Optimal outcome in individuals with a history of autism / Deborah A. FEIN in Journal of Child Psychology and Psychiatry, 54-2 (February 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.195-205 Titre : Optimal outcome in individuals with a history of autism Type de document : Texte imprimé et/ou numérique Auteurs : Deborah A. FEIN, Auteur ; Marianne L. BARTON, Auteur ; Inge-Marie EIGSTI, Auteur ; Elizabeth KELLEY, Auteur ; Letitia R. NAIGLES, Auteur ; Robert T. SCHULTZ, Auteur ; Michael C. STEVENS, Auteur ; Molly HELT, Auteur ; Alyssa ORINSTEIN, Auteur ; Michael A. ROSENTHAL, Auteur ; Eva TROYB, Auteur ; Katherine E. TYSON, Auteur Année de publication : 2013 Article en page(s) : p.195-205 Langues : Anglais (eng) Mots-clés : Autism  outcome  optimal Index. décimale : PER Périodiques Résumé : Background: Although autism spectrum disorders (ASDs) are generally considered lifelong disabilities, literature suggests that a minority of individuals with an ASD will lose the diagnosis. However, the existence of this phenomenon, as well as its frequency and interpretation, is still controversial: were they misdiagnosed initially, is this a rare event, did they lose the full diagnosis, but still suffer significant social and communication impairments or did they lose all symptoms of ASD and function socially within the normal range? Methods: The present study documents a group of these optimal outcome individuals (OO group, n = 34) by comparing their functioning on standardized measures to age, sex, and nonverbal IQ matched individuals with high-functioning autism (HFA group, n = 44) or typical development (TD group, n = 34). For this study, ‘optimal outcome' requires losing all symptoms of ASD in addition to the diagnosis, and functioning within the nonautistic range of social interaction and communication. Domains explored include language, face recognition, socialization, communication, and autism symptoms. Results: Optimal outcome and TD groups' mean scores did not differ on socialization, communication, face recognition, or most language subscales, although three OO individuals showed below-average scores on face recognition. Early in their development, the OO group displayed milder symptoms than the HFA group in the social domain, but had equally severe difficulties with communication and repetitive behaviors. Conclusions: Although possible deficits in more subtle aspects of social interaction or cognition are not ruled out, the results substantiate the possibility of OO from autism spectrum disorders and demonstrate an overall level of functioning within normal limits for this group. En ligne : http://dx.doi.org/10.1111/jcpp.12037 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 [article] Optimal outcome in individuals with a history of autism [Texte imprimé et/ou numérique] / Deborah A. FEIN, Auteur ; Marianne L. BARTON, Auteur ; Inge-Marie EIGSTI, Auteur ; Elizabeth KELLEY, Auteur ; Letitia R. NAIGLES, Auteur ; Robert T. SCHULTZ, Auteur ; Michael C. STEVENS, Auteur ; Molly HELT, Auteur ; Alyssa ORINSTEIN, Auteur ; Michael A. ROSENTHAL, Auteur ; Eva TROYB, Auteur ; Katherine E. TYSON, Auteur . - 2013 . - p.195-205. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.195-205 Mots-clés : Autism  outcome  optimal Index. décimale : PER Périodiques Résumé : Background: Although autism spectrum disorders (ASDs) are generally considered lifelong disabilities, literature suggests that a minority of individuals with an ASD will lose the diagnosis. However, the existence of this phenomenon, as well as its frequency and interpretation, is still controversial: were they misdiagnosed initially, is this a rare event, did they lose the full diagnosis, but still suffer significant social and communication impairments or did they lose all symptoms of ASD and function socially within the normal range? Methods: The present study documents a group of these optimal outcome individuals (OO group, n = 34) by comparing their functioning on standardized measures to age, sex, and nonverbal IQ matched individuals with high-functioning autism (HFA group, n = 44) or typical development (TD group, n = 34). For this study, ‘optimal outcome' requires losing all symptoms of ASD in addition to the diagnosis, and functioning within the nonautistic range of social interaction and communication. Domains explored include language, face recognition, socialization, communication, and autism symptoms. Results: Optimal outcome and TD groups' mean scores did not differ on socialization, communication, face recognition, or most language subscales, although three OO individuals showed below-average scores on face recognition. Early in their development, the OO group displayed milder symptoms than the HFA group in the social domain, but had equally severe difficulties with communication and repetitive behaviors. Conclusions: Although possible deficits in more subtle aspects of social interaction or cognition are not ruled out, the results substantiate the possibility of OO from autism spectrum disorders and demonstrate an overall level of functioning within normal limits for this group. En ligne : http://dx.doi.org/10.1111/jcpp.12037 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188

A pediatric twin study of brain morphometry / Gregory L. WALLACE in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.987–993 Titre : A pediatric twin study of brain morphometry Type de document : Texte imprimé et/ou numérique Auteurs : Gregory L. WALLACE, Auteur ; Michael A. ROSENTHAL, Auteur ; Michael C. NEALE, Auteur ; Kenneth S. KENDLER, Auteur ; Liv S. CLASEN, Auteur ; Elizabeth A. MOLLOY, Auteur ; Sarah ORDAZ, Auteur ; Essi VIDING, Auteur ; Rhoshel LENROOT, Auteur ; J. Eric SCHMITT, Auteur ; Jay N. GIEDD, Auteur Année de publication : 2007 Article en page(s) : p.987–993 Langues : Anglais (eng) Mots-clés : Brain-development brain-imaging pediatric twin behavioral-genetics Index. décimale : PER Périodiques Résumé : Background: Longitudinal pediatric neuroimaging studies have demonstrated increasing volumes of white matter and regionally-specific inverted U shaped developmental trajectories of gray matter volumes during childhood and adolescence. Studies of monozygotic and dyzygotic twins during this developmental period allow exploration of genetic and non-genetic influences on these developmental trajectories. Method: Magnetic resonance imaging brain scans were acquired on a pediatric sample of 90 monozygotic twin pairs, 38 same-sex dyzygotic twin pairs, and 158 unrelated typically developing singletons. Structural equation modeling was used to estimate the additive genetic, common environment, and unique environment effects, as well as age by heritability interactions, on measures of brain volumes from these images. Results: Consistent with previous adult studies, additive genetic effects accounted for a substantial portion of variability in nearly all brain regions with the notable exception of the cerebellum. Significant age by heritability interactions were observed with gray matter volumes showing a reduction in heritability with increasing age, while white matter volume heritability increased with greater age. Conclusion: Understanding the relative contributions of genetic and nongenetic factors on developmental brain trajectories may have implications for better understanding brain-based disorders and typical cognitive development. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01676.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=788 [article] A pediatric twin study of brain morphometry [Texte imprimé et/ou numérique] / Gregory L. WALLACE, Auteur ; Michael A. ROSENTHAL, Auteur ; Michael C. NEALE, Auteur ; Kenneth S. KENDLER, Auteur ; Liv S. CLASEN, Auteur ; Elizabeth A. MOLLOY, Auteur ; Sarah ORDAZ, Auteur ; Essi VIDING, Auteur ; Rhoshel LENROOT, Auteur ; J. Eric SCHMITT, Auteur ; Jay N. GIEDD, Auteur . - 2007 . - p.987–993. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.987–993 Mots-clés : Brain-development brain-imaging pediatric twin behavioral-genetics Index. décimale : PER Périodiques Résumé : Background: Longitudinal pediatric neuroimaging studies have demonstrated increasing volumes of white matter and regionally-specific inverted U shaped developmental trajectories of gray matter volumes during childhood and adolescence. Studies of monozygotic and dyzygotic twins during this developmental period allow exploration of genetic and non-genetic influences on these developmental trajectories. Method: Magnetic resonance imaging brain scans were acquired on a pediatric sample of 90 monozygotic twin pairs, 38 same-sex dyzygotic twin pairs, and 158 unrelated typically developing singletons. Structural equation modeling was used to estimate the additive genetic, common environment, and unique environment effects, as well as age by heritability interactions, on measures of brain volumes from these images. Results: Consistent with previous adult studies, additive genetic effects accounted for a substantial portion of variability in nearly all brain regions with the notable exception of the cerebellum. Significant age by heritability interactions were observed with gray matter volumes showing a reduction in heritability with increasing age, while white matter volume heritability increased with greater age. Conclusion: Understanding the relative contributions of genetic and nongenetic factors on developmental brain trajectories may have implications for better understanding brain-based disorders and typical cognitive development. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01676.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=788

Predictors of Optimal Outcome in Toddlers Diagnosed with Autism Spectrum Disorders / Saasha SUTERA in Journal of Autism and Developmental Disorders, 37-1 (January 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-1 (January 2007) . - p.98-107 Titre : Predictors of Optimal Outcome in Toddlers Diagnosed with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Saasha SUTERA, Auteur ; Deborah A. FEIN, Auteur ; Thyde DUMONT-MATHIEU, Auteur ; Diana L. ROBINS, Auteur ; Sarah HODGSON, Auteur ; James GREEN, Auteur ; Leandra B. WILSON, Auteur ; Michael A. ROSENTHAL, Auteur ; Emma L. ESSER, Auteur ; Juhi PANDEY, Auteur ; Marianne L. BARTON, Auteur Année de publication : 2007 Article en page(s) : p.98-107 Langues : Anglais (eng) Mots-clés : Autism Autistic-spectrum Optimal-outcome Recovery Index. décimale : PER Périodiques Résumé : A diagnosis of autism spectrum disorder (ASD) is usually taken to be permanent. In this study, 13 two-year-old children with ASD lost the diagnosis by age 4, at which time they scored within the normal range on standardized measures of cognitive and adaptive functioning. No differences were found in symptom severity, socialization, or communication between children who lost the ASD diagnosis and children who did not, but children with PDD-NOS were significantly more likely than those with full autistic disorder to move off the spectrum. The clearest distinguishing factor was motor skills at age 2. Results support the idea that some toddlers with ASD can lose their diagnosis and suggest that this is difficult to predict. En ligne : http://dx.doi.org/10.1007/s10803-006-0340-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=617 [article] Predictors of Optimal Outcome in Toddlers Diagnosed with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Saasha SUTERA, Auteur ; Deborah A. FEIN, Auteur ; Thyde DUMONT-MATHIEU, Auteur ; Diana L. ROBINS, Auteur ; Sarah HODGSON, Auteur ; James GREEN, Auteur ; Leandra B. WILSON, Auteur ; Michael A. ROSENTHAL, Auteur ; Emma L. ESSER, Auteur ; Juhi PANDEY, Auteur ; Marianne L. BARTON, Auteur . - 2007 . - p.98-107. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-1 (January 2007) . - p.98-107 Mots-clés : Autism Autistic-spectrum Optimal-outcome Recovery Index. décimale : PER Périodiques Résumé : A diagnosis of autism spectrum disorder (ASD) is usually taken to be permanent. In this study, 13 two-year-old children with ASD lost the diagnosis by age 4, at which time they scored within the normal range on standardized measures of cognitive and adaptive functioning. No differences were found in symptom severity, socialization, or communication between children who lost the ASD diagnosis and children who did not, but children with PDD-NOS were significantly more likely than those with full autistic disorder to move off the spectrum. The clearest distinguishing factor was motor skills at age 2. Results support the idea that some toddlers with ASD can lose their diagnosis and suggest that this is difficult to predict. En ligne : http://dx.doi.org/10.1007/s10803-006-0340-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=617

The Modified Checklist for Autism in Toddlers: A Follow-up Study Investigating the Early Detection of Autism Spectrum Disorders / Jamie KLEINMAN in Journal of Autism and Developmental Disorders, 38-5 (May 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-5 (May 2008) . - p.827-839 Titre : The Modified Checklist for Autism in Toddlers: A Follow-up Study Investigating the Early Detection of Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jamie KLEINMAN, Auteur ; Fred R. VOLKMAR, Auteur ; Deborah A. FEIN, Auteur ; Alyssa D. VERBALIS, Auteur ; Hilary BOORSTEIN, Auteur ; Pamela VENTOLA, Auteur ; Thyde DUMONT-MATHIEU, Auteur ; Diana L. ROBINS, Auteur ; Sarah HODGSON, Auteur ; James GREEN, Auteur ; Leandra B. WILSON, Auteur ; Michael A. ROSENTHAL, Auteur ; Emma L. ESSER, Auteur ; Juhi PANDEY, Auteur ; Saasha SUTERA, Auteur ; Katarzyna CHAWARSKA, Auteur ; Ami KLIN, Auteur ; Marianne L. BARTON, Auteur Année de publication : 2008 Article en page(s) : p.827-839 Langues : Anglais (eng) Mots-clés : Autism Early-identification Pediatric-screening Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) often go undetected in toddlers. The Modified Checklist for Autism in Toddlers (M-CHAT) was used to screen 3,793 children aged 16–30 months from low- and high-risk sources; screen positive cases were diagnostically evaluated. Re-screening was performed on 1,416 children aged 42–54 months. Time1 Positive Predictive Value (PPV) was .36 for the initial screening and .74 for the screening plus follow-up telephone interview; values were similar for Time2 PPV. When separating referral sources, PPV was low for the low-risk sample but acceptable with the follow-up telephone interview. Children with ASD from the low-risk and high-risk samples were highly similar. Results indicate that the M-CHAT continues to be a promising instrument for the early detection of ASD. En ligne : http://dx.doi.org/10.1007/s10803-007-0450-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 [article] The Modified Checklist for Autism in Toddlers: A Follow-up Study Investigating the Early Detection of Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Jamie KLEINMAN, Auteur ; Fred R. VOLKMAR, Auteur ; Deborah A. FEIN, Auteur ; Alyssa D. VERBALIS, Auteur ; Hilary BOORSTEIN, Auteur ; Pamela VENTOLA, Auteur ; Thyde DUMONT-MATHIEU, Auteur ; Diana L. ROBINS, Auteur ; Sarah HODGSON, Auteur ; James GREEN, Auteur ; Leandra B. WILSON, Auteur ; Michael A. ROSENTHAL, Auteur ; Emma L. ESSER, Auteur ; Juhi PANDEY, Auteur ; Saasha SUTERA, Auteur ; Katarzyna CHAWARSKA, Auteur ; Ami KLIN, Auteur ; Marianne L. BARTON, Auteur . - 2008 . - p.827-839. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-5 (May 2008) . - p.827-839 Mots-clés : Autism Early-identification Pediatric-screening Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) often go undetected in toddlers. The Modified Checklist for Autism in Toddlers (M-CHAT) was used to screen 3,793 children aged 16–30 months from low- and high-risk sources; screen positive cases were diagnostically evaluated. Re-screening was performed on 1,416 children aged 42–54 months. Time1 Positive Predictive Value (PPV) was .36 for the initial screening and .74 for the screening plus follow-up telephone interview; values were similar for Time2 PPV. When separating referral sources, PPV was low for the low-risk sample but acceptable with the follow-up telephone interview. Children with ASD from the low-risk and high-risk samples were highly similar. Results indicate that the M-CHAT continues to be a promising instrument for the early detection of ASD. En ligne : http://dx.doi.org/10.1007/s10803-007-0450-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416

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