6 recherche sur le mot-clé 'N400'

Implicit Semantic Processing of Linguistic and Non-linguistic Stimuli in Adults with Autism Spectrum Disorder / E. O'ROURKE in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2611-2630 Titre : Implicit Semantic Processing of Linguistic and Non-linguistic Stimuli in Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. O'ROURKE, Auteur ; E. L. CODERRE, Auteur Article en page(s) : p.2611-2630 Langues : Anglais (eng) Mots-clés : Acoustic Stimulation/psychology  Adolescent  Adult  Autism Spectrum Disorder/physiopathology/psychology  Autistic Disorder  Electroencephalography  Evoked Potentials/physiology  Humans  Language  Male  Semantics  Autism  Event-related potentials  N400  Semantic integration Index. décimale : PER Périodiques Résumé : While many individuals with autism spectrum disorder (ASD) experience difficulties with language processing, non-linguistic semantic processing may be intact. We examined neural responses to an implicit semantic priming task by comparing N400 responses-an event-related potential related to semantic processing-in response to semantically related or unrelated pairs of words or pictures. Adults with ASD showed larger N400 responses than typically developing adults for pictures, but no group differences occurred for words. However, we also observed complex modulations of N400 amplitude by age and by level of autistic traits. These results offer important implications for how groups are delineated and compared in autism research. En ligne : http://dx.doi.org/10.1007/s10803-020-04736-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Implicit Semantic Processing of Linguistic and Non-linguistic Stimuli in Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / E. O'ROURKE, Auteur ; E. L. CODERRE, Auteur . - p.2611-2630. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2611-2630 Mots-clés : Acoustic Stimulation/psychology  Adolescent  Adult  Autism Spectrum Disorder/physiopathology/psychology  Autistic Disorder  Electroencephalography  Evoked Potentials/physiology  Humans  Language  Male  Semantics  Autism  Event-related potentials  N400  Semantic integration Index. décimale : PER Périodiques Résumé : While many individuals with autism spectrum disorder (ASD) experience difficulties with language processing, non-linguistic semantic processing may be intact. We examined neural responses to an implicit semantic priming task by comparing N400 responses-an event-related potential related to semantic processing-in response to semantically related or unrelated pairs of words or pictures. Adults with ASD showed larger N400 responses than typically developing adults for pictures, but no group differences occurred for words. However, we also observed complex modulations of N400 amplitude by age and by level of autistic traits. These results offer important implications for how groups are delineated and compared in autism research. En ligne : http://dx.doi.org/10.1007/s10803-020-04736-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Neural patterns elicited by sentence processing uniquely characterize typical development, SLI recovery, and SLI persistence / Eileen HAEBIG in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.22 Titre : Neural patterns elicited by sentence processing uniquely characterize typical development, SLI recovery, and SLI persistence Type de document : Texte imprimé et/ou numérique Auteurs : Eileen HAEBIG, Auteur ; C. WEBER, Auteur ; L. B. LEONARD, Auteur ; P. DEEVY, Auteur ; J. B. TOMBLIN, Auteur Article en page(s) : p.22 Langues : Anglais (eng) Mots-clés : Event-related brain potentials  Language trajectories  N400  P600  Sentence processing  Specific language impairment Index. décimale : PER Périodiques Résumé : BACKGROUND: A substantial amount of work has examined language abilities in young children with specific language impairment (SLI); however, our understanding of the developmental trajectory of language impairment is limited. Along with studying the behavioral changes that occur across development, it is important to examine the neural indices of language processing for children with different language trajectories. The current study sought to examine behavioral and neural bases of language processing in adolescents showing three different trajectories: those with normal language development (NL), those exhibiting persistent SLI (SLI-Persistent), and those with a history of SLI who appear to have recovered (SLI-Recovered). METHODS: Through a sentence judgment task, we examined semantic and syntactic processing. Adolescents judged whether or not each sentence was semantically and syntactically correct. Stimuli consisted of naturally spoken sentences that were either correct, contained a semantic verb error, or contained a syntactic verb agreement error. Verb agreement errors consisted of omission and commission violations of the third-person singular -s. Behavioral button-press responses and electroencephalographic recordings were collected. Behavioral judgments and mean amplitude of the N400 and P600 components were examined. RESULTS: Adolescents in the SLI-Persistent group had lower sentence judgment accuracy overall, relative to the NL and SLI-Recovered groups. Accuracy in judging omission and commission syntactic errors were marginally different, with marginally lower accuracy for commission errors. All groups demonstrated an N400 component elicited by semantic violations. However, adolescents in the SLI-Persistent group demonstrated a less robust P600 component for syntactic violations. Furthermore, adolescents in the SLI-Recovered group exhibited a similar neural profile to the NL group for the semantic and syntactic omission violations. However, a unique profile with initial negativity was observed in the SLI-Recovered group in the commission violation condition. CONCLUSIONS: Adolescents with persistent language impairment continue to demonstrate delays in language processing at the behavioral and neural levels. Conversely, the adolescents in the SLI-Recovered group appear to have made gains in language processing skills to overcome their initial impairments. However, our findings suggest that the adolescents in the SLI-Recovered group may have compensatory processing strategies for some aspects of language, as evidenced by a unique event-related potential profile. En ligne : http://dx.doi.org/10.1186/s11689-017-9201-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 [article] Neural patterns elicited by sentence processing uniquely characterize typical development, SLI recovery, and SLI persistence [Texte imprimé et/ou numérique] / Eileen HAEBIG, Auteur ; C. WEBER, Auteur ; L. B. LEONARD, Auteur ; P. DEEVY, Auteur ; J. B. TOMBLIN, Auteur . - p.22. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.22 Mots-clés : Event-related brain potentials  Language trajectories  N400  P600  Sentence processing  Specific language impairment Index. décimale : PER Périodiques Résumé : BACKGROUND: A substantial amount of work has examined language abilities in young children with specific language impairment (SLI); however, our understanding of the developmental trajectory of language impairment is limited. Along with studying the behavioral changes that occur across development, it is important to examine the neural indices of language processing for children with different language trajectories. The current study sought to examine behavioral and neural bases of language processing in adolescents showing three different trajectories: those with normal language development (NL), those exhibiting persistent SLI (SLI-Persistent), and those with a history of SLI who appear to have recovered (SLI-Recovered). METHODS: Through a sentence judgment task, we examined semantic and syntactic processing. Adolescents judged whether or not each sentence was semantically and syntactically correct. Stimuli consisted of naturally spoken sentences that were either correct, contained a semantic verb error, or contained a syntactic verb agreement error. Verb agreement errors consisted of omission and commission violations of the third-person singular -s. Behavioral button-press responses and electroencephalographic recordings were collected. Behavioral judgments and mean amplitude of the N400 and P600 components were examined. RESULTS: Adolescents in the SLI-Persistent group had lower sentence judgment accuracy overall, relative to the NL and SLI-Recovered groups. Accuracy in judging omission and commission syntactic errors were marginally different, with marginally lower accuracy for commission errors. All groups demonstrated an N400 component elicited by semantic violations. However, adolescents in the SLI-Persistent group demonstrated a less robust P600 component for syntactic violations. Furthermore, adolescents in the SLI-Recovered group exhibited a similar neural profile to the NL group for the semantic and syntactic omission violations. However, a unique profile with initial negativity was observed in the SLI-Recovered group in the commission violation condition. CONCLUSIONS: Adolescents with persistent language impairment continue to demonstrate delays in language processing at the behavioral and neural levels. Conversely, the adolescents in the SLI-Recovered group appear to have made gains in language processing skills to overcome their initial impairments. However, our findings suggest that the adolescents in the SLI-Recovered group may have compensatory processing strategies for some aspects of language, as evidenced by a unique event-related potential profile. En ligne : http://dx.doi.org/10.1186/s11689-017-9201-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350

Neural systems mediating processing of sound units of language distinguish recovery versus persistence in stuttering / R. MOHAN in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.28 Titre : Neural systems mediating processing of sound units of language distinguish recovery versus persistence in stuttering Type de document : Texte imprimé et/ou numérique Auteurs : R. MOHAN, Auteur ; C. WEBER, Auteur Article en page(s) : p.28 Langues : Anglais (eng) Mots-clés : Lateralization  N400  Phonological processing  Rhyme effect  Stuttering persistence Index. décimale : PER Périodiques Résumé : BACKGROUND: Developmental stuttering is a multi-factorial disorder. Measures of neural activity while children processed the phonological (language sound unit) properties of words have revealed neurodevelopmental differences between fluent children and those who stutter. However, there is limited evidence to show whether the neural bases of phonological processing can be used to identify stuttering recovery status. As an initial step, we aimed to determine if differences in neural activity during phonological processing could aid in distinguishing children who had recovered from stuttering and those whose stuttering persisted. METHODS: We examined neural activity mediating phonological processing in forty-three 7-8 year old children. Groups included children who had recovered from stuttering (CWS-Rec), those whose stuttering persisted (CWS-Per), and children who did not stutter (CWNS). All children demonstrated normal non-verbal intelligence and language skills. Electroencephalograms were recorded as the children listened to pairs of pseudo-words (primes-targets) that either rhymed or did not. Behavioral rhyme judgments along with peak latency and mean amplitude of the N400s elicited by prime and target stimuli were examined. RESULTS: All the groups were very accurate in their rhyme judgments and displayed a typical ERP rhyme effect, characterized by increased N400 amplitudes over central parietal sites for nonrhyming targets compared to rhyming targets. However, over anterior electrode sites, an earlier onset of the N400 for rhyming compared to non-rhyming targets, indexing phonological segmentation and rehearsal, was observed in the CWNS and CWS-Rec groups. This effect occurred bilaterally for the CWNS, was greater over the right hemisphere in the CWS-Rec, and was absent in the CWS-Per. CONCLUSIONS: These results are the first to show that differences in ERPs reflecting phonological processing are marked by atypical lateralization in childhood even after stuttering recovery and more pronounced atypical neural patterns for the children whose stuttering persisted. Despite comparable language and phonological skills as revealed by standardized tests, the neural activity mediating phonological segmentation and rehearsal differentiated 7-8 year old children whose stuttering persisted from those who had recovered from stuttering and typically developing peers. En ligne : http://dx.doi.org/10.1186/s11689-015-9124-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348 [article] Neural systems mediating processing of sound units of language distinguish recovery versus persistence in stuttering [Texte imprimé et/ou numérique] / R. MOHAN, Auteur ; C. WEBER, Auteur . - p.28. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.28 Mots-clés : Lateralization  N400  Phonological processing  Rhyme effect  Stuttering persistence Index. décimale : PER Périodiques Résumé : BACKGROUND: Developmental stuttering is a multi-factorial disorder. Measures of neural activity while children processed the phonological (language sound unit) properties of words have revealed neurodevelopmental differences between fluent children and those who stutter. However, there is limited evidence to show whether the neural bases of phonological processing can be used to identify stuttering recovery status. As an initial step, we aimed to determine if differences in neural activity during phonological processing could aid in distinguishing children who had recovered from stuttering and those whose stuttering persisted. METHODS: We examined neural activity mediating phonological processing in forty-three 7-8 year old children. Groups included children who had recovered from stuttering (CWS-Rec), those whose stuttering persisted (CWS-Per), and children who did not stutter (CWNS). All children demonstrated normal non-verbal intelligence and language skills. Electroencephalograms were recorded as the children listened to pairs of pseudo-words (primes-targets) that either rhymed or did not. Behavioral rhyme judgments along with peak latency and mean amplitude of the N400s elicited by prime and target stimuli were examined. RESULTS: All the groups were very accurate in their rhyme judgments and displayed a typical ERP rhyme effect, characterized by increased N400 amplitudes over central parietal sites for nonrhyming targets compared to rhyming targets. However, over anterior electrode sites, an earlier onset of the N400 for rhyming compared to non-rhyming targets, indexing phonological segmentation and rehearsal, was observed in the CWNS and CWS-Rec groups. This effect occurred bilaterally for the CWNS, was greater over the right hemisphere in the CWS-Rec, and was absent in the CWS-Per. CONCLUSIONS: These results are the first to show that differences in ERPs reflecting phonological processing are marked by atypical lateralization in childhood even after stuttering recovery and more pronounced atypical neural patterns for the children whose stuttering persisted. Despite comparable language and phonological skills as revealed by standardized tests, the neural activity mediating phonological segmentation and rehearsal differentiated 7-8 year old children whose stuttering persisted from those who had recovered from stuttering and typically developing peers. En ligne : http://dx.doi.org/10.1186/s11689-015-9124-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348

Neurodevelopment for syntactic processing distinguishes childhood stuttering recovery versus persistence / E. USLER in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.4 Titre : Neurodevelopment for syntactic processing distinguishes childhood stuttering recovery versus persistence Type de document : Texte imprimé et/ou numérique Auteurs : E. USLER, Auteur ; C. WEBER-FOX, Auteur Article en page(s) : p.4 Langues : Anglais (eng) Mots-clés : Children  Event-related potentials  Language development  Language processing  N400  P600  Stuttering Index. décimale : PER Périodiques Résumé : BACKGROUND: Characterized by the presence of involuntary speech disfluencies, developmental stuttering is a neurodevelopmental disorder of atypical speech-motor coordination. Although the etiology of stuttering is multifactorial, language development during early childhood may influence both the onset of the disorder and the likelihood of recovery. The purpose of this study was to determine whether differences in neural indices mediating language processing are associated with persistence or recovery in school-age children who stutter. METHODS: Event-related brain potentials (ERPs) were obtained from 31 6-7-year-olds, including nine children who do not stutter (CWNS), 11 children who had recovered from stuttering (CWS-Rec), and 11 children who persisted in stuttering (CWS-Per), matched for age, and all with similar socioeconomic status, nonverbal intelligence, and language ability. We examined ERPs elicited by semantic and syntactic (phrase structure) violations within an auditory narrative consisting of English and Jabberwocky sentences. In Jabberwocky sentences, content words were replaced with pseudowords to limit semantic context. A mixed effects repeated measures analysis of variance (ANOVA) was computed for ERP components with four within-subject factors, including condition, hemisphere, anterior/posterior distribution, and laterality. RESULTS: During the comprehension of English sentences, ERP activity mediating semantic and syntactic (phrase structure) processing did not distinguish CWS-Per, CWS-Rec, and CWNS. Semantic violations elicited a qualitatively similar N400 component across groups. Phrase structure violations within English sentences also elicited a similar P600 component in all groups. However, identical phrase structure violations within Jabberwocky sentences elicited a P600 in CWNS and CWS-Rec, but an N400-like effect in CWS-Per. CONCLUSIONS: The distinguishing neural patterns mediating syntactic, but not semantic, processing provide evidence that specific brain functions for some aspects of language processing may be associated with stuttering persistence. Unlike CWS-Rec and CWNS, the lack of semantic context in Jabberwocky sentences seemed to affect the syntactic processing strategies of CWS-Per, resulting in the elicitation of semantically based N400-like activity during syntactic (phrase structure) violations. This vulnerability suggests neural mechanisms associated with the processing of syntactic structure may be less mature in 6-7-year-old children whose stuttering persisted compared to their fluent or recovered peers. En ligne : http://dx.doi.org/10.1186/1866-1955-7-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] Neurodevelopment for syntactic processing distinguishes childhood stuttering recovery versus persistence [Texte imprimé et/ou numérique] / E. USLER, Auteur ; C. WEBER-FOX, Auteur . - p.4. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.4 Mots-clés : Children  Event-related potentials  Language development  Language processing  N400  P600  Stuttering Index. décimale : PER Périodiques Résumé : BACKGROUND: Characterized by the presence of involuntary speech disfluencies, developmental stuttering is a neurodevelopmental disorder of atypical speech-motor coordination. Although the etiology of stuttering is multifactorial, language development during early childhood may influence both the onset of the disorder and the likelihood of recovery. The purpose of this study was to determine whether differences in neural indices mediating language processing are associated with persistence or recovery in school-age children who stutter. METHODS: Event-related brain potentials (ERPs) were obtained from 31 6-7-year-olds, including nine children who do not stutter (CWNS), 11 children who had recovered from stuttering (CWS-Rec), and 11 children who persisted in stuttering (CWS-Per), matched for age, and all with similar socioeconomic status, nonverbal intelligence, and language ability. We examined ERPs elicited by semantic and syntactic (phrase structure) violations within an auditory narrative consisting of English and Jabberwocky sentences. In Jabberwocky sentences, content words were replaced with pseudowords to limit semantic context. A mixed effects repeated measures analysis of variance (ANOVA) was computed for ERP components with four within-subject factors, including condition, hemisphere, anterior/posterior distribution, and laterality. RESULTS: During the comprehension of English sentences, ERP activity mediating semantic and syntactic (phrase structure) processing did not distinguish CWS-Per, CWS-Rec, and CWNS. Semantic violations elicited a qualitatively similar N400 component across groups. Phrase structure violations within English sentences also elicited a similar P600 component in all groups. However, identical phrase structure violations within Jabberwocky sentences elicited a P600 in CWNS and CWS-Rec, but an N400-like effect in CWS-Per. CONCLUSIONS: The distinguishing neural patterns mediating syntactic, but not semantic, processing provide evidence that specific brain functions for some aspects of language processing may be associated with stuttering persistence. Unlike CWS-Rec and CWNS, the lack of semantic context in Jabberwocky sentences seemed to affect the syntactic processing strategies of CWS-Per, resulting in the elicitation of semantically based N400-like activity during syntactic (phrase structure) violations. This vulnerability suggests neural mechanisms associated with the processing of syntactic structure may be less mature in 6-7-year-old children whose stuttering persisted compared to their fluent or recovered peers. En ligne : http://dx.doi.org/10.1186/1866-1955-7-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

Visual and Verbal Narrative Comprehension in Children and Adolescents with Autism Spectrum Disorders: An ERP Study / Mirella MANFREDI in Journal of Autism and Developmental Disorders, 50-8 (August 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2658-2672 Titre : Visual and Verbal Narrative Comprehension in Children and Adolescents with Autism Spectrum Disorders: An ERP Study Type de document : Texte imprimé et/ou numérique Auteurs : Mirella MANFREDI, Auteur ; Neil COHN, Auteur ; Pamella SANCHEZ MELLO, Auteur ; Elizabeth FERNANDEZ, Auteur ; Paulo Sérgio BOGGIO, Auteur Article en page(s) : p.2658-2672 Langues : Anglais (eng) Mots-clés : Autism  Lp  N400  Semantic processing  Visual narrative Index. décimale : PER Périodiques Résumé : We examined semantic processing in ASD children by presenting sentences with congruent or incongruent final words and visual narratives with congruent or incongruent final panels. An N400 effect to incongruent words appeared as compared to congruent ones, which was attenuated for the ASD children. We observed a negativity sustained to incongruous than congruous words, but only for the TD children. Incongruent panels evoked a greater fronto-central N400 amplitude than congruent panels in both groups. In addition, incongruent panels evoked a centro-parietal late positivity, only in controls. In conclusion, ASD children face processing deficits in both verbal and visual materials when integrating meaning across information, though such impairments may arise in different parts of the interpretive process, depending on the modality. En ligne : http://dx.doi.org/10.1007/s10803-020-04374-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428 [article] Visual and Verbal Narrative Comprehension in Children and Adolescents with Autism Spectrum Disorders: An ERP Study [Texte imprimé et/ou numérique] / Mirella MANFREDI, Auteur ; Neil COHN, Auteur ; Pamella SANCHEZ MELLO, Auteur ; Elizabeth FERNANDEZ, Auteur ; Paulo Sérgio BOGGIO, Auteur . - p.2658-2672. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2658-2672 Mots-clés : Autism  Lp  N400  Semantic processing  Visual narrative Index. décimale : PER Périodiques Résumé : We examined semantic processing in ASD children by presenting sentences with congruent or incongruent final words and visual narratives with congruent or incongruent final panels. An N400 effect to incongruent words appeared as compared to congruent ones, which was attenuated for the ASD children. We observed a negativity sustained to incongruous than congruous words, but only for the TD children. Incongruent panels evoked a greater fronto-central N400 amplitude than congruent panels in both groups. In addition, incongruent panels evoked a centro-parietal late positivity, only in controls. In conclusion, ASD children face processing deficits in both verbal and visual materials when integrating meaning across information, though such impairments may arise in different parts of the interpretive process, depending on the modality. En ligne : http://dx.doi.org/10.1007/s10803-020-04374-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428

Autistic Adults are Not Impaired at Maintaining or Switching Between Counterfactual and Factual Worlds: An ERP Study / H. J. FERGUSON in Journal of Autism and Developmental Disorders, 52-1 (January 2022)  

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