Age of First Walking and Associations with Symptom Severity in Children with Suspected or Diagnosed Autism Spectrum Disorder / Lise REINDAL in Journal of Autism and Developmental Disorders, 50-9 (September 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3216-3232 Titre : Age of First Walking and Associations with Symptom Severity in Children with Suspected or Diagnosed Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lise REINDAL, Auteur ; Terje NÆRLAND, Auteur ; Bernhard WEIDLE, Auteur ; Stian LYDERSEN, Auteur ; Ole A. ANDREASSEN, Auteur ; Anne Mari SUND, Auteur Article en page(s) : p.3216-3232 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Intellectual disability  Motor  Sex differences  Symptom severity  Walking Index. décimale : PER Périodiques Résumé : Age of first walking (AOW) is reported to be later in autism spectrum disorder (ASD) compared with typical development. However, the relationship between AOW and variations in ASD symptoms across different neurodevelopmental disorders is largely unknown. This study investigated AOW and its association with autism symptom severity in a large sample of children (N?=?490, 23% females) clinically evaluated for suspected ASD, differentiated into ASD (n?=?376) and non-ASD (n?=?114) diagnoses. Children with ASD achieved independent walking significantly later than children with non-ASD diagnoses. AOW was significantly associated with ASD symptom severity, and females had a non-significant later AOW. The current findings suggest that in cases with delayed AOW, ASD should be considered as an actual differential diagnosis, perhaps particularly in girls. En ligne : http://dx.doi.org/10.1007/s10803-019-04112-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Age of First Walking and Associations with Symptom Severity in Children with Suspected or Diagnosed Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lise REINDAL, Auteur ; Terje NÆRLAND, Auteur ; Bernhard WEIDLE, Auteur ; Stian LYDERSEN, Auteur ; Ole A. ANDREASSEN, Auteur ; Anne Mari SUND, Auteur . - p.3216-3232. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3216-3232 Mots-clés : Autism spectrum disorder  Intellectual disability  Motor  Sex differences  Symptom severity  Walking Index. décimale : PER Périodiques Résumé : Age of first walking (AOW) is reported to be later in autism spectrum disorder (ASD) compared with typical development. However, the relationship between AOW and variations in ASD symptoms across different neurodevelopmental disorders is largely unknown. This study investigated AOW and its association with autism symptom severity in a large sample of children (N?=?490, 23% females) clinically evaluated for suspected ASD, differentiated into ASD (n?=?376) and non-ASD (n?=?114) diagnoses. Children with ASD achieved independent walking significantly later than children with non-ASD diagnoses. AOW was significantly associated with ASD symptom severity, and females had a non-significant later AOW. The current findings suggest that in cases with delayed AOW, ASD should be considered as an actual differential diagnosis, perhaps particularly in girls. En ligne : http://dx.doi.org/10.1007/s10803-019-04112-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment / Sanne JENSEN in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.969-978 Titre : Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment Type de document : Texte imprimé et/ou numérique Auteurs : Sanne JENSEN, Auteur ; Davíð R. M. A. HØJGAARD, Auteur ; Katja A HYBEL, Auteur ; Erik Lykke MORTENSEN, Auteur ; Gudmundur SKARPHEDINSSON, Auteur ; Karin MELIN, Auteur ; Tord IVARSSON, Auteur ; Judith Becker NISSEN, Auteur ; Bernhard WEIDLE, Auteur ; Robert VALDERHAUG, Auteur ; Nor Christian TORP, Auteur ; Kitty DAHL, Auteur ; Scott COMPTON, Auteur ; Per Hove THOMSEN, Auteur Article en page(s) : p.969-978 Langues : Anglais (eng) Mots-clés : Obsessive-compulsive disorder  children and adolescents  latent class growth analysis  longitudinal study  outcome predictors  stepped-care treatment  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: First-line treatments for pediatric obsessive-compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. METHOD: The study included 269 OCD patients aged 7-17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. TRIAL REGISTRY: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. RESULTS: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination/cleaning and anxiety symptoms. CONCLUSIONS: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning and anxiety symptoms who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment [Texte imprimé et/ou numérique] / Sanne JENSEN, Auteur ; Davíð R. M. A. HØJGAARD, Auteur ; Katja A HYBEL, Auteur ; Erik Lykke MORTENSEN, Auteur ; Gudmundur SKARPHEDINSSON, Auteur ; Karin MELIN, Auteur ; Tord IVARSSON, Auteur ; Judith Becker NISSEN, Auteur ; Bernhard WEIDLE, Auteur ; Robert VALDERHAUG, Auteur ; Nor Christian TORP, Auteur ; Kitty DAHL, Auteur ; Scott COMPTON, Auteur ; Per Hove THOMSEN, Auteur . - p.969-978. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.969-978 Mots-clés : Obsessive-compulsive disorder  children and adolescents  latent class growth analysis  longitudinal study  outcome predictors  stepped-care treatment  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: First-line treatments for pediatric obsessive-compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. METHOD: The study included 269 OCD patients aged 7-17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. TRIAL REGISTRY: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. RESULTS: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination/cleaning and anxiety symptoms. CONCLUSIONS: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning and anxiety symptoms who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Structural and Pragmatic Language Impairments in Children Evaluated for Autism Spectrum Disorder (ASD) / Terje NÆRLAND ; Bernhard WEIDLE ; Stian LYDERSEN ; Ole A. ANDREASSEN ; Anne Mari SUND in Journal of Autism and Developmental Disorders, 53-2 (February 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-2 (February 2023) . - p.701-719 Titre : Structural and Pragmatic Language Impairments in Children Evaluated for Autism Spectrum Disorder (ASD) Type de document : Texte imprimé et/ou numérique Auteurs : Terje NÆRLAND, Auteur ; Bernhard WEIDLE, Auteur ; Stian LYDERSEN, Auteur ; Ole A. ANDREASSEN, Auteur ; Anne Mari SUND, Auteur Article en page(s) : p.701-719 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Pragmatic language impairments are common in neurodevelopmental disorders, especially in autism spectrum disorder (ASD). The relationship between structural language skills and pragmatic competence in children with autistic symptoms, however, is largely unknown. We investigated this relationship based on the Children's Communication Checklist-2 and early language delay among children (N = 177, 19% females) clinically evaluated for ASD, differentiated into ASD (n = 148) and non-ASD (n = 29). Structural language deficits were common and associated with reduced pragmatic competence in both groups. Pragmatic language impairments were most profound in children with ASD. Early language delay and structural language deficits were less common in females. Our findings suggest that assessment of structural language skills should be included in the evaluation of children with suspected ASD. En ligne : https://doi.org/10.1007/s10803-020-04853-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495 [article] Structural and Pragmatic Language Impairments in Children Evaluated for Autism Spectrum Disorder (ASD) [Texte imprimé et/ou numérique] / Terje NÆRLAND, Auteur ; Bernhard WEIDLE, Auteur ; Stian LYDERSEN, Auteur ; Ole A. ANDREASSEN, Auteur ; Anne Mari SUND, Auteur . - p.701-719. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-2 (February 2023) . - p.701-719 Index. décimale : PER Périodiques Résumé : Pragmatic language impairments are common in neurodevelopmental disorders, especially in autism spectrum disorder (ASD). The relationship between structural language skills and pragmatic competence in children with autistic symptoms, however, is largely unknown. We investigated this relationship based on the Children's Communication Checklist-2 and early language delay among children (N = 177, 19% females) clinically evaluated for ASD, differentiated into ASD (n = 148) and non-ASD (n = 29). Structural language deficits were common and associated with reduced pragmatic competence in both groups. Pragmatic language impairments were most profound in children with ASD. Early language delay and structural language deficits were less common in females. Our findings suggest that assessment of structural language skills should be included in the evaluation of children with suspected ASD. En ligne : https://doi.org/10.1007/s10803-020-04853-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495

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