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Auteur Jan K. BUITELAAR |
Documents disponibles écrits par cet auteur (107)
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The opposite end of the attention deficit hyperactivity disorder continuum: genetic and environmental aetiologies of extremely low ADHD traits / Corina U. GREVEN in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)
[article]
Titre : The opposite end of the attention deficit hyperactivity disorder continuum: genetic and environmental aetiologies of extremely low ADHD traits Type de document : Texte imprimé et/ou numérique Auteurs : Corina U. GREVEN, Auteur ; Andrew MERWOOD, Auteur ; Jolanda M. J. VAN DER MEER, Auteur ; Claire M. A. HAWORTH, Auteur ; Nanda N. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : p.523-531 Langues : Anglais (eng) Mots-clés : Attention deficit hyperactivity disorder quantitative trait twin extremes positive genetics Index. décimale : PER Périodiques Résumé : Background Although attention deficit hyperactivity disorder (ADHD) is thought to reflect a continuously distributed quantitative trait, it is assessed through binary diagnosis or skewed measures biased towards its high, symptomatic extreme. A growing trend is to study the positive tail of normally distributed traits, a promising avenue, for example, to study high intelligence to increase power for gene-hunting for intelligence. However, the emergence of such a ‘positive genetics’ model has been tempered for ADHD due to poor phenotypic resolution at the low extreme. Overcoming this methodological limitation, we conduct the first study to assess the aetiologies of low extreme ADHD traits. Methods In a population-representative sample of 2,143 twins, the Strength and Weaknesses of ADHD Symptoms and Normal behaviour (SWAN) questionnaire was used to assess ADHD traits on a continuum from low to high. Aetiological influences on extreme ADHD traits were estimated using DeFries–Fulker extremes analysis. ADHD traits were related to behavioural, cognitive and home environmental outcomes using regression. Results Low extreme ADHD traits were significantly influenced by shared environmental factors (23–35%) but were not significantly heritable. In contrast, high-extreme ADHD traits showed significant heritability (39–51%) but no shared environmental influences. Compared to individuals with high extreme or with average levels of ADHD traits, individuals with low extreme ADHD traits showed fewer internalizing and externalizing behaviour problems, better cognitive performance and more positive behaviours and positive home environmental outcomes. Conclusions Shared environmental influences on low extreme ADHD traits may reflect passive gene-environment correlation, which arises because parents provide environments as well as passing on genes. Studying the low extreme opens new avenues to study mechanisms underlying previously neglected positive behaviours. This is different from the current deficit-based model of intervention, but congruent with a population-level approach to improving youth wellbeing. En ligne : http://dx.doi.org/10.1111/jcpp.12475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285
in Journal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.523-531[article] The opposite end of the attention deficit hyperactivity disorder continuum: genetic and environmental aetiologies of extremely low ADHD traits [Texte imprimé et/ou numérique] / Corina U. GREVEN, Auteur ; Andrew MERWOOD, Auteur ; Jolanda M. J. VAN DER MEER, Auteur ; Claire M. A. HAWORTH, Auteur ; Nanda N. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur . - p.523-531.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.523-531
Mots-clés : Attention deficit hyperactivity disorder quantitative trait twin extremes positive genetics Index. décimale : PER Périodiques Résumé : Background Although attention deficit hyperactivity disorder (ADHD) is thought to reflect a continuously distributed quantitative trait, it is assessed through binary diagnosis or skewed measures biased towards its high, symptomatic extreme. A growing trend is to study the positive tail of normally distributed traits, a promising avenue, for example, to study high intelligence to increase power for gene-hunting for intelligence. However, the emergence of such a ‘positive genetics’ model has been tempered for ADHD due to poor phenotypic resolution at the low extreme. Overcoming this methodological limitation, we conduct the first study to assess the aetiologies of low extreme ADHD traits. Methods In a population-representative sample of 2,143 twins, the Strength and Weaknesses of ADHD Symptoms and Normal behaviour (SWAN) questionnaire was used to assess ADHD traits on a continuum from low to high. Aetiological influences on extreme ADHD traits were estimated using DeFries–Fulker extremes analysis. ADHD traits were related to behavioural, cognitive and home environmental outcomes using regression. Results Low extreme ADHD traits were significantly influenced by shared environmental factors (23–35%) but were not significantly heritable. In contrast, high-extreme ADHD traits showed significant heritability (39–51%) but no shared environmental influences. Compared to individuals with high extreme or with average levels of ADHD traits, individuals with low extreme ADHD traits showed fewer internalizing and externalizing behaviour problems, better cognitive performance and more positive behaviours and positive home environmental outcomes. Conclusions Shared environmental influences on low extreme ADHD traits may reflect passive gene-environment correlation, which arises because parents provide environments as well as passing on genes. Studying the low extreme opens new avenues to study mechanisms underlying previously neglected positive behaviours. This is different from the current deficit-based model of intervention, but congruent with a population-level approach to improving youth wellbeing. En ligne : http://dx.doi.org/10.1111/jcpp.12475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 The Reciprocal Relationship of ASD, ADHD, Depressive Symptoms and Stress in Parents of Children with ASD and/or ADHD / Daphne J. STEIJN in Journal of Autism and Developmental Disorders, 44-5 (May 2014)
[article]
Titre : The Reciprocal Relationship of ASD, ADHD, Depressive Symptoms and Stress in Parents of Children with ASD and/or ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Daphne J. STEIJN, Auteur ; Anoek M. OERLEMANS, Auteur ; Marcel A. G. AKEN, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur Année de publication : 2014 Article en page(s) : p.1064-1076 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Attention-deficit/hyperactivity disorder Parenting stress Depressive symptoms Parental symptoms Child pathology Index. décimale : PER Périodiques Résumé : This study investigated the role of parental Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and depressive symptoms on parenting stress in 174 families with children with ASD and/or ADHD, using generalized linear models and structural equation models. Fathers and mothers reported more stress when parenting with their child with ASD and/or ADHD than when parenting with the unaffected sibling; they also experienced more stress than a norm population. Depressive symptoms were most pronounced in the parents of children with ASD and ASD+ADHD. Spouse correlations were found for ASD, depression, and parenting stress. Paternal ASD and maternal ADHD symptoms were related to increased parenting stress, and parental ADHD symptoms with depressive symptoms and parenting stress. The results highlight the increased burden of raising a child with ASD and/or ADHD and the reciprocal relationship this has with parents’ ASD, ADHD, and depressive symptoms, and levels of stress. En ligne : http://dx.doi.org/10.1007/s10803-013-1958-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232
in Journal of Autism and Developmental Disorders > 44-5 (May 2014) . - p.1064-1076[article] The Reciprocal Relationship of ASD, ADHD, Depressive Symptoms and Stress in Parents of Children with ASD and/or ADHD [Texte imprimé et/ou numérique] / Daphne J. STEIJN, Auteur ; Anoek M. OERLEMANS, Auteur ; Marcel A. G. AKEN, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur . - 2014 . - p.1064-1076.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-5 (May 2014) . - p.1064-1076
Mots-clés : Autism spectrum disorder Attention-deficit/hyperactivity disorder Parenting stress Depressive symptoms Parental symptoms Child pathology Index. décimale : PER Périodiques Résumé : This study investigated the role of parental Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and depressive symptoms on parenting stress in 174 families with children with ASD and/or ADHD, using generalized linear models and structural equation models. Fathers and mothers reported more stress when parenting with their child with ASD and/or ADHD than when parenting with the unaffected sibling; they also experienced more stress than a norm population. Depressive symptoms were most pronounced in the parents of children with ASD and ASD+ADHD. Spouse correlations were found for ASD, depression, and parenting stress. Paternal ASD and maternal ADHD symptoms were related to increased parenting stress, and parental ADHD symptoms with depressive symptoms and parenting stress. The results highlight the increased burden of raising a child with ASD and/or ADHD and the reciprocal relationship this has with parents’ ASD, ADHD, and depressive symptoms, and levels of stress. En ligne : http://dx.doi.org/10.1007/s10803-013-1958-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder / Dennis VAN DER MEER in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)
[article]
Titre : The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Dennis VAN DER MEER, Auteur ; Catharina A. HARTMAN, Auteur ; Jennifer RICHARDS, Auteur ; Janita B. BRALTEN, Auteur ; Barbara FRANKE, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Stephen V. FARAONE, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur Article en page(s) : p.1363-1371 Langues : Anglais (eng) Mots-clés : ADHD gene–environment interaction (GxE) stress serotonin transporter (5-HTTLPR) Index. décimale : PER Périodiques Résumé : Introduction The role of the serotonin transporter gene polymorphism 5-HTTLPR in attention-deficit/hyperactivity disorder (ADHD) is unclear. Heterogeneity of findings may be explained by gene–environment interactions (GxE), as it has been suggested that S-allele carriers are more reactive to psychosocial stress than L-allele homozygotes. This study aimed to investigate whether 5-HTTLPR genotype moderates the effects of stress on ADHD in a multisite prospective ADHD cohort study. Methods 5-HTTLPR genotype, as well as the number of stressful life events in the past 5 years and ongoing long-term difficulties, was determined in 671 adolescents and young adults with ADHD, their siblings, and healthy controls (57.4% male, average age 17.3 years). Linear mixed models, accounting for family relatedness, were applied to investigate the effects of genotype, experienced stress, and their interaction on ADHD severity at time point T2, while controlling for ADHD severity at T1 (mean follow-up time 5.9 years) and for comorbid internalizing problems at T2. Results The interaction between genotype and stress significantly predicted ADHD severity at T2 (p = .006), which was driven by the effect on hyperactivity–impulsivity (p = .004). Probing of the interaction effect made clear that S-allele carriers had a significantly more positive correlation between stress and ADHD severity than L-allele homozygotes. Conclusion The results show that the interaction between 5-HTTLPR and stress is a mechanism involved particularly in the hyperactivity/impulsivity dimension of ADHD, and that this is independent of comorbid internalizing problems. Further research into the neurobiological mechanisms underlying this interaction effect is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1363-1371[article] The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Dennis VAN DER MEER, Auteur ; Catharina A. HARTMAN, Auteur ; Jennifer RICHARDS, Auteur ; Janita B. BRALTEN, Auteur ; Barbara FRANKE, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Stephen V. FARAONE, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur . - p.1363-1371.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1363-1371
Mots-clés : ADHD gene–environment interaction (GxE) stress serotonin transporter (5-HTTLPR) Index. décimale : PER Périodiques Résumé : Introduction The role of the serotonin transporter gene polymorphism 5-HTTLPR in attention-deficit/hyperactivity disorder (ADHD) is unclear. Heterogeneity of findings may be explained by gene–environment interactions (GxE), as it has been suggested that S-allele carriers are more reactive to psychosocial stress than L-allele homozygotes. This study aimed to investigate whether 5-HTTLPR genotype moderates the effects of stress on ADHD in a multisite prospective ADHD cohort study. Methods 5-HTTLPR genotype, as well as the number of stressful life events in the past 5 years and ongoing long-term difficulties, was determined in 671 adolescents and young adults with ADHD, their siblings, and healthy controls (57.4% male, average age 17.3 years). Linear mixed models, accounting for family relatedness, were applied to investigate the effects of genotype, experienced stress, and their interaction on ADHD severity at time point T2, while controlling for ADHD severity at T1 (mean follow-up time 5.9 years) and for comorbid internalizing problems at T2. Results The interaction between genotype and stress significantly predicted ADHD severity at T2 (p = .006), which was driven by the effect on hyperactivity–impulsivity (p = .004). Probing of the interaction effect made clear that S-allele carriers had a significantly more positive correlation between stress and ADHD severity than L-allele homozygotes. Conclusion The results show that the interaction between 5-HTTLPR and stress is a mechanism involved particularly in the hyperactivity/impulsivity dimension of ADHD, and that this is independent of comorbid internalizing problems. Further research into the neurobiological mechanisms underlying this interaction effect is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 The Structure of Autism Spectrum Disorder Symptoms in the General Population at 18 Months / Karin T. BEUKER in Journal of Autism and Developmental Disorders, 43-1 (January 2013)
[article]
Titre : The Structure of Autism Spectrum Disorder Symptoms in the General Population at 18 Months Type de document : Texte imprimé et/ou numérique Auteurs : Karin T. BEUKER, Auteur ; Synnve SCHJØLBERG, Auteur ; Kari Kveim LIE, Auteur ; Rogier DONDERS, Auteur ; Martijn LAPPENSCHAAR, Auteur ; Sophie H. N. SWINKELS, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : p.45-56 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Symptom domains General population Infants MoBa Confirmatory factor analysis (CFA) Latent class analysis (LCA) Index. décimale : PER Périodiques Résumé : It is unclear whether symptoms of autism spectrum disorder (ASD) in young children in the population fit the three-factor structure of ASD as described in the DSM-IV, and cluster together in individual subjects. This study analysed questionnaire data on ASD symptoms filled in by mothers of 11,332 18-month-old children that was collected in the context of the Norwegian Mother and Child Cohort Study conducted by the Norwegian Institute of Public Health. Confirmatory Factor Analyses showed that the three-factor model had a significantly better fit then the two- and one-factor model of ASD symptoms. Latent class analysis revealed four homogeneous groups of children (classes) with different scores for Social Interaction and Communication at one hand and Stereotypies/Rigidity at the other hand. En ligne : http://dx.doi.org/10.1007/s10803-012-1546-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187
in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.45-56[article] The Structure of Autism Spectrum Disorder Symptoms in the General Population at 18 Months [Texte imprimé et/ou numérique] / Karin T. BEUKER, Auteur ; Synnve SCHJØLBERG, Auteur ; Kari Kveim LIE, Auteur ; Rogier DONDERS, Auteur ; Martijn LAPPENSCHAAR, Auteur ; Sophie H. N. SWINKELS, Auteur ; Jan K. BUITELAAR, Auteur . - p.45-56.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.45-56
Mots-clés : Autism spectrum disorders Symptom domains General population Infants MoBa Confirmatory factor analysis (CFA) Latent class analysis (LCA) Index. décimale : PER Périodiques Résumé : It is unclear whether symptoms of autism spectrum disorder (ASD) in young children in the population fit the three-factor structure of ASD as described in the DSM-IV, and cluster together in individual subjects. This study analysed questionnaire data on ASD symptoms filled in by mothers of 11,332 18-month-old children that was collected in the context of the Norwegian Mother and Child Cohort Study conducted by the Norwegian Institute of Public Health. Confirmatory Factor Analyses showed that the three-factor model had a significantly better fit then the two- and one-factor model of ASD symptoms. Latent class analysis revealed four homogeneous groups of children (classes) with different scores for Social Interaction and Communication at one hand and Stereotypies/Rigidity at the other hand. En ligne : http://dx.doi.org/10.1007/s10803-012-1546-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 The Variation of Psychopharmacological Prescription Rates for People With Autism Spectrum Disorder (ASD) in 30 Countries / Angel Y. S. WONG in Autism Research, 7-5 (October 2014)
[article]
Titre : The Variation of Psychopharmacological Prescription Rates for People With Autism Spectrum Disorder (ASD) in 30 Countries Type de document : Texte imprimé et/ou numérique Auteurs : Angel Y. S. WONG, Auteur ; Yingfen HSIA, Auteur ; Esther W. CHAN, Auteur ; Declan G. M. MURPHY, Auteur ; Emily SIMONOFF, Auteur ; Jan K. BUITELAAR, Auteur ; Ian C. K. WONG, Auteur Article en page(s) : p.543-554 Langues : Anglais (eng) Mots-clés : epidemiology Gross Domestic Product Psychopharmacology Multinational study Index. décimale : PER Périodiques Résumé : There is significant variation in prescriptions among countries in clinical practice for the treatment of comorbidities associated with autism spectrum disorder (ASD). It has been suggested that many people with mental health disorders in low-/middle-income countries do not receive adequate treatment. Hence, this study investigated psychopharmacological treatment patterns for ASD comorbidities in 30 countries and the association between country's income and prescription rates. The IMS Prescribing Insights database was used to investigate prescription patterns for ASD comorbidity treatment from 2007 to 2012. Data were obtained from 30 countries in continents of Europe, Asia, Oceania, Central America, South America, and Africa. The gross domestic product (GDP) per capita was used as a proxy for each country's income. Spearman correlation was used to examine the association between prescription rate and GDP per capita. The highest prescription rates were found in Western Europe (3.89–36.36/10,000) while the lowest prescription rates were found in Asian countries, such as Turkey, Indonesia, Saudi Arabia, and Pakistan (0.04–0.82/10,000). The most commonly prescribed drug for ASD comorbidity treatment in most of the countries was risperidone, but antidepressants and antiepileptic drugs were also frequently prescribed. There was a significant positive correlation between GDP per capita and prescription rate (Spearman ??=?0.60; P?=?0.0011; 95% confidence interval 0.27–0.81), that is, the higher the GDP per capita, the higher the prescription rate. There are marked international differences in prescription rates, and this is partially accounted by economic factors. Future research should combine more data for ASD comorbidity treatment to explore the disparity of psychopharmacological treatment between countries. Autism Res 2014, 7: 543–554. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1391 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Autism Research > 7-5 (October 2014) . - p.543-554[article] The Variation of Psychopharmacological Prescription Rates for People With Autism Spectrum Disorder (ASD) in 30 Countries [Texte imprimé et/ou numérique] / Angel Y. S. WONG, Auteur ; Yingfen HSIA, Auteur ; Esther W. CHAN, Auteur ; Declan G. M. MURPHY, Auteur ; Emily SIMONOFF, Auteur ; Jan K. BUITELAAR, Auteur ; Ian C. K. WONG, Auteur . - p.543-554.
Langues : Anglais (eng)
in Autism Research > 7-5 (October 2014) . - p.543-554
Mots-clés : epidemiology Gross Domestic Product Psychopharmacology Multinational study Index. décimale : PER Périodiques Résumé : There is significant variation in prescriptions among countries in clinical practice for the treatment of comorbidities associated with autism spectrum disorder (ASD). It has been suggested that many people with mental health disorders in low-/middle-income countries do not receive adequate treatment. Hence, this study investigated psychopharmacological treatment patterns for ASD comorbidities in 30 countries and the association between country's income and prescription rates. The IMS Prescribing Insights database was used to investigate prescription patterns for ASD comorbidity treatment from 2007 to 2012. Data were obtained from 30 countries in continents of Europe, Asia, Oceania, Central America, South America, and Africa. The gross domestic product (GDP) per capita was used as a proxy for each country's income. Spearman correlation was used to examine the association between prescription rate and GDP per capita. The highest prescription rates were found in Western Europe (3.89–36.36/10,000) while the lowest prescription rates were found in Asian countries, such as Turkey, Indonesia, Saudi Arabia, and Pakistan (0.04–0.82/10,000). The most commonly prescribed drug for ASD comorbidity treatment in most of the countries was risperidone, but antidepressants and antiepileptic drugs were also frequently prescribed. There was a significant positive correlation between GDP per capita and prescription rate (Spearman ??=?0.60; P?=?0.0011; 95% confidence interval 0.27–0.81), that is, the higher the GDP per capita, the higher the prescription rate. There are marked international differences in prescription rates, and this is partially accounted by economic factors. Future research should combine more data for ASD comorbidity treatment to explore the disparity of psychopharmacological treatment between countries. Autism Res 2014, 7: 543–554. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1391 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 Towards robust and replicable sex differences in the intrinsic brain function of autism / D. L. FLORIS in Molecular Autism, 12 (2021)
PermalinkUnique dynamic profiles of social attention in autistic females / Teresa DEL BIANCO in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)
PermalinkUse of early intervention for young children with autism spectrum disorder across Europe / Erica SALOMONE in Autism, 20-2 (February 2016)
PermalinkVerbal Memory and Performance IQ Predict Theory of Mind and Emotion Recognition Ability in Children with Autistic Spectrum Disorders and in Psychiatric Control Children / Jan K. BUITELAAR in Journal of Child Psychology and Psychiatry, 40-6 (September 1999)
PermalinkWhite matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder / Winke FRANCX in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)
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