A neural substrate for sensory over-responsivity defined by exogenous and endogenous brain systems / Hannah L. CHOI in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : A neural substrate for sensory over-responsivity defined by exogenous and endogenous brain systems Type de document : texte imprimé Auteurs : Hannah L. CHOI, Auteur ; Maia C. LAZERWITZ, Auteur ; Rachel POWERS, Auteur ; Mikaela ROWE, Auteur ; Jamie WREN-JARVIS, Auteur ; Amir SADIKOV, Auteur ; Lanya T. CAI, Auteur ; Robyn CHU, Auteur ; LaShelle RULLAN, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur Langues : Anglais (eng) Mots-clés : Emotional regulation  Functional MRI connectivity  Multimodal neuroimaging  Neurodevelopment  Resilience  Sensory over-responsivity  Sensory processing disorder  involving behavioral and neuroimaging data collection of human participants  between ages 8–12 years old was approved by the UCSF institutional review board.  Written informed consent from the parent or caregiver and assent from the  participant were collected. Consent for publication: All authors have provided  approval of the manuscript. This work was made publicly available as a preprint  uploaded to PsyArXiv at this link: https://osf.io/preprints/psyarxiv/ajs9w_v1  prior to publishing. It has not been published elsewhere. Competing interests:  The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Exogenous (outward-directed) and endogenous (inward-directed) neural systems are essential for cognition and behavior. However, how they are altered in neurodiverse (ND) children remains unanswered in part due to heterogeneity. Sensory over-responsivity (SOR), the most prevalent form of sensory processing disorder (SPD), serves as a quintessential paradigm for investigating the interaction between exogenous and endogenous brain networks given that both basic and higher-order sensory processing are substantially implicated in this condition. METHODS: Neurodiverse children ages 8–12 years old (n = 83; 30 females and 53 males) were directly assessed for SOR using a structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment (SP3D:A), and underwent 3 Tesla MRI. 39 ND children presented with SOR (ND/SOR) and 44 ND children presented without SOR (ND/NO-SOR). Exogenous and endogenous functional connectivity networks (FCNs) were generated through independent component analysis and investigated with two local functional connectivity (FC) measures, fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), as well as a long-range FC measure, dual regression (DR). Moreover, we examined FC in the context of behavioral regulation as assessed through the Behavioral Assessment System for Children, 3rd edition (BASC-3), categorizing children as "resilient" or "dysregulated" through latent profile analysis. RESULTS: In general, ND/SOR children exhibit reduced long-range exogenous FC. However, in terms of local FC, we find that ND/SOR children have reduced exogenous and elevated endogenous FC which is diametrically opposed to ND/NO-SOR children. Furthermore, this double dissociation is specific to ND children who are behaviorally resilient, while emotionally dysregulated ND children possess a distinct pattern. CONCLUSION: Achieving optimal brain system connectivity—a balanced contrast—is influenced by sensory over-responsivity and essential for resilience. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-025-09656-y. En ligne : https://dx.doi.org/10.1186/s11689-025-09656-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] A neural substrate for sensory over-responsivity defined by exogenous and endogenous brain systems [texte imprimé] / Hannah L. CHOI, Auteur ; Maia C. LAZERWITZ, Auteur ; Rachel POWERS, Auteur ; Mikaela ROWE, Auteur ; Jamie WREN-JARVIS, Auteur ; Amir SADIKOV, Auteur ; Lanya T. CAI, Auteur ; Robyn CHU, Auteur ; LaShelle RULLAN, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Emotional regulation  Functional MRI connectivity  Multimodal neuroimaging  Neurodevelopment  Resilience  Sensory over-responsivity  Sensory processing disorder  involving behavioral and neuroimaging data collection of human participants  between ages 8–12 years old was approved by the UCSF institutional review board.  Written informed consent from the parent or caregiver and assent from the  participant were collected. Consent for publication: All authors have provided  approval of the manuscript. This work was made publicly available as a preprint  uploaded to PsyArXiv at this link: https://osf.io/preprints/psyarxiv/ajs9w_v1  prior to publishing. It has not been published elsewhere. Competing interests:  The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Exogenous (outward-directed) and endogenous (inward-directed) neural systems are essential for cognition and behavior. However, how they are altered in neurodiverse (ND) children remains unanswered in part due to heterogeneity. Sensory over-responsivity (SOR), the most prevalent form of sensory processing disorder (SPD), serves as a quintessential paradigm for investigating the interaction between exogenous and endogenous brain networks given that both basic and higher-order sensory processing are substantially implicated in this condition. METHODS: Neurodiverse children ages 8–12 years old (n = 83; 30 females and 53 males) were directly assessed for SOR using a structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment (SP3D:A), and underwent 3 Tesla MRI. 39 ND children presented with SOR (ND/SOR) and 44 ND children presented without SOR (ND/NO-SOR). Exogenous and endogenous functional connectivity networks (FCNs) were generated through independent component analysis and investigated with two local functional connectivity (FC) measures, fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), as well as a long-range FC measure, dual regression (DR). Moreover, we examined FC in the context of behavioral regulation as assessed through the Behavioral Assessment System for Children, 3rd edition (BASC-3), categorizing children as "resilient" or "dysregulated" through latent profile analysis. RESULTS: In general, ND/SOR children exhibit reduced long-range exogenous FC. However, in terms of local FC, we find that ND/SOR children have reduced exogenous and elevated endogenous FC which is diametrically opposed to ND/NO-SOR children. Furthermore, this double dissociation is specific to ND children who are behaviorally resilient, while emotionally dysregulated ND children possess a distinct pattern. CONCLUSION: Achieving optimal brain system connectivity—a balanced contrast—is influenced by sensory over-responsivity and essential for resilience. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-025-09656-y. En ligne : https://dx.doi.org/10.1186/s11689-025-09656-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

White matter microstructure of children with sensory over-responsivity is associated with affective behavior / Jamie WREN-JARVIS in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : White matter microstructure of children with sensory over-responsivity is associated with affective behavior Type de document : texte imprimé Auteurs : Jamie WREN-JARVIS, Auteur ; Rachel POWERS, Auteur ; Maia C. LAZERWITZ, Auteur ; Jaclyn XIAO, Auteur ; Lanya T. CAI, Auteur ; Hannah L. CHOI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Mikaela A. ROWE, Auteur ; Mary C. STEELE, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur Langues : Anglais (eng) Mots-clés : Male  Child  Female  Humans  White Matter/diagnostic imaging  Diffusion Tensor Imaging/methods  Diffusion Magnetic Resonance Imaging  Magnetic Resonance Imaging  Cerebellum  Dti  Depression  Mri  Sensory over-responsivity  Sensory processing disorder  Somatization  White matter  commercial or financial relationships that could be construed as a potential  conflict of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory over-responsivity (SOR), a form of SPD, affects at least 2.5% of all children and has substantial deleterious impact on learning and mental health. However, SOR has not been well studied using microstructural imaging such as diffusion MRI (dMRI). Since SOR involves hypersensitivity to external stimuli, we test the hypothesis that children with SOR require compensatory neuroplasticity in the form of superior WM microstructural integrity to protect against internalizing behavior, leaving those with impaired WM microstructure vulnerable to somatization and depression. METHODS: Children ages 8-12 years old with neurodevelopmental concerns were assessed for SOR using a comprehensive structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment, and underwent 3 Tesla MRI with multishell multiband dMRI. Tract-based spatial statistics was used to measure diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics from global WM and nineteen selected WM tracts. Correlations of DTI and NODDI measures with measures of somatization and emotional disturbance from the Behavioral Assessment System for Children, 3rd edition (BASC-3), were computed in the SOR group and in matched children with neurodevelopmental concerns but not SOR. RESULTS: Global WM fractional anisotropy (FA) is negatively correlated with somatization and with emotional disturbance in the SOR group but not the non-SOR group. Also observed in children with SOR are positive correlations of radial diffusivity (RD) and free water fraction (FISO) with somatization and, in most cases, emotional disturbance. These effects are significant in boys with SOR, whereas the study is underpowered for girls. The most affected white matter are medial lemniscus and internal capsule sensory tracts, although effects of SOR are observed in many cerebral, cerebellar, and brainstem tracts. CONCLUSION: White matter microstructure is related to affective behavior in children with SOR. En ligne : https://dx.doi.org/10.1186/s11689-023-09513-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] White matter microstructure of children with sensory over-responsivity is associated with affective behavior [texte imprimé] / Jamie WREN-JARVIS, Auteur ; Rachel POWERS, Auteur ; Maia C. LAZERWITZ, Auteur ; Jaclyn XIAO, Auteur ; Lanya T. CAI, Auteur ; Hannah L. CHOI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Mikaela A. ROWE, Auteur ; Mary C. STEELE, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Male  Child  Female  Humans  White Matter/diagnostic imaging  Diffusion Tensor Imaging/methods  Diffusion Magnetic Resonance Imaging  Magnetic Resonance Imaging  Cerebellum  Dti  Depression  Mri  Sensory over-responsivity  Sensory processing disorder  Somatization  White matter  commercial or financial relationships that could be construed as a potential  conflict of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory over-responsivity (SOR), a form of SPD, affects at least 2.5% of all children and has substantial deleterious impact on learning and mental health. However, SOR has not been well studied using microstructural imaging such as diffusion MRI (dMRI). Since SOR involves hypersensitivity to external stimuli, we test the hypothesis that children with SOR require compensatory neuroplasticity in the form of superior WM microstructural integrity to protect against internalizing behavior, leaving those with impaired WM microstructure vulnerable to somatization and depression. METHODS: Children ages 8-12 years old with neurodevelopmental concerns were assessed for SOR using a comprehensive structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment, and underwent 3 Tesla MRI with multishell multiband dMRI. Tract-based spatial statistics was used to measure diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics from global WM and nineteen selected WM tracts. Correlations of DTI and NODDI measures with measures of somatization and emotional disturbance from the Behavioral Assessment System for Children, 3rd edition (BASC-3), were computed in the SOR group and in matched children with neurodevelopmental concerns but not SOR. RESULTS: Global WM fractional anisotropy (FA) is negatively correlated with somatization and with emotional disturbance in the SOR group but not the non-SOR group. Also observed in children with SOR are positive correlations of radial diffusivity (RD) and free water fraction (FISO) with somatization and, in most cases, emotional disturbance. These effects are significant in boys with SOR, whereas the study is underpowered for girls. The most affected white matter are medial lemniscus and internal capsule sensory tracts, although effects of SOR are observed in many cerebral, cerebellar, and brainstem tracts. CONCLUSION: White matter microstructure is related to affective behavior in children with SOR. En ligne : https://dx.doi.org/10.1186/s11689-023-09513-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

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