A cross-lagged twin study of emotional symptoms, social isolation and peer victimisation from early adolescence to emerging adulthood / Geneviève MORNEAU-VAILLANCOURT in Journal of Child Psychology and Psychiatry, 64-11 (November 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1569-1582 Titre : A cross-lagged twin study of emotional symptoms, social isolation and peer victimisation from early adolescence to emerging adulthood Type de document : texte imprimé Auteurs : Geneviève MORNEAU-VAILLANCOURT, Auteur ; Olakunle OGINNI, Auteur ; Elham ASSARY, Auteur ; Georgina KREBS, Auteur ; Ellen J. THOMPSON, Auteur ; Elisavet PALAIOLOGOU, Auteur ; Celestine LOCKHART, Auteur ; Louise ARSENEAULT, Auteur ; Thalia C. ELEY, Auteur Article en page(s) : p.1569-1582 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Emotional symptoms, such as anxiety and depressive symptoms, are common during adolescence, often persist over time, and can precede the emergence of severe anxiety and depressive disorders. Studies suggest that a vicious cycle of reciprocal influences between emotional symptoms and interpersonal difficulties may explain why some adolescents suffer from persisting emotional symptoms. However, the role of different types of interpersonal difficulties, such as social isolation and peer victimisation, in these reciprocal associations is still unclear. In addition, the lack of longitudinal twin studies conducted on emotional symptoms during adolescence means that the genetic and environmental contributions to these relationships during adolescence remain unknown. Methods Participants (N=15,869) from the Twins Early Development Study completed self-reports of emotional symptoms, social isolation and peer victimisation at 12, 16 and 21 years old. A phenotypic cross-lagged model examined reciprocal associations between variables over time, and a genetic extension of this model examined the aetiology of the relationships between variables at each timepoint. Results First, emotional symptoms were reciprocally and independently associated with both social isolation and peer victimisation over time, indicating that different forms of interpersonal difficulties uniquely contributed to emotional symptoms during adolescence and vice versa. Second, early peer victimisation predicted later emotional symptoms via social isolation in mid-adolescence, indicating that social isolation may constitute an intermediate pathway through which peer victimisation predicts longer-term emotional symptoms. Finally, individual differences in emotional symptoms were mostly accounted for by non-shared environmental factors at each timepoint, and both gene-environment and individual-specific environmental mechanisms were involved in the relationships between emotional symptoms and interpersonal difficulties. Conclusions Our study highlights the necessity to intervene early in adolescence to prevent the escalation of emotional symptoms over time and to consider social isolation and peer victimisation as important risk factors for the long-term persistence of emotional symptoms. En ligne : https://doi.org/10.1111/jcpp.13847 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] A cross-lagged twin study of emotional symptoms, social isolation and peer victimisation from early adolescence to emerging adulthood [texte imprimé] / Geneviève MORNEAU-VAILLANCOURT, Auteur ; Olakunle OGINNI, Auteur ; Elham ASSARY, Auteur ; Georgina KREBS, Auteur ; Ellen J. THOMPSON, Auteur ; Elisavet PALAIOLOGOU, Auteur ; Celestine LOCKHART, Auteur ; Louise ARSENEAULT, Auteur ; Thalia C. ELEY, Auteur . - p.1569-1582. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1569-1582 Index. décimale : PER Périodiques Résumé : Background Emotional symptoms, such as anxiety and depressive symptoms, are common during adolescence, often persist over time, and can precede the emergence of severe anxiety and depressive disorders. Studies suggest that a vicious cycle of reciprocal influences between emotional symptoms and interpersonal difficulties may explain why some adolescents suffer from persisting emotional symptoms. However, the role of different types of interpersonal difficulties, such as social isolation and peer victimisation, in these reciprocal associations is still unclear. In addition, the lack of longitudinal twin studies conducted on emotional symptoms during adolescence means that the genetic and environmental contributions to these relationships during adolescence remain unknown. Methods Participants (N=15,869) from the Twins Early Development Study completed self-reports of emotional symptoms, social isolation and peer victimisation at 12, 16 and 21 years old. A phenotypic cross-lagged model examined reciprocal associations between variables over time, and a genetic extension of this model examined the aetiology of the relationships between variables at each timepoint. Results First, emotional symptoms were reciprocally and independently associated with both social isolation and peer victimisation over time, indicating that different forms of interpersonal difficulties uniquely contributed to emotional symptoms during adolescence and vice versa. Second, early peer victimisation predicted later emotional symptoms via social isolation in mid-adolescence, indicating that social isolation may constitute an intermediate pathway through which peer victimisation predicts longer-term emotional symptoms. Finally, individual differences in emotional symptoms were mostly accounted for by non-shared environmental factors at each timepoint, and both gene-environment and individual-specific environmental mechanisms were involved in the relationships between emotional symptoms and interpersonal difficulties. Conclusions Our study highlights the necessity to intervene early in adolescence to prevent the escalation of emotional symptoms over time and to consider social isolation and peer victimisation as important risk factors for the long-term persistence of emotional symptoms. En ligne : https://doi.org/10.1111/jcpp.13847 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression / Isabelle OUELLET-MORIN in Development and Psychopathology, 38-2 (May 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-2 (May 2026) . - p.852-865 Titre : Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression Type de document : texte imprimé Auteurs : Isabelle OUELLET-MORIN, Auteur ; Marie-Claude GEOFFROY, Auteur ; Pascal LOUIS, Auteur ; Ivan VORONIN, Auteur ; Geneviève MORNEAU-VAILLANCOURT, Auteur ; Rachel LANGEVIN, Auteur ; Delphine COLLIN-VÉZINA, Auteur ; Charles-Édouard GIGUERE, Auteur ; Mélanie BOULIANE, Auteur ; Amélie PETITCLERC, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Richard Ernest TREMBLAY, Auteur ; Michel BOIVIN, Auteur Article en page(s) : p.852-865 Langues : Anglais (eng) Mots-clés : Childhood maltreatment  genetics  gene–environmental correlation (rGE)  longitudinal studies: proactive and reactive aggression Index. décimale : PER Périodiques Résumé : Background:Childhood maltreatment is a robust predictor of aggression. Research indicates that both maltreatment experiences and aggression are moderately heritable. It has been hypothesized that gene–environment correlation may be at play, whereby genetic predispositions to aggression in parents and children may be confounded with family environments conducive to its expression. Building on this framework, we tested whether maltreatment mediates the association between a polygenic score for aggression (PGSAGG) and school-age aggression, and whether this varied for reactive and proactive aggression.Methods:The sample comprised 721 participants (44.9% males; 99.0% White) with prospective assessments of maltreatment from 5 months to 12 years (10 assessments;1998–2010), and teachers-reported aggression from ages 6 to 13 (6 assessments; 2004–2011). The PGSAGG was derived using a Bayesian estimation method (PRS-CS).Results:PGSAGG was associated with most aggression measures across specific ages and trajectories. Maltreatment experiences partially mediated the association between PGSAGG and the Childhood-Limited trajectory of reactive – but not proactive – aggression.Conclusion:Children with higher genetic propensities for aggression were more likely to experience maltreatment, which partly explained the association between PGSAGG and a Childhood-Limited trajectory of reactive aggression during elementary school. This finding reinforces the possibility of confounding influences between genetic liability for aggression and maltreatment experiences. En ligne : https://dx.doi.org/10.1017/S0954579425100801 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression [texte imprimé] / Isabelle OUELLET-MORIN, Auteur ; Marie-Claude GEOFFROY, Auteur ; Pascal LOUIS, Auteur ; Ivan VORONIN, Auteur ; Geneviève MORNEAU-VAILLANCOURT, Auteur ; Rachel LANGEVIN, Auteur ; Delphine COLLIN-VÉZINA, Auteur ; Charles-Édouard GIGUERE, Auteur ; Mélanie BOULIANE, Auteur ; Amélie PETITCLERC, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Richard Ernest TREMBLAY, Auteur ; Michel BOIVIN, Auteur . - p.852-865. Langues : Anglais (eng) in Development and Psychopathology > 38-2 (May 2026) . - p.852-865 Mots-clés : Childhood maltreatment  genetics  gene–environmental correlation (rGE)  longitudinal studies: proactive and reactive aggression Index. décimale : PER Périodiques Résumé : Background:Childhood maltreatment is a robust predictor of aggression. Research indicates that both maltreatment experiences and aggression are moderately heritable. It has been hypothesized that gene–environment correlation may be at play, whereby genetic predispositions to aggression in parents and children may be confounded with family environments conducive to its expression. Building on this framework, we tested whether maltreatment mediates the association between a polygenic score for aggression (PGSAGG) and school-age aggression, and whether this varied for reactive and proactive aggression.Methods:The sample comprised 721 participants (44.9% males; 99.0% White) with prospective assessments of maltreatment from 5 months to 12 years (10 assessments;1998–2010), and teachers-reported aggression from ages 6 to 13 (6 assessments; 2004–2011). The PGSAGG was derived using a Bayesian estimation method (PRS-CS).Results:PGSAGG was associated with most aggression measures across specific ages and trajectories. Maltreatment experiences partially mediated the association between PGSAGG and the Childhood-Limited trajectory of reactive – but not proactive – aggression.Conclusion:Children with higher genetic propensities for aggression were more likely to experience maltreatment, which partly explained the association between PGSAGG and a Childhood-Limited trajectory of reactive aggression during elementary school. This finding reinforces the possibility of confounding influences between genetic liability for aggression and maltreatment experiences. En ligne : https://dx.doi.org/10.1017/S0954579425100801 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development / Léa C. PERRET in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.388-396 Titre : Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development Type de document : texte imprimé Auteurs : Léa C. PERRET, Auteur ; Michel BOIVIN, Auteur ; Geneviève MORNEAU-VAILLANCOURT, Auteur ; Till F.M. ANDLAUER, Auteur ; Stéphane PAQUIN, Auteur ; Stéphanie LANGEVIN, Auteur ; Alain GIRARD, Auteur ; Gustavo TURECKI, Auteur ; Kieran J. O'DONNELL, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Jean-Philippe GOUIN, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Marie-Claude GEOFFROY, Auteur Article en page(s) : p.388-396 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Peer victimisation has been associated with depressive symptoms during adolescence, however not all peer victimised adolescents will exhibit such symptoms. This study tested whether having a genetic predisposition to developing depression increased the risk of experiencing depressive symptoms in peer victimised youth. To date, no study has explored such gene-environment interaction using a polygenic risk score for depression (PRS-depression) in the context of peer victimisation and depressive symptoms in adolescence. Methods The sample included 748 participants born in 1997/98 from the Quebec Longitudinal Study of Child Development with genotype data and prospectively collected information on peer victimisation (12-13 years) obtained from both self- and teacher-reports, as well as self-reported depressive symptoms (15-17 years). The PRS-depression was based on the genome-wide association meta-analysis of broad depression by Howard et al. (2019). Results Self- and teacher-reported peer victimisation in early adolescence were both associated with depressive symptoms in adolescence (ÃŽ2=0.34, p < .001; ÃŽ2=0.14, p=.001 respectively), and this association remained significant when accounting for PRS-depression (ÃŽ2=0.33, p < .001; ÃŽ2=0.13, p=.002 respectively). PRS-depression was independently associated with depressive symptoms, but there was no significant PRS-depression by peer victimisation interaction (self-reported and teacher-reported). PRS-depression was correlated with self-reported, but not teacher-reported, peer victimisation. Conclusions Our findings suggested that a partial measure of an individual's genetic predisposition to depression, as measured by PRS-depression, and being exposed to peer victimisation (self- and teacher-reported) were independently associated with depressive symptoms in adolescence. Furthermore, PRS-depression did not exacerbate the risk of depressive symptoms among adolescents who had been peer victimised. Lastly, we found evidence of a gene-environment correlation between PRS-depression and self-reported peer victimisation. Future studies are needed to replicate this finding and to further understand the role of genetic predispositions in experiencing depressive symptoms following peer victimisation. En ligne : https://doi.org/10.1111/jcpp.13706 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development [texte imprimé] / Léa C. PERRET, Auteur ; Michel BOIVIN, Auteur ; Geneviève MORNEAU-VAILLANCOURT, Auteur ; Till F.M. ANDLAUER, Auteur ; Stéphane PAQUIN, Auteur ; Stéphanie LANGEVIN, Auteur ; Alain GIRARD, Auteur ; Gustavo TURECKI, Auteur ; Kieran J. O'DONNELL, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Jean-Philippe GOUIN, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Marie-Claude GEOFFROY, Auteur . - p.388-396. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.388-396 Index. décimale : PER Périodiques Résumé : Background Peer victimisation has been associated with depressive symptoms during adolescence, however not all peer victimised adolescents will exhibit such symptoms. This study tested whether having a genetic predisposition to developing depression increased the risk of experiencing depressive symptoms in peer victimised youth. To date, no study has explored such gene-environment interaction using a polygenic risk score for depression (PRS-depression) in the context of peer victimisation and depressive symptoms in adolescence. Methods The sample included 748 participants born in 1997/98 from the Quebec Longitudinal Study of Child Development with genotype data and prospectively collected information on peer victimisation (12-13 years) obtained from both self- and teacher-reports, as well as self-reported depressive symptoms (15-17 years). The PRS-depression was based on the genome-wide association meta-analysis of broad depression by Howard et al. (2019). Results Self- and teacher-reported peer victimisation in early adolescence were both associated with depressive symptoms in adolescence (ÃŽ2=0.34, p < .001; ÃŽ2=0.14, p=.001 respectively), and this association remained significant when accounting for PRS-depression (ÃŽ2=0.33, p < .001; ÃŽ2=0.13, p=.002 respectively). PRS-depression was independently associated with depressive symptoms, but there was no significant PRS-depression by peer victimisation interaction (self-reported and teacher-reported). PRS-depression was correlated with self-reported, but not teacher-reported, peer victimisation. Conclusions Our findings suggested that a partial measure of an individual's genetic predisposition to depression, as measured by PRS-depression, and being exposed to peer victimisation (self- and teacher-reported) were independently associated with depressive symptoms in adolescence. Furthermore, PRS-depression did not exacerbate the risk of depressive symptoms among adolescents who had been peer victimised. Lastly, we found evidence of a gene-environment correlation between PRS-depression and self-reported peer victimisation. Future studies are needed to replicate this finding and to further understand the role of genetic predispositions in experiencing depressive symptoms following peer victimisation. En ligne : https://doi.org/10.1111/jcpp.13706 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood / Geneviève MORNEAU-VAILLANCOURT in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1320-1329 Titre : Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood Type de document : texte imprimé Auteurs : Geneviève MORNEAU-VAILLANCOURT, Auteur ; Till F.M. ANDLAUER, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Stéphane PAQUIN, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Jean-Philippe GOUIN, Auteur ; Jean R. SEGUIN, Auteur ; Éloi GAGNON, Auteur ; Rosa CHEESMAN, Auteur ; Nadine FORGET-DUBOIS, Auteur ; Guy A. ROULEAU, Auteur ; Gustavo TURECKI, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Ginette DIONNE, Auteur ; Michel BOIVIN, Auteur Article en page(s) : p.1320-1329 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Child  Humans  Infant, Newborn  Loneliness  Longitudinal Studies  Multifactorial Inheritance/genetics  Prospective Studies  Social withdrawal  polygenic scores  preference for solitude  social wariness  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: Children who consistently withdraw from social situations face increased risk for later socioemotional difficulties. Twin studies indicate that genetic factors substantially account for the persistence of social withdrawal over time. However, the molecular genetic etiology of chronic courses of social wariness and preference for solitude, two dimensions of social withdrawal, remains undocumented. The objectives of the present study were (a) to identify high-risk trajectories for social wariness and preference for solitude in childhood and (b) to examine whether falling on these high-risk trajectories can be predicted by specific polygenic scores for mental health traits and disorders and by a general polygenic predisposition to these traits. METHODS: Teachers evaluated 971 genotyped children at five occasions (age 6 to 12 years) from two prospective longitudinal studies, the Quebec Newborn Twin Study and the Quebec Longitudinal Study of Child Development. Developmental trajectories for social wariness and preference for solitude were identified. We tested whether polygenic scores for attention deficit hyperactivity disorder, autism spectrum disorder, depression, loneliness, and subjective well-being, as well as a general mental health genetic risk score derived across these traits, were associated with the developmental trajectories. RESULTS: Polygenic scores differentially predicted social wariness and preference for solitude. Only the loneliness polygenic score significantly predicted the high trajectory for social wariness. By contrast, the general mental health genetic risk score factor was associated with the trajectory depicting high-chronic preference for solitude. CONCLUSIONS: Distinct associations were uncovered between the polygenic scores, social wariness, and preference for solitude. En ligne : http://dx.doi.org/10.1111/jcpp.13459 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood [texte imprimé] / Geneviève MORNEAU-VAILLANCOURT, Auteur ; Till F.M. ANDLAUER, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Stéphane PAQUIN, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Jean-Philippe GOUIN, Auteur ; Jean R. SEGUIN, Auteur ; Éloi GAGNON, Auteur ; Rosa CHEESMAN, Auteur ; Nadine FORGET-DUBOIS, Auteur ; Guy A. ROULEAU, Auteur ; Gustavo TURECKI, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Ginette DIONNE, Auteur ; Michel BOIVIN, Auteur . - p.1320-1329. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1320-1329 Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Child  Humans  Infant, Newborn  Loneliness  Longitudinal Studies  Multifactorial Inheritance/genetics  Prospective Studies  Social withdrawal  polygenic scores  preference for solitude  social wariness  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: Children who consistently withdraw from social situations face increased risk for later socioemotional difficulties. Twin studies indicate that genetic factors substantially account for the persistence of social withdrawal over time. However, the molecular genetic etiology of chronic courses of social wariness and preference for solitude, two dimensions of social withdrawal, remains undocumented. The objectives of the present study were (a) to identify high-risk trajectories for social wariness and preference for solitude in childhood and (b) to examine whether falling on these high-risk trajectories can be predicted by specific polygenic scores for mental health traits and disorders and by a general polygenic predisposition to these traits. METHODS: Teachers evaluated 971 genotyped children at five occasions (age 6 to 12 years) from two prospective longitudinal studies, the Quebec Newborn Twin Study and the Quebec Longitudinal Study of Child Development. Developmental trajectories for social wariness and preference for solitude were identified. We tested whether polygenic scores for attention deficit hyperactivity disorder, autism spectrum disorder, depression, loneliness, and subjective well-being, as well as a general mental health genetic risk score derived across these traits, were associated with the developmental trajectories. RESULTS: Polygenic scores differentially predicted social wariness and preference for solitude. Only the loneliness polygenic score significantly predicted the high trajectory for social wariness. By contrast, the general mental health genetic risk score factor was associated with the trajectory depicting high-chronic preference for solitude. CONCLUSIONS: Distinct associations were uncovered between the polygenic scores, social wariness, and preference for solitude. En ligne : http://dx.doi.org/10.1111/jcpp.13459 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

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