Autistic Traits and Abnormal Sensory Experiences in Adults / Jamie HORDER in Journal of Autism and Developmental Disorders, 44-6 (June 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1461-1469 Titre : Autistic Traits and Abnormal Sensory Experiences in Adults Type de document : texte imprimé Auteurs : Jamie HORDER, Auteur ; C. Ellie WILSON, Auteur ; M. Andreina MENDEZ, Auteur ; Declan G. M. MURPHY, Auteur Article en page(s) : p.1461-1469 Langues : Anglais (eng) Mots-clés : Adults  Anxiety  Autism  Comorbidities  Sensory Index. décimale : PER Périodiques Résumé : Sensory processing abnormalities are common in autism spectrum disorders (ASD), and now form part of the Diagnostic and Statistical Manual 5th Edition (DSM-5) diagnostic criteria, but it is unclear whether they characterize the ‘broader phenotype’ of the disorder. We recruited adults (n = 772) with and without an ASD and administered the Autism Quotient (AQ) along with the Adult/Adolescent Sensory Profile (AASP), the Cardiff Anomalous Perceptions Scale (CAPS), and the Glasgow Sensory Questionnaire (GSQ), all questionnaire measures of abnormal sensory responsivity. Autism traits were significantly correlated with scores on all three sensory scales (AQ/GSQ r = 0.478; AQ/AASP r = 0.344; AQ/CAPS r = 0.333; all p 0.001). This relationship was linear across the whole range of AQ scores and was true both in those with, and without, an ASD diagnosis. It survived correction for anxiety trait scores, and other potential confounds such as mental illness and migraine. En ligne : http://dx.doi.org/10.1007/s10803-013-2012-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 [article] Autistic Traits and Abnormal Sensory Experiences in Adults [texte imprimé] / Jamie HORDER, Auteur ; C. Ellie WILSON, Auteur ; M. Andreina MENDEZ, Auteur ; Declan G. M. MURPHY, Auteur . - p.1461-1469. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1461-1469 Mots-clés : Adults  Anxiety  Autism  Comorbidities  Sensory Index. décimale : PER Périodiques Résumé : Sensory processing abnormalities are common in autism spectrum disorders (ASD), and now form part of the Diagnostic and Statistical Manual 5th Edition (DSM-5) diagnostic criteria, but it is unclear whether they characterize the ‘broader phenotype’ of the disorder. We recruited adults (n = 772) with and without an ASD and administered the Autism Quotient (AQ) along with the Adult/Adolescent Sensory Profile (AASP), the Cardiff Anomalous Perceptions Scale (CAPS), and the Glasgow Sensory Questionnaire (GSQ), all questionnaire measures of abnormal sensory responsivity. Autism traits were significantly correlated with scores on all three sensory scales (AQ/GSQ r = 0.478; AQ/AASP r = 0.344; AQ/CAPS r = 0.333; all p 0.001). This relationship was linear across the whole range of AQ scores and was true both in those with, and without, an ASD diagnosis. It survived correction for anxiety trait scores, and other potential confounds such as mental illness and migraine. En ligne : http://dx.doi.org/10.1007/s10803-013-2012-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233

Cortical and subcortical glutathione levels in adults with autism spectrum disorder / Alice M. S. DURIEUX in Autism Research, 9-4 (April 2016)  

Public ISBD [article]  inAutism Research > 9-4 (April 2016) . - p.429-435 Titre : Cortical and subcortical glutathione levels in adults with autism spectrum disorder Type de document : texte imprimé Auteurs : Alice M. S. DURIEUX, Auteur ; Jamie HORDER, Auteur ; M. Andreina MENDEZ, Auteur ; Alice EGERTON, Auteur ; Steven C. R. WILLIAMS, Auteur ; C. Ellie WILSON, Auteur ; Debbie SPAIN, Auteur ; Clodagh M. MURPHY, Auteur ; Dene ROBERTSON, Auteur ; Gareth J. BARKER, Auteur ; Declan G. M. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur Article en page(s) : p.429-435 Langues : Anglais (eng) Mots-clés : autism  magnetic resonance spectroscopy  glutathione  oxidative stress  redox Index. décimale : PER Périodiques Résumé : Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. Autism Res 2016, 9: 429–435. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. En ligne : http://dx.doi.org/10.1002/aur.1522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 [article] Cortical and subcortical glutathione levels in adults with autism spectrum disorder [texte imprimé] / Alice M. S. DURIEUX, Auteur ; Jamie HORDER, Auteur ; M. Andreina MENDEZ, Auteur ; Alice EGERTON, Auteur ; Steven C. R. WILLIAMS, Auteur ; C. Ellie WILSON, Auteur ; Debbie SPAIN, Auteur ; Clodagh M. MURPHY, Auteur ; Dene ROBERTSON, Auteur ; Gareth J. BARKER, Auteur ; Declan G. M. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur . - p.429-435. Langues : Anglais (eng) in Autism Research > 9-4 (April 2016) . - p.429-435 Mots-clés : autism  magnetic resonance spectroscopy  glutathione  oxidative stress  redox Index. décimale : PER Périodiques Résumé : Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. Autism Res 2016, 9: 429–435. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. En ligne : http://dx.doi.org/10.1002/aur.1522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287

Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy / Aine RODDY ; Martin KNAPP ; Celso ARANGO ; M. Andreina MENDEZ ; James CUSACK ; Declan G. M. MURPHY ; Roberto CANITANO ; Bethany OAKLEY ; Vinciane QUOIDBACH in Journal of Autism and Developmental Disorders, 54-7 (July 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2733-2741 Titre : Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy Type de document : texte imprimé Auteurs : Aine RODDY, Auteur ; Martin KNAPP, Auteur ; Celso ARANGO, Auteur ; M. Andreina MENDEZ, Auteur ; James CUSACK, Auteur ; Declan G. M. MURPHY, Auteur ; Roberto CANITANO, Auteur ; Bethany OAKLEY, Auteur ; Vinciane QUOIDBACH, Auteur Article en page(s) : p.2733-2741 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children s families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For England and Spain, oxcarbazepine is the most cost-effective treatment when taken as additional treatment for those children whose response to monotherapy is suboptimal. In Ireland and Italy, gabapentin is the most cost-effective option. Our additional scenario analysis presents the aggregate cost to families with autistic children who are being treated for epilepsy: this cost is considerably higher than healthcare provider expenditure. En ligne : https://doi.org/10.1007/s10803-023-05941-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy [texte imprimé] / Aine RODDY, Auteur ; Martin KNAPP, Auteur ; Celso ARANGO, Auteur ; M. Andreina MENDEZ, Auteur ; James CUSACK, Auteur ; Declan G. M. MURPHY, Auteur ; Roberto CANITANO, Auteur ; Bethany OAKLEY, Auteur ; Vinciane QUOIDBACH, Auteur . - p.2733-2741. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2733-2741 Index. décimale : PER Périodiques Résumé : We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children s families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For England and Spain, oxcarbazepine is the most cost-effective treatment when taken as additional treatment for those children whose response to monotherapy is suboptimal. In Ireland and Italy, gabapentin is the most cost-effective option. Our additional scenario analysis presents the aggregate cost to families with autistic children who are being treated for epilepsy: this cost is considerably higher than healthcare provider expenditure. En ligne : https://doi.org/10.1007/s10803-023-05941-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin / C. M. PRETZSCH in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 49 p. Titre : Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin Type de document : texte imprimé Auteurs : C. M. PRETZSCH, Auteur ; Dorothea L. FLORIS, Auteur ; B. VOINESCU, Auteur ; M. ELSAHIB, Auteur ; M. Andreina MENDEZ, Auteur ; R. WICHERS, Auteur ; L. AJRAM, Auteur ; G. IVIN, Auteur ; M. HEASMAN, Auteur ; E. PRETZSCH, Auteur ; S. WILLIAMS, Auteur ; Declan G. M. MURPHY, Auteur ; Eileen DALY, Auteur ; Gráinne M. MCALONAN, Auteur Article en page(s) : 49 p. Langues : Anglais (eng) Mots-clés : Autism spectrum condition  Autism spectrum disorder  Cbdv  Cannabidivarin  Functional connectivity  Striatum Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) has a high cost to affected individuals and society, but treatments for core symptoms are lacking. To expand intervention options, it is crucial to gain a better understanding of potential treatment targets, and their engagement, in the brain. For instance, the striatum (caudate, putamen, and nucleus accumbens) plays a central role during development and its (atypical) functional connectivity (FC) may contribute to multiple ASD symptoms. We have previously shown, in the adult autistic and neurotypical brain, the non-intoxicating cannabinoid cannabidivarin (CBDV) alters the balance of striatal 'excitatory-inhibitory' metabolites, which help regulate FC, but the effects of CBDV on (atypical) striatal FC are unknown. METHODS: To examine this in a small pilot study, we acquired resting state functional magnetic resonance imaging data from 28 men (15 neurotypicals, 13 ASD) on two occasions in a repeated-measures, double-blind, placebo-controlled study. We then used a seed-based approach to (1) compare striatal FC between groups and (2) examine the effect of pharmacological probing (600 mg CBDV/matched placebo) on atypical striatal FC in ASD. Visits were separated by at least 13 days to allow for drug washout. RESULTS: Compared to the neurotypicals, ASD individuals had lower FC between the ventral striatum and frontal and pericentral regions (which have been associated with emotion, motor, and vision processing). Further, they had higher intra-striatal FC and higher putamenal FC with temporal regions involved in speech and language. In ASD, CBDV reduced hyperconnectivity to the neurotypical level. LIMITATIONS: Our findings should be considered in light of several methodological aspects, in particular our participant group (restricted to male adults), which limits the generalizability of our findings to the wider and heterogeneous ASD population. CONCLUSION: In conclusion, here we show atypical striatal FC with regions commonly associated with ASD symptoms. We further provide preliminary proof of concept that, in the adult autistic brain, acute CBDV administration can modulate atypical striatal circuitry towards neurotypical function. Future studies are required to determine whether modulation of striatal FC is associated with a change in ASD symptoms. TRIAL REGISTRATION: clinicaltrials.gov, Identifier: NCT03537950. Registered May 25th, 2018-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03537950 term=NCT03537950&draw=2&rank=1 . En ligne : http://dx.doi.org/10.1186/s13229-021-00454-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin [texte imprimé] / C. M. PRETZSCH, Auteur ; Dorothea L. FLORIS, Auteur ; B. VOINESCU, Auteur ; M. ELSAHIB, Auteur ; M. Andreina MENDEZ, Auteur ; R. WICHERS, Auteur ; L. AJRAM, Auteur ; G. IVIN, Auteur ; M. HEASMAN, Auteur ; E. PRETZSCH, Auteur ; S. WILLIAMS, Auteur ; Declan G. M. MURPHY, Auteur ; Eileen DALY, Auteur ; Gráinne M. MCALONAN, Auteur . - 49 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 49 p. Mots-clés : Autism spectrum condition  Autism spectrum disorder  Cbdv  Cannabidivarin  Functional connectivity  Striatum Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) has a high cost to affected individuals and society, but treatments for core symptoms are lacking. To expand intervention options, it is crucial to gain a better understanding of potential treatment targets, and their engagement, in the brain. For instance, the striatum (caudate, putamen, and nucleus accumbens) plays a central role during development and its (atypical) functional connectivity (FC) may contribute to multiple ASD symptoms. We have previously shown, in the adult autistic and neurotypical brain, the non-intoxicating cannabinoid cannabidivarin (CBDV) alters the balance of striatal 'excitatory-inhibitory' metabolites, which help regulate FC, but the effects of CBDV on (atypical) striatal FC are unknown. METHODS: To examine this in a small pilot study, we acquired resting state functional magnetic resonance imaging data from 28 men (15 neurotypicals, 13 ASD) on two occasions in a repeated-measures, double-blind, placebo-controlled study. We then used a seed-based approach to (1) compare striatal FC between groups and (2) examine the effect of pharmacological probing (600 mg CBDV/matched placebo) on atypical striatal FC in ASD. Visits were separated by at least 13 days to allow for drug washout. RESULTS: Compared to the neurotypicals, ASD individuals had lower FC between the ventral striatum and frontal and pericentral regions (which have been associated with emotion, motor, and vision processing). Further, they had higher intra-striatal FC and higher putamenal FC with temporal regions involved in speech and language. In ASD, CBDV reduced hyperconnectivity to the neurotypical level. LIMITATIONS: Our findings should be considered in light of several methodological aspects, in particular our participant group (restricted to male adults), which limits the generalizability of our findings to the wider and heterogeneous ASD population. CONCLUSION: In conclusion, here we show atypical striatal FC with regions commonly associated with ASD symptoms. We further provide preliminary proof of concept that, in the adult autistic brain, acute CBDV administration can modulate atypical striatal circuitry towards neurotypical function. Future studies are required to determine whether modulation of striatal FC is associated with a change in ASD symptoms. TRIAL REGISTRATION: clinicaltrials.gov, Identifier: NCT03537950. Registered May 25th, 2018-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03537950 term=NCT03537950&draw=2&rank=1 . En ligne : http://dx.doi.org/10.1186/s13229-021-00454-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Social anxiety in adult males with autism spectrum disorders / Debbie SPAIN in Research in Autism Spectrum Disorders, 32 (December 2016)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 32 (December 2016) . - p.13-23 Titre : Social anxiety in adult males with autism spectrum disorders Type de document : texte imprimé Auteurs : Debbie SPAIN, Auteur ; Francesca HAPPE, Auteur ; Patrick JOHNSTON, Auteur ; Malcolm CAMPBELL, Auteur ; Jacqueline SIN, Auteur ; Eileen DALY, Auteur ; Christine ECKER, Auteur ; Martin ANSON, Auteur ; Eddie CHAPLIN, Auteur ; Karen GLASER, Auteur ; M. Andreina MENDEZ, Auteur ; Karina LOVELL, Auteur ; Declan G. M. MURPHY, Auteur Article en page(s) : p.13-23 Langues : Anglais (eng) Mots-clés : Autism spectrum  Social anxiety  Social phobia  Adults  Self-report questionnaires Index. décimale : PER Périodiques Résumé : AbstractBackground Psychiatric conditions, notably anxiety, commonly co-occur with autism spectrum disorders (ASD). Method This study investigated self-reported behavioural, cognitive and affective symptoms of social anxiety (SA) in 50 adult males with ASD. Associations between SA, core ASD symptoms and facets of neuropsychological functioning were also examined. Results Twenty-six participants (52%) endorsed levels of SA that exceeded the suggested caseness threshold for social anxiety disorder. Categorical and dimensional data analyses indicated that there were no relationships between SA symptoms, present-state or childhood ASD symptom-severity, or measures of socio-emotional processing in this sample. Conclusions Study findings suggest that severity of SA is not merely a reflection of ASD symptom-severity. Further research is needed to ascertain the prevalence of SA in adult ASD epidemiological samples, and identify causal and maintaining mechanisms for these co-morbid symptoms. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.08.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=296 [article] Social anxiety in adult males with autism spectrum disorders [texte imprimé] / Debbie SPAIN, Auteur ; Francesca HAPPE, Auteur ; Patrick JOHNSTON, Auteur ; Malcolm CAMPBELL, Auteur ; Jacqueline SIN, Auteur ; Eileen DALY, Auteur ; Christine ECKER, Auteur ; Martin ANSON, Auteur ; Eddie CHAPLIN, Auteur ; Karen GLASER, Auteur ; M. Andreina MENDEZ, Auteur ; Karina LOVELL, Auteur ; Declan G. M. MURPHY, Auteur . - p.13-23. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 32 (December 2016) . - p.13-23 Mots-clés : Autism spectrum  Social anxiety  Social phobia  Adults  Self-report questionnaires Index. décimale : PER Périodiques Résumé : AbstractBackground Psychiatric conditions, notably anxiety, commonly co-occur with autism spectrum disorders (ASD). Method This study investigated self-reported behavioural, cognitive and affective symptoms of social anxiety (SA) in 50 adult males with ASD. Associations between SA, core ASD symptoms and facets of neuropsychological functioning were also examined. Results Twenty-six participants (52%) endorsed levels of SA that exceeded the suggested caseness threshold for social anxiety disorder. Categorical and dimensional data analyses indicated that there were no relationships between SA symptoms, present-state or childhood ASD symptom-severity, or measures of socio-emotional processing in this sample. Conclusions Study findings suggest that severity of SA is not merely a reflection of ASD symptom-severity. Further research is needed to ascertain the prevalence of SA in adult ASD epidemiological samples, and identify causal and maintaining mechanisms for these co-morbid symptoms. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.08.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=296

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