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Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment / Sanne JENSEN in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)
[article]
Titre : Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment Type de document : Texte imprimé et/ou numérique Auteurs : Sanne JENSEN, Auteur ; Davíð R. M. A. HØJGAARD, Auteur ; Katja A HYBEL, Auteur ; Erik Lykke MORTENSEN, Auteur ; Gudmundur SKARPHEDINSSON, Auteur ; Karin MELIN, Auteur ; Tord IVARSSON, Auteur ; Judith Becker NISSEN, Auteur ; Bernhard WEIDLE, Auteur ; Robert VALDERHAUG, Auteur ; Nor Christian TORP, Auteur ; Kitty DAHL, Auteur ; Scott COMPTON, Auteur ; Per Hove THOMSEN, Auteur Article en page(s) : p.969-978 Langues : Anglais (eng) Mots-clés : Obsessive-compulsive disorder children and adolescents latent class growth analysis longitudinal study outcome predictors stepped-care treatment trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: First-line treatments for pediatric obsessive-compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. METHOD: The study included 269 OCD patients aged 7-17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. TRIAL REGISTRY: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. RESULTS: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination/cleaning and anxiety symptoms. CONCLUSIONS: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning and anxiety symptoms who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430
in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.969-978[article] Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment [Texte imprimé et/ou numérique] / Sanne JENSEN, Auteur ; Davíð R. M. A. HØJGAARD, Auteur ; Katja A HYBEL, Auteur ; Erik Lykke MORTENSEN, Auteur ; Gudmundur SKARPHEDINSSON, Auteur ; Karin MELIN, Auteur ; Tord IVARSSON, Auteur ; Judith Becker NISSEN, Auteur ; Bernhard WEIDLE, Auteur ; Robert VALDERHAUG, Auteur ; Nor Christian TORP, Auteur ; Kitty DAHL, Auteur ; Scott COMPTON, Auteur ; Per Hove THOMSEN, Auteur . - p.969-978.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.969-978
Mots-clés : Obsessive-compulsive disorder children and adolescents latent class growth analysis longitudinal study outcome predictors stepped-care treatment trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: First-line treatments for pediatric obsessive-compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. METHOD: The study included 269 OCD patients aged 7-17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. TRIAL REGISTRY: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. RESULTS: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination/cleaning and anxiety symptoms. CONCLUSIONS: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning and anxiety symptoms who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 Trajectories of depression and anxiety symptoms over time in the transition to university: Their co-occurrence and the role of self-critical perfectionism / Shelby L. LEVINE in Development and Psychopathology, 35-1 (February 2023)
[article]
Titre : Trajectories of depression and anxiety symptoms over time in the transition to university: Their co-occurrence and the role of self-critical perfectionism Type de document : Texte imprimé et/ou numérique Auteurs : Shelby L. LEVINE, Auteur ; Nassim TABRI, Auteur ; Marina MILYAVSKAYA, Auteur Article en page(s) : p.345-356 Langues : Anglais (eng) Mots-clés : anxiety depression latent class growth analysis perfectionism university Index. décimale : PER Périodiques Résumé : Little is known about how mental health symptoms develop during the transition to university. Most anxiety and depression research fails to consider how symptom development differs over time across different individuals, and how symptom co-occurrence influences the severity of mental health problems. Students (N = 658) completed online surveys on mental health prior to starting university and every 2 months until April. To better understand mental health problems during this transitional period, latent class growth curve analyses were run to determine how anxiety and depressive symptoms co-develop over time, as well, if self-critical perfectionism was a transdiagnostic risk factor for more severe symptom trajectories in this transition. About 40% of students experienced depression and anxiety symptoms prior to entering/during the transition to university. There is substantial variation between students in terms of how they experience depression and anxiety symptoms, and research needs to take this heterogeneity into account to properly identify which students might benefit most from resources. Self-critical perfectionism was a transdiagnostic risk factor, such that students higher in this trait experienced more severe anxiety and depressive symptom trajectories during this transition. This research further implicates the importance of understanding and studying individual differences in symptom development. En ligne : https://doi.org/10.1017/S0954579421000626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499
in Development and Psychopathology > 35-1 (February 2023) . - p.345-356[article] Trajectories of depression and anxiety symptoms over time in the transition to university: Their co-occurrence and the role of self-critical perfectionism [Texte imprimé et/ou numérique] / Shelby L. LEVINE, Auteur ; Nassim TABRI, Auteur ; Marina MILYAVSKAYA, Auteur . - p.345-356.
Langues : Anglais (eng)
in Development and Psychopathology > 35-1 (February 2023) . - p.345-356
Mots-clés : anxiety depression latent class growth analysis perfectionism university Index. décimale : PER Périodiques Résumé : Little is known about how mental health symptoms develop during the transition to university. Most anxiety and depression research fails to consider how symptom development differs over time across different individuals, and how symptom co-occurrence influences the severity of mental health problems. Students (N = 658) completed online surveys on mental health prior to starting university and every 2 months until April. To better understand mental health problems during this transitional period, latent class growth curve analyses were run to determine how anxiety and depressive symptoms co-develop over time, as well, if self-critical perfectionism was a transdiagnostic risk factor for more severe symptom trajectories in this transition. About 40% of students experienced depression and anxiety symptoms prior to entering/during the transition to university. There is substantial variation between students in terms of how they experience depression and anxiety symptoms, and research needs to take this heterogeneity into account to properly identify which students might benefit most from resources. Self-critical perfectionism was a transdiagnostic risk factor, such that students higher in this trait experienced more severe anxiety and depressive symptom trajectories during this transition. This research further implicates the importance of understanding and studying individual differences in symptom development. En ligne : https://doi.org/10.1017/S0954579421000626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 A long-term look at ?early starters?: Predicting adult psychosocial outcomes from childhood conduct problem trajectories / Maeve CYR in Development and Psychopathology, 34-1 (February 2022)
[article]
Titre : A long-term look at ?early starters?: Predicting adult psychosocial outcomes from childhood conduct problem trajectories Type de document : Texte imprimé et/ou numérique Auteurs : Maeve CYR, Auteur ; Yao ZHENG, Auteur ; Robert J. MCMAHON, Auteur Article en page(s) : p.225-240 Langues : Anglais (eng) Mots-clés : adult outcomes conduct problems early starters latent class growth analysis trajectories Index. décimale : PER Périodiques Résumé : Current evidence suggests that multiple pathways of ?early-starting? conduct problems exist, including persisting and declining trajectories. Since relatively little is known about the early onset-declining pathway, this study examined the long-term outcomes of different childhood conduct problem trajectories in a disproportionately high-risk sample (N = 754). Parents reported on children's conduct problems at six time points (kindergarten to grade 7). At age 25, psychosocial outcomes were assessed across five domains (psychopathology, substance use, risky sexual behavior, antisocial behavior, and adaptive outcomes). Four childhood conduct problem trajectories were identified: extremely high increasing (EHI; 3.7%), high stable (HS; 22.0%), moderate decreasing (MD; 38.8%), and low decreasing (LD; 35.5%). The EHI and HS groups displayed the poorest psychosocial functioning at age 25, whereas the LD group exhibited the most positive adjustment. Although individuals in the MD group displayed relatively positive adjustment on some outcomes, they displayed more psychopathology and lower well-being in adulthood than the LD group. These findings suggest that there are diverse pathways of early-starting conduct problems, and that all early starters are at risk for later maladjustment. However, the degree and type of risk is related to the severity of conduct problems throughout childhood. En ligne : http://dx.doi.org/10.1017/s0954579420000760 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474
in Development and Psychopathology > 34-1 (February 2022) . - p.225-240[article] A long-term look at ?early starters?: Predicting adult psychosocial outcomes from childhood conduct problem trajectories [Texte imprimé et/ou numérique] / Maeve CYR, Auteur ; Yao ZHENG, Auteur ; Robert J. MCMAHON, Auteur . - p.225-240.
Langues : Anglais (eng)
in Development and Psychopathology > 34-1 (February 2022) . - p.225-240
Mots-clés : adult outcomes conduct problems early starters latent class growth analysis trajectories Index. décimale : PER Périodiques Résumé : Current evidence suggests that multiple pathways of ?early-starting? conduct problems exist, including persisting and declining trajectories. Since relatively little is known about the early onset-declining pathway, this study examined the long-term outcomes of different childhood conduct problem trajectories in a disproportionately high-risk sample (N = 754). Parents reported on children's conduct problems at six time points (kindergarten to grade 7). At age 25, psychosocial outcomes were assessed across five domains (psychopathology, substance use, risky sexual behavior, antisocial behavior, and adaptive outcomes). Four childhood conduct problem trajectories were identified: extremely high increasing (EHI; 3.7%), high stable (HS; 22.0%), moderate decreasing (MD; 38.8%), and low decreasing (LD; 35.5%). The EHI and HS groups displayed the poorest psychosocial functioning at age 25, whereas the LD group exhibited the most positive adjustment. Although individuals in the MD group displayed relatively positive adjustment on some outcomes, they displayed more psychopathology and lower well-being in adulthood than the LD group. These findings suggest that there are diverse pathways of early-starting conduct problems, and that all early starters are at risk for later maladjustment. However, the degree and type of risk is related to the severity of conduct problems throughout childhood. En ligne : http://dx.doi.org/10.1017/s0954579420000760 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474