Affective–motivational brain responses to direct gaze in children with autism spectrum disorder / Anneli KYLLIAINEN in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.790-797 Titre : Affective–motivational brain responses to direct gaze in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Anneli KYLLIAINEN, Auteur ; Simon WALLACE, Auteur ; Marc N. COUTANCHE, Auteur ; Jukka M. LEPPANEN, Auteur ; James CUSACK, Auteur ; Anthony J. BAILEY, Auteur ; Jari K. HIETANEN, Auteur Année de publication : 2012 Article en page(s) : p.790-797 Langues : Anglais (eng) Mots-clés : Direct gaze  eye contact  autism spectrum disorders  frontal EEG asymmetry  skin conductance Index. décimale : PER Périodiques Résumé : Background:  It is unclear why children with autism spectrum disorders (ASD) tend to be inattentive to, or even avoid eye contact. The goal of this study was to investigate affective–motivational brain responses to direct gaze in children with ASD. To this end, we combined two measurements: skin conductance responses (SCR), a robust arousal measure, and asymmetry in frontal electroencephalography (EEG) activity which is associated with motivational approach and avoidance tendencies. We also explored whether degree of eye openness and face familiarity modulated these responses. Methods:  Skin conductance responses and frontal EEG activity were recorded from 14 children with ASD and 15 typically developing children whilst they looked at familiar and unfamiliar faces with eyes shut, normally open or wide-open. Stimuli were presented in such a way that they appeared to be looming towards the children. Results:  In typically developing children, there were no significant differences in SCRs between the different eye conditions, whereas in the ASD group the SCRs were attenuated to faces with closed eyes and increased as a function of the degree of eye openness. In both groups, familiar faces elicited marginally greater SCRs than unfamiliar faces. In typically developing children, normally open eyes elicited greater relative left-sided frontal EEG activity (associated with motivational approach) than shut eyes and wide-open eyes. In the ASD group, there were no significant differences between the gaze conditions in frontal EEG activity. Conclusions:  Collectively, the results replicate previous finding in showing atypical modulation of arousal in response to direct gaze in children with ASD but do not support the assumption that this response is associated with an avoidant motivational tendency. Instead, children with ASD may lack normative approach-related motivational response to eye contact. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02522.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Affective–motivational brain responses to direct gaze in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Anneli KYLLIAINEN, Auteur ; Simon WALLACE, Auteur ; Marc N. COUTANCHE, Auteur ; Jukka M. LEPPANEN, Auteur ; James CUSACK, Auteur ; Anthony J. BAILEY, Auteur ; Jari K. HIETANEN, Auteur . - 2012 . - p.790-797. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.790-797 Mots-clés : Direct gaze  eye contact  autism spectrum disorders  frontal EEG asymmetry  skin conductance Index. décimale : PER Périodiques Résumé : Background:  It is unclear why children with autism spectrum disorders (ASD) tend to be inattentive to, or even avoid eye contact. The goal of this study was to investigate affective–motivational brain responses to direct gaze in children with ASD. To this end, we combined two measurements: skin conductance responses (SCR), a robust arousal measure, and asymmetry in frontal electroencephalography (EEG) activity which is associated with motivational approach and avoidance tendencies. We also explored whether degree of eye openness and face familiarity modulated these responses. Methods:  Skin conductance responses and frontal EEG activity were recorded from 14 children with ASD and 15 typically developing children whilst they looked at familiar and unfamiliar faces with eyes shut, normally open or wide-open. Stimuli were presented in such a way that they appeared to be looming towards the children. Results:  In typically developing children, there were no significant differences in SCRs between the different eye conditions, whereas in the ASD group the SCRs were attenuated to faces with closed eyes and increased as a function of the degree of eye openness. In both groups, familiar faces elicited marginally greater SCRs than unfamiliar faces. In typically developing children, normally open eyes elicited greater relative left-sided frontal EEG activity (associated with motivational approach) than shut eyes and wide-open eyes. In the ASD group, there were no significant differences between the gaze conditions in frontal EEG activity. Conclusions:  Collectively, the results replicate previous finding in showing atypical modulation of arousal in response to direct gaze in children with ASD but do not support the assumption that this response is associated with an avoidant motivational tendency. Instead, children with ASD may lack normative approach-related motivational response to eye contact. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02522.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

Atypical physiological orienting to direct gaze in low-functioning children with autism spectrum disorder / Terhi M. HELMINEN in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.810-820 Titre : Atypical physiological orienting to direct gaze in low-functioning children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Terhi M. HELMINEN, Auteur ; Jukka M. LEPPANEN, Auteur ; Kai ERIKSSON, Auteur ; Arto LUOMA, Auteur ; Jari K. HIETANEN, Auteur ; Anneli KYLLIAINEN, Auteur Article en page(s) : p.810-820 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  eye contact  attention  orienting  heart rate Index. décimale : PER Périodiques Résumé : Reduced use of eye contact is a prominent feature in individuals with autism spectrum disorder (ASD). It has been proposed that direct gaze does not capture the attention of individuals with ASD. Experimental evidence is, however, mainly restricted to relatively high-functioning school-aged children or adults with ASD. This study investigated whether 2–5-year-old low-functioning children with severe ASD differ from control children in orienting to gaze stimuli, as measured with the heart rate deceleration response. Responses were measured to computerized presentations of dynamic shifts of gaze direction either toward (direct) or away (averted) from the observing child. The results showed a significant group by gaze direction interaction effect on heart rate responses (permuted P?=?.004), reflecting a stronger orienting response to direct versus averted gaze in typically developing (N?=?17) and developmentally delayed (N?=?16) children but not in children with ASD (N?=?12). The lack of enhanced orienting response to direct gaze in the ASD group was not caused by a lack of looking at the eye region, as confirmed by eye tracking. The results suggest that direct gaze is not a socially salient, attention-grabbing signal for low-functioning children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1738 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Atypical physiological orienting to direct gaze in low-functioning children with autism spectrum disorder [Texte imprimé et/ou numérique] / Terhi M. HELMINEN, Auteur ; Jukka M. LEPPANEN, Auteur ; Kai ERIKSSON, Auteur ; Arto LUOMA, Auteur ; Jari K. HIETANEN, Auteur ; Anneli KYLLIAINEN, Auteur . - p.810-820. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.810-820 Mots-clés : autism spectrum disorder  eye contact  attention  orienting  heart rate Index. décimale : PER Périodiques Résumé : Reduced use of eye contact is a prominent feature in individuals with autism spectrum disorder (ASD). It has been proposed that direct gaze does not capture the attention of individuals with ASD. Experimental evidence is, however, mainly restricted to relatively high-functioning school-aged children or adults with ASD. This study investigated whether 2–5-year-old low-functioning children with severe ASD differ from control children in orienting to gaze stimuli, as measured with the heart rate deceleration response. Responses were measured to computerized presentations of dynamic shifts of gaze direction either toward (direct) or away (averted) from the observing child. The results showed a significant group by gaze direction interaction effect on heart rate responses (permuted P?=?.004), reflecting a stronger orienting response to direct versus averted gaze in typically developing (N?=?17) and developmentally delayed (N?=?16) children but not in children with ASD (N?=?12). The lack of enhanced orienting response to direct gaze in the ASD group was not caused by a lack of looking at the eye region, as confirmed by eye tracking. The results suggest that direct gaze is not a socially salient, attention-grabbing signal for low-functioning children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1738 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants / Linda FORSSMAN in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.793-801 Titre : Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants Type de document : Texte imprimé et/ou numérique Auteurs : Linda FORSSMAN, Auteur ; Mikko J. PELTOLA, Auteur ; Santeri YRTTIAHO, Auteur ; Kaija PUURA, Auteur ; Nina MONONEN, Auteur ; Terho LEHTIMAKI, Auteur ; Jukka M. LEPPANEN, Auteur Article en page(s) : p.793-801 Langues : Anglais (eng) Mots-clés : Attention  facial expression  fear  tryptophan hydroxylase 2 gene  infancy  maternal stress Index. décimale : PER Périodiques Résumé : Background Cross-species evidence suggests that genetic and experiential factors act early in development to establish individual emotional traits, but little is known about the mechanisms that emerge during this period to mediate long-term outcomes. Here, we tested the hypothesis that known genetic and environmental risk conditions may heighten infants' natural tendency to attend to threat-alerting stimuli, resulting in a cognitive bias that may contribute to emotional vulnerability. Methods Data from two samples of 5–7-month-old infants (N = 139) were used to examine whether established candidate variations in the serotonin-system genes, i.e., TPH2 SNP rs4570625 (-703 G/T) and HTR1A SNP rs6295 (-1019 G/C), and early rearing condition (maternal stress and depressive symptoms) are associated with alterations in infants' attention to facial expressions. Infants were tested with a paradigm that assesses the ability to disengage attention from a centrally presented stimulus (a nonface control stimulus or a neutral, happy, or fearful facial expression) toward the location of a new stimulus in the visual periphery (a geometric shape). Results TPH2 -703 T-carrier genotype (i.e., TT homozygotes and heterozygotes), presence of maternal stress and depressive symptoms, and a combination of the T-carrier genotype and maternal depressive symptoms were associated with a relatively greater difficulty disengaging attention from fearful facial expressions. No associations were found with infants' temperamental traits. Conclusions Alterations in infants' natural attentional bias toward fearful facial expressions may emerge prior to the manifestation of emotional and social behaviors and provide a sensitive marker of early emotional development. En ligne : http://dx.doi.org/10.1111/jcpp.12181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235 [article] Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants [Texte imprimé et/ou numérique] / Linda FORSSMAN, Auteur ; Mikko J. PELTOLA, Auteur ; Santeri YRTTIAHO, Auteur ; Kaija PUURA, Auteur ; Nina MONONEN, Auteur ; Terho LEHTIMAKI, Auteur ; Jukka M. LEPPANEN, Auteur . - p.793-801. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.793-801 Mots-clés : Attention  facial expression  fear  tryptophan hydroxylase 2 gene  infancy  maternal stress Index. décimale : PER Périodiques Résumé : Background Cross-species evidence suggests that genetic and experiential factors act early in development to establish individual emotional traits, but little is known about the mechanisms that emerge during this period to mediate long-term outcomes. Here, we tested the hypothesis that known genetic and environmental risk conditions may heighten infants' natural tendency to attend to threat-alerting stimuli, resulting in a cognitive bias that may contribute to emotional vulnerability. Methods Data from two samples of 5–7-month-old infants (N = 139) were used to examine whether established candidate variations in the serotonin-system genes, i.e., TPH2 SNP rs4570625 (-703 G/T) and HTR1A SNP rs6295 (-1019 G/C), and early rearing condition (maternal stress and depressive symptoms) are associated with alterations in infants' attention to facial expressions. Infants were tested with a paradigm that assesses the ability to disengage attention from a centrally presented stimulus (a nonface control stimulus or a neutral, happy, or fearful facial expression) toward the location of a new stimulus in the visual periphery (a geometric shape). Results TPH2 -703 T-carrier genotype (i.e., TT homozygotes and heterozygotes), presence of maternal stress and depressive symptoms, and a combination of the T-carrier genotype and maternal depressive symptoms were associated with a relatively greater difficulty disengaging attention from fearful facial expressions. No associations were found with infants' temperamental traits. Conclusions Alterations in infants' natural attentional bias toward fearful facial expressions may emerge prior to the manifestation of emotional and social behaviors and provide a sensitive marker of early emotional development. En ligne : http://dx.doi.org/10.1111/jcpp.12181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235

Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants / Jukka M. LEPPANEN in Journal of Child Psychology and Psychiatry, 52-11 (November 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-11 (November 2011) . - p.1144-1152 Titre : Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants Type de document : Texte imprimé et/ou numérique Auteurs : Jukka M. LEPPANEN, Auteur ; Mikko J. PELTOLA, Auteur ; Kaija PUURA, Auteur ; Mirjami MANTYMAA, Auteur ; Nina MONONEN, Auteur ; Terho LEHTIMAKI, Auteur Année de publication : 2011 Article en page(s) : p.1144-1152 Langues : Anglais (eng) Mots-clés : Attention  cognition  development  emotion  infancy  serotonin Index. décimale : PER Périodiques Résumé : Background:  Allelic variation in the promoter region of a gene that encodes tryptophan hydroxylase isoform 2 (TPH2), a rate-limiting enzyme of serotonin synthesis in the central nervous system, has been associated with variations in cognitive function and vulnerability to affective spectrum disorders. Little is known about the effects of this gene variant on cognition during development and about possible intermediate developmental steps that lead to the adult phenotype. Here, we examined the hypothesis that the TPH2 -703 may act during early stages of development and bias the acquisition of elementary cognitive processes involved in attention and emotion regulation. Methods:  Seven-month-old infants (n = 66) were genotyped for the TPH2 -703 G/T polymorphism (rs4570625) and tested for the efficiency of attention shifts from a stimulus at fixation to a new stimulus in the visual periphery. Results:  Compared to TPH2 G/G homozygotes, infants with the T-carrier genotype exhibited a significantly higher number of missing attention shifts. This genotype effect tended to be particularly pronounced when infants had to disengage from an affectively salient stimulus before shifting attention to the peripheral stimulus. The results also showed that TPH2 genotype was indirectly associated, via its effect on attention disengagement, with temperamental emotion regulation (soothability). Conclusions:  Together, these results implicate serotonin system genes in early cognitive development and suggest variations in the early-emerging cognitive capacities as a potential developmental precursor of individual differences in emotion regulation and vulnerability to affective disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02391.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=145 [article] Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants [Texte imprimé et/ou numérique] / Jukka M. LEPPANEN, Auteur ; Mikko J. PELTOLA, Auteur ; Kaija PUURA, Auteur ; Mirjami MANTYMAA, Auteur ; Nina MONONEN, Auteur ; Terho LEHTIMAKI, Auteur . - 2011 . - p.1144-1152. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-11 (November 2011) . - p.1144-1152 Mots-clés : Attention  cognition  development  emotion  infancy  serotonin Index. décimale : PER Périodiques Résumé : Background:  Allelic variation in the promoter region of a gene that encodes tryptophan hydroxylase isoform 2 (TPH2), a rate-limiting enzyme of serotonin synthesis in the central nervous system, has been associated with variations in cognitive function and vulnerability to affective spectrum disorders. Little is known about the effects of this gene variant on cognition during development and about possible intermediate developmental steps that lead to the adult phenotype. Here, we examined the hypothesis that the TPH2 -703 may act during early stages of development and bias the acquisition of elementary cognitive processes involved in attention and emotion regulation. Methods:  Seven-month-old infants (n = 66) were genotyped for the TPH2 -703 G/T polymorphism (rs4570625) and tested for the efficiency of attention shifts from a stimulus at fixation to a new stimulus in the visual periphery. Results:  Compared to TPH2 G/G homozygotes, infants with the T-carrier genotype exhibited a significantly higher number of missing attention shifts. This genotype effect tended to be particularly pronounced when infants had to disengage from an affectively salient stimulus before shifting attention to the peripheral stimulus. The results also showed that TPH2 genotype was indirectly associated, via its effect on attention disengagement, with temperamental emotion regulation (soothability). Conclusions:  Together, these results implicate serotonin system genes in early cognitive development and suggest variations in the early-emerging cognitive capacities as a potential developmental precursor of individual differences in emotion regulation and vulnerability to affective disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02391.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=145

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