Copy number variation in Han Chinese individuals with autism spectrum disorder / MatthewJ GAZZELLONE in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.34 Titre : Copy number variation in Han Chinese individuals with autism spectrum disorder Type de document : texte imprimé Auteurs : MatthewJ GAZZELLONE, Auteur ; Xue ZHOU, Auteur ; Anath C. LIONEL, Auteur ; Mohammed UDDIN, Auteur ; Bhooma THIRUVAHINDRAPURAM, Auteur ; Shuang LIANG, Auteur ; Caihong SUN, Auteur ; Jing WANG, Auteur ; Mingyang ZOU, Auteur ; Kristiina TAMMIMIES, Auteur ; Susan WALKER, Auteur ; Thanuja SELVANAYAGAM, Auteur ; John WEI, Auteur ; Ziqi WANG, Auteur ; Lijie WU, Auteur ; Stephen SCHERER, Auteur Article en page(s) : p.34 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Copy number variations (CNVs)  Han Chinese  Microarray diagnostic testing Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASDs) are a group of neurodevelopmental conditions with a demonstrated genetic etiology. Rare (<1% frequency) copy number variations (CNVs) account for a proportion of the genetic events involved, but the contribution of these events in non-European ASD populations has not been well studied. Here, we report on rare CNVs detected in a cohort of individuals with ASD of Han Chinese background. METHODS: DNA samples were obtained from 104 ASD probands and their parents who were recruited from Harbin, China. Samples were genotyped on the Affymetrix CytoScan HD platform. Rare CNVs were identified by comparing data with 873 technology-matched controls from Ontario and 1,235 additional population controls of Han Chinese ethnicity. RESULTS: Of the probands, 8.6% had at least 1 de novo CNV (overlapping the GIGYF2, SPRY1, 16p13.3, 16p11.2, 17p13.3-17p13.2, DMD, and NAP1L6 genes/loci). Rare inherited CNVs affected other plausible neurodevelopmental candidate genes including GRID2, LINGO2, and SLC39A12. A 24-kb duplication was also identified at YWHAE, a gene previously implicated in ASD and other developmental disorders. This duplication is observed at a similar frequency in cases and in population controls and is likely a benign Asian-specific copy number polymorphism. CONCLUSIONS: Our findings help define genomic features relevant to ASD in the Han Chinese and emphasize the importance of using ancestry-matched controls in medical genetic interpretations. En ligne : http://dx.doi.org/10.1186/1866-1955-6-34 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 [article] Copy number variation in Han Chinese individuals with autism spectrum disorder [texte imprimé] / MatthewJ GAZZELLONE, Auteur ; Xue ZHOU, Auteur ; Anath C. LIONEL, Auteur ; Mohammed UDDIN, Auteur ; Bhooma THIRUVAHINDRAPURAM, Auteur ; Shuang LIANG, Auteur ; Caihong SUN, Auteur ; Jing WANG, Auteur ; Mingyang ZOU, Auteur ; Kristiina TAMMIMIES, Auteur ; Susan WALKER, Auteur ; Thanuja SELVANAYAGAM, Auteur ; John WEI, Auteur ; Ziqi WANG, Auteur ; Lijie WU, Auteur ; Stephen SCHERER, Auteur . - p.34. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.34 Mots-clés : Autism spectrum disorder (ASD)  Copy number variations (CNVs)  Han Chinese  Microarray diagnostic testing Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASDs) are a group of neurodevelopmental conditions with a demonstrated genetic etiology. Rare (<1% frequency) copy number variations (CNVs) account for a proportion of the genetic events involved, but the contribution of these events in non-European ASD populations has not been well studied. Here, we report on rare CNVs detected in a cohort of individuals with ASD of Han Chinese background. METHODS: DNA samples were obtained from 104 ASD probands and their parents who were recruited from Harbin, China. Samples were genotyped on the Affymetrix CytoScan HD platform. Rare CNVs were identified by comparing data with 873 technology-matched controls from Ontario and 1,235 additional population controls of Han Chinese ethnicity. RESULTS: Of the probands, 8.6% had at least 1 de novo CNV (overlapping the GIGYF2, SPRY1, 16p13.3, 16p11.2, 17p13.3-17p13.2, DMD, and NAP1L6 genes/loci). Rare inherited CNVs affected other plausible neurodevelopmental candidate genes including GRID2, LINGO2, and SLC39A12. A 24-kb duplication was also identified at YWHAE, a gene previously implicated in ASD and other developmental disorders. This duplication is observed at a similar frequency in cases and in population controls and is likely a benign Asian-specific copy number polymorphism. CONCLUSIONS: Our findings help define genomic features relevant to ASD in the Han Chinese and emphasize the importance of using ancestry-matched controls in medical genetic interpretations. En ligne : http://dx.doi.org/10.1186/1866-1955-6-34 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346

Developmental prediction modeling based on diffusion tensor imaging uncovering age-dependent heterogeneity in early childhood autistic brain / Yating MING ; Weixing ZHAO ; Rui FENG ; Yuanyue ZHOU ; Lijie WU ; Jia WANG ; Jinming XIAO ; Lei LI ; Xiaolong SHAN ; Jing CAO ; Xiaodong KANG ; Huafu CHEN ; Xujun DUAN in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 41 p. Titre : Developmental prediction modeling based on diffusion tensor imaging uncovering age-dependent heterogeneity in early childhood autistic brain Type de document : texte imprimé Auteurs : Yating MING, Auteur ; Weixing ZHAO, Auteur ; Rui FENG, Auteur ; Yuanyue ZHOU, Auteur ; Lijie WU, Auteur ; Jia WANG, Auteur ; Jinming XIAO, Auteur ; Lei LI, Auteur ; Xiaolong SHAN, Auteur ; Jing CAO, Auteur ; Xiaodong KANG, Auteur ; Huafu CHEN, Auteur ; Xujun DUAN, Auteur Article en page(s) : 41 p. Langues : Anglais (eng) Mots-clés : Child  Humans  Child, Preschool  Diffusion Tensor Imaging/methods  *Autistic Disorder/diagnostic imaging  Brain/diagnostic imaging  *White Matter/diagnostic imaging  Cluster Analysis Index. décimale : PER Périodiques Résumé : OBJECTIVE: There has been increasing evidence for atypical white matter (WM) microstructure in autistic people, but findings have been divergent. The development of autistic people in early childhood is clouded by the concurrently rapid brain growth, which might lead to the inconsistent findings of atypical WM microstructure in autism. Here, we aimed to reveal the developmental nature of autistic children and delineate atypical WM microstructure throughout early childhood while taking developmental considerations into account. METHOD: In this study, diffusion tensor imaging was acquired from two independent cohorts, containing 91 autistic children and 100 typically developing children (TDC), aged 4-7 years. Developmental prediction modeling using support vector regression based on TDC participants was conducted to estimate the WM atypical development index of autistic children. Then, subgroups of autistic children were identified by using the k-means clustering method and were compared to each other on the basis of demographic information, WM atypical development index, and autistic trait by using two-sample t-test. Relationship of the WM atypical development index with age was estimated by using partial correlation. Furthermore, we performed threshold-free cluster enhancement-based two-sample t-test for the group comparison in WM microstructures of each subgroup of autistic children with the rematched subsets of TDC. RESULTS: We clustered autistic children into two subgroups according to WM atypical development index. The two subgroups exhibited distinct developmental stages and age-dependent diversity. WM atypical development index was found negatively associated with age. Moreover, an inverse pattern of atypical WM microstructures and different clinical manifestations in the two stages, with subgroup 1 showing overgrowth with low level of autistic traits and subgroup 2 exhibiting delayed maturation with high level of autistic traits, were revealed. CONCLUSION: This study illustrated age-dependent heterogeneity in early childhood autistic children and delineated developmental stage-specific difference that ranged from an overgrowth pattern to a delayed pattern. Trial registration This study has been registered at ClinicalTrials.gov (Identifier: NCT02807766) on June 21, 2016 ( https://clinicaltrials.gov/ct2/show/NCT02807766 ). En ligne : https://dx.doi.org/10.1186/s13229-023-00573-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Developmental prediction modeling based on diffusion tensor imaging uncovering age-dependent heterogeneity in early childhood autistic brain [texte imprimé] / Yating MING, Auteur ; Weixing ZHAO, Auteur ; Rui FENG, Auteur ; Yuanyue ZHOU, Auteur ; Lijie WU, Auteur ; Jia WANG, Auteur ; Jinming XIAO, Auteur ; Lei LI, Auteur ; Xiaolong SHAN, Auteur ; Jing CAO, Auteur ; Xiaodong KANG, Auteur ; Huafu CHEN, Auteur ; Xujun DUAN, Auteur . - 41 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 41 p. Mots-clés : Child  Humans  Child, Preschool  Diffusion Tensor Imaging/methods  *Autistic Disorder/diagnostic imaging  Brain/diagnostic imaging  *White Matter/diagnostic imaging  Cluster Analysis Index. décimale : PER Périodiques Résumé : OBJECTIVE: There has been increasing evidence for atypical white matter (WM) microstructure in autistic people, but findings have been divergent. The development of autistic people in early childhood is clouded by the concurrently rapid brain growth, which might lead to the inconsistent findings of atypical WM microstructure in autism. Here, we aimed to reveal the developmental nature of autistic children and delineate atypical WM microstructure throughout early childhood while taking developmental considerations into account. METHOD: In this study, diffusion tensor imaging was acquired from two independent cohorts, containing 91 autistic children and 100 typically developing children (TDC), aged 4-7 years. Developmental prediction modeling using support vector regression based on TDC participants was conducted to estimate the WM atypical development index of autistic children. Then, subgroups of autistic children were identified by using the k-means clustering method and were compared to each other on the basis of demographic information, WM atypical development index, and autistic trait by using two-sample t-test. Relationship of the WM atypical development index with age was estimated by using partial correlation. Furthermore, we performed threshold-free cluster enhancement-based two-sample t-test for the group comparison in WM microstructures of each subgroup of autistic children with the rematched subsets of TDC. RESULTS: We clustered autistic children into two subgroups according to WM atypical development index. The two subgroups exhibited distinct developmental stages and age-dependent diversity. WM atypical development index was found negatively associated with age. Moreover, an inverse pattern of atypical WM microstructures and different clinical manifestations in the two stages, with subgroup 1 showing overgrowth with low level of autistic traits and subgroup 2 exhibiting delayed maturation with high level of autistic traits, were revealed. CONCLUSION: This study illustrated age-dependent heterogeneity in early childhood autistic children and delineated developmental stage-specific difference that ranged from an overgrowth pattern to a delayed pattern. Trial registration This study has been registered at ClinicalTrials.gov (Identifier: NCT02807766) on June 21, 2016 ( https://clinicaltrials.gov/ct2/show/NCT02807766 ). En ligne : https://dx.doi.org/10.1186/s13229-023-00573-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China / Ting YANG ; Jie CHEN ; Li CHEN ; Ying DAI ; Hua WEI ; Feiyong JIA ; Lijie WU ; Yan HAO ; Ling LI ; Jie ZHANG ; Xiaoyan KE ; Mingji YI ; Qi HONG ; Jinjin CHEN ; Shuanfeng FANG ; Yichao WANG ; Qi WANG ; Chunhua JIN ; Tingyu LI in Research in Autism Spectrum Disorders, 111 (March 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 111 (March 2024) . - p.102309 Titre : Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China Type de document : texte imprimé Auteurs : Ting YANG, Auteur ; Jie CHEN, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Hua WEI, Auteur ; Feiyong JIA, Auteur ; Lijie WU, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Xiaoyan KE, Auteur ; Mingji YI, Auteur ; Qi HONG, Auteur ; Jinjin CHEN, Auteur ; Shuanfeng FANG, Auteur ; Yichao WANG, Auteur ; Qi WANG, Auteur ; Chunhua JIN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.102309 Mots-clés : Vitamin D  Multivitamin  Pregnancy  Autism spectrum disorder  Symptom  Children Index. décimale : PER Périodiques Résumé : Background We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Results Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [? =  1.342 ( 2.275, 0.409), P = 0.005] and communication warning behavior [? =  6.631 ( 9.899, 3.363), P < 0.001] scores and higher personal-social quotient [? = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal-social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms. En ligne : https://doi.org/10.1016/j.rasd.2023.102309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521 [article] Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China [texte imprimé] / Ting YANG, Auteur ; Jie CHEN, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Hua WEI, Auteur ; Feiyong JIA, Auteur ; Lijie WU, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Xiaoyan KE, Auteur ; Mingji YI, Auteur ; Qi HONG, Auteur ; Jinjin CHEN, Auteur ; Shuanfeng FANG, Auteur ; Yichao WANG, Auteur ; Qi WANG, Auteur ; Chunhua JIN, Auteur ; Tingyu LI, Auteur . - p.102309. in Research in Autism Spectrum Disorders > 111 (March 2024) . - p.102309 Mots-clés : Vitamin D  Multivitamin  Pregnancy  Autism spectrum disorder  Symptom  Children Index. décimale : PER Périodiques Résumé : Background We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Results Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [? =  1.342 ( 2.275, 0.409), P = 0.005] and communication warning behavior [? =  6.631 ( 9.899, 3.363), P < 0.001] scores and higher personal-social quotient [? = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal-social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms. En ligne : https://doi.org/10.1016/j.rasd.2023.102309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521

Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression / Xian LIU in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539 Titre : Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression Type de document : texte imprimé Auteurs : Xian LIU, Auteur ; Mingyang ZOU, Auteur ; Caihong SUN, Auteur ; Lijie WU, Auteur ; Wen-Xiong CHEN, Auteur Article en page(s) : p.522-539 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/chemically induced/epidemiology  Diet  Dietary Supplements  Female  Folic Acid  Humans  Pregnancy  Vitamins  Autism spectrum disorder  Folic acid  Meta-analysis  Meta-regression  Prenatal Index. décimale : PER Périodiques Résumé : We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04951-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression [texte imprimé] / Xian LIU, Auteur ; Mingyang ZOU, Auteur ; Caihong SUN, Auteur ; Lijie WU, Auteur ; Wen-Xiong CHEN, Auteur . - p.522-539. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539 Mots-clés : Autism Spectrum Disorder/chemically induced/epidemiology  Diet  Dietary Supplements  Female  Folic Acid  Humans  Pregnancy  Vitamins  Autism spectrum disorder  Folic acid  Meta-analysis  Meta-regression  Prenatal Index. décimale : PER Périodiques Résumé : We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04951-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis / Xian LIU in Autism, 26-1 (January 2022)  

Public ISBD [article]  inAutism > 26-1 (January 2022) . - p.33-50 Titre : Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis Type de document : texte imprimé Auteurs : Xian LIU, Auteur ; Xin SUN, Auteur ; Caihong SUN, Auteur ; Mingyang ZOU, Auteur ; Yiru CHEN, Auteur ; Junping HUANG, Auteur ; Lijie WU, Auteur ; Wen-Xiong CHEN, Auteur Année de publication : 2022 Article en page(s) : p.33-50 Langues : Anglais (eng) Mots-clés : adulthood  autism spectrum disorder (ASD)  childhood  co-occurrence  epilepsy  meta-analyses Index. décimale : PER Périodiques Résumé : Autistic individuals experience higher co-occurring medical conditions than the general population, and yet the estimates of autistic individuals with epilepsy are not updated. Co-occurrence of epilepsy in autistic individuals often aggravated cognitive impairment and increased the risk of poor long-term prognosis. Thus, an updated systematic review and meta-analysis was conducted to study the relevant articles published from inception to 2020, evaluate the prevalence of epilepsy in autistic individuals, and further explore the putative factors influencing the prevalence. A total of 66 studies from 53 articles were included in this study. The results showed that epilepsy is more common in autistic individuals than in the general population. The prevalence of epilepsy in autistic individuals in the clinical sample-based studies was higher than that in the population-based based cross-sectional or cohort studies. The prevalence of epilepsy in autistic adults was higher than that in autistic children. A significantly increased prevalence of epilepsy was detected in the autistic adolescent group (11-17 years old), and a higher trend of prevalence of epilepsy was observed in the autistic pre-school group (⩽ 6 -years-old) than that of the autistic school-aged group (7-10 years-old). The prevalence of epilepsy increased with age, female rate, and low intellectual function rate of autistic individuals. However, the human development index of countries was negatively associated with the pooled prevalence, which could be attributed to the different levels of awareness, diagnostic technologies, and autism-service support worldwide. About 1/10 autistic individuals also had epilepsy, which was common in the clinical setting, adolescents, adults, females, or patients with intellectual disability and less common in the country with high human development index. Thus, these findings provided critical and innovative views on the prevalence of epilepsy in autistic individuals and contributed to the targeted clinical management and preventive measures. En ligne : http://dx.doi.org/10.1177/13623613211045029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis [texte imprimé] / Xian LIU, Auteur ; Xin SUN, Auteur ; Caihong SUN, Auteur ; Mingyang ZOU, Auteur ; Yiru CHEN, Auteur ; Junping HUANG, Auteur ; Lijie WU, Auteur ; Wen-Xiong CHEN, Auteur . - 2022 . - p.33-50. Langues : Anglais (eng) in Autism > 26-1 (January 2022) . - p.33-50 Mots-clés : adulthood  autism spectrum disorder (ASD)  childhood  co-occurrence  epilepsy  meta-analyses Index. décimale : PER Périodiques Résumé : Autistic individuals experience higher co-occurring medical conditions than the general population, and yet the estimates of autistic individuals with epilepsy are not updated. Co-occurrence of epilepsy in autistic individuals often aggravated cognitive impairment and increased the risk of poor long-term prognosis. Thus, an updated systematic review and meta-analysis was conducted to study the relevant articles published from inception to 2020, evaluate the prevalence of epilepsy in autistic individuals, and further explore the putative factors influencing the prevalence. A total of 66 studies from 53 articles were included in this study. The results showed that epilepsy is more common in autistic individuals than in the general population. The prevalence of epilepsy in autistic individuals in the clinical sample-based studies was higher than that in the population-based based cross-sectional or cohort studies. The prevalence of epilepsy in autistic adults was higher than that in autistic children. A significantly increased prevalence of epilepsy was detected in the autistic adolescent group (11-17 years old), and a higher trend of prevalence of epilepsy was observed in the autistic pre-school group (⩽ 6 -years-old) than that of the autistic school-aged group (7-10 years-old). The prevalence of epilepsy increased with age, female rate, and low intellectual function rate of autistic individuals. However, the human development index of countries was negatively associated with the pooled prevalence, which could be attributed to the different levels of awareness, diagnostic technologies, and autism-service support worldwide. About 1/10 autistic individuals also had epilepsy, which was common in the clinical setting, adolescents, adults, females, or patients with intellectual disability and less common in the country with high human development index. Thus, these findings provided critical and innovative views on the prevalence of epilepsy in autistic individuals and contributed to the targeted clinical management and preventive measures. En ligne : http://dx.doi.org/10.1177/13623613211045029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis / Weili YAN in Autism, 26-7 (October 2022)  

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Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis / Weili YAN in Autism, 25-7 (October 2021)  

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Supporting access to comprehensive services: A scoping review of national policies related to autism in mainland China / Yujiao HAN ; Meiyu JIN ; Wei XIE ; Chuang SHANG ; Tiantian LI ; Liwen FENG ; Caihong SUN ; Saisai ZHANG ; Lijie WU in Autism, 29-7 (July 2025)  

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