Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort / Marie-Claude GEOFFROY ; Rachel LANGEVIN ; Léa C. PERRET ; Delphine COLLIN-VÉZINA ; Ivan VORONIN ; Jean-Philippe GOUIN ; Xiangfei MENG ; Michel BOIVIN ; Isabelle OUELLET-MORIN in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.2099-2110 Titre : Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort Type de document : texte imprimé Auteurs : Marie-Claude GEOFFROY, Auteur ; Rachel LANGEVIN, Auteur ; Léa C. PERRET, Auteur ; Delphine COLLIN-VÉZINA, Auteur ; Ivan VORONIN, Auteur ; Jean-Philippe GOUIN, Auteur ; Xiangfei MENG, Auteur ; Michel BOIVIN, Auteur ; Isabelle OUELLET-MORIN, Auteur Article en page(s) : p.2099-2110 Langues : Anglais (eng) Mots-clés : Childhood maltreatment  depression  polygenic risk score  prospective  retrospective Index. décimale : PER Périodiques Résumé : Childhood maltreatment is linked with later depressive symptoms, but not every maltreated child will experience symptoms later in life. Therefore, we investigate whether genetic predisposition for depression (i.e., polygenic score for depression, PGSDEP) modifies the association between maltreatment and depressive symptoms, while accounting for different types of maltreatment and whether it was evaluated through prospective and retrospective reports. The sample included 541-617 participants from the Quebec Longitudinal Study of Child Development with information on maltreatment, including threat, deprivation, assessed prospectively (5 months-17 years) and retrospectively (reported at 23 years), PGSDEP and self-reported depressive symptoms (20-23 years). Using hierarchical linear regressions, we found that retrospective, but not prospective indicators of maltreatment (threat/deprivation/cumulative) were associated with later depressive symptoms, above and beyond the PGSDEP. Our findings also show the presence of gene-environment interactions, whereby the association between maltreatment (retrospective cumulative maltreatment/threat, prospective deprivation) and depression was strengthened among youth with higher PGSDEP scores. Consistent with the Diathesis-Stress hypothesis, our findings suggest that a genetic predisposition for depression may exacerbate the putative impact of maltreatment on later depressive symptoms, especially when maltreatment is retrospective. Understanding the gene-environment interplay emerging in the context of maltreatment has the potential to guide prevention efforts. En ligne : https://dx.doi.org/10.1017/S0954579424001688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort [texte imprimé] / Marie-Claude GEOFFROY, Auteur ; Rachel LANGEVIN, Auteur ; Léa C. PERRET, Auteur ; Delphine COLLIN-VÉZINA, Auteur ; Ivan VORONIN, Auteur ; Jean-Philippe GOUIN, Auteur ; Xiangfei MENG, Auteur ; Michel BOIVIN, Auteur ; Isabelle OUELLET-MORIN, Auteur . - p.2099-2110. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.2099-2110 Mots-clés : Childhood maltreatment  depression  polygenic risk score  prospective  retrospective Index. décimale : PER Périodiques Résumé : Childhood maltreatment is linked with later depressive symptoms, but not every maltreated child will experience symptoms later in life. Therefore, we investigate whether genetic predisposition for depression (i.e., polygenic score for depression, PGSDEP) modifies the association between maltreatment and depressive symptoms, while accounting for different types of maltreatment and whether it was evaluated through prospective and retrospective reports. The sample included 541-617 participants from the Quebec Longitudinal Study of Child Development with information on maltreatment, including threat, deprivation, assessed prospectively (5 months-17 years) and retrospectively (reported at 23 years), PGSDEP and self-reported depressive symptoms (20-23 years). Using hierarchical linear regressions, we found that retrospective, but not prospective indicators of maltreatment (threat/deprivation/cumulative) were associated with later depressive symptoms, above and beyond the PGSDEP. Our findings also show the presence of gene-environment interactions, whereby the association between maltreatment (retrospective cumulative maltreatment/threat, prospective deprivation) and depression was strengthened among youth with higher PGSDEP scores. Consistent with the Diathesis-Stress hypothesis, our findings suggest that a genetic predisposition for depression may exacerbate the putative impact of maltreatment on later depressive symptoms, especially when maltreatment is retrospective. Understanding the gene-environment interplay emerging in the context of maltreatment has the potential to guide prevention efforts. En ligne : https://dx.doi.org/10.1017/S0954579424001688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort / Muzi LI in Development and Psychopathology, 36-1 (February 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-1 (February 2024) . - p.50-61 Titre : To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort Type de document : texte imprimé Auteurs : Muzi LI, Auteur ; Kieran J. O'DONNELL, Auteur ; Jean CARON, Auteur ; Michael J. MEANEY, Auteur ; Michael KOBOR, Auteur ; Carl D'ARCY, Auteur ; Yingying SU, Auteur ; Aihua LIU, Auteur ; Xiangfei MENG, Auteur Article en page(s) : p.50-61 Langues : Anglais (eng) Mots-clés : childhood maltreatment  coping strategies  depression  resilience  social support Index. décimale : PER Périodiques Résumé : This study aimed to articulate the roles of social support and coping strategies in the relation between childhood maltreatment (CM) and subsequent major depressive disorder (MDD) with a comprehensive exploration of potential factors in a longitudinal community-based cohort. Parallel and serial mediation analyses were applied to estimate the direct effect (DE) (from CM to MDD) and indirect effects (from CM to MDD through social support and coping strategies, simultaneously and sequentially). Sociodemographic characteristics and genetic predispositions of MDD were considered in the modeling process. A total of 902 participants were included in the analyses. CM was significantly associated with MDD (DE coefficient (?) = 0.015, 95% confidence interval (CI) = 0.002 0.028). This relation was partially mediated by social support (indirect ? = 0.004, 95% CI = 0.0001 0.008) and negative coping (indirect ? = 0.013, 95% CI = 0.008 0.020), respectively. Social support, positive coping, and negative coping also influenced each other and collectively mediated the association between CM and MDD. This study provides robust evidence that although CM has a detrimental effect on later-on MDD, social support and coping strategies could be viable solutions to minimize the risk of MDD. Intervention and prevention programs should primarily focus on weakening negative coping strategies, then strengthening social support and positive coping strategies. En ligne : https://dx.doi.org/10.1017/S0954579422000918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort [texte imprimé] / Muzi LI, Auteur ; Kieran J. O'DONNELL, Auteur ; Jean CARON, Auteur ; Michael J. MEANEY, Auteur ; Michael KOBOR, Auteur ; Carl D'ARCY, Auteur ; Yingying SU, Auteur ; Aihua LIU, Auteur ; Xiangfei MENG, Auteur . - p.50-61. Langues : Anglais (eng) in Development and Psychopathology > 36-1 (February 2024) . - p.50-61 Mots-clés : childhood maltreatment  coping strategies  depression  resilience  social support Index. décimale : PER Périodiques Résumé : This study aimed to articulate the roles of social support and coping strategies in the relation between childhood maltreatment (CM) and subsequent major depressive disorder (MDD) with a comprehensive exploration of potential factors in a longitudinal community-based cohort. Parallel and serial mediation analyses were applied to estimate the direct effect (DE) (from CM to MDD) and indirect effects (from CM to MDD through social support and coping strategies, simultaneously and sequentially). Sociodemographic characteristics and genetic predispositions of MDD were considered in the modeling process. A total of 902 participants were included in the analyses. CM was significantly associated with MDD (DE coefficient (?) = 0.015, 95% confidence interval (CI) = 0.002 0.028). This relation was partially mediated by social support (indirect ? = 0.004, 95% CI = 0.0001 0.008) and negative coping (indirect ? = 0.013, 95% CI = 0.008 0.020), respectively. Social support, positive coping, and negative coping also influenced each other and collectively mediated the association between CM and MDD. This study provides robust evidence that although CM has a detrimental effect on later-on MDD, social support and coping strategies could be viable solutions to minimize the risk of MDD. Intervention and prevention programs should primarily focus on weakening negative coping strategies, then strengthening social support and positive coping strategies. En ligne : https://dx.doi.org/10.1017/S0954579422000918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

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