Exploring camouflaging by the Chinese version Camouflaging Autistic Traits Questionnaire in Taiwanese autistic and non-autistic adolescents: An initial development / Chun-Hao LIU in Autism, 28-3 (March 2024)  

Public ISBD [article]  inAutism > 28-3 (March 2024) . - p.690-704 Titre : Exploring camouflaging by the Chinese version Camouflaging Autistic Traits Questionnaire in Taiwanese autistic and non-autistic adolescents: An initial development Type de document : texte imprimé Auteurs : Chun-Hao LIU, Auteur ; Yi-Lung CHEN, Auteur ; Pei-Jung CHEN, Auteur ; Hsing-Chang NI, Auteur ; Meng-Chuan LAI, Auteur Article en page(s) : p.690-704 Langues : Anglais (eng) Mots-clés : adolescent  autism  camouflaging  psychometrics  reliability Index. décimale : PER Périodiques Résumé : Camouflaging is a strategy adopted by neurodivergent individuals to cope in neurotypical social contexts, likely related to perceived stress. Despite increasing research in autistic adults, studies of camouflaging in adolescents remain sparse. The self-reported Camouflaging Autistic Traits Questionnaire has been validated in adults in some Western societies, but not in non-Western populations. We examined the psychometric properties of the self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire in Taiwanese adolescents. We enrolled 100 autistic and 105 non-autistic adolescents (aged 12-18 years) and their caregivers. As an initial development, we found a two-factor structure ("compensation-masking" and "assimilation") via exploratory factor analysis, alongside good internal consistency and test-retest reliability, for both the self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire. Self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire scores were moderately to highly correlated. Autistic adolescents showed higher total Chinese version Camouflaging Autistic Traits Questionnaire and assimilation scores than non-autistic adolescents in both males and females. Female autistic adolescents showed higher assimilation than male autistic adolescents, but there was no significant difference between sex assigned at birth on compensation-masking in either autistic or non-autistic adolescents. Assimilation correlated with higher self-perceived stress for both autistic and non-autistic adolescents. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were reliable and offered meaningful information to understand social coping of Taiwanese autistic and non-autistic adolescents. Lay abstract Camouflaging is a coping strategy used by some autistic and other neurodivergent people to fit in neurotypical social contexts. The self-reported Camouflaging Autistic Traits Questionnaire has been validated for use in research with adults in some Western societies, but not in non-Western cultural-ethnic groups. We translated Camouflaging Autistic Traits Questionnaire into traditional Chinese and examined the use of this measure in Taiwanese adolescents via both self-report and caregiver-report in 100 autistic and 105 non-autistic adolescents. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were composed of two factors (i.e. a "compensation-masking" subscale and an "assimilation" subscale). Both adolescent self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire total score and subscales were reliable in measurement, and they highly correlated with each other. Taiwanese autistic adolescents were more likely to camouflage than non-autistic adolescents, especially on assimilation. Female autistic adolescents showed higher assimilation than male autistic adolescents. Higher camouflaging, especially assimilation, was associated with higher stress in autistic and non-autistic adolescents alike. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were reliable and offered meaningful information to help us understand the social coping experiences of autistic and non-autistic adolescents. En ligne : https://dx.doi.org/10.1177/13623613231181732 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Exploring camouflaging by the Chinese version Camouflaging Autistic Traits Questionnaire in Taiwanese autistic and non-autistic adolescents: An initial development [texte imprimé] / Chun-Hao LIU, Auteur ; Yi-Lung CHEN, Auteur ; Pei-Jung CHEN, Auteur ; Hsing-Chang NI, Auteur ; Meng-Chuan LAI, Auteur . - p.690-704. Langues : Anglais (eng) in Autism > 28-3 (March 2024) . - p.690-704 Mots-clés : adolescent  autism  camouflaging  psychometrics  reliability Index. décimale : PER Périodiques Résumé : Camouflaging is a strategy adopted by neurodivergent individuals to cope in neurotypical social contexts, likely related to perceived stress. Despite increasing research in autistic adults, studies of camouflaging in adolescents remain sparse. The self-reported Camouflaging Autistic Traits Questionnaire has been validated in adults in some Western societies, but not in non-Western populations. We examined the psychometric properties of the self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire in Taiwanese adolescents. We enrolled 100 autistic and 105 non-autistic adolescents (aged 12-18 years) and their caregivers. As an initial development, we found a two-factor structure ("compensation-masking" and "assimilation") via exploratory factor analysis, alongside good internal consistency and test-retest reliability, for both the self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire. Self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire scores were moderately to highly correlated. Autistic adolescents showed higher total Chinese version Camouflaging Autistic Traits Questionnaire and assimilation scores than non-autistic adolescents in both males and females. Female autistic adolescents showed higher assimilation than male autistic adolescents, but there was no significant difference between sex assigned at birth on compensation-masking in either autistic or non-autistic adolescents. Assimilation correlated with higher self-perceived stress for both autistic and non-autistic adolescents. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were reliable and offered meaningful information to understand social coping of Taiwanese autistic and non-autistic adolescents. Lay abstract Camouflaging is a coping strategy used by some autistic and other neurodivergent people to fit in neurotypical social contexts. The self-reported Camouflaging Autistic Traits Questionnaire has been validated for use in research with adults in some Western societies, but not in non-Western cultural-ethnic groups. We translated Camouflaging Autistic Traits Questionnaire into traditional Chinese and examined the use of this measure in Taiwanese adolescents via both self-report and caregiver-report in 100 autistic and 105 non-autistic adolescents. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were composed of two factors (i.e. a "compensation-masking" subscale and an "assimilation" subscale). Both adolescent self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire total score and subscales were reliable in measurement, and they highly correlated with each other. Taiwanese autistic adolescents were more likely to camouflage than non-autistic adolescents, especially on assimilation. Female autistic adolescents showed higher assimilation than male autistic adolescents. Higher camouflaging, especially assimilation, was associated with higher stress in autistic and non-autistic adolescents alike. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were reliable and offered meaningful information to help us understand the social coping experiences of autistic and non-autistic adolescents. En ligne : https://dx.doi.org/10.1177/13623613231181732 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Feasibility and Tolerability of Daily Theta Burst Stimulation in Autistic Youth with Intellectual Disabilities and Minimally Speaking Status: A Pilot Double-Blind Randomized Sham-Controlled Trial / Hsing-Chang NI in Journal of Autism and Developmental Disorders, 55-12 (December 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-12 (December 2025) . - p.4262-4271 Titre : Feasibility and Tolerability of Daily Theta Burst Stimulation in Autistic Youth with Intellectual Disabilities and Minimally Speaking Status: A Pilot Double-Blind Randomized Sham-Controlled Trial Type de document : texte imprimé Auteurs : Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : p.4262-4271 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Scarce clinical trials involving autistic people with intellectual disability (ID) and minimally speaking (MS) status have been a substantial unmet research need in the field. Although earlier studies have demonstrated the feasibility and beneficial potentials of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) in intellectually able autistic people, the feasibility and tolerability of applying rTMS in autistic people with ID/MS has never been studied. We conducted the world-first 4-week randomized, double-blind, sham-controlled pilot trial to investigate the feasibility, tolerability, and safety of intermittent theta burst stimulation (iTBS, a variant of excitatory rTMS) over the left DLPFC in autistic youth with ID/MS. 25 autistic youth with ID/MS (aged 8-30 years) were randomized to a 20-session 4-week daily iTBS (n = 13) vs. sham stimulation (n = 12) with follow-up 4 and 8 weeks, respectively, after the last stimulation. A retention rate was 100% in our study. Adverse events of local pain (38%) and dizziness (8%) were only noted in the active group. All adverse events were mild and transient. There were no seizures, new behavioral problems, or other severe/serious adverse events noted. No participants dropped out due to adverse events. With a small sample size, we did not find any beneficial signal of DLPFC iTBS. Our pilot data suggest regular daily TBS treatment for four weeks is feasible, well tolerated and safe in autistic youth with ID/MS. Future randomized controlled trials with sufficiently powered samples are needed to investigate the beneficial potential of rTMS/TBS for autistic people with ID/MS. En ligne : https://doi.org/10.1007/s10803-024-06477-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Feasibility and Tolerability of Daily Theta Burst Stimulation in Autistic Youth with Intellectual Disabilities and Minimally Speaking Status: A Pilot Double-Blind Randomized Sham-Controlled Trial [texte imprimé] / Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Hsiang-Yuan LIN, Auteur . - p.4262-4271. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-12 (December 2025) . - p.4262-4271 Index. décimale : PER Périodiques Résumé : Scarce clinical trials involving autistic people with intellectual disability (ID) and minimally speaking (MS) status have been a substantial unmet research need in the field. Although earlier studies have demonstrated the feasibility and beneficial potentials of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) in intellectually able autistic people, the feasibility and tolerability of applying rTMS in autistic people with ID/MS has never been studied. We conducted the world-first 4-week randomized, double-blind, sham-controlled pilot trial to investigate the feasibility, tolerability, and safety of intermittent theta burst stimulation (iTBS, a variant of excitatory rTMS) over the left DLPFC in autistic youth with ID/MS. 25 autistic youth with ID/MS (aged 8-30 years) were randomized to a 20-session 4-week daily iTBS (n = 13) vs. sham stimulation (n = 12) with follow-up 4 and 8 weeks, respectively, after the last stimulation. A retention rate was 100% in our study. Adverse events of local pain (38%) and dizziness (8%) were only noted in the active group. All adverse events were mild and transient. There were no seizures, new behavioral problems, or other severe/serious adverse events noted. No participants dropped out due to adverse events. With a small sample size, we did not find any beneficial signal of DLPFC iTBS. Our pilot data suggest regular daily TBS treatment for four weeks is feasible, well tolerated and safe in autistic youth with ID/MS. Future randomized controlled trials with sufficiently powered samples are needed to investigate the beneficial potential of rTMS/TBS for autistic people with ID/MS. En ligne : https://doi.org/10.1007/s10803-024-06477-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention / Hsing-Chang NI in Autism, 25-5 (July 2021)  

Public ISBD [article]  inAutism > 25-5 (July 2021) . - p.1279-1294 Titre : Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention Type de document : texte imprimé Auteurs : Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : p.1279-1294 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy  Child  Double-Blind Method  Humans  Single-Blind Method  Temporal Lobe  Transcranial Magnetic Stimulation  Treatment Outcome  autism spectrum disorder  children and adolescents  intervention  posterior superior temporal sulcus  theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8 weeks. Those in the sham group received two-session/week sham stimulations in the first 4 weeks and then active intervention for the following 4 weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention [texte imprimé] / Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur . - p.1279-1294. Langues : Anglais (eng) in Autism > 25-5 (July 2021) . - p.1279-1294 Mots-clés : Autism Spectrum Disorder/therapy  Child  Double-Blind Method  Humans  Single-Blind Method  Temporal Lobe  Transcranial Magnetic Stimulation  Treatment Outcome  autism spectrum disorder  children and adolescents  intervention  posterior superior temporal sulcus  theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8 weeks. Those in the sham group received two-session/week sham stimulations in the first 4 weeks and then active intervention for the following 4 weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention / Hsing-Chang NI in Autism, 26-5 (July 2022)  

Public ISBD [article]  inAutism > 26-5 (July 2022) . - p.1279-1294 Titre : Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention Type de document : texte imprimé Auteurs : Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : p.1279-1294 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy  Child  Double-Blind Method  Humans  Single-Blind Method  Temporal Lobe  Transcranial Magnetic Stimulation  Treatment Outcome  autism spectrum disorder  children and adolescents  intervention  posterior superior temporal sulcus  theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8weeks. Those in the sham group received two-session/week sham stimulations in the first 4weeks and then active intervention for the following 4weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention [texte imprimé] / Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur . - p.1279-1294. Langues : Anglais (eng) in Autism > 26-5 (July 2022) . - p.1279-1294 Mots-clés : Autism Spectrum Disorder/therapy  Child  Double-Blind Method  Humans  Single-Blind Method  Temporal Lobe  Transcranial Magnetic Stimulation  Treatment Outcome  autism spectrum disorder  children and adolescents  intervention  posterior superior temporal sulcus  theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8weeks. Those in the sham group received two-session/week sham stimulations in the first 4weeks and then active intervention for the following 4weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

A lack of efficacy of continuous theta burst stimulation over the left dorsolateral prefrontal cortex in autism: A double blind randomized sham-controlled trial / Hsing-Chang NI in Autism Research, 16-6 (June 2023)  

Public ISBD [article]  inAutism Research > 16-6 (June 2023) . - p.1247-1262 Titre : A lack of efficacy of continuous theta burst stimulation over the left dorsolateral prefrontal cortex in autism: A double blind randomized sham-controlled trial Type de document : texte imprimé Auteurs : Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Rao-Shayn CHEN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : p.1247-1262 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  dorsolateral prefrontal cortex  inhibitory paradigm  randomized sham-controlled trial  repetitive magnetic stimulation  theta burst stimulation Index. décimale : PER Périodiques Résumé : Abstract Although previous open-label trials suggest the therapeutic potential of inhibitory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) in autism spectrum disorder (ASD), methodological caveats exist. We conducted an 8-week randomized, double-blind sham-controlled trial to investigate the efficacy of inhibitory continuous theta burst stimulation (cTBS, a variant of rTMS) over the left DLPFC in individuals with ASD. Sixty children, adolescents and young adults (aged 8 30 years) with ASD without co-occurring intellectual disabilities were randomized to a 16-session 8-week cTBS versus sham stimulation course, with a follow-up 4 weeks after the trial. The Active group was not superior to the Sham group in any clinical or neuropsychological metrics at Week 8 or Week 12. Time effects of 8-week cTBS on symptoms and executive function were remarkable in both Active and Sham groups, with comparable response rates and effect sizes of changes in symptoms/cognition between groups. Our results from a sufficiently powered sample do not endorse the superior efficacy of cTBS over the left DLPFC to the shamed stimulation for children, adolescents and adults with ASD. These findings suggest that earlier positive open-label trial findings may be generalized by generalized/placebo effects. This highlights the urgent need for more rTMS/TBS studies with rigorous trial designs in ASD. En ligne : https://doi.org/10.1002/aur.2954 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507 [article] A lack of efficacy of continuous theta burst stimulation over the left dorsolateral prefrontal cortex in autism: A double blind randomized sham-controlled trial [texte imprimé] / Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Rao-Shayn CHEN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Hsiang-Yuan LIN, Auteur . - p.1247-1262. Langues : Anglais (eng) in Autism Research > 16-6 (June 2023) . - p.1247-1262 Mots-clés : autism spectrum disorder  dorsolateral prefrontal cortex  inhibitory paradigm  randomized sham-controlled trial  repetitive magnetic stimulation  theta burst stimulation Index. décimale : PER Périodiques Résumé : Abstract Although previous open-label trials suggest the therapeutic potential of inhibitory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) in autism spectrum disorder (ASD), methodological caveats exist. We conducted an 8-week randomized, double-blind sham-controlled trial to investigate the efficacy of inhibitory continuous theta burst stimulation (cTBS, a variant of rTMS) over the left DLPFC in individuals with ASD. Sixty children, adolescents and young adults (aged 8 30 years) with ASD without co-occurring intellectual disabilities were randomized to a 16-session 8-week cTBS versus sham stimulation course, with a follow-up 4 weeks after the trial. The Active group was not superior to the Sham group in any clinical or neuropsychological metrics at Week 8 or Week 12. Time effects of 8-week cTBS on symptoms and executive function were remarkable in both Active and Sham groups, with comparable response rates and effect sizes of changes in symptoms/cognition between groups. Our results from a sufficiently powered sample do not endorse the superior efficacy of cTBS over the left DLPFC to the shamed stimulation for children, adolescents and adults with ASD. These findings suggest that earlier positive open-label trial findings may be generalized by generalized/placebo effects. This highlights the urgent need for more rTMS/TBS studies with rigorous trial designs in ASD. En ligne : https://doi.org/10.1002/aur.2954 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507

Lower Risk of Burn Injury in Children and Adolescents with Autism Spectrum Disorder: A Nationwide Population-Based Study / Yi-Hsuan HSIEH ; Chiao-Fan LIN ; Hsin-Yi LIANG ; Su-Shin LEE ; Jun-Cheng WENG ; Min-Jing LEE ; Yi-Lung CHEN ; Vincent Chin-Hung CHEN ; Michael GOSSOP in Journal of Autism and Developmental Disorders, 53-2 (February 2023)  

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Peer preferences and characteristics of same-group and cross-group social interactions among autistic and non-autistic adolescents / Yi-Lung CHEN in Autism, 25-7 (October 2021)  

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Suicidality in Children with Elevated Autistic Traits / Ying-Yeh CHEN in Autism Research, 13-10 (October 2020)  

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