Amniotic Fluid MMP-9 and Neurotrophins in Autism Spectrum Disorders: An Exploratory Study / Morsi W. ABDALLAH in Autism Research, 5-6 (December 2012)  

Public ISBD [article]  inAutism Research > 5-6 (December 2012) . - p.428-433 Titre : Amniotic Fluid MMP-9 and Neurotrophins in Autism Spectrum Disorders: An Exploratory Study Type de document : Texte imprimé et/ou numérique Auteurs : Morsi W. ABDALLAH, Auteur ; Brad D. PEARCE, Auteur ; Nanna LARSEN, Auteur ; Kirstin GREAVES-LORD, Auteur ; Bent NØRGAARD-PEDERSEN, Auteur ; David M. HOUGAARD, Auteur ; Erik Lykke MORTENSEN, Auteur ; Jakob GROVE, Auteur Article en page(s) : p.428-433 Mots-clés : neuronal plasticity  autistic disorder  amniotic fluid  matrix metalloproteinase  neurotrophins Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1254 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 [article] Amniotic Fluid MMP-9 and Neurotrophins in Autism Spectrum Disorders: An Exploratory Study [Texte imprimé et/ou numérique] / Morsi W. ABDALLAH, Auteur ; Brad D. PEARCE, Auteur ; Nanna LARSEN, Auteur ; Kirstin GREAVES-LORD, Auteur ; Bent NØRGAARD-PEDERSEN, Auteur ; David M. HOUGAARD, Auteur ; Erik Lykke MORTENSEN, Auteur ; Jakob GROVE, Auteur . - p.428-433. in Autism Research > 5-6 (December 2012) . - p.428-433 Mots-clés : neuronal plasticity  autistic disorder  amniotic fluid  matrix metalloproteinase  neurotrophins Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1254 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187

Brief Report: Cognitive Flexibility and Focused Attention in Children and Adolescents with Asperger Syndrome or High-Functioning Autism as Measured on the Computerized Version of the Wisconsin Card Sorting Test / Nils KALAND in Journal of Autism and Developmental Disorders, 38-6 (July 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1161-1165 Titre : Brief Report: Cognitive Flexibility and Focused Attention in Children and Adolescents with Asperger Syndrome or High-Functioning Autism as Measured on the Computerized Version of the Wisconsin Card Sorting Test Type de document : Texte imprimé et/ou numérique Auteurs : Nils KALAND, Auteur ; Erik Lykke MORTENSEN, Auteur ; Lars SMITH, Auteur Année de publication : 2008 Article en page(s) : p.1161-1165 Langues : Anglais (eng) Mots-clés : Asperger-syndrome High-functioning-autism Executive-function Wisconsin-Card-Sorting-Test Attention-problems Index. décimale : PER Périodiques Résumé : The aim of the present study was to assess mental flexibility and set maintenance of a group of individuals with Asperger syndrome (AS) or high-functioning autism (HFA) (N = 13; mean age 16,4), as compared with a matched group of typically developing children and adolescents (N = 13; mean age 15,6) on the computerized version of the Wisconsin Card Sorting Test (WCST). The participants in the AS/HFA group performed less well than the controls on all categories of the WCST, but the differences did not reach conventional statistical significance on most categories of the WCST. On the category failure to maintain set, however, the AS/HFA participants performed significantly less well than the controls, suggesting a deficit of focused attention. En ligne : http://dx.doi.org/10.1007/s10803-007-0474-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Brief Report: Cognitive Flexibility and Focused Attention in Children and Adolescents with Asperger Syndrome or High-Functioning Autism as Measured on the Computerized Version of the Wisconsin Card Sorting Test [Texte imprimé et/ou numérique] / Nils KALAND, Auteur ; Erik Lykke MORTENSEN, Auteur ; Lars SMITH, Auteur . - 2008 . - p.1161-1165. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1161-1165 Mots-clés : Asperger-syndrome High-functioning-autism Executive-function Wisconsin-Card-Sorting-Test Attention-problems Index. décimale : PER Périodiques Résumé : The aim of the present study was to assess mental flexibility and set maintenance of a group of individuals with Asperger syndrome (AS) or high-functioning autism (HFA) (N = 13; mean age 16,4), as compared with a matched group of typically developing children and adolescents (N = 13; mean age 15,6) on the computerized version of the Wisconsin Card Sorting Test (WCST). The participants in the AS/HFA group performed less well than the controls on all categories of the WCST, but the differences did not reach conventional statistical significance on most categories of the WCST. On the category failure to maintain set, however, the AS/HFA participants performed significantly less well than the controls, suggesting a deficit of focused attention. En ligne : http://dx.doi.org/10.1007/s10803-007-0474-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Disembedding performance in children and adolescents with Asperger syndrome or high-functioning autism / Nils KALAND in Autism, 11-1 (January 2007)  

Public ISBD [article]  inAutism > 11-1 (January 2007) . - p.81-92 Titre : Disembedding performance in children and adolescents with Asperger syndrome or high-functioning autism Type de document : Texte imprimé et/ou numérique Auteurs : Nils KALAND, Auteur ; Erik Lykke MORTENSEN, Auteur ; Lars SMITH, Auteur Année de publication : 2007 Article en page(s) : p.81-92 Langues : Anglais (eng) Mots-clés : Asperger-syndrome High-functioning-autism Non-social-cognitive-tests Response-times Index. décimale : PER Périodiques Résumé : The aim of the present study was to assess the findings, reported in earlier studies, that individuals with autism spectrum disorders process visuo-spatial tasks faster than typically developing control persons. The participants in the present study were children and adolescents with Asperger syndrome (AS) or high-functioning autism (HFA) (N = 13), and a matched group of typically developing children and adolescents (N = 13). The results showed that the participants in the clinical group performed marginally less well than those in the control group on both the Block Design Test and the Embedded Figures Test, but the differences were not statistically significant. Thus, earlier findings suggesting that individuals with autism spectrum disorders solve non-social cognitive tasks faster than typically developing control persons were not replicated. The results are discussed with special reference to the hypothesis of weak central coherence. En ligne : http://dx.doi.org/10.1177/1362361307070988 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Disembedding performance in children and adolescents with Asperger syndrome or high-functioning autism [Texte imprimé et/ou numérique] / Nils KALAND, Auteur ; Erik Lykke MORTENSEN, Auteur ; Lars SMITH, Auteur . - 2007 . - p.81-92. Langues : Anglais (eng) in Autism > 11-1 (January 2007) . - p.81-92 Mots-clés : Asperger-syndrome High-functioning-autism Non-social-cognitive-tests Response-times Index. décimale : PER Périodiques Résumé : The aim of the present study was to assess the findings, reported in earlier studies, that individuals with autism spectrum disorders process visuo-spatial tasks faster than typically developing control persons. The participants in the present study were children and adolescents with Asperger syndrome (AS) or high-functioning autism (HFA) (N = 13), and a matched group of typically developing children and adolescents (N = 13). The results showed that the participants in the clinical group performed marginally less well than those in the control group on both the Block Design Test and the Embedded Figures Test, but the differences were not statistically significant. Thus, earlier findings suggesting that individuals with autism spectrum disorders solve non-social cognitive tasks faster than typically developing control persons were not replicated. The results are discussed with special reference to the hypothesis of weak central coherence. En ligne : http://dx.doi.org/10.1177/1362361307070988 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment / Sanne JENSEN in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.969-978 Titre : Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment Type de document : Texte imprimé et/ou numérique Auteurs : Sanne JENSEN, Auteur ; Davíð R. M. A. HØJGAARD, Auteur ; Katja A HYBEL, Auteur ; Erik Lykke MORTENSEN, Auteur ; Gudmundur SKARPHEDINSSON, Auteur ; Karin MELIN, Auteur ; Tord IVARSSON, Auteur ; Judith Becker NISSEN, Auteur ; Bernhard WEIDLE, Auteur ; Robert VALDERHAUG, Auteur ; Nor Christian TORP, Auteur ; Kitty DAHL, Auteur ; Scott COMPTON, Auteur ; Per Hove THOMSEN, Auteur Article en page(s) : p.969-978 Langues : Anglais (eng) Mots-clés : Obsessive-compulsive disorder  children and adolescents  latent class growth analysis  longitudinal study  outcome predictors  stepped-care treatment  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: First-line treatments for pediatric obsessive-compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. METHOD: The study included 269 OCD patients aged 7-17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. TRIAL REGISTRY: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. RESULTS: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination/cleaning and anxiety symptoms. CONCLUSIONS: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning and anxiety symptoms who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment [Texte imprimé et/ou numérique] / Sanne JENSEN, Auteur ; Davíð R. M. A. HØJGAARD, Auteur ; Katja A HYBEL, Auteur ; Erik Lykke MORTENSEN, Auteur ; Gudmundur SKARPHEDINSSON, Auteur ; Karin MELIN, Auteur ; Tord IVARSSON, Auteur ; Judith Becker NISSEN, Auteur ; Bernhard WEIDLE, Auteur ; Robert VALDERHAUG, Auteur ; Nor Christian TORP, Auteur ; Kitty DAHL, Auteur ; Scott COMPTON, Auteur ; Per Hove THOMSEN, Auteur . - p.969-978. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.969-978 Mots-clés : Obsessive-compulsive disorder  children and adolescents  latent class growth analysis  longitudinal study  outcome predictors  stepped-care treatment  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: First-line treatments for pediatric obsessive-compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. METHOD: The study included 269 OCD patients aged 7-17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. TRIAL REGISTRY: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. RESULTS: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination/cleaning and anxiety symptoms. CONCLUSIONS: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning and anxiety symptoms who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Parental socioeconomic position and risk of autism spectrum disorders in offspring: A cohort study of 9,648 individuals in Denmark 1976-2013 / Emilie Rune HEGELUND in Research in Autism Spectrum Disorders, 56 (December 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 56 (December 2018) . - p.1-8 Titre : Parental socioeconomic position and risk of autism spectrum disorders in offspring: A cohort study of 9,648 individuals in Denmark 1976-2013 Type de document : Texte imprimé et/ou numérique Auteurs : Emilie Rune HEGELUND, Auteur ; Trine FLENSBORG-MADSEN, Auteur ; Ditte VASSARD, Auteur ; Leonard A. ROSENBLUM, Auteur ; June Machover REINISCH, Auteur ; Erik Lykke MORTENSEN, Auteur Article en page(s) : p.1-8 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Socioeconomic factors  Cohort studies  Denmark Index. décimale : PER Périodiques Résumé : Background The results of studies of the association between parental socioeconomic position (SEP) and risk of autism spectrum disorder (ASD) in offspring are inconsistent, perhaps due to contextual differences in health care systems and their influence on risk of ASD diagnosis among different socioeconomic groups. The present study investigated the association between parental SEP in adulthood and risk of ASD diagnosis in offspring in a Nordic welfare state and whether this association was modified by parental childhood SEP. Method The study population comprised 9648 live-born singletons who were followed in the Psychiatric Central Register from birth in 1976–1996 until 2013. Cox regression was used to estimate hazard ratios for ASD diagnosis according to parental SEP in adulthood. Results The crude results showed a tendency towards higher parental SEP in adulthood being associated with higher risk of ASD diagnosis in offspring. However, the association was reversed after adjustment for possible confounders. The reversion of the direction of the association was entirely attributable to the strong confounding effect of calendar year. Further, the results showed that parental childhood SEP modified the association between parental SEP in adulthood and risk of ASD diagnosis in offspring. Conclusions Both methodological and contextual issues may be of great importance for the observed association between parental SEP and risk of ASD diagnosis in offspring. Particularly, the secular trends in ASD diagnoses seem to be of great importance suggesting that changes in diagnostic patterns may influence the association between parental SEP and risk of being diagnosed with ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Parental socioeconomic position and risk of autism spectrum disorders in offspring: A cohort study of 9,648 individuals in Denmark 1976-2013 [Texte imprimé et/ou numérique] / Emilie Rune HEGELUND, Auteur ; Trine FLENSBORG-MADSEN, Auteur ; Ditte VASSARD, Auteur ; Leonard A. ROSENBLUM, Auteur ; June Machover REINISCH, Auteur ; Erik Lykke MORTENSEN, Auteur . - p.1-8. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 56 (December 2018) . - p.1-8 Mots-clés : Autism spectrum disorder  Socioeconomic factors  Cohort studies  Denmark Index. décimale : PER Périodiques Résumé : Background The results of studies of the association between parental socioeconomic position (SEP) and risk of autism spectrum disorder (ASD) in offspring are inconsistent, perhaps due to contextual differences in health care systems and their influence on risk of ASD diagnosis among different socioeconomic groups. The present study investigated the association between parental SEP in adulthood and risk of ASD diagnosis in offspring in a Nordic welfare state and whether this association was modified by parental childhood SEP. Method The study population comprised 9648 live-born singletons who were followed in the Psychiatric Central Register from birth in 1976–1996 until 2013. Cox regression was used to estimate hazard ratios for ASD diagnosis according to parental SEP in adulthood. Results The crude results showed a tendency towards higher parental SEP in adulthood being associated with higher risk of ASD diagnosis in offspring. However, the association was reversed after adjustment for possible confounders. The reversion of the direction of the association was entirely attributable to the strong confounding effect of calendar year. Further, the results showed that parental childhood SEP modified the association between parental SEP in adulthood and risk of ASD diagnosis in offspring. Conclusions Both methodological and contextual issues may be of great importance for the observed association between parental SEP and risk of ASD diagnosis in offspring. Particularly, the secular trends in ASD diagnoses seem to be of great importance suggesting that changes in diagnostic patterns may influence the association between parental SEP and risk of being diagnosed with ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Performance of Children and Adolescents with Asperger Syndrome or High-functioning Autism on Advanced Theory of Mind Tasks / Nils KALAND in Journal of Autism and Developmental Disorders, 38-6 (July 2008)  

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Response Times of Children and Adolescents with Asperger Syndrome on an ‘Advanced’ Test of Theory of Mind / Nils KALAND in Journal of Autism and Developmental Disorders, 37-2 (February 2007)  

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Social communication impairments in children and adolescents with Asperger syndrome: Slow response time and the impact of prompting / Nils KALAND in Research in Autism Spectrum Disorders, 5-3 (July-September 2011)  

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