Diagnostic and Physical Effects in Parasympathetic Response to Social Evaluation in Youth With and Without Autism Spectrum Disorder / Rachael A. MUSCATELLO in Journal of Autism and Developmental Disorders, 52-8 (August 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-8 (August 2022) . - p.3427-3442 Titre : Diagnostic and Physical Effects in Parasympathetic Response to Social Evaluation in Youth With and Without Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.3427-3442 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/diagnosis  Autonomic Nervous System  Humans  Autonomic  Obesity  Parasympathetic  Puberty  Stress  no conflict of interest. Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) may demonstrate atypical autonomic (ANS) responses; however, research remains inconsistent. This study examined parasympathetic response during social evaluation in 241 youth (10-13 years) with ASD (n=138) or typical development (TD; n=103). Diagnosis, age, pubertal development, and body mass index (BMI) were hypothesized to be associated with ANS function. Linear mixed effects models demonstrated lower RSA in ASD relative to TD in a base model with no covariates. However, when accounting for differences in BMI, there was no evidence of atypical parasympathetic regulation in youth with ASD. As lower parasympathetic regulation may increase susceptibility for a number of conditions, it will be important to elucidate the link between BMI and the ANS, especially in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05224-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Diagnostic and Physical Effects in Parasympathetic Response to Social Evaluation in Youth With and Without Autism Spectrum Disorder [texte imprimé] / Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur . - p.3427-3442. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-8 (August 2022) . - p.3427-3442 Mots-clés : Adolescent  Autism Spectrum Disorder/diagnosis  Autonomic Nervous System  Humans  Autonomic  Obesity  Parasympathetic  Puberty  Stress  no conflict of interest. Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) may demonstrate atypical autonomic (ANS) responses; however, research remains inconsistent. This study examined parasympathetic response during social evaluation in 241 youth (10-13 years) with ASD (n=138) or typical development (TD; n=103). Diagnosis, age, pubertal development, and body mass index (BMI) were hypothesized to be associated with ANS function. Linear mixed effects models demonstrated lower RSA in ASD relative to TD in a base model with no covariates. However, when accounting for differences in BMI, there was no evidence of atypical parasympathetic regulation in youth with ASD. As lower parasympathetic regulation may increase susceptibility for a number of conditions, it will be important to elucidate the link between BMI and the ANS, especially in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05224-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth / Blythe A. CORBETT in Autism Research, 15-10 (October 2022)  

Public ISBD [article]  inAutism Research > 15-10 (October 2022) . - p.1894-1908 Titre : Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth Type de document : texte imprimé Auteurs : Blythe A. CORBETT, Auteur ; Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Sara DUFFUS, Auteur ; Sloane SPARKS, Auteur ; Yasas TANGUTURI, Auteur Article en page(s) : p.1894-1908 Langues : Anglais (eng) Mots-clés : adolescence  autism  development  female  puberty Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired social communication and poor adaptation to change; thus, pubertal development may be precarious. Pubertal timing and tempo were measured in 244 youth (7.9% Black, 83.3% White, and 8.7% multiracial) with ASD (N = 140) and typical development (N = 104). Pubertal development was measured using Tanner staging of Genital (G, males), Breast (B, females), and pubic hair (PH) in both sexes at Year 1 (10-13 years), Year 2 (11-14 years), and Year 3 (12-15 years). Nonlinear mixed effects models analyzed interindividual differences in timing and tempo. For both sexes, ASD and higher body mass index were associated with earlier pubertal timing. Males generally exhibited faster tempo than females. Linear regression models did not show associations between pubertal timing and internalizing symptoms at time three. Findings showing advanced pubertal maturation in ASD youth suggest greater risk of psychological, social, and physiological challenges. LAY SUMMARY: Youth with ASD have difficulty in social communication and adaption to change, thus puberty may be a challenging transition. The study examined onset (timing) and progression (tempo) of puberty over three years, using physical exam, in 244 adolescents with and without ASD, enrolled at ages 10-13. ASD youth started puberty earlier, while males generally progressed at a faster pace. Further examination of puberty in ASD should identify impact on social, behavioral, and mental health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2786 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth [texte imprimé] / Blythe A. CORBETT, Auteur ; Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Sara DUFFUS, Auteur ; Sloane SPARKS, Auteur ; Yasas TANGUTURI, Auteur . - p.1894-1908. Langues : Anglais (eng) in Autism Research > 15-10 (October 2022) . - p.1894-1908 Mots-clés : adolescence  autism  development  female  puberty Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired social communication and poor adaptation to change; thus, pubertal development may be precarious. Pubertal timing and tempo were measured in 244 youth (7.9% Black, 83.3% White, and 8.7% multiracial) with ASD (N = 140) and typical development (N = 104). Pubertal development was measured using Tanner staging of Genital (G, males), Breast (B, females), and pubic hair (PH) in both sexes at Year 1 (10-13 years), Year 2 (11-14 years), and Year 3 (12-15 years). Nonlinear mixed effects models analyzed interindividual differences in timing and tempo. For both sexes, ASD and higher body mass index were associated with earlier pubertal timing. Males generally exhibited faster tempo than females. Linear regression models did not show associations between pubertal timing and internalizing symptoms at time three. Findings showing advanced pubertal maturation in ASD youth suggest greater risk of psychological, social, and physiological challenges. LAY SUMMARY: Youth with ASD have difficulty in social communication and adaption to change, thus puberty may be a challenging transition. The study examined onset (timing) and progression (tempo) of puberty over three years, using physical exam, in 244 adolescents with and without ASD, enrolled at ages 10-13. ASD youth started puberty earlier, while males generally progressed at a faster pace. Further examination of puberty in ASD should identify impact on social, behavioral, and mental health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2786 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Exploring trajectories of anxiety symptoms in autistic and non-autistic youth over adolescence using parent- and self-report measures / Meredith COLA in Research in Autism, 132 (April 2026)  

Public ISBD [article]  inResearch in Autism > 132 (April 2026) . - 202830 Titre : Exploring trajectories of anxiety symptoms in autistic and non-autistic youth over adolescence using parent- and self-report measures Type de document : texte imprimé Auteurs : Meredith COLA, Auteur ; Rachael A. MUSCATELLO, Auteur ; Xinyu ZHANG, Auteur ; Simon VANDEKAR, Auteur ; Trey MCGONIGLE, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : 202830 Langues : Anglais (eng) Mots-clés : Autism  Adolescence  Anxiety  Puberty  Development Résumé : Background Autistic youth frequently experience co-occurring anxiety. In non-autistic populations, females are more likely to be diagnosed with anxiety and demonstrate distinct symptom trajectories across adolescence. Prior research has demonstrated diagnostic group differences in parent- and self-reported anxiety symptoms; however, it is largely unknown if and how symptoms change over puberty. We examine trajectories of anxiety symptoms for autistic and non-autistic youth over a four-year (Y1-Y4) longitudinal study. Methods Autistic (N = 140) and non-autistic (N = 104) youth (ages 10–13 years at Y1) completed the parent- and self-report versions of the Multidimensional Anxiety Scale for Children, 2nd Edition (MASC-2). Linear mixed effects models were used to examine the impact of age, sex, and diagnosis on anxiety symptoms. Results There was a significant diagnosis-sex interaction (pFDR=0.005) on the parent-report of anxiety and a main effect of age (p < 0.001). Autistic and non-autistic females showed an increase in anxiety symptoms over time; autistic males showed a slight decrease. There was a main effect of diagnosis (pFDR=0.003) on the child-report measure of anxiety symptoms; the effects of age (pFDR=0.117) and sex were not significant (pFDR=0.305). The relationship between pubertal development and anxiety symptoms differed between the subgroups. Conclusions Our main findings – that autistic youth demonstrate greater anxiety symptoms than non-autistic youth, with distinct symptom trajectories emerging in females versus males – add to the growing literature aimed at understanding the biopsychosocial factors impacting puberty and emotional functioning across adolescence. En ligne : https://doi.org/10.1016/j.reia.2026.202830 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Exploring trajectories of anxiety symptoms in autistic and non-autistic youth over adolescence using parent- and self-report measures [texte imprimé] / Meredith COLA, Auteur ; Rachael A. MUSCATELLO, Auteur ; Xinyu ZHANG, Auteur ; Simon VANDEKAR, Auteur ; Trey MCGONIGLE, Auteur ; Blythe A. CORBETT, Auteur . - 202830. Langues : Anglais (eng) in Research in Autism > 132 (April 2026) . - 202830 Mots-clés : Autism  Adolescence  Anxiety  Puberty  Development Résumé : Background Autistic youth frequently experience co-occurring anxiety. In non-autistic populations, females are more likely to be diagnosed with anxiety and demonstrate distinct symptom trajectories across adolescence. Prior research has demonstrated diagnostic group differences in parent- and self-reported anxiety symptoms; however, it is largely unknown if and how symptoms change over puberty. We examine trajectories of anxiety symptoms for autistic and non-autistic youth over a four-year (Y1-Y4) longitudinal study. Methods Autistic (N = 140) and non-autistic (N = 104) youth (ages 10–13 years at Y1) completed the parent- and self-report versions of the Multidimensional Anxiety Scale for Children, 2nd Edition (MASC-2). Linear mixed effects models were used to examine the impact of age, sex, and diagnosis on anxiety symptoms. Results There was a significant diagnosis-sex interaction (pFDR=0.005) on the parent-report of anxiety and a main effect of age (p < 0.001). Autistic and non-autistic females showed an increase in anxiety symptoms over time; autistic males showed a slight decrease. There was a main effect of diagnosis (pFDR=0.003) on the child-report measure of anxiety symptoms; the effects of age (pFDR=0.117) and sex were not significant (pFDR=0.305). The relationship between pubertal development and anxiety symptoms differed between the subgroups. Conclusions Our main findings – that autistic youth demonstrate greater anxiety symptoms than non-autistic youth, with distinct symptom trajectories emerging in females versus males – add to the growing literature aimed at understanding the biopsychosocial factors impacting puberty and emotional functioning across adolescence. En ligne : https://doi.org/10.1016/j.reia.2026.202830 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Gender diversity in autistic and neurotypical youth over adolescence and puberty: A longitudinal study / Rachael A. MUSCATELLO ; Melissa CYPERSKI ; Eleonora SADIKOVA ; E. Kale EDMISTON ; Trey MCGONIGLE ; Rachel CALVOSA ; Simon VANDEKAR in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1450-1463 Titre : Gender diversity in autistic and neurotypical youth over adolescence and puberty: A longitudinal study Type de document : texte imprimé Auteurs : Rachael A. MUSCATELLO, Auteur ; Melissa CYPERSKI, Auteur ; Eleonora SADIKOVA, Auteur ; E. Kale EDMISTON, Auteur ; Trey MCGONIGLE, Auteur ; Rachel CALVOSA, Auteur ; Simon VANDEKAR, Auteur Article en page(s) : p.1450-1463 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Recent research in autism spectrum disorder (ASD) has suggested a higher prevalence of gender diversity in individuals diagnosed with ASD. Adolescence is a critical period for the consolidation of gender identity, yet the extent to which the experience of gender diversity is stable over adolescence and puberty in autistic youth is poorly understood. The aim of the study was to examine the consistency of gender diversity using the gender diversity screening questionnaire for self- and parent-report of youth (GDSQ-S, GDSQ-P) over a four-year longitudinal study of pubertal development in youth with ASD (N = 140, 36 assigned-female-at birth (AFAB)) and typical development (TD, N = 104, 58 assigned-male-at-birth [AMAB]) and their parents. The extent to which diagnosis (ASD vs. TD), assigned sex (AFAB vs. AMAB) and developmental level (age, puberty) predict GDSQ trajectory over time was explored. There was a significant diagnosis by sex-assigned-at-birth by age interaction for GDSQ-S Gender Diversity, p = 0.002, showing higher scores in autistic AFAB youth over adolescence, and TD AFAB showing initially lower, then increasing levels over adolescence. For GDSQ-P, Gender Incongruence was significantly different between the groups, p = 0.032, showing higher incongruence for autistic AFAB around age 10, decreasing between age 12-14 before increasing again, while TD AFAB evidence the inverse trend. AMAB trends were stable. The significant diagnostic, developmental and sex-based differences indicate AFAB youth experience greater gender diversity that evolves over development. Findings suggest gender identity formation is nuanced and may be influenced by pubertal progression, hormonal patterns, and psychosocial factors. Results underscore the need for enhanced understanding of the unique, dynamic profiles of females-assigned-at-birth. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Gender diversity in autistic and neurotypical youth over adolescence and puberty: A longitudinal study [texte imprimé] / Rachael A. MUSCATELLO, Auteur ; Melissa CYPERSKI, Auteur ; Eleonora SADIKOVA, Auteur ; E. Kale EDMISTON, Auteur ; Trey MCGONIGLE, Auteur ; Rachel CALVOSA, Auteur ; Simon VANDEKAR, Auteur . - p.1450-1463. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1450-1463 Index. décimale : PER Périodiques Résumé : Abstract Recent research in autism spectrum disorder (ASD) has suggested a higher prevalence of gender diversity in individuals diagnosed with ASD. Adolescence is a critical period for the consolidation of gender identity, yet the extent to which the experience of gender diversity is stable over adolescence and puberty in autistic youth is poorly understood. The aim of the study was to examine the consistency of gender diversity using the gender diversity screening questionnaire for self- and parent-report of youth (GDSQ-S, GDSQ-P) over a four-year longitudinal study of pubertal development in youth with ASD (N = 140, 36 assigned-female-at birth (AFAB)) and typical development (TD, N = 104, 58 assigned-male-at-birth [AMAB]) and their parents. The extent to which diagnosis (ASD vs. TD), assigned sex (AFAB vs. AMAB) and developmental level (age, puberty) predict GDSQ trajectory over time was explored. There was a significant diagnosis by sex-assigned-at-birth by age interaction for GDSQ-S Gender Diversity, p = 0.002, showing higher scores in autistic AFAB youth over adolescence, and TD AFAB showing initially lower, then increasing levels over adolescence. For GDSQ-P, Gender Incongruence was significantly different between the groups, p = 0.032, showing higher incongruence for autistic AFAB around age 10, decreasing between age 12-14 before increasing again, while TD AFAB evidence the inverse trend. AMAB trends were stable. The significant diagnostic, developmental and sex-based differences indicate AFAB youth experience greater gender diversity that evolves over development. Findings suggest gender identity formation is nuanced and may be influenced by pubertal progression, hormonal patterns, and psychosocial factors. Results underscore the need for enhanced understanding of the unique, dynamic profiles of females-assigned-at-birth. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder / Blythe A. CORBETT ; Alexandra P. KEY ; Mark E. KLEMENCIC ; Rachael A. MUSCATELLO ; Dorita JONES ; Jennifer PILKINGTON ; Christina BURROUGHS ; Simon VANDEKAR in Journal of Autism and Developmental Disorders, 55-1 (January 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-1 (January 2025) . - p.130-146 Titre : Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder : Journal of Autism and Developmental Disorders Type de document : texte imprimé Auteurs : Blythe A. CORBETT, Auteur ; Alexandra P. KEY, Auteur ; Mark E. KLEMENCIC, Auteur ; Rachael A. MUSCATELLO, Auteur ; Dorita JONES, Auteur ; Jennifer PILKINGTON, Auteur ; Christina BURROUGHS, Auteur ; Simon VANDEKAR, Auteur Article en page(s) : p.130-146 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by challenges in social competence that persist in adulthood, yet few treatment options exist. A pilot randomized clinical trial (RCT) of a peer-mediated, theatre-based intervention with established efficacy in youth with ASD was examined in autistic adults. The final sample consisted of forty-seven 18-to-40-year-old participants randomized to the experimental (EXP N = 23) or waitlist control (WLC N = 24) condition. A multimodal, social interdependent model was employed to examine social competence changes in brain (incidental face memory (IFM) using event-related potentials), cognition (Wechsler Memory Scale-III), behavior (Contextual Assessment of Social Skills) and function (Social Responsiveness Scale (SRS); Adaptive Behavior Assessment Scale (ABAS) Social Composite). Using analysis of covariance in which pretest was controlled in the model, posttest between-group differences were observed on IFM (p = 0.016, 2 = 0.139, d = 0.79) and several social and adaptive functional (SRS, ABAS) outcomes in social communication and interaction (SCI) (p = 0.019, 2 = 0.121, d = -00.45), communication (p = 0.044 2 = 0.09, d = -00.31), and motivation (p = 0.001, 2 = 0.229, d = -0.79) domains. At two-month follow-up, gains in social motivation remained (p = 0.041, 2 = 0.100, d = -0.77). The results offer preliminary support for a unique theatre-based social skills intervention for autistic adults who have few treatment options to enhance social competence. The trial was pre-registered with ClinicalTrials.gov (Identifier: NCT04349644). En ligne : https://doi.org/10.1007/s10803-023-06214-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder : Journal of Autism and Developmental Disorders [texte imprimé] / Blythe A. CORBETT, Auteur ; Alexandra P. KEY, Auteur ; Mark E. KLEMENCIC, Auteur ; Rachael A. MUSCATELLO, Auteur ; Dorita JONES, Auteur ; Jennifer PILKINGTON, Auteur ; Christina BURROUGHS, Auteur ; Simon VANDEKAR, Auteur . - p.130-146. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-1 (January 2025) . - p.130-146 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by challenges in social competence that persist in adulthood, yet few treatment options exist. A pilot randomized clinical trial (RCT) of a peer-mediated, theatre-based intervention with established efficacy in youth with ASD was examined in autistic adults. The final sample consisted of forty-seven 18-to-40-year-old participants randomized to the experimental (EXP N = 23) or waitlist control (WLC N = 24) condition. A multimodal, social interdependent model was employed to examine social competence changes in brain (incidental face memory (IFM) using event-related potentials), cognition (Wechsler Memory Scale-III), behavior (Contextual Assessment of Social Skills) and function (Social Responsiveness Scale (SRS); Adaptive Behavior Assessment Scale (ABAS) Social Composite). Using analysis of covariance in which pretest was controlled in the model, posttest between-group differences were observed on IFM (p = 0.016, 2 = 0.139, d = 0.79) and several social and adaptive functional (SRS, ABAS) outcomes in social communication and interaction (SCI) (p = 0.019, 2 = 0.121, d = -00.45), communication (p = 0.044 2 = 0.09, d = -00.31), and motivation (p = 0.001, 2 = 0.229, d = -0.79) domains. At two-month follow-up, gains in social motivation remained (p = 0.041, 2 = 0.100, d = -0.77). The results offer preliminary support for a unique theatre-based social skills intervention for autistic adults who have few treatment options to enhance social competence. The trial was pre-registered with ClinicalTrials.gov (Identifier: NCT04349644). En ligne : https://doi.org/10.1007/s10803-023-06214-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Pubertal developmental, body mass index, and cardiovascular autonomic function in children and adolescents with and without autism spectrum disorder: a four-time point accelerated longitudinal study / Rachael A. MUSCATELLO in Journal of Neurodevelopmental Disorders, 17 (2025)  

Permalink

Pubertal Timing During Early Adolescence: Advanced Pubertal Onset in Females with Autism Spectrum Disorder / Blythe A. CORBETT in Autism Research, 13-12 (December 2020)  

Permalink

Salivary testosterone in male and female youth with and without autism spectrum disorder: considerations of development, sex, and diagnosis / Rachael A. MUSCATELLO in Molecular Autism, 13 (2022)  

Permalink

Social context in stress and autism: comparing physiological profiles across two social paradigms in youth with and without autism spectrum disorder / Rachael A. MUSCATELLO in Research in Autism Spectrum Disorders, 112 (April 2024)  

Permalink

The developmental trajectory of diurnal cortisol in autistic and neurotypical youth / Blythe A. CORBETT in Development and Psychopathology, 36-4 (October 2024)  

Permalink

The intersection and developmental trajectory of morning cortisol and testosterone in autistic and neurotypical youth / Trey MCGONIGLE ; Rachael A. MUSCATELLO ; Simon VANDEKAR ; Rachel CALVOSA in Molecular Autism, 16 (2025)  

Permalink

Trajectory of depressive symptoms over adolescence in autistic and neurotypical youth / Blythe A. CORBETT in Molecular Autism, 15 (2024)  

Permalink

Use of ECT in Autism Spectrum Disorder and/or Intellectual Disability: A Single Site Retrospective Analysis / Joshua R. SMITH in Journal of Autism and Developmental Disorders, 54-3 (March 2024)  

Permalink

---

1 (1 - 13 / 13) Par page : 25 50 100 200