Reward- and threat-related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil / Leehyun YOON in Journal of Child Psychology and Psychiatry, 63-5 (May 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.579-590 Titre : Reward- and threat-related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil Type de document : texte imprimé Auteurs : Leehyun YOON, Auteur ; Fernanda ROHRSETZER, Auteur ; Lucas BATTEL, Auteur ; Mauricio ANÉS, Auteur ; Pedro H. MANFRO, Auteur ; Luis Augusto ROHDE, Auteur ; Anna VIDUANI, Auteur ; Zuzanna ZAJKOWSKA, Auteur ; Valeria MONDELLI, Auteur ; Christian KIELING, Auteur ; Johnna R. SWARTZ, Auteur Article en page(s) : p.579-590 Langues : Anglais (eng) Mots-clés : Adolescent  Brain/diagnostic imaging  Brain Mapping/methods  Brazil/epidemiology  Depression/epidemiology  Humans  Magnetic Resonance Imaging/methods  Reward  Risk Factors  Depression  adolescence  functional MRI (fMRI) Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimaging studies on adolescents at risk for depression have relied on a single risk factor and focused on adolescents in high-income countries. Using a composite risk score, this study aims to examine neural activity and connectivity associated with risk and presence of depression in adolescents in Brazil. METHODS: Depression risk was defined with the Identifying Depression Early in Adolescence Risk Score (IDEA-RS), calculated using a prognostic model that included 11 socio-demographic risk factors. Adolescents recruited from schools in Porto Alegre were classified into a low-risk (i.e., low IDEA-RS and no lifetime depression), high-risk (i.e., high IDEA-RS and no lifetime depression), or clinically depressed group (i.e., high IDEA-RS and depression diagnosis). One hundred fifty adolescents underwent a functional MRI scan while completing a reward-related gambling and a threat-related face-matching task. We compared group differences in activity and connectivity of the ventral striatum (VS) and amygdala during the gambling and face-matching tasks, respectively, and group differences in whole-brain neural activity. RESULTS: Although there was no group difference in reward-related VS or threat-related amygdala activity, the depressed group showed elevated VS activity to punishment relative to high-risk adolescents. The whole-brain analysis found reduced reward-related activity in the lateral prefrontal cortex of patients and high-risk adolescents compared with low-risk adolescents. Compared with low-risk adolescents, high-risk and depressed adolescents showed reduced threat-related left amygdala connectivity with thalamus, superior temporal gyrus, inferior parietal gyrus, precentral gyrus, and supplementary motor area. CONCLUSIONS: We identified neural correlates associated with risk and presence of depression in a well-characterized sample of adolescents. These findings enhance knowledge of the neurobiological underpinnings of risk and presence of depression in Brazil. Future longitudinal studies are needed to examine whether the observed neural patterns of high-risk adolescents predict the development of depression. En ligne : http://dx.doi.org/10.1111/jcpp.13496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Reward- and threat-related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil [texte imprimé] / Leehyun YOON, Auteur ; Fernanda ROHRSETZER, Auteur ; Lucas BATTEL, Auteur ; Mauricio ANÉS, Auteur ; Pedro H. MANFRO, Auteur ; Luis Augusto ROHDE, Auteur ; Anna VIDUANI, Auteur ; Zuzanna ZAJKOWSKA, Auteur ; Valeria MONDELLI, Auteur ; Christian KIELING, Auteur ; Johnna R. SWARTZ, Auteur . - p.579-590. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.579-590 Mots-clés : Adolescent  Brain/diagnostic imaging  Brain Mapping/methods  Brazil/epidemiology  Depression/epidemiology  Humans  Magnetic Resonance Imaging/methods  Reward  Risk Factors  Depression  adolescence  functional MRI (fMRI) Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimaging studies on adolescents at risk for depression have relied on a single risk factor and focused on adolescents in high-income countries. Using a composite risk score, this study aims to examine neural activity and connectivity associated with risk and presence of depression in adolescents in Brazil. METHODS: Depression risk was defined with the Identifying Depression Early in Adolescence Risk Score (IDEA-RS), calculated using a prognostic model that included 11 socio-demographic risk factors. Adolescents recruited from schools in Porto Alegre were classified into a low-risk (i.e., low IDEA-RS and no lifetime depression), high-risk (i.e., high IDEA-RS and no lifetime depression), or clinically depressed group (i.e., high IDEA-RS and depression diagnosis). One hundred fifty adolescents underwent a functional MRI scan while completing a reward-related gambling and a threat-related face-matching task. We compared group differences in activity and connectivity of the ventral striatum (VS) and amygdala during the gambling and face-matching tasks, respectively, and group differences in whole-brain neural activity. RESULTS: Although there was no group difference in reward-related VS or threat-related amygdala activity, the depressed group showed elevated VS activity to punishment relative to high-risk adolescents. The whole-brain analysis found reduced reward-related activity in the lateral prefrontal cortex of patients and high-risk adolescents compared with low-risk adolescents. Compared with low-risk adolescents, high-risk and depressed adolescents showed reduced threat-related left amygdala connectivity with thalamus, superior temporal gyrus, inferior parietal gyrus, precentral gyrus, and supplementary motor area. CONCLUSIONS: We identified neural correlates associated with risk and presence of depression in a well-characterized sample of adolescents. These findings enhance knowledge of the neurobiological underpinnings of risk and presence of depression in Brazil. Future longitudinal studies are needed to examine whether the observed neural patterns of high-risk adolescents predict the development of depression. En ligne : http://dx.doi.org/10.1111/jcpp.13496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Within-person longitudinal associations between depressive symptoms and interpersonal problems in adolescent girls / Leehyun YOON in Journal of Child Psychology and Psychiatry, 67-10 (October 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-10 (October 2026) . - p. 1701-1713 Titre : Within-person longitudinal associations between depressive symptoms and interpersonal problems in adolescent girls Type de document : texte imprimé Auteurs : Leehyun YOON, Auteur ; Kelsey E. MAGEE, Auteur ; Stephanie D. STEPP, Auteur ; Erika E. FORBES, Auteur ; Kate E. KEENAN, Auteur ; Alison E. HIPWELL, Auteur ; Amanda E. GUYER, Auteur Article en page(s) : p. 1701-1713 Langues : Anglais (eng) Mots-clés : Adolescence  girls  depressive symptoms  interpersonal problems  longitudinal modeling Index. décimale : PER Périodiques Résumé : Background Adolescence, particularly for girls, is a period of heightened risk for depressive symptoms and increased interpersonal stress. Although depressive symptoms and interpersonal problems are known to co-occur, prior work has predominantly examined between-person associations, leaving within-person processes unclear. This study addressed this gap by testing longitudinal within-person associations between depressive symptoms and interpersonal problems in adolescent girls over 4?years, evaluating whether links were reciprocal or unidirectional. Methods Participants included 543 adolescent girls from the Pittsburgh Girls Study. Across four waves (mean ages?=?16.5?19.3?years), girls self-reported depressive symptoms and eight types of interpersonal problems: domineering, vindictive, cold, socially avoidant, nonassertive, exploitable, overly nurturant, and intrusive. For each interpersonal problem, we fit both constrained and unconstrained random intercept cross-lagged panel models and selected the constrained model unless it demonstrated a significantly poorer fit than the unconstrained model, prioritizing parsimony. Results The selected models demonstrated good fit for all eight interpersonal problems. Within-person increases in depressive symptoms predicted subsequent within-person increases in overly nurturant and socially avoidant problems, whereas these interpersonal problems did not predict subsequent within-person increases in depressive symptoms. By contrast, depressive symptoms and domineering problems reciprocally predicted one another over time. Conclusions This study clarifies how depressive symptoms and interpersonal problems influence one another over time within individuals in adolescent girls. Findings highlight domineering problems as a potential intervention target for breaking cycles of mutual reinforcement with depressive symptoms. Moreover, addressing depressive symptoms may yield social benefits by reducing subsequent overly nurturant and socially avoidant problems. En ligne : https://doi.org/10.1111/jcpp.70171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Within-person longitudinal associations between depressive symptoms and interpersonal problems in adolescent girls [texte imprimé] / Leehyun YOON, Auteur ; Kelsey E. MAGEE, Auteur ; Stephanie D. STEPP, Auteur ; Erika E. FORBES, Auteur ; Kate E. KEENAN, Auteur ; Alison E. HIPWELL, Auteur ; Amanda E. GUYER, Auteur . - p. 1701-1713. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-10 (October 2026) . - p. 1701-1713 Mots-clés : Adolescence  girls  depressive symptoms  interpersonal problems  longitudinal modeling Index. décimale : PER Périodiques Résumé : Background Adolescence, particularly for girls, is a period of heightened risk for depressive symptoms and increased interpersonal stress. Although depressive symptoms and interpersonal problems are known to co-occur, prior work has predominantly examined between-person associations, leaving within-person processes unclear. This study addressed this gap by testing longitudinal within-person associations between depressive symptoms and interpersonal problems in adolescent girls over 4?years, evaluating whether links were reciprocal or unidirectional. Methods Participants included 543 adolescent girls from the Pittsburgh Girls Study. Across four waves (mean ages?=?16.5?19.3?years), girls self-reported depressive symptoms and eight types of interpersonal problems: domineering, vindictive, cold, socially avoidant, nonassertive, exploitable, overly nurturant, and intrusive. For each interpersonal problem, we fit both constrained and unconstrained random intercept cross-lagged panel models and selected the constrained model unless it demonstrated a significantly poorer fit than the unconstrained model, prioritizing parsimony. Results The selected models demonstrated good fit for all eight interpersonal problems. Within-person increases in depressive symptoms predicted subsequent within-person increases in overly nurturant and socially avoidant problems, whereas these interpersonal problems did not predict subsequent within-person increases in depressive symptoms. By contrast, depressive symptoms and domineering problems reciprocally predicted one another over time. Conclusions This study clarifies how depressive symptoms and interpersonal problems influence one another over time within individuals in adolescent girls. Findings highlight domineering problems as a potential intervention target for breaking cycles of mutual reinforcement with depressive symptoms. Moreover, addressing depressive symptoms may yield social benefits by reducing subsequent overly nurturant and socially avoidant problems. En ligne : https://doi.org/10.1111/jcpp.70171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

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