Atypical Postural Control Variability and Coordination Persist Into Middle and Older Adulthood in Autism Spectrum Disorder / Jingying WANG ; Desirae J. SHIRLEY ; Hanna M. GEMMELL ; Danielle CHRISTENSEN ; Ann-Marie ORLANDO ; Regilda A. ROMERO ; Brandon A. ZIELINSKI ; Zheng WANG in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.752-764 Titre : Atypical Postural Control Variability and Coordination Persist Into Middle and Older Adulthood in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Jingying WANG, Auteur ; Desirae J. SHIRLEY, Auteur ; Hanna M. GEMMELL, Auteur ; Danielle CHRISTENSEN, Auteur ; Ann-Marie ORLANDO, Auteur ; Regilda A. ROMERO, Auteur ; Brandon A. ZIELINSKI, Auteur ; Zheng WANG, Auteur Article en page(s) : p.752-764 Langues : Anglais (eng) Mots-clés : aging  autism spectrum disorder  dynamic postural sway  middle aged and older  postural control  static stance Index. décimale : PER Périodiques Résumé : ABSTRACT Postural control deviations remain largely unexplored in middle aged and older autistic adults. With the increased prevalence of neurodegenerative conditions and heightened fall risk, precise quantification of postural variability and coordination may provide valuable insights into aging associated neuromotor deviations in autistic adults. Forty-seven autistic and 48 non-autistic individuals completed static stance, anterior?posterior (AP), and mediolateral (ML) postural sway on a force platform. Center of pressure (COP) metrics were derived and interpreted using ANCOVAs for between-group comparisons and multilinear regressions for group? ? ?age interaction. Correlations between clinical measures and COP variables that differentiated groups were explored. Compared to non-autistic individuals, autistic adults exhibited greater COP standard deviation (COPSD) and COP trajectory length during static stance and demonstrated significant COPSD-AP reductions in older age. Autistic adults also exhibited decreased COP range of motion (ROM) but increased ROM variability in the target direction during dynamic stance. Autistic adults' postural sway was jerkier during dynamic stance, and increased ROM variability during dynamic AP sway was moderately associated with lower verbal IQ in autistic adults. Our findings highlight persistent postural control deviations in middle aged and older autistic adults. Static and dynamic stance are differentially associated with unique profiles of postural control in ASD. Specifically, autistic adults demonstrated pronounced increases in postural sway variability during static stance, while reducing coordination during dynamic conditions. The extent to which postural control deviations found in autistic adults are predictive to the onset of neurodegenerative conditions and the severity of falls warrants future longitudinal research. En ligne : https://doi.org/10.1002/aur.70024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Atypical Postural Control Variability and Coordination Persist Into Middle and Older Adulthood in Autism Spectrum Disorder [texte imprimé] / Jingying WANG, Auteur ; Desirae J. SHIRLEY, Auteur ; Hanna M. GEMMELL, Auteur ; Danielle CHRISTENSEN, Auteur ; Ann-Marie ORLANDO, Auteur ; Regilda A. ROMERO, Auteur ; Brandon A. ZIELINSKI, Auteur ; Zheng WANG, Auteur . - p.752-764. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.752-764 Mots-clés : aging  autism spectrum disorder  dynamic postural sway  middle aged and older  postural control  static stance Index. décimale : PER Périodiques Résumé : ABSTRACT Postural control deviations remain largely unexplored in middle aged and older autistic adults. With the increased prevalence of neurodegenerative conditions and heightened fall risk, precise quantification of postural variability and coordination may provide valuable insights into aging associated neuromotor deviations in autistic adults. Forty-seven autistic and 48 non-autistic individuals completed static stance, anterior?posterior (AP), and mediolateral (ML) postural sway on a force platform. Center of pressure (COP) metrics were derived and interpreted using ANCOVAs for between-group comparisons and multilinear regressions for group? ? ?age interaction. Correlations between clinical measures and COP variables that differentiated groups were explored. Compared to non-autistic individuals, autistic adults exhibited greater COP standard deviation (COPSD) and COP trajectory length during static stance and demonstrated significant COPSD-AP reductions in older age. Autistic adults also exhibited decreased COP range of motion (ROM) but increased ROM variability in the target direction during dynamic stance. Autistic adults' postural sway was jerkier during dynamic stance, and increased ROM variability during dynamic AP sway was moderately associated with lower verbal IQ in autistic adults. Our findings highlight persistent postural control deviations in middle aged and older autistic adults. Static and dynamic stance are differentially associated with unique profiles of postural control in ASD. Specifically, autistic adults demonstrated pronounced increases in postural sway variability during static stance, while reducing coordination during dynamic conditions. The extent to which postural control deviations found in autistic adults are predictive to the onset of neurodegenerative conditions and the severity of falls warrants future longitudinal research. En ligne : https://doi.org/10.1002/aur.70024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Atypical Visually Guided Precision Grip Control in Middle-Aged and Older Autistic Adults / Zheng WANG in Autism Research, 19-2 (February 2026)  

Public ISBD [article]  inAutism Research > 19-2 (February 2026) . - e70154 Titre : Atypical Visually Guided Precision Grip Control in Middle-Aged and Older Autistic Adults Type de document : texte imprimé Auteurs : Zheng WANG, Auteur ; Hang QU, Auteur ; Danielle CHRISTENSEN, Auteur ; Hanna M. GEMMELL, Auteur ; Ellen M. PARKS, Auteur ; Kyla E. WETHERINGTON, Auteur ; Ann-Marie ORLANDO, Auteur ; Regilda A. ROMERO, Auteur ; Bikram KARMAKAR, Auteur ; David E. VAILLANCOURT, Auteur Article en page(s) : e70154 Langues : Anglais (eng) Mots-clés : aging  autism spectrum disorder  fine motor control  middle-aged and older adults  precision grip Index. décimale : PER Périodiques Résumé : ABSTRACT Sensorimotor impairments are well documented in autism spectrum disorder (ASD). However, little is known about how these difficulties present in middle-aged and older autistic adults or how they relate to demographic factors and autistic traits. In this study, 52 autistic and 56 age- and sex-matched non-autistic adults (aged 30?73?years) completed a visually guided precision grip task designed to assess temporal (reaction time, duration), spatial (force accuracy, variability), and dynamic (rate of force change) features of grip control under two conditions: varying motor output demands (target force test) and visual feedback (visual gain test). Autistic adults showed prolonged duration, delayed reaction time, and greater target overshooting at lower force levels during the rise phase. During the sustained phase, they exhibited increased grip force variability across both tasks. In contrast, autistic adults demonstrated shorter reaction times during the relaxation phase. Subgroup analyses revealed that the middle-aged autistic subgroup displayed elevated grip force variability, whereas the older autistic subgroup showed broader impairments affecting both spatial and temporal aspects of precision gripping. Within the autistic group, temporal grip force variables under the low target force condition were significantly associated with age and repetitive behaviors. These findings demonstrate that manual motor impairments persist into adulthood in ASD, and suggest shared neurobiological networks that underlie both motor dysfunction and core autistic traits. En ligne : https://doi.org/10.1002/aur.70154 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582 [article] Atypical Visually Guided Precision Grip Control in Middle-Aged and Older Autistic Adults [texte imprimé] / Zheng WANG, Auteur ; Hang QU, Auteur ; Danielle CHRISTENSEN, Auteur ; Hanna M. GEMMELL, Auteur ; Ellen M. PARKS, Auteur ; Kyla E. WETHERINGTON, Auteur ; Ann-Marie ORLANDO, Auteur ; Regilda A. ROMERO, Auteur ; Bikram KARMAKAR, Auteur ; David E. VAILLANCOURT, Auteur . - e70154. Langues : Anglais (eng) in Autism Research > 19-2 (February 2026) . - e70154 Mots-clés : aging  autism spectrum disorder  fine motor control  middle-aged and older adults  precision grip Index. décimale : PER Périodiques Résumé : ABSTRACT Sensorimotor impairments are well documented in autism spectrum disorder (ASD). However, little is known about how these difficulties present in middle-aged and older autistic adults or how they relate to demographic factors and autistic traits. In this study, 52 autistic and 56 age- and sex-matched non-autistic adults (aged 30?73?years) completed a visually guided precision grip task designed to assess temporal (reaction time, duration), spatial (force accuracy, variability), and dynamic (rate of force change) features of grip control under two conditions: varying motor output demands (target force test) and visual feedback (visual gain test). Autistic adults showed prolonged duration, delayed reaction time, and greater target overshooting at lower force levels during the rise phase. During the sustained phase, they exhibited increased grip force variability across both tasks. In contrast, autistic adults demonstrated shorter reaction times during the relaxation phase. Subgroup analyses revealed that the middle-aged autistic subgroup displayed elevated grip force variability, whereas the older autistic subgroup showed broader impairments affecting both spatial and temporal aspects of precision gripping. Within the autistic group, temporal grip force variables under the low target force condition were significantly associated with age and repetitive behaviors. These findings demonstrate that manual motor impairments persist into adulthood in ASD, and suggest shared neurobiological networks that underlie both motor dysfunction and core autistic traits. En ligne : https://doi.org/10.1002/aur.70154 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582

Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years / Danielle CHRISTENSEN ; Jingying WANG ; Desirae J. SHIRLEY ; Ann-Marie ORLANDO ; Regilda A. ROMERO ; David E. VAILLANCOURT ; Bradley J. WILKES ; Stephen A. COOMBES ; Zheng WANG in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 16 Titre : Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years Type de document : texte imprimé Auteurs : Danielle CHRISTENSEN, Auteur ; Jingying WANG, Auteur ; Desirae J. SHIRLEY, Auteur ; Ann-Marie ORLANDO, Auteur ; Regilda A. ROMERO, Auteur ; David E. VAILLANCOURT, Auteur ; Bradley J. WILKES, Auteur ; Stephen A. COOMBES, Auteur ; Zheng WANG, Auteur Article en page(s) : 16 Langues : Anglais (eng) Mots-clés : Humans  Male  Gray Matter/diagnostic imaging/pathology  White Matter/diagnostic imaging/pathology  Female  Adult  Middle Aged  Aged  Case-Control Studies  Autistic Disorder/diagnostic imaging/pathology  Corpus Callosum/diagnostic imaging/pathology  Autism Spectrum Disorder/diagnostic imaging/pathology  Anisotropy  Diffusion Magnetic Resonance Imaging  Aging  Autism spectrum disorder  Autistic adults  Diffusion MRI  Free water  Free water corrected fractional anisotropy  Free water corrected mean diffusivity  Gray matter  Transcallosal tracts  White matter  in this study were approved by the Institutional Review Board (IRB) at the  University of Florida following the Declaration of Helsinki. The IRB number is  202100659, with an approval date of July 26, 2022. Consent for publication: All  authors have read and approved the submission. Competing interests: The authors  declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a lifelong condition that profoundly impacts health, independence, and quality of life. However, research on brain aging in autistic adults is limited, and microstructural variations in white and gray matter remain poorly understood. To address this critical gap, we assessed novel diffusion MRI (dMRI) biomarkers, free water, and free water corrected fractional anisotropy (fwcFA), and mean diffusivity (fwcMD) across 32 transcallosal tracts and their corresponding homotopic grey matter origin/endpoint regions of interest (ROIs) in middle and old aged autistic adults. METHODS: Forty-three autistic adults aged 30-73 and 43 age-, sex-, and IQ-matched neurotypical controls underwent dMRI scans. We examined free water, fwcFA, fwcMD differences between the two groups and age-related pattern of each dMRI metric across the whole brain for each group. The relationships between clinical measures of ASD and free water in regions that significantly differentiated autistic adults from neurotypical controls were also explored. In supplementary analyses, we also assessed free water uncorrected FA and MD using conventional single tensor modeling. RESULTS: Autistic adults exhibited significantly elevated free water in seven frontal transcallosal tracts compared to controls. In controls, age-related increases in free water and decreases in fwcFA were observed across most transcallosal tracts. However, these age-associated patterns were entirely absent in autistic adults. In gray matter, autistic adults showed elevated free water in the calcarine cortices and lower fwcMD in the dorsal premotor cortices compared to controls. Lastly, age-related increases in free water were found across all white matter and gray matter ROIs in neurotypical controls, whereas no age-related associations were detected in any dMRI metrics for autistic adults. LIMITATIONS: We only recruited cognitively capable autistic adults, which limits the generalizability of our findings across the full autism spectrum. The cross-sectional design precludes inferences about microstructural changes over time in middle and old aged autistic adults. CONCLUSIONS: Our findings revealed increased free water load in frontal white matter in autistic adults and identified distinct age-associated microstructural variations between the two groups. These findings highlight more heterogeneous brain aging profiles in autistic adults. Our study also demonstrated the importance of quantifying free water in dMRI studies of ASD. En ligne : https://dx.doi.org/10.1186/s13229-025-00652-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years [texte imprimé] / Danielle CHRISTENSEN, Auteur ; Jingying WANG, Auteur ; Desirae J. SHIRLEY, Auteur ; Ann-Marie ORLANDO, Auteur ; Regilda A. ROMERO, Auteur ; David E. VAILLANCOURT, Auteur ; Bradley J. WILKES, Auteur ; Stephen A. COOMBES, Auteur ; Zheng WANG, Auteur . - 16. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 16 Mots-clés : Humans  Male  Gray Matter/diagnostic imaging/pathology  White Matter/diagnostic imaging/pathology  Female  Adult  Middle Aged  Aged  Case-Control Studies  Autistic Disorder/diagnostic imaging/pathology  Corpus Callosum/diagnostic imaging/pathology  Autism Spectrum Disorder/diagnostic imaging/pathology  Anisotropy  Diffusion Magnetic Resonance Imaging  Aging  Autism spectrum disorder  Autistic adults  Diffusion MRI  Free water  Free water corrected fractional anisotropy  Free water corrected mean diffusivity  Gray matter  Transcallosal tracts  White matter  in this study were approved by the Institutional Review Board (IRB) at the  University of Florida following the Declaration of Helsinki. The IRB number is  202100659, with an approval date of July 26, 2022. Consent for publication: All  authors have read and approved the submission. Competing interests: The authors  declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a lifelong condition that profoundly impacts health, independence, and quality of life. However, research on brain aging in autistic adults is limited, and microstructural variations in white and gray matter remain poorly understood. To address this critical gap, we assessed novel diffusion MRI (dMRI) biomarkers, free water, and free water corrected fractional anisotropy (fwcFA), and mean diffusivity (fwcMD) across 32 transcallosal tracts and their corresponding homotopic grey matter origin/endpoint regions of interest (ROIs) in middle and old aged autistic adults. METHODS: Forty-three autistic adults aged 30-73 and 43 age-, sex-, and IQ-matched neurotypical controls underwent dMRI scans. We examined free water, fwcFA, fwcMD differences between the two groups and age-related pattern of each dMRI metric across the whole brain for each group. The relationships between clinical measures of ASD and free water in regions that significantly differentiated autistic adults from neurotypical controls were also explored. In supplementary analyses, we also assessed free water uncorrected FA and MD using conventional single tensor modeling. RESULTS: Autistic adults exhibited significantly elevated free water in seven frontal transcallosal tracts compared to controls. In controls, age-related increases in free water and decreases in fwcFA were observed across most transcallosal tracts. However, these age-associated patterns were entirely absent in autistic adults. In gray matter, autistic adults showed elevated free water in the calcarine cortices and lower fwcMD in the dorsal premotor cortices compared to controls. Lastly, age-related increases in free water were found across all white matter and gray matter ROIs in neurotypical controls, whereas no age-related associations were detected in any dMRI metrics for autistic adults. LIMITATIONS: We only recruited cognitively capable autistic adults, which limits the generalizability of our findings across the full autism spectrum. The cross-sectional design precludes inferences about microstructural changes over time in middle and old aged autistic adults. CONCLUSIONS: Our findings revealed increased free water load in frontal white matter in autistic adults and identified distinct age-associated microstructural variations between the two groups. These findings highlight more heterogeneous brain aging profiles in autistic adults. Our study also demonstrated the importance of quantifying free water in dMRI studies of ASD. En ligne : https://dx.doi.org/10.1186/s13229-025-00652-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

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