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Auteur Terho LEHTIMAKI |
Documents disponibles écrits par cet auteur (3)



Bidirectional pathways between psychosocial risk factors and paranoid ideation in a general nonclinical population / Aino SAARINEN in Development and Psychopathology, 34-1 (February 2022)
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[article]
Titre : Bidirectional pathways between psychosocial risk factors and paranoid ideation in a general nonclinical population Type de document : Texte imprimé et/ou numérique Auteurs : Aino SAARINEN, Auteur ; Niklas GRANÖ, Auteur ; Mirka HINTSANEN, Auteur ; Terho LEHTIMAKI, Auteur ; C. Robert CLONINGER, Auteur ; Liisa KELTIKANGAS-JARVINEN, Auteur Article en page(s) : p.421-430 Langues : Anglais (eng) Mots-clés : alcohol use paranoid sleep social isolation stress Index. décimale : PER Périodiques Résumé : We investigated (a) whether psychosocial factors (experienced stress, anticipatory worry, social detachment, sleeping disturbances, alcohol use) predict the course of paranoid ideation between the ages of 24 to 50 years and (b) whether the predictive relationships are more likely to proceed from the psychosocial factors to paranoid ideation, or vice versa. The participants (N = 1534?1553) came from the population-based Young Finns study. Paranoid ideation and psychosocial factors were assessed by reliable self-report questionnaires in 2001, 2007, and 2011/2012. The data were analyzed using growth curve and structural equation models. High experienced stress, anticipatory worry, social detachment, frequent sleeping disturbances, and frequent alcohol use predicted more paranoid ideation. More risk factors predicted increasing paranoid ideation. There were bidirectional predictive relationships of paranoid ideation with experienced stress, anticipatory worry, social detachment, and sleeping disturbances. The link between alcohol use and paranoid ideation was only correlative. In conclusion, paranoid ideation increases by reciprocal interactions with stress, worry, social detachment, and sleeping disturbances. The findings support the threat?anticipation model of paranoid ideation, providing important implications for treatment of paranoia. En ligne : http://dx.doi.org/10.1017/s0954579420001030 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474
in Development and Psychopathology > 34-1 (February 2022) . - p.421-430[article] Bidirectional pathways between psychosocial risk factors and paranoid ideation in a general nonclinical population [Texte imprimé et/ou numérique] / Aino SAARINEN, Auteur ; Niklas GRANÖ, Auteur ; Mirka HINTSANEN, Auteur ; Terho LEHTIMAKI, Auteur ; C. Robert CLONINGER, Auteur ; Liisa KELTIKANGAS-JARVINEN, Auteur . - p.421-430.
Langues : Anglais (eng)
in Development and Psychopathology > 34-1 (February 2022) . - p.421-430
Mots-clés : alcohol use paranoid sleep social isolation stress Index. décimale : PER Périodiques Résumé : We investigated (a) whether psychosocial factors (experienced stress, anticipatory worry, social detachment, sleeping disturbances, alcohol use) predict the course of paranoid ideation between the ages of 24 to 50 years and (b) whether the predictive relationships are more likely to proceed from the psychosocial factors to paranoid ideation, or vice versa. The participants (N = 1534?1553) came from the population-based Young Finns study. Paranoid ideation and psychosocial factors were assessed by reliable self-report questionnaires in 2001, 2007, and 2011/2012. The data were analyzed using growth curve and structural equation models. High experienced stress, anticipatory worry, social detachment, frequent sleeping disturbances, and frequent alcohol use predicted more paranoid ideation. More risk factors predicted increasing paranoid ideation. There were bidirectional predictive relationships of paranoid ideation with experienced stress, anticipatory worry, social detachment, and sleeping disturbances. The link between alcohol use and paranoid ideation was only correlative. In conclusion, paranoid ideation increases by reciprocal interactions with stress, worry, social detachment, and sleeping disturbances. The findings support the threat?anticipation model of paranoid ideation, providing important implications for treatment of paranoia. En ligne : http://dx.doi.org/10.1017/s0954579420001030 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants / Linda FORSSMAN in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)
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[article]
Titre : Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants Type de document : Texte imprimé et/ou numérique Auteurs : Linda FORSSMAN, Auteur ; Mikko J. PELTOLA, Auteur ; Santeri YRTTIAHO, Auteur ; Kaija PUURA, Auteur ; Nina MONONEN, Auteur ; Terho LEHTIMAKI, Auteur ; Jukka M. LEPPANEN, Auteur Article en page(s) : p.793-801 Langues : Anglais (eng) Mots-clés : Attention facial expression fear tryptophan hydroxylase 2 gene infancy maternal stress Index. décimale : PER Périodiques Résumé : Background Cross-species evidence suggests that genetic and experiential factors act early in development to establish individual emotional traits, but little is known about the mechanisms that emerge during this period to mediate long-term outcomes. Here, we tested the hypothesis that known genetic and environmental risk conditions may heighten infants' natural tendency to attend to threat-alerting stimuli, resulting in a cognitive bias that may contribute to emotional vulnerability. Methods Data from two samples of 5–7-month-old infants (N = 139) were used to examine whether established candidate variations in the serotonin-system genes, i.e., TPH2 SNP rs4570625 (-703 G/T) and HTR1A SNP rs6295 (-1019 G/C), and early rearing condition (maternal stress and depressive symptoms) are associated with alterations in infants' attention to facial expressions. Infants were tested with a paradigm that assesses the ability to disengage attention from a centrally presented stimulus (a nonface control stimulus or a neutral, happy, or fearful facial expression) toward the location of a new stimulus in the visual periphery (a geometric shape). Results TPH2 -703 T-carrier genotype (i.e., TT homozygotes and heterozygotes), presence of maternal stress and depressive symptoms, and a combination of the T-carrier genotype and maternal depressive symptoms were associated with a relatively greater difficulty disengaging attention from fearful facial expressions. No associations were found with infants' temperamental traits. Conclusions Alterations in infants' natural attentional bias toward fearful facial expressions may emerge prior to the manifestation of emotional and social behaviors and provide a sensitive marker of early emotional development. En ligne : http://dx.doi.org/10.1111/jcpp.12181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235
in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.793-801[article] Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants [Texte imprimé et/ou numérique] / Linda FORSSMAN, Auteur ; Mikko J. PELTOLA, Auteur ; Santeri YRTTIAHO, Auteur ; Kaija PUURA, Auteur ; Nina MONONEN, Auteur ; Terho LEHTIMAKI, Auteur ; Jukka M. LEPPANEN, Auteur . - p.793-801.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.793-801
Mots-clés : Attention facial expression fear tryptophan hydroxylase 2 gene infancy maternal stress Index. décimale : PER Périodiques Résumé : Background Cross-species evidence suggests that genetic and experiential factors act early in development to establish individual emotional traits, but little is known about the mechanisms that emerge during this period to mediate long-term outcomes. Here, we tested the hypothesis that known genetic and environmental risk conditions may heighten infants' natural tendency to attend to threat-alerting stimuli, resulting in a cognitive bias that may contribute to emotional vulnerability. Methods Data from two samples of 5–7-month-old infants (N = 139) were used to examine whether established candidate variations in the serotonin-system genes, i.e., TPH2 SNP rs4570625 (-703 G/T) and HTR1A SNP rs6295 (-1019 G/C), and early rearing condition (maternal stress and depressive symptoms) are associated with alterations in infants' attention to facial expressions. Infants were tested with a paradigm that assesses the ability to disengage attention from a centrally presented stimulus (a nonface control stimulus or a neutral, happy, or fearful facial expression) toward the location of a new stimulus in the visual periphery (a geometric shape). Results TPH2 -703 T-carrier genotype (i.e., TT homozygotes and heterozygotes), presence of maternal stress and depressive symptoms, and a combination of the T-carrier genotype and maternal depressive symptoms were associated with a relatively greater difficulty disengaging attention from fearful facial expressions. No associations were found with infants' temperamental traits. Conclusions Alterations in infants' natural attentional bias toward fearful facial expressions may emerge prior to the manifestation of emotional and social behaviors and provide a sensitive marker of early emotional development. En ligne : http://dx.doi.org/10.1111/jcpp.12181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235 Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants / Jukka M. LEPPANEN in Journal of Child Psychology and Psychiatry, 52-11 (November 2011)
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Titre : Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants Type de document : Texte imprimé et/ou numérique Auteurs : Jukka M. LEPPANEN, Auteur ; Mikko J. PELTOLA, Auteur ; Kaija PUURA, Auteur ; Mirjami MANTYMAA, Auteur ; Nina MONONEN, Auteur ; Terho LEHTIMAKI, Auteur Année de publication : 2011 Article en page(s) : p.1144-1152 Langues : Anglais (eng) Mots-clés : Attention cognition development emotion infancy serotonin Index. décimale : PER Périodiques Résumé : Background: Allelic variation in the promoter region of a gene that encodes tryptophan hydroxylase isoform 2 (TPH2), a rate-limiting enzyme of serotonin synthesis in the central nervous system, has been associated with variations in cognitive function and vulnerability to affective spectrum disorders. Little is known about the effects of this gene variant on cognition during development and about possible intermediate developmental steps that lead to the adult phenotype. Here, we examined the hypothesis that the TPH2 -703 may act during early stages of development and bias the acquisition of elementary cognitive processes involved in attention and emotion regulation.
Methods: Seven-month-old infants (n = 66) were genotyped for the TPH2 -703 G/T polymorphism (rs4570625) and tested for the efficiency of attention shifts from a stimulus at fixation to a new stimulus in the visual periphery.
Results: Compared to TPH2 G/G homozygotes, infants with the T-carrier genotype exhibited a significantly higher number of missing attention shifts. This genotype effect tended to be particularly pronounced when infants had to disengage from an affectively salient stimulus before shifting attention to the peripheral stimulus. The results also showed that TPH2 genotype was indirectly associated, via its effect on attention disengagement, with temperamental emotion regulation (soothability).
Conclusions: Together, these results implicate serotonin system genes in early cognitive development and suggest variations in the early-emerging cognitive capacities as a potential developmental precursor of individual differences in emotion regulation and vulnerability to affective disorders.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02391.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=145
in Journal of Child Psychology and Psychiatry > 52-11 (November 2011) . - p.1144-1152[article] Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants [Texte imprimé et/ou numérique] / Jukka M. LEPPANEN, Auteur ; Mikko J. PELTOLA, Auteur ; Kaija PUURA, Auteur ; Mirjami MANTYMAA, Auteur ; Nina MONONEN, Auteur ; Terho LEHTIMAKI, Auteur . - 2011 . - p.1144-1152.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-11 (November 2011) . - p.1144-1152
Mots-clés : Attention cognition development emotion infancy serotonin Index. décimale : PER Périodiques Résumé : Background: Allelic variation in the promoter region of a gene that encodes tryptophan hydroxylase isoform 2 (TPH2), a rate-limiting enzyme of serotonin synthesis in the central nervous system, has been associated with variations in cognitive function and vulnerability to affective spectrum disorders. Little is known about the effects of this gene variant on cognition during development and about possible intermediate developmental steps that lead to the adult phenotype. Here, we examined the hypothesis that the TPH2 -703 may act during early stages of development and bias the acquisition of elementary cognitive processes involved in attention and emotion regulation.
Methods: Seven-month-old infants (n = 66) were genotyped for the TPH2 -703 G/T polymorphism (rs4570625) and tested for the efficiency of attention shifts from a stimulus at fixation to a new stimulus in the visual periphery.
Results: Compared to TPH2 G/G homozygotes, infants with the T-carrier genotype exhibited a significantly higher number of missing attention shifts. This genotype effect tended to be particularly pronounced when infants had to disengage from an affectively salient stimulus before shifting attention to the peripheral stimulus. The results also showed that TPH2 genotype was indirectly associated, via its effect on attention disengagement, with temperamental emotion regulation (soothability).
Conclusions: Together, these results implicate serotonin system genes in early cognitive development and suggest variations in the early-emerging cognitive capacities as a potential developmental precursor of individual differences in emotion regulation and vulnerability to affective disorders.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02391.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=145