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Auteur Jeremy VEENSTRA-VANDERWEELE |
Documents disponibles écrits par cet auteur (25)
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Is there sexual dimorphism of hyperserotonemia in autism spectrum disorder? / Lauren C. SHUFFREY in Autism Research, 10-8 (August 2017)
[article]
Titre : Is there sexual dimorphism of hyperserotonemia in autism spectrum disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Lauren C. SHUFFREY, Auteur ; Stephen J. GUTER, Auteur ; Shannon DELANEY, Auteur ; Suma JACOB, Auteur ; George M. ANDERSON, Auteur ; James S. SUTCLIFFE, Auteur ; Edwin H. Jr COOK, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.1417-1423 Langues : Anglais (eng) Mots-clés : serotonin 5-HT autism spectrum disorder hyperserotonemia Index. décimale : PER Périodiques Résumé : Approximately 30% of individuals with autism spectrum disorder (ASD) have elevated whole blood serotonin (5-HT) levels. Genetic linkage and association studies of ASD and of whole blood 5-HT levels as a quantitative trait have revealed sexual dimorphism. Few studies have examined the presence of a sex difference on hyperserotonemia within ASD. To assess whether the rate of hyperserotonemia is different in males than in females with ASD, we measured whole blood 5-HT levels in 292 children and adolescents with ASD, the largest sample in which this biomarker has been assessed. Based upon previous work suggesting that hyperserotonemia is more common prior to puberty, we focused our analysis on the 182 pre-pubertal children with ASD. 42% of pre-pubertal participants were within the hyperserotonemia range. In this population, we found that males were significantly more likely to manifest hyperserotonemia than females (P?=?0.03). As expected, no significant difference was found in the post-pubertal population. Additional work will be needed to replicate this intriguing finding and to understand whether it could potentially explain differences in patterns of ASD risk between males and females. En ligne : http://dx.doi.org/10.1002/aur.1791 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310
in Autism Research > 10-8 (August 2017) . - p.1417-1423[article] Is there sexual dimorphism of hyperserotonemia in autism spectrum disorder? [Texte imprimé et/ou numérique] / Lauren C. SHUFFREY, Auteur ; Stephen J. GUTER, Auteur ; Shannon DELANEY, Auteur ; Suma JACOB, Auteur ; George M. ANDERSON, Auteur ; James S. SUTCLIFFE, Auteur ; Edwin H. Jr COOK, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.1417-1423.
Langues : Anglais (eng)
in Autism Research > 10-8 (August 2017) . - p.1417-1423
Mots-clés : serotonin 5-HT autism spectrum disorder hyperserotonemia Index. décimale : PER Périodiques Résumé : Approximately 30% of individuals with autism spectrum disorder (ASD) have elevated whole blood serotonin (5-HT) levels. Genetic linkage and association studies of ASD and of whole blood 5-HT levels as a quantitative trait have revealed sexual dimorphism. Few studies have examined the presence of a sex difference on hyperserotonemia within ASD. To assess whether the rate of hyperserotonemia is different in males than in females with ASD, we measured whole blood 5-HT levels in 292 children and adolescents with ASD, the largest sample in which this biomarker has been assessed. Based upon previous work suggesting that hyperserotonemia is more common prior to puberty, we focused our analysis on the 182 pre-pubertal children with ASD. 42% of pre-pubertal participants were within the hyperserotonemia range. In this population, we found that males were significantly more likely to manifest hyperserotonemia than females (P?=?0.03). As expected, no significant difference was found in the post-pubertal population. Additional work will be needed to replicate this intriguing finding and to understand whether it could potentially explain differences in patterns of ASD risk between males and females. En ligne : http://dx.doi.org/10.1002/aur.1791 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 Large multicenter randomized trials in autism: key insights gained from the balovaptan clinical development program / Suma JACOB in Molecular Autism, 13 (2022)
Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical / Charisma R. SHAH in Autism Research, 6-3 (June 2013)
[article]
Titre : Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical Type de document : Texte imprimé et/ou numérique Auteurs : Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Année de publication : 2013 Article en page(s) : p.212-220 Langues : Anglais (eng) Mots-clés : animal models behavioral analysis of animal models??animal models genetics gamma-aminobutyric acid neurochemistry Index. décimale : PER Périodiques Résumé : Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a “typical” way. We hypothesized that mice could be used to make a similar judgment if they prefer “typical” over “atypical” social interactions with mouse models relevant to ASD. We used wild-type C57BL/6 (B6) mice as “judges” and evaluated their preference for a chamber containing a “typical” (B6 or 129S6) or an “atypical” mouse. For our atypical mouse stimuli, we chose two inbred strains with well-documented social phenotypes (BTBR and BALB/c), as well a mutant line with abnormal social behavior and seizures (Gabrb3 +/?). Overall, we observed a stimulus by time interaction (P??0.0001), with B6 mice preferring the typical mouse chamber during the last 10?min of the 30-min test. For two of the individual stimulus pairings, we observed a similar chamber by time interaction (BALB/c vs. 129S6, P?=?0.0007; Gabrb3 +/? vs. 129S6, P?=?0.033). For the third stimulus pairing, we found a trend for preference of the typical mouse across time (BTBR vs. B6, P?=?0.051). We repeated the experiments using 129S6 mice as judges and found a significant overall interaction (P?=?0.034), but only one stimulus pairing reached significance on its own (BALB/c vs. 129S6, P?=?0.0021). These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls. En ligne : http://dx.doi.org/10.1002/aur.1280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202
in Autism Research > 6-3 (June 2013) . - p.212-220[article] Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical [Texte imprimé et/ou numérique] / Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - 2013 . - p.212-220.
Langues : Anglais (eng)
in Autism Research > 6-3 (June 2013) . - p.212-220
Mots-clés : animal models behavioral analysis of animal models??animal models genetics gamma-aminobutyric acid neurochemistry Index. décimale : PER Périodiques Résumé : Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a “typical” way. We hypothesized that mice could be used to make a similar judgment if they prefer “typical” over “atypical” social interactions with mouse models relevant to ASD. We used wild-type C57BL/6 (B6) mice as “judges” and evaluated their preference for a chamber containing a “typical” (B6 or 129S6) or an “atypical” mouse. For our atypical mouse stimuli, we chose two inbred strains with well-documented social phenotypes (BTBR and BALB/c), as well a mutant line with abnormal social behavior and seizures (Gabrb3 +/?). Overall, we observed a stimulus by time interaction (P??0.0001), with B6 mice preferring the typical mouse chamber during the last 10?min of the 30-min test. For two of the individual stimulus pairings, we observed a similar chamber by time interaction (BALB/c vs. 129S6, P?=?0.0007; Gabrb3 +/? vs. 129S6, P?=?0.033). For the third stimulus pairing, we found a trend for preference of the typical mouse across time (BTBR vs. B6, P?=?0.051). We repeated the experiments using 129S6 mice as judges and found a significant overall interaction (P?=?0.034), but only one stimulus pairing reached significance on its own (BALB/c vs. 129S6, P?=?0.0021). These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls. En ligne : http://dx.doi.org/10.1002/aur.1280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical / Charisma R. SHAH in Autism Research, 8-1 (February 2015)
[article]
Titre : Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical Type de document : Texte imprimé et/ou numérique Auteurs : Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.120-120 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256
in Autism Research > 8-1 (February 2015) . - p.120-120[article] Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical [Texte imprimé et/ou numérique] / Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.120-120.
Langues : Anglais (eng)
in Autism Research > 8-1 (February 2015) . - p.120-120
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 Medical Conditions and Demographic, Service and Clinical Factors Associated with Atypical Antipsychotic Medication Use Among Children with An Autism Spectrum Disorder / Johanna K. LAKE in Journal of Autism and Developmental Disorders, 47-5 (May 2017)
[article]
Titre : Medical Conditions and Demographic, Service and Clinical Factors Associated with Atypical Antipsychotic Medication Use Among Children with An Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Johanna K. LAKE, Auteur ; Danica DENTON, Auteur ; Yona LUNSKY, Auteur ; Amy M. SHUI, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.1391-1402 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Atypical antipsychotic medication Children Index. décimale : PER Périodiques Résumé : This study aimed to describe rates of antipsychotic medication use and the association between their use and demographics, clinical variables, and the use of behavioral/education services among children with ASD. For children with ASD ages 2–11 (n?=?4749) and those 12–17 (n?=?401), 5.4 and 17.7% were prescribed at least one atypical antipsychotic medication respectively. In the multivariable model of young children, older age, use of multiple psychotropic medications, prior ASD diagnosis, non-white Hispanic race/ethnicity, and oppositional defiant problems were associated with antipsychotic use. Among older children, only older age was associated with antipsychotic use. In at least one age group, antipsychotic medication use was also related to behaviour, family and occupational therapy, public insurance, site region, externalizing problems, body mass index, and sleep and gastrointestinal problems. En ligne : http://dx.doi.org/10.1007/s10803-017-3058-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305
in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1391-1402[article] Medical Conditions and Demographic, Service and Clinical Factors Associated with Atypical Antipsychotic Medication Use Among Children with An Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Johanna K. LAKE, Auteur ; Danica DENTON, Auteur ; Yona LUNSKY, Auteur ; Amy M. SHUI, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.1391-1402.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1391-1402
Mots-clés : Autism spectrum disorder Atypical antipsychotic medication Children Index. décimale : PER Périodiques Résumé : This study aimed to describe rates of antipsychotic medication use and the association between their use and demographics, clinical variables, and the use of behavioral/education services among children with ASD. For children with ASD ages 2–11 (n?=?4749) and those 12–17 (n?=?401), 5.4 and 17.7% were prescribed at least one atypical antipsychotic medication respectively. In the multivariable model of young children, older age, use of multiple psychotropic medications, prior ASD diagnosis, non-white Hispanic race/ethnicity, and oppositional defiant problems were associated with antipsychotic use. Among older children, only older age was associated with antipsychotic use. In at least one age group, antipsychotic medication use was also related to behaviour, family and occupational therapy, public insurance, site region, externalizing problems, body mass index, and sleep and gastrointestinal problems. En ligne : http://dx.doi.org/10.1007/s10803-017-3058-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 Patterns of Risk for Multiple Co-Occurring Medical Conditions Replicate Across Distinct Cohorts of Children with Autism Spectrum Disorder / Kimberly A. ALDINGER in Autism Research, 8-6 (December 2015)
PermalinkPsychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder / Bradley J. FERGUSON in Autism Research, 10-2 (February 2017)
PermalinkPsychotic symptoms in 16p11.2 copy-number variant carriers / Amandeep JUTLA in Autism Research, 13-2 (February 2020)
PermalinkRigid–Compulsive Behaviors are Associated with Mixed Bowel Symptoms in Autism Spectrum Disorder / Brittany PETERS in Journal of Autism and Developmental Disorders, 44-6 (June 2014)
PermalinkTraining of child and adolescent psychiatry fellows in autism and intellectual disability / Natasha MARRUS in Autism, 18-4 (May 2014)
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