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Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research / Lindsay M. OBERMAN in Autism Research, 9-2 (February 2016)
[article]
Titre : Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay M. OBERMAN, Auteur ; Peter G. ENTICOTT, Auteur ; Manuel F. CASANOVA, Auteur ; Alexander ROTENBERG, Auteur ; Alvaro PASCUAL-LEONE, Auteur ; James T. MCCRACKEN, Auteur ; T. M. S. IN A. S. D. CONSENSUS GROUP, THE, Auteur Article en page(s) : p.184-203 Langues : Anglais (eng) Mots-clés : autism spectrum disorder transcranial magnetic stimulation consensus review treatment Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a behaviorally defined complex neurodevelopmental syndrome characterized by impairments in social communication, by the presence of restricted and repetitive behaviors, interests and activities, and by abnormalities in sensory reactivity. Transcranial magnetic stimulation (TMS) is a promising, emerging tool for the study and potential treatment of ASD. Recent studies suggest that TMS measures provide rapid and noninvasive pathophysiological ASD biomarkers. Furthermore, repetitive TMS (rTMS) may represent a novel treatment strategy for reducing some of the core and associated ASD symptoms. However, the available literature on the TMS use in ASD is preliminary, composed of studies with methodological limitations. Thus, off-label clinical rTMS use for therapeutic interventions in ASD without an investigational device exemption and outside of an IRB approved research trial is premature pending further, adequately powered and controlled trials. Leaders in this field have gathered annually for a two-day conference (prior to the 2014 and 2015 International Meeting for Autism Research, IMFAR) to share recent progress, promote collaboration across laboratories, and establish consensus on protocols. Here we review the literature in the use of TMS in ASD in the context of the unique challenges required for the study and exploration of treatment strategies in this population. We also suggest future directions for this field of investigations. While its true potential in ASD has yet to be delineated, TMS represents an innovative research tool and a novel, possibly transformative approach to the treatment of neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.1567 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-2 (February 2016) . - p.184-203[article] Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research [Texte imprimé et/ou numérique] / Lindsay M. OBERMAN, Auteur ; Peter G. ENTICOTT, Auteur ; Manuel F. CASANOVA, Auteur ; Alexander ROTENBERG, Auteur ; Alvaro PASCUAL-LEONE, Auteur ; James T. MCCRACKEN, Auteur ; T. M. S. IN A. S. D. CONSENSUS GROUP, THE, Auteur . - p.184-203.
Langues : Anglais (eng)
in Autism Research > 9-2 (February 2016) . - p.184-203
Mots-clés : autism spectrum disorder transcranial magnetic stimulation consensus review treatment Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a behaviorally defined complex neurodevelopmental syndrome characterized by impairments in social communication, by the presence of restricted and repetitive behaviors, interests and activities, and by abnormalities in sensory reactivity. Transcranial magnetic stimulation (TMS) is a promising, emerging tool for the study and potential treatment of ASD. Recent studies suggest that TMS measures provide rapid and noninvasive pathophysiological ASD biomarkers. Furthermore, repetitive TMS (rTMS) may represent a novel treatment strategy for reducing some of the core and associated ASD symptoms. However, the available literature on the TMS use in ASD is preliminary, composed of studies with methodological limitations. Thus, off-label clinical rTMS use for therapeutic interventions in ASD without an investigational device exemption and outside of an IRB approved research trial is premature pending further, adequately powered and controlled trials. Leaders in this field have gathered annually for a two-day conference (prior to the 2014 and 2015 International Meeting for Autism Research, IMFAR) to share recent progress, promote collaboration across laboratories, and establish consensus on protocols. Here we review the literature in the use of TMS in ASD in the context of the unique challenges required for the study and exploration of treatment strategies in this population. We also suggest future directions for this field of investigations. While its true potential in ASD has yet to be delineated, TMS represents an innovative research tool and a novel, possibly transformative approach to the treatment of neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.1567 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Broken or socially mistuned mirroring in ASD? An investigation via transcranial magnetic stimulation / Jellina PRINSEN in Autism Research, 15-6 (June 2022)
[article]
Titre : Broken or socially mistuned mirroring in ASD? An investigation via transcranial magnetic stimulation Type de document : Texte imprimé et/ou numérique Auteurs : Jellina PRINSEN, Auteur ; Kaat ALAERTS, Auteur Article en page(s) : p.1056-1067 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder Autistic Disorder Brain Hand/physiology Humans Transcranial Magnetic Stimulation action observation eye contact mirror system Index. décimale : PER Périodiques Résumé : Individuals with an autism spectrum disorder (ASD) experience persistent difficulties during social interactions and communication. Previously, it has been suggested that deficits in the so-called "mirror system," active during both action execution and observation, may underlie these social difficulties. It is still a topic of debate however whether deficiencies in the simulation of others' actions (i.e., "broken" mirroring) forms a general feature of ASD, or whether these mostly reflect a lack of social attunement. The latter would suggest an overall intact mirror system, but an impaired modulation of mirror activity according to variable social contexts. In this study, 25 adults with ASD and 28 age- and IQ-matched control participants underwent transcranial magnetic stimulation during the observation of hand movements under variable conditions. Hand movements were presented via a live interaction partner, either without social context to assess basic motor mirroring or in combination with direct and averted gaze from the actor to assess socially modulated mirroring. Overall, no significant group differences were revealed, indicating no generally diminished mirror activity in ASD. Interestingly however, regression analyses revealed that, among ASD participants, higher symptom severity was associated with both reduced basic motor mirroring and aberrant socially modulated mirroring (i.e., no enhancement of mirror system activity upon observation of the interaction partner's direct vs. averted gaze). These findings further challenge the notion that mirror system dysfunctions constitute a principal feature of ASD, but demonstrate that variations in mirroring may be related to differential expressions of ASD symptom severity. LAY SUMMARY: Our findings show similar activity levels in brain regions responsible for action simulation and understanding in adults with autism, compared to adults without autism. However, the presence of more severe autism symptoms was linked to reduced activity in these regions. This suggests lower levels of brain activity during action understanding in some, but not all, persons with autism, which may contribute to the social difficulties these persons experience in daily life. En ligne : http://dx.doi.org/10.1002/aur.2720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Autism Research > 15-6 (June 2022) . - p.1056-1067[article] Broken or socially mistuned mirroring in ASD? An investigation via transcranial magnetic stimulation [Texte imprimé et/ou numérique] / Jellina PRINSEN, Auteur ; Kaat ALAERTS, Auteur . - p.1056-1067.
Langues : Anglais (eng)
in Autism Research > 15-6 (June 2022) . - p.1056-1067
Mots-clés : Adult Autism Spectrum Disorder Autistic Disorder Brain Hand/physiology Humans Transcranial Magnetic Stimulation action observation eye contact mirror system Index. décimale : PER Périodiques Résumé : Individuals with an autism spectrum disorder (ASD) experience persistent difficulties during social interactions and communication. Previously, it has been suggested that deficits in the so-called "mirror system," active during both action execution and observation, may underlie these social difficulties. It is still a topic of debate however whether deficiencies in the simulation of others' actions (i.e., "broken" mirroring) forms a general feature of ASD, or whether these mostly reflect a lack of social attunement. The latter would suggest an overall intact mirror system, but an impaired modulation of mirror activity according to variable social contexts. In this study, 25 adults with ASD and 28 age- and IQ-matched control participants underwent transcranial magnetic stimulation during the observation of hand movements under variable conditions. Hand movements were presented via a live interaction partner, either without social context to assess basic motor mirroring or in combination with direct and averted gaze from the actor to assess socially modulated mirroring. Overall, no significant group differences were revealed, indicating no generally diminished mirror activity in ASD. Interestingly however, regression analyses revealed that, among ASD participants, higher symptom severity was associated with both reduced basic motor mirroring and aberrant socially modulated mirroring (i.e., no enhancement of mirror system activity upon observation of the interaction partner's direct vs. averted gaze). These findings further challenge the notion that mirror system dysfunctions constitute a principal feature of ASD, but demonstrate that variations in mirroring may be related to differential expressions of ASD symptom severity. LAY SUMMARY: Our findings show similar activity levels in brain regions responsible for action simulation and understanding in adults with autism, compared to adults without autism. However, the presence of more severe autism symptoms was linked to reduced activity in these regions. This suggests lower levels of brain activity during action understanding in some, but not all, persons with autism, which may contribute to the social difficulties these persons experience in daily life. En ligne : http://dx.doi.org/10.1002/aur.2720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 Effects of repetitive transcranial magnetic stimulation in performing eye–hand integration tasks: Four preliminary studies with children showing low-functioning autism / Simonetta PANERAI in Autism, 18-6 (August 2014)
[article]
Titre : Effects of repetitive transcranial magnetic stimulation in performing eye–hand integration tasks: Four preliminary studies with children showing low-functioning autism Type de document : Texte imprimé et/ou numérique Auteurs : Simonetta PANERAI, Auteur ; Domenica TASCA, Auteur ; Bartolo LANUZZA, Auteur ; Grazia TRUBIA, Auteur ; Raffaele FERRI, Auteur ; Sabrina MUSSO, Auteur ; Giovanna ALAGONA, Auteur ; Giuseppe DI GUARDO, Auteur ; Concetta BARONE, Auteur ; Maria P. GAGLIONE, Auteur ; Maurizio ELIA, Auteur Article en page(s) : p.638-650 Langues : Anglais (eng) Mots-clés : autism spectrum disorders premotor cortex rehabilitation transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : This report, based on four studies with children with low-functioning autism, aimed at evaluating the effects of repetitive transcranial magnetic stimulation delivered on the left and right premotor cortices on eye–hand integration tasks; defining the long-lasting effects of high-frequency repetitive transcranial magnetic stimulation; and investigating the real efficacy of high-frequency repetitive transcranial magnetic stimulation by comparing three kinds of treatments (high-frequency repetitive transcranial magnetic stimulation, a traditional eye–hand integration training, and both treatments combined). Results showed a significant increase in eye–hand performances only when high-frequency repetitive transcranial magnetic stimulation was delivered on the left premotor cortex; a persistent improvement up to 1 h after the end of the stimulation; better outcomes in the treatment combining high-frequency repetitive transcranial magnetic stimulation and eye–hand integration training. Based on these preliminary findings, further evaluations on the usefulness of high-frequency repetitive transcranial magnetic stimulation in rehabilitation of children with autism are strongly recommended. En ligne : http://dx.doi.org/10.1177/1362361313495717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237
in Autism > 18-6 (August 2014) . - p.638-650[article] Effects of repetitive transcranial magnetic stimulation in performing eye–hand integration tasks: Four preliminary studies with children showing low-functioning autism [Texte imprimé et/ou numérique] / Simonetta PANERAI, Auteur ; Domenica TASCA, Auteur ; Bartolo LANUZZA, Auteur ; Grazia TRUBIA, Auteur ; Raffaele FERRI, Auteur ; Sabrina MUSSO, Auteur ; Giovanna ALAGONA, Auteur ; Giuseppe DI GUARDO, Auteur ; Concetta BARONE, Auteur ; Maria P. GAGLIONE, Auteur ; Maurizio ELIA, Auteur . - p.638-650.
Langues : Anglais (eng)
in Autism > 18-6 (August 2014) . - p.638-650
Mots-clés : autism spectrum disorders premotor cortex rehabilitation transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : This report, based on four studies with children with low-functioning autism, aimed at evaluating the effects of repetitive transcranial magnetic stimulation delivered on the left and right premotor cortices on eye–hand integration tasks; defining the long-lasting effects of high-frequency repetitive transcranial magnetic stimulation; and investigating the real efficacy of high-frequency repetitive transcranial magnetic stimulation by comparing three kinds of treatments (high-frequency repetitive transcranial magnetic stimulation, a traditional eye–hand integration training, and both treatments combined). Results showed a significant increase in eye–hand performances only when high-frequency repetitive transcranial magnetic stimulation was delivered on the left premotor cortex; a persistent improvement up to 1 h after the end of the stimulation; better outcomes in the treatment combining high-frequency repetitive transcranial magnetic stimulation and eye–hand integration training. Based on these preliminary findings, further evaluations on the usefulness of high-frequency repetitive transcranial magnetic stimulation in rehabilitation of children with autism are strongly recommended. En ligne : http://dx.doi.org/10.1177/1362361313495717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237 Use of Transcranial Magnetic Stimulation in Autism Spectrum Disorders / Lindsay M. OBERMAN in Journal of Autism and Developmental Disorders, 45-2 (February 2015)
[article]
Titre : Use of Transcranial Magnetic Stimulation in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay M. OBERMAN, Auteur ; Alexander ROTENBERG, Auteur ; Alvaro PASCUAL-LEONE, Auteur Article en page(s) : p.524-536 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Transcranial magnetic stimulation TMS Diagnosis Therapy Index. décimale : PER Périodiques Résumé : The clinical, social and financial burden of autism spectrum disorder (ASD) is staggering. We urgently need valid and reliable biomarkers for diagnosis and effective treatments targeting the often debilitating symptoms. Transcranial magnetic stimulation (TMS) is beginning to be used by a number of centers worldwide and may represent a novel technique with both diagnostic and therapeutic potential. Here we critically review the current scientific evidence for the use of TMS in ASD. Though preliminary data suggests promise, there is simply not enough evidence yet to conclusively support the clinical widespread use of TMS in ASD, neither diagnostically nor therapeutically. Carefully designed and properly controlled clinical trials are warranted to evaluate the true potential of TMS in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1960-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258
in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.524-536[article] Use of Transcranial Magnetic Stimulation in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Lindsay M. OBERMAN, Auteur ; Alexander ROTENBERG, Auteur ; Alvaro PASCUAL-LEONE, Auteur . - p.524-536.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.524-536
Mots-clés : Autism spectrum disorder Transcranial magnetic stimulation TMS Diagnosis Therapy Index. décimale : PER Périodiques Résumé : The clinical, social and financial burden of autism spectrum disorder (ASD) is staggering. We urgently need valid and reliable biomarkers for diagnosis and effective treatments targeting the often debilitating symptoms. Transcranial magnetic stimulation (TMS) is beginning to be used by a number of centers worldwide and may represent a novel technique with both diagnostic and therapeutic potential. Here we critically review the current scientific evidence for the use of TMS in ASD. Though preliminary data suggests promise, there is simply not enough evidence yet to conclusively support the clinical widespread use of TMS in ASD, neither diagnostically nor therapeutically. Carefully designed and properly controlled clinical trials are warranted to evaluate the true potential of TMS in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1960-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention / Hsing-Chang NI in Autism, 25-5 (July 2021)
[article]
Titre : Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention Type de document : Texte imprimé et/ou numérique Auteurs : Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : p.1279-1294 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy Child Double-Blind Method Humans Single-Blind Method Temporal Lobe Transcranial Magnetic Stimulation Treatment Outcome autism spectrum disorder children and adolescents intervention posterior superior temporal sulcus theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8?weeks. Those in the sham group received two-session/week sham stimulations in the first 4?weeks and then active intervention for the following 4?weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475
in Autism > 25-5 (July 2021) . - p.1279-1294[article] Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention [Texte imprimé et/ou numérique] / Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur . - p.1279-1294.
Langues : Anglais (eng)
in Autism > 25-5 (July 2021) . - p.1279-1294
Mots-clés : Autism Spectrum Disorder/therapy Child Double-Blind Method Humans Single-Blind Method Temporal Lobe Transcranial Magnetic Stimulation Treatment Outcome autism spectrum disorder children and adolescents intervention posterior superior temporal sulcus theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8?weeks. Those in the sham group received two-session/week sham stimulations in the first 4?weeks and then active intervention for the following 4?weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention / Hsing-Chang NI in Autism, 26-5 (July 2022)
PermalinkLooking Back at the Next 40 Years of ASD Neuroscience Research / J. C. MCPARTLAND in Journal of Autism and Developmental Disorders, 51-12 (December 2021)
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