25-2 (February 2021)  

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Prenatal maternal stress events and phenotypic outcomes in Autism Spectrum Disorder / Kandice J. VARCIN in Autism Research, 10-11 (November 2017)  

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Prevalence of Motor Difficulties in Autism Spectrum Disorder: Analysis of a Population-Based Cohort / Melissa K. LICARI in Autism Research, 13-2 (February 2020)  

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Relationship between early motor milestones and severity of restricted and repetitive behaviors in children and adolescents with autism spectrum disorder / Mirko ULJAREVIC in Autism Research, 10-6 (June 2017)  

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