Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial / Yun WANG in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1381-1391 Titre : Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial Type de document : Texte imprimé et/ou numérique Auteurs : Yun WANG, Auteur ; Ellen KESSEL, Auteur ; Seonjoo LEE, Auteur ; Susie HONG, Auteur ; Elizabeth RAFFANELLO, Auteur ; Leslie A. HULVERSHORN, Auteur ; Amy MARGOLIS, Auteur ; Bradley S. PETERSON, Auteur ; Jonathan POSNER, Auteur Article en page(s) : p.1381-1391 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Lisdexamfetamine Dimesylate/pharmacology/therapeutic use  Central Nervous System Stimulants/pharmacology  Attention Deficit Disorder with Hyperactivity  Brain Mapping  Brain/diagnostic imaging  Magnetic Resonance Imaging  Adhd  Dynamic Functional MRI (fMRI)  Lisdexamfetamine  Striatum  Structural Equation Modeling  Thalamus Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics. METHODS: We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n=46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) were identified using static (time-averaged) and dynamic (time-varying) measures and then correlated with symptom improvement. Analyses were repeated in independent samples from the Adolescent Brain Cognitive Development study (n=103) and the ADHD-200 Consortium (n=213). RESULTS: In 49 participants (25 LDEX; 24 Placebo), LDEX increased static and decreased dynamic FC (DFC). However, only DFC was associated with the therapeutic effects of LDEX. Additionally, at baseline, DFC was elevated in unmedicated-ADHD participants relative to HCs. Independent samples yielded similar findings - ADHD was associated with increased DFC, and psychostimulants with reduced DFC. Static FC findings were inconsistent across samples. CONCLUSIONS: Changes in dynamic, but not static, FC were associated with the therapeutic effects of psychostimulants. While prior research has focused on static FC, DFC may offer a more reliable target for new ADHD interventions aimed at stabilizing network dynamics, though this needs confirmation with subsequent investigations. En ligne : http://dx.doi.org/10.1111/jcpp.13585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial [Texte imprimé et/ou numérique] / Yun WANG, Auteur ; Ellen KESSEL, Auteur ; Seonjoo LEE, Auteur ; Susie HONG, Auteur ; Elizabeth RAFFANELLO, Auteur ; Leslie A. HULVERSHORN, Auteur ; Amy MARGOLIS, Auteur ; Bradley S. PETERSON, Auteur ; Jonathan POSNER, Auteur . - p.1381-1391. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1381-1391 Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Lisdexamfetamine Dimesylate/pharmacology/therapeutic use  Central Nervous System Stimulants/pharmacology  Attention Deficit Disorder with Hyperactivity  Brain Mapping  Brain/diagnostic imaging  Magnetic Resonance Imaging  Adhd  Dynamic Functional MRI (fMRI)  Lisdexamfetamine  Striatum  Structural Equation Modeling  Thalamus Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics. METHODS: We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n=46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) were identified using static (time-averaged) and dynamic (time-varying) measures and then correlated with symptom improvement. Analyses were repeated in independent samples from the Adolescent Brain Cognitive Development study (n=103) and the ADHD-200 Consortium (n=213). RESULTS: In 49 participants (25 LDEX; 24 Placebo), LDEX increased static and decreased dynamic FC (DFC). However, only DFC was associated with the therapeutic effects of LDEX. Additionally, at baseline, DFC was elevated in unmedicated-ADHD participants relative to HCs. Independent samples yielded similar findings - ADHD was associated with increased DFC, and psychostimulants with reduced DFC. Static FC findings were inconsistent across samples. CONCLUSIONS: Changes in dynamic, but not static, FC were associated with the therapeutic effects of psychostimulants. While prior research has focused on static FC, DFC may offer a more reliable target for new ADHD interventions aimed at stabilizing network dynamics, though this needs confirmation with subsequent investigations. En ligne : http://dx.doi.org/10.1111/jcpp.13585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Interparental conflict and depressive symptoms among Chinese adolescents: A longitudinal moderated mediation model / Rui LUO in Development and Psychopathology, 35-2 (May 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-2 (May 2023) . - p.972-981 Titre : Interparental conflict and depressive symptoms among Chinese adolescents: A longitudinal moderated mediation model Type de document : Texte imprimé et/ou numérique Auteurs : Rui LUO, Auteur ; Fumei CHEN, Auteur ; Li KE, Auteur ; Yun WANG, Auteur ; Yunyan ZHAO, Auteur ; Yuhan LUO, Auteur Article en page(s) : p.972-981 Langues : Anglais (eng) Mots-clés : interparental conflict  adolescent depressive symptoms  family functioning  cultural beliefs about adversity Index. décimale : PER Périodiques Résumé : While the detrimental effect of interparental conflict on adolescent depression is well-established, the underlying mechanisms linking the two continue to be inadequately understood. This study investigated the mediating role of family functioning and the moderating role of cultural beliefs about adversity in the association between interparental conflict and adolescent depression. The samples included 651 Chinese adolescents (mean age at Time 1 = 13.27 years; 56.5% girls) from a two-wave longitudinal study with data spanning 1 year. The findings from path modeling analyses provided evidence for the mediating role of family functioning; these findings indicated that interparental conflict can damage family functioning, which in turn exacerbates the risk of adolescent depression. The moderating role of cultural beliefs about adversity was also demonstrated by interactions between interparental conflict and cultural beliefs about adversity, as well as, family functioning and cultural beliefs about adversity. The results indicated a buffering role of cultural beliefs about adversity on the deleterious effect of interparental conflict on adolescent depression. They also suggested that lower levels of family functioning was associated with increased depression among adolescents were lower in cultural beliefs about adversity. En ligne : http://dx.doi.org/10.1017/S0954579422000190 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Interparental conflict and depressive symptoms among Chinese adolescents: A longitudinal moderated mediation model [Texte imprimé et/ou numérique] / Rui LUO, Auteur ; Fumei CHEN, Auteur ; Li KE, Auteur ; Yun WANG, Auteur ; Yunyan ZHAO, Auteur ; Yuhan LUO, Auteur . - p.972-981. Langues : Anglais (eng) in Development and Psychopathology > 35-2 (May 2023) . - p.972-981 Mots-clés : interparental conflict  adolescent depressive symptoms  family functioning  cultural beliefs about adversity Index. décimale : PER Périodiques Résumé : While the detrimental effect of interparental conflict on adolescent depression is well-established, the underlying mechanisms linking the two continue to be inadequately understood. This study investigated the mediating role of family functioning and the moderating role of cultural beliefs about adversity in the association between interparental conflict and adolescent depression. The samples included 651 Chinese adolescents (mean age at Time 1 = 13.27 years; 56.5% girls) from a two-wave longitudinal study with data spanning 1 year. The findings from path modeling analyses provided evidence for the mediating role of family functioning; these findings indicated that interparental conflict can damage family functioning, which in turn exacerbates the risk of adolescent depression. The moderating role of cultural beliefs about adversity was also demonstrated by interactions between interparental conflict and cultural beliefs about adversity, as well as, family functioning and cultural beliefs about adversity. The results indicated a buffering role of cultural beliefs about adversity on the deleterious effect of interparental conflict on adolescent depression. They also suggested that lower levels of family functioning was associated with increased depression among adolescents were lower in cultural beliefs about adversity. En ligne : http://dx.doi.org/10.1017/S0954579422000190 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

Predicting internalizing problems in Chinese children: The unique and interactive effects of parenting and child temperament / Luma MUHTADIE in Development and Psychopathology, 25-3 (August 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-3 (August 2013) . - p.653-667 Titre : Predicting internalizing problems in Chinese children: The unique and interactive effects of parenting and child temperament Type de document : Texte imprimé et/ou numérique Auteurs : Luma MUHTADIE, Auteur ; Qing ZHOU, Auteur ; Nancy EISENBERG, Auteur ; Yun WANG, Auteur Article en page(s) : p.653-667 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The additive and interactive relations of parenting styles (authoritative and authoritarian parenting) and child temperament (anger/frustration, sadness, and effortful control) to children's internalizing problems were examined in a 3.8-year longitudinal study of 425 Chinese children (aged 6–9 years) from Beijing. At Wave 1, parents self-reported on their parenting styles, and parents and teachers rated child temperament. At Wave 2, parents, teachers, and children rated children's internalizing problems. Structural equation modeling indicated that the main effect of authoritative parenting and the interactions of Authoritarian Parenting × Effortful Control and Authoritative Parenting × Anger/Frustration (parents' reports only) prospectively and uniquely predicted internalizing problems. The above results did not vary by child sex and remained significant after controlling for co-occurring externalizing problems. These findings suggest that (a) children with low effortful control may be particularly susceptible to the adverse effect of authoritarian parenting and (b) the benefit of authoritative parenting may be especially important for children with high anger/frustration. En ligne : http://dx.doi.org/10.1017/S0954579413000084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 [article] Predicting internalizing problems in Chinese children: The unique and interactive effects of parenting and child temperament [Texte imprimé et/ou numérique] / Luma MUHTADIE, Auteur ; Qing ZHOU, Auteur ; Nancy EISENBERG, Auteur ; Yun WANG, Auteur . - p.653-667. Langues : Anglais (eng) in Development and Psychopathology > 25-3 (August 2013) . - p.653-667 Index. décimale : PER Périodiques Résumé : The additive and interactive relations of parenting styles (authoritative and authoritarian parenting) and child temperament (anger/frustration, sadness, and effortful control) to children's internalizing problems were examined in a 3.8-year longitudinal study of 425 Chinese children (aged 6–9 years) from Beijing. At Wave 1, parents self-reported on their parenting styles, and parents and teachers rated child temperament. At Wave 2, parents, teachers, and children rated children's internalizing problems. Structural equation modeling indicated that the main effect of authoritative parenting and the interactions of Authoritarian Parenting × Effortful Control and Authoritative Parenting × Anger/Frustration (parents' reports only) prospectively and uniquely predicted internalizing problems. The above results did not vary by child sex and remained significant after controlling for co-occurring externalizing problems. These findings suggest that (a) children with low effortful control may be particularly susceptible to the adverse effect of authoritarian parenting and (b) the benefit of authoritative parenting may be especially important for children with high anger/frustration. En ligne : http://dx.doi.org/10.1017/S0954579413000084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210

Self-Monitoring of Gaze in High Functioning Autism / Ouriel GRYNSZPAN in Journal of Autism and Developmental Disorders, 42-8 (August 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1642-1650 Titre : Self-Monitoring of Gaze in High Functioning Autism Type de document : Texte imprimé et/ou numérique Auteurs : Ouriel GRYNSZPAN, Auteur ; Jacqueline NADEL, Auteur ; Jean-Claude MARTIN, Auteur ; Jérôme SIMONIN, Auteur ; Pauline BAILLEUL, Auteur ; Yun WANG, Auteur ; Daniel GEPNER, Auteur ; Florence LE BARILLIER, Auteur ; Jacques CONSTANT, Auteur Année de publication : 2012 Article en page(s) : p.1642-1650 Langues : Anglais (eng) Mots-clés : High functioning autism  Action-monitoring  Agency  Eye-tracking  Virtual reality  Pragmatics Index. décimale : PER Périodiques Résumé : Atypical visual behaviour has been recently proposed to account for much of social misunderstanding in autism. Using an eye-tracking system and a gaze-contingent lens display, the present study explores self-monitoring of eye motion in two conditions: free visual exploration and guided exploration via blurring the visual field except for the focal area of vision. During these conditions, thirteen students with High Functioning Autism Spectrum Disorders (HFASD) and fourteen typical individuals were presented naturalistic and interactive social stimuli using virtual reality. Fixation data showed a weaker modulation of eye movements according to the conditions in the HFASD group, thus suggesting impairments in self-monitoring of gaze. Moreover, the gaze-contingent lens induced a visual behaviour whereby social understanding scores were correlated with the time spent gazing at faces. The device could be useful for treating gaze monitoring deficiencies in HFASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1404-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Self-Monitoring of Gaze in High Functioning Autism [Texte imprimé et/ou numérique] / Ouriel GRYNSZPAN, Auteur ; Jacqueline NADEL, Auteur ; Jean-Claude MARTIN, Auteur ; Jérôme SIMONIN, Auteur ; Pauline BAILLEUL, Auteur ; Yun WANG, Auteur ; Daniel GEPNER, Auteur ; Florence LE BARILLIER, Auteur ; Jacques CONSTANT, Auteur . - 2012 . - p.1642-1650. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1642-1650 Mots-clés : High functioning autism  Action-monitoring  Agency  Eye-tracking  Virtual reality  Pragmatics Index. décimale : PER Périodiques Résumé : Atypical visual behaviour has been recently proposed to account for much of social misunderstanding in autism. Using an eye-tracking system and a gaze-contingent lens display, the present study explores self-monitoring of eye motion in two conditions: free visual exploration and guided exploration via blurring the visual field except for the focal area of vision. During these conditions, thirteen students with High Functioning Autism Spectrum Disorders (HFASD) and fourteen typical individuals were presented naturalistic and interactive social stimuli using virtual reality. Fixation data showed a weaker modulation of eye movements according to the conditions in the HFASD group, thus suggesting impairments in self-monitoring of gaze. Moreover, the gaze-contingent lens induced a visual behaviour whereby social understanding scores were correlated with the time spent gazing at faces. The device could be useful for treating gaze monitoring deficiencies in HFASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1404-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

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