Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression / Meghan E. Carey in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2975-2985 Titre : Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression Type de document : Texte imprimé et/ou numérique Auteurs : Meghan E. Carey, Auteur ; Juliette RANDO, Auteur ; Stepan MELNYK, Auteur ; S. Jill JAMES, Auteur ; Nathaniel SNYDER, Auteur ; Carolyn SALAFIA, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Heather VOLK, Auteur ; Craig NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.2975-2985 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling?s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile ?: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. En ligne : https://doi.org/10.1007/s10803-022-05625-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression [Texte imprimé et/ou numérique] / Meghan E. Carey, Auteur ; Juliette RANDO, Auteur ; Stepan MELNYK, Auteur ; S. Jill JAMES, Auteur ; Nathaniel SNYDER, Auteur ; Carolyn SALAFIA, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Heather VOLK, Auteur ; Craig NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.2975-2985. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2975-2985 Index. décimale : PER Périodiques Résumé : We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling?s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile ?: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. En ligne : https://doi.org/10.1007/s10803-022-05625-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Gestational thyroid hormones and autism-related traits in the EARLI and HOME studies / Caichen ZHONG in Autism Research, 17-4 (April 2024)  

Public ISBD [article]  inAutism Research > 17-4 (April 2024) . - p.716-727 Titre : Gestational thyroid hormones and autism-related traits in the EARLI and HOME studies Type de document : Texte imprimé et/ou numérique Auteurs : Caichen ZHONG, Auteur ; Juliette RANDO, Auteur ; Marisa A. PATTI, Auteur ; Joseph M. BRAUN, Auteur ; Aimin CHEN, Auteur ; Yingying XU, Auteur ; Bruce P. LANPHEAR, Auteur ; Kimberly YOLTON, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.716-727 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Thyroid hormones are essential for neurodevelopment. Few studies have considered associations with quantitatively measured autism spectrum disorder (ASD)-related traits, which may help elucidate associations for a broader population. Participants were drawn from two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI), enrolling pregnant women who already had a child with ASD, and the Health Outcomes and Measures of the Environment (HOME) Study, following pregnant women from the greater Cincinnati, OH area. Gestational thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured in mid-pregnancy 16 (+3) weeks gestation serum samples. ASD-related traits were measured using the Social Responsiveness Scale (SRS) at ages 3-8?years. The association was examined using quantile regression, adjusting for maternal and sociodemographic factors. 278 participants (132 from EARLI, 146 from HOME) were included. TSH distributions were similar across cohorts, while FT4 levels were higher in EARLI compared to HOME. In pooled analyses, particularly for those in the highest SRS quantile (95th percentile), higher FT4 levels were associated with increasing SRS scores (? = 5.21, 95% CI = 0.93, 9.48), and higher TSH levels were associated with decreasing SRS scores (? = ?6.94, 95% CI = ?11.04, ?2.83). The association between TSH and SRS remained significant in HOME for the 95% percentile of SRS scores (? = ?6.48, 95% CI = ?12.16, ?0.80), but not EARLI. Results for FT4 were attenuated when examined in the individual cohorts. Our results add to evidence that gestational thyroid hormones may be associated with ASD-related outcomes by suggesting that relationships may differ across the distribution of ASD-related traits and by familial likelihood of ASD. En ligne : https://doi.org/10.1002/aur.3115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Gestational thyroid hormones and autism-related traits in the EARLI and HOME studies [Texte imprimé et/ou numérique] / Caichen ZHONG, Auteur ; Juliette RANDO, Auteur ; Marisa A. PATTI, Auteur ; Joseph M. BRAUN, Auteur ; Aimin CHEN, Auteur ; Yingying XU, Auteur ; Bruce P. LANPHEAR, Auteur ; Kimberly YOLTON, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.716-727. Langues : Anglais (eng) in Autism Research > 17-4 (April 2024) . - p.716-727 Index. décimale : PER Périodiques Résumé : Abstract Thyroid hormones are essential for neurodevelopment. Few studies have considered associations with quantitatively measured autism spectrum disorder (ASD)-related traits, which may help elucidate associations for a broader population. Participants were drawn from two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI), enrolling pregnant women who already had a child with ASD, and the Health Outcomes and Measures of the Environment (HOME) Study, following pregnant women from the greater Cincinnati, OH area. Gestational thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured in mid-pregnancy 16 (+3) weeks gestation serum samples. ASD-related traits were measured using the Social Responsiveness Scale (SRS) at ages 3-8?years. The association was examined using quantile regression, adjusting for maternal and sociodemographic factors. 278 participants (132 from EARLI, 146 from HOME) were included. TSH distributions were similar across cohorts, while FT4 levels were higher in EARLI compared to HOME. In pooled analyses, particularly for those in the highest SRS quantile (95th percentile), higher FT4 levels were associated with increasing SRS scores (? = 5.21, 95% CI = 0.93, 9.48), and higher TSH levels were associated with decreasing SRS scores (? = ?6.94, 95% CI = ?11.04, ?2.83). The association between TSH and SRS remained significant in HOME for the 95% percentile of SRS scores (? = ?6.48, 95% CI = ?12.16, ?0.80), but not EARLI. Results for FT4 were attenuated when examined in the individual cohorts. Our results add to evidence that gestational thyroid hormones may be associated with ASD-related outcomes by suggesting that relationships may differ across the distribution of ASD-related traits and by familial likelihood of ASD. En ligne : https://doi.org/10.1002/aur.3115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study / Emily E. JOYCE in Autism Research, 15-5 (May 2022)  

Public ISBD [article]  inAutism Research > 15-5 (May 2022) . - p.957-970 Titre : Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study Type de document : Texte imprimé et/ou numérique Auteurs : Emily E. JOYCE, Auteur ; Jorge E. CHAVARRO, Auteur ; Juliette RANDO, Auteur ; Ashley Y. SONG, Auteur ; Lisa A. CROEN, Auteur ; M Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.957-970 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Child, Preschool  Diet  Female  Humans  Mothers  Pesticide Residues  Pesticides/adverse effects  Pregnancy  Prenatal Exposure Delayed Effects  autism-related traits  fruit  prenatal diet  vegetables Index. décimale : PER Périodiques Résumé : Prior work has suggested associations between prenatal exposure to several classes of pesticides and child autism spectrum disorder (ASD). We examined a previously developed pesticide residue burden score (PRBS) and intake of high pesticide residue foods in association with ASD-related traits. Participants were drawn from the Early Autism Risk Longitudinal Investigation (EARLI) (n = 256), a cohort following mothers who previously had a child with ASD through a subsequent pregnancy and that child's development. ASD-related traits were captured according to total Social Responsiveness Scale (SRS) scores at age 3 (mean raw total SRS score = 35.8). Dietary intake was assessed through a food frequency questionnaire collected during pregnancy. We also incorporated organic intake and fatty foods in modified versions of the PRBS. Associations between high-residue fruit and vegetable intake, the overall PRBS and modified versions of it, and SRS scores were assessed using multivariable linear regression. Overall, we did not observe associations between pesticide residues in foods and ASD-related outcomes, and modified versions of the PRBS yielded similar findings. However, reductions in ASD-related traits were observed with higher overall fruit and vegetable intake (adjusted estimates for Q4 vs. Q1: ? -12.76, 95%CI -27.8, 2.3). Thus, findings from this high familial probability cohort did not suggest relationships between pesticide residues in the diet according to the PRBS and ASD-related traits. Beneficial effects of fruit and vegetable intake may influence these relationships. Future work should consider fruit and vegetable intake in association with ASD-related outcomes. LAY SUMMARY: Diet is the main source of exposure to most pesticides in use today. In this study, we examined the relationship between pesticide exposure from residues in the diet during pregnancy and child autism-related traits. We found that these pesticide residues from the diet were not related to child autism-related outcomes at age three. However, higher prenatal fruit and vegetable intake was associated with reductions in child autism-related traits. En ligne : http://dx.doi.org/10.1002/aur.2698 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study [Texte imprimé et/ou numérique] / Emily E. JOYCE, Auteur ; Jorge E. CHAVARRO, Auteur ; Juliette RANDO, Auteur ; Ashley Y. SONG, Auteur ; Lisa A. CROEN, Auteur ; M Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.957-970. Langues : Anglais (eng) in Autism Research > 15-5 (May 2022) . - p.957-970 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Child, Preschool  Diet  Female  Humans  Mothers  Pesticide Residues  Pesticides/adverse effects  Pregnancy  Prenatal Exposure Delayed Effects  autism-related traits  fruit  prenatal diet  vegetables Index. décimale : PER Périodiques Résumé : Prior work has suggested associations between prenatal exposure to several classes of pesticides and child autism spectrum disorder (ASD). We examined a previously developed pesticide residue burden score (PRBS) and intake of high pesticide residue foods in association with ASD-related traits. Participants were drawn from the Early Autism Risk Longitudinal Investigation (EARLI) (n = 256), a cohort following mothers who previously had a child with ASD through a subsequent pregnancy and that child's development. ASD-related traits were captured according to total Social Responsiveness Scale (SRS) scores at age 3 (mean raw total SRS score = 35.8). Dietary intake was assessed through a food frequency questionnaire collected during pregnancy. We also incorporated organic intake and fatty foods in modified versions of the PRBS. Associations between high-residue fruit and vegetable intake, the overall PRBS and modified versions of it, and SRS scores were assessed using multivariable linear regression. Overall, we did not observe associations between pesticide residues in foods and ASD-related outcomes, and modified versions of the PRBS yielded similar findings. However, reductions in ASD-related traits were observed with higher overall fruit and vegetable intake (adjusted estimates for Q4 vs. Q1: ? -12.76, 95%CI -27.8, 2.3). Thus, findings from this high familial probability cohort did not suggest relationships between pesticide residues in the diet according to the PRBS and ASD-related traits. Beneficial effects of fruit and vegetable intake may influence these relationships. Future work should consider fruit and vegetable intake in association with ASD-related outcomes. LAY SUMMARY: Diet is the main source of exposure to most pesticides in use today. In this study, we examined the relationship between pesticide exposure from residues in the diet during pregnancy and child autism-related traits. We found that these pesticide residues from the diet were not related to child autism-related outcomes at age three. However, higher prenatal fruit and vegetable intake was associated with reductions in child autism-related traits. En ligne : http://dx.doi.org/10.1002/aur.2698 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

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