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Faire une suggestionThe Neurobiology of Semantic Processing in Autism Spectrum Disorder: An Activation Likelihood Estimation Analysis / Lee PHAN in Journal of Autism and Developmental Disorders, 51-9 (September 2021)
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Titre : The Neurobiology of Semantic Processing in Autism Spectrum Disorder: An Activation Likelihood Estimation Analysis Type de document : texte imprimé Auteurs : Lee PHAN, Auteur ; Alina TARIQ, Auteur ; Garbo LAM, Auteur ; Elizabeth W. PANG, Auteur ; Claude ALAIN, Auteur Article en page(s) : p.3266-3279 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Brain/diagnostic imaging Brain Mapping Humans Likelihood Functions Magnetic Resonance Imaging Semantics Activation likelihood estimation Autism spectrum disorder Functional magnetic resonance imaging (fMRI) Left inferior frontal gyrus Semantic processing Index. décimale : PER Périodiques Résumé : Semantic processing impairments are present in a proportion of individuals with autism spectrum disorder (ASD). Despite the numerous imaging studies investigating this language domain in ASD, there is a lack of consensus regarding the brain structures showing abnormal pattern of activity. This meta-analysis aimed to identify neural activation patterns present during semantic processing in ASD. Findings reveal activation of areas associated with semantic processing and executive functions in ASD. However, the activation was less concise in comparison to controls and there was less activation in the right hemisphere and in areas associated with executive functions. This provides strong support for impaired semantic processing in ASD that is consistently associated with abnormal patterns of neural activity in the semantic network. En ligne : http://dx.doi.org/10.1007/s10803-020-04794-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3266-3279[article] The Neurobiology of Semantic Processing in Autism Spectrum Disorder: An Activation Likelihood Estimation Analysis [texte imprimé] / Lee PHAN, Auteur ; Alina TARIQ, Auteur ; Garbo LAM, Auteur ; Elizabeth W. PANG, Auteur ; Claude ALAIN, Auteur . - p.3266-3279.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3266-3279
Mots-clés : Autism Spectrum Disorder Brain/diagnostic imaging Brain Mapping Humans Likelihood Functions Magnetic Resonance Imaging Semantics Activation likelihood estimation Autism spectrum disorder Functional magnetic resonance imaging (fMRI) Left inferior frontal gyrus Semantic processing Index. décimale : PER Périodiques Résumé : Semantic processing impairments are present in a proportion of individuals with autism spectrum disorder (ASD). Despite the numerous imaging studies investigating this language domain in ASD, there is a lack of consensus regarding the brain structures showing abnormal pattern of activity. This meta-analysis aimed to identify neural activation patterns present during semantic processing in ASD. Findings reveal activation of areas associated with semantic processing and executive functions in ASD. However, the activation was less concise in comparison to controls and there was less activation in the right hemisphere and in areas associated with executive functions. This provides strong support for impaired semantic processing in ASD that is consistently associated with abnormal patterns of neural activity in the semantic network. En ligne : http://dx.doi.org/10.1007/s10803-020-04794-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 Differences in age-dependent neural correlates of semantic processing between youths with autism spectrum disorder and typically developing youths / Pin-Jane CHEN in Autism Research, 9-12 (December 2016)
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Titre : Differences in age-dependent neural correlates of semantic processing between youths with autism spectrum disorder and typically developing youths Type de document : texte imprimé Auteurs : Pin-Jane CHEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Shu-Hui LEE, Auteur ; Tai-Li CHOU, Auteur Article en page(s) : p.1263-1273 Langues : Anglais (eng) Mots-clés : autism spectrum disorders (ASD) fMRI semantic processing age-dependent Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) have aberrant neural activity during semantic judgments. We aimed to examine age-dependent neural correlates of semantic processing in boys with ASD as compared to typically developing boys (TD). We used functional MRI to investigate 37 boys with ASD (mean age = 13.3 years, standard deviation = 2.4) and 35 age-, sex-, Intelligence quotient (IQ)- and handedness-matched TD boys (mean age = 13.3 years, standard deviation = 2.7) from age 8 to 18 years. Participants had to indicate whether pairs of Chinese characters presented visually were related in meaning. Group (ASD, TD) × Age (Old, Young) ANOVA was used to examine the difference of age-related changes. Direct comparisons between the adolescent group and the child group were also performed. The behavioral results showed that the ASD group had lower accuracy in the related condition relative to the TD group. The neuroimaging results showed greater activation in the cuneus and less activation in the left inferior frontal gyrus in boys with ASD than TD boys. Children with ASD produced greater activation in the cuneus than TD children. Adolescents with ASD showed reduced left IFG activation as compared to TD adolescents. Our findings suggest that TD boys may engage more in higher-level processing of retrieving or selecting semantic features while boys with ASD may rely more on lower-level visual processing during semantic judgments. The findings imply different functional organizations of the semantic system between the two groups. En ligne : http://dx.doi.org/10.1002/aur.1616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
in Autism Research > 9-12 (December 2016) . - p.1263-1273[article] Differences in age-dependent neural correlates of semantic processing between youths with autism spectrum disorder and typically developing youths [texte imprimé] / Pin-Jane CHEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Shu-Hui LEE, Auteur ; Tai-Li CHOU, Auteur . - p.1263-1273.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1263-1273
Mots-clés : autism spectrum disorders (ASD) fMRI semantic processing age-dependent Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) have aberrant neural activity during semantic judgments. We aimed to examine age-dependent neural correlates of semantic processing in boys with ASD as compared to typically developing boys (TD). We used functional MRI to investigate 37 boys with ASD (mean age = 13.3 years, standard deviation = 2.4) and 35 age-, sex-, Intelligence quotient (IQ)- and handedness-matched TD boys (mean age = 13.3 years, standard deviation = 2.7) from age 8 to 18 years. Participants had to indicate whether pairs of Chinese characters presented visually were related in meaning. Group (ASD, TD) × Age (Old, Young) ANOVA was used to examine the difference of age-related changes. Direct comparisons between the adolescent group and the child group were also performed. The behavioral results showed that the ASD group had lower accuracy in the related condition relative to the TD group. The neuroimaging results showed greater activation in the cuneus and less activation in the left inferior frontal gyrus in boys with ASD than TD boys. Children with ASD produced greater activation in the cuneus than TD children. Adolescents with ASD showed reduced left IFG activation as compared to TD adolescents. Our findings suggest that TD boys may engage more in higher-level processing of retrieving or selecting semantic features while boys with ASD may rely more on lower-level visual processing during semantic judgments. The findings imply different functional organizations of the semantic system between the two groups. En ligne : http://dx.doi.org/10.1002/aur.1616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Higher autism trait severity in children associates with diminished integration of angry prosody in semantic processing / Ming LUI ; Andrea HILDEBRANDT ; Werner SOMMER ; Changsong ZHOU in Research in Autism Spectrum Disorders, 111 (March 2024)
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Titre : Higher autism trait severity in children associates with diminished integration of angry prosody in semantic processing Type de document : texte imprimé Auteurs : Ming LUI, Auteur ; Andrea HILDEBRANDT, Auteur ; Werner SOMMER, Auteur ; Changsong ZHOU, Auteur Article en page(s) : p.102325 Mots-clés : Autism traits Emotional prosody Semantic processing Speech Communication Event-related potentials Index. décimale : PER Périodiques Résumé : Background Previous studies examined group differences of individuals with and without autism. This study investigated individual differences in automatic integration of emotional prosody during semantic processing at the behavioral and neural levels among children using a continuous measure of autism trait severity. Method Event-related potentials (ERPs) of 46 children, 21 of them diagnosed with ASD, were measured. Children determined the semantic valence of spoken words, and ignored the emotional prosody, which was either congruent or incongruent with the semantic valence. Results Independent of congruency, higher autism trait severity and Intelligence Quotient (IQ) were associated with faster reaction times (RTs), while higher IQ and language ability were associated with higher accuracy. The difference between congruent and incongruent conditions (congruency effect) indicates automatic integration of emotional prosody in semantic processing. In ERPs, higher autism trait severity and higher IQ were associated with smaller congruency effects on P2 amplitudes for angry (but not happy) prosodic stimuli. Conclusion The findings suggest a stronger tendency to ignore angry prosodies among children with higher autism trait severity. This has implications for educational practices and parent counseling regarding communication with children with high autism trait severity. En ligne : https://doi.org/10.1016/j.rasd.2023.102325 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521
in Research in Autism Spectrum Disorders > 111 (March 2024) . - p.102325[article] Higher autism trait severity in children associates with diminished integration of angry prosody in semantic processing [texte imprimé] / Ming LUI, Auteur ; Andrea HILDEBRANDT, Auteur ; Werner SOMMER, Auteur ; Changsong ZHOU, Auteur . - p.102325.
in Research in Autism Spectrum Disorders > 111 (March 2024) . - p.102325
Mots-clés : Autism traits Emotional prosody Semantic processing Speech Communication Event-related potentials Index. décimale : PER Périodiques Résumé : Background Previous studies examined group differences of individuals with and without autism. This study investigated individual differences in automatic integration of emotional prosody during semantic processing at the behavioral and neural levels among children using a continuous measure of autism trait severity. Method Event-related potentials (ERPs) of 46 children, 21 of them diagnosed with ASD, were measured. Children determined the semantic valence of spoken words, and ignored the emotional prosody, which was either congruent or incongruent with the semantic valence. Results Independent of congruency, higher autism trait severity and Intelligence Quotient (IQ) were associated with faster reaction times (RTs), while higher IQ and language ability were associated with higher accuracy. The difference between congruent and incongruent conditions (congruency effect) indicates automatic integration of emotional prosody in semantic processing. In ERPs, higher autism trait severity and higher IQ were associated with smaller congruency effects on P2 amplitudes for angry (but not happy) prosodic stimuli. Conclusion The findings suggest a stronger tendency to ignore angry prosodies among children with higher autism trait severity. This has implications for educational practices and parent counseling regarding communication with children with high autism trait severity. En ligne : https://doi.org/10.1016/j.rasd.2023.102325 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521 Linguistic and Non-Linguistic Semantic Processing in Individuals with Autism Spectrum Disorders: An ERP Study / Emily L. CODERRE in Journal of Autism and Developmental Disorders, 47-3 (March 2017)
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Titre : Linguistic and Non-Linguistic Semantic Processing in Individuals with Autism Spectrum Disorders: An ERP Study Type de document : texte imprimé Auteurs : Emily L. CODERRE, Auteur ; Mariya CHERNENOK, Auteur ; Barry GORDON, Auteur ; Kerry LEDOUX, Auteur Article en page(s) : p.795-812 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Semantic processing ERP Language Pictures Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) experience difficulties with language, particularly higher-level functions like semantic integration. Yet some studies indicate that semantic processing of non-linguistic stimuli is not impaired, suggesting a language-specific deficit in semantic processing. Using a semantic priming task, we compared event-related potentials (ERPs) in response to lexico-semantic processing (written words) and visuo-semantic processing (pictures) in adults with ASD and adults with typical development (TD). The ASD group showed successful lexico-semantic and visuo-semantic processing, indicated by similar N400 effects between groups for word and picture stimuli. However, differences in N400 latency and topography in word conditions suggested different lexico-semantic processing mechanisms: an expectancy-based strategy for the TD group but a controlled post-lexical integration strategy for the ASD group. En ligne : http://dx.doi.org/10.1007/s10803-016-2985-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304
in Journal of Autism and Developmental Disorders > 47-3 (March 2017) . - p.795-812[article] Linguistic and Non-Linguistic Semantic Processing in Individuals with Autism Spectrum Disorders: An ERP Study [texte imprimé] / Emily L. CODERRE, Auteur ; Mariya CHERNENOK, Auteur ; Barry GORDON, Auteur ; Kerry LEDOUX, Auteur . - p.795-812.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-3 (March 2017) . - p.795-812
Mots-clés : Autism spectrum disorders Semantic processing ERP Language Pictures Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) experience difficulties with language, particularly higher-level functions like semantic integration. Yet some studies indicate that semantic processing of non-linguistic stimuli is not impaired, suggesting a language-specific deficit in semantic processing. Using a semantic priming task, we compared event-related potentials (ERPs) in response to lexico-semantic processing (written words) and visuo-semantic processing (pictures) in adults with ASD and adults with typical development (TD). The ASD group showed successful lexico-semantic and visuo-semantic processing, indicated by similar N400 effects between groups for word and picture stimuli. However, differences in N400 latency and topography in word conditions suggested different lexico-semantic processing mechanisms: an expectancy-based strategy for the TD group but a controlled post-lexical integration strategy for the ASD group. En ligne : http://dx.doi.org/10.1007/s10803-016-2985-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 Neural patterns elicited by lexical processing in adolescents with specific language impairment: support for the procedural deficit hypothesis? / Julia L. EVANS in Journal of Neurodevelopmental Disorders, 14 (2022)
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Titre : Neural patterns elicited by lexical processing in adolescents with specific language impairment: support for the procedural deficit hypothesis? Type de document : texte imprimé Auteurs : Julia L. EVANS, Auteur ; Mandy J. MAGUIRE, Auteur ; Marisa L. SIZEMORE, Auteur Langues : Anglais (eng) Mots-clés : Adolescent Electroencephalography Evoked Potentials Female Humans Language Development Disorders Language Tests Male Specific Language Disorder Developmental language disorder (DLD) Event-related potentials Imageability N400 N700 Procedural deficit hypothesis Procedural memory Semantic processing Specific language impairment (SLI) Spoken word processing Index. décimale : PER Périodiques Résumé : BACKGROUND: Deficits in procedural memory have been proposed to account for the language deficits in specific language impairment (SLI). A key aspect of the procedural deficit hypothesis (PDH) account of SLI is that declarative memory is intact and functions as a compensatory mechanism in the acquisition of language in individuals with SLI. The current study examined the neural correlates of lexical-phonological and lexical-semantic processing with respect to these predictions in a group of adolescents with SLI with procedural memory impairment and a group of chronologically age-matched (CA) normal controls. METHODS: Participants completed tasks designed to measure procedural and declarative memory and two ERP tasks designed to assess lexical-semantic and lexical-phonological processing in the auditory modality. Procedural memory was assessed using a statistical learning task. Lexical-semantic processing was assessed using a sentence judgment task modulating semantic congruency and lexical-phonological processing was assessed using a word/nonword decision task modulating word frequency. Behavioral performance on the tasks, mean amplitude of the cortical response, and animated topographs were examined. RESULTS: Performance on the statistical word-learning task was at chance for the adolescents with SLI, whereas declarative memory was no different from the CA controls. Behavioral accuracy on the lexical-semantic task was the same for the adolescents with SLI and CA controls but accuracy on the lexical-phonological task was significantly poorer for the adolescents with SLI as compared to the CA controls. An N400 component was elicited in response to semantic congruency on the lexical-semantic task for both groups but differences were noted in both the location and time course of the cortical response for the SLI and CA groups. An N400 component was elicited by word frequency on the lexical-phonological task for the CA controls not for the adolescents with SLI. In contrast, post hoc analysis revealed a cortical response based on imageability for the adolescents with SLI, but not CA controls. Statistical word learning was significantly correlated with speed of processing on the lexical decision task for the CA controls but not for the adolescents with SLI. In contrast, statistical word learning ability was not correlated with the modulation of the N400 on either task for either group. CONCLUSION: The behavioral data suggests intact semantic conceptual knowledge, but impaired lexical phonological processing for the adolescents with SLI, consistent with the PDH. The pattern of cortical activation in response to semantic congruency and word frequency suggests, however, that the processing of lexical-semantic and lexical-phonological information by adolescents with a history of SLI may be supported by both overlapping and nonoverlapping neural generators to those of CA controls, and a greater reliance on declarative memory strategies. Taken together, the findings from this study suggest that the underlying representations of words in the lexicons of adolescents with a history of SLI may differ qualitatively from those of their typical peers, but these differences may only be evident when behavioral data and neural cortical patterns of activation are examined together. En ligne : https://dx.doi.org/10.1186/s11689-022-09419-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574
in Journal of Neurodevelopmental Disorders > 14 (2022)[article] Neural patterns elicited by lexical processing in adolescents with specific language impairment: support for the procedural deficit hypothesis? [texte imprimé] / Julia L. EVANS, Auteur ; Mandy J. MAGUIRE, Auteur ; Marisa L. SIZEMORE, Auteur.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 14 (2022)
Mots-clés : Adolescent Electroencephalography Evoked Potentials Female Humans Language Development Disorders Language Tests Male Specific Language Disorder Developmental language disorder (DLD) Event-related potentials Imageability N400 N700 Procedural deficit hypothesis Procedural memory Semantic processing Specific language impairment (SLI) Spoken word processing Index. décimale : PER Périodiques Résumé : BACKGROUND: Deficits in procedural memory have been proposed to account for the language deficits in specific language impairment (SLI). A key aspect of the procedural deficit hypothesis (PDH) account of SLI is that declarative memory is intact and functions as a compensatory mechanism in the acquisition of language in individuals with SLI. The current study examined the neural correlates of lexical-phonological and lexical-semantic processing with respect to these predictions in a group of adolescents with SLI with procedural memory impairment and a group of chronologically age-matched (CA) normal controls. METHODS: Participants completed tasks designed to measure procedural and declarative memory and two ERP tasks designed to assess lexical-semantic and lexical-phonological processing in the auditory modality. Procedural memory was assessed using a statistical learning task. Lexical-semantic processing was assessed using a sentence judgment task modulating semantic congruency and lexical-phonological processing was assessed using a word/nonword decision task modulating word frequency. Behavioral performance on the tasks, mean amplitude of the cortical response, and animated topographs were examined. RESULTS: Performance on the statistical word-learning task was at chance for the adolescents with SLI, whereas declarative memory was no different from the CA controls. Behavioral accuracy on the lexical-semantic task was the same for the adolescents with SLI and CA controls but accuracy on the lexical-phonological task was significantly poorer for the adolescents with SLI as compared to the CA controls. An N400 component was elicited in response to semantic congruency on the lexical-semantic task for both groups but differences were noted in both the location and time course of the cortical response for the SLI and CA groups. An N400 component was elicited by word frequency on the lexical-phonological task for the CA controls not for the adolescents with SLI. In contrast, post hoc analysis revealed a cortical response based on imageability for the adolescents with SLI, but not CA controls. Statistical word learning was significantly correlated with speed of processing on the lexical decision task for the CA controls but not for the adolescents with SLI. In contrast, statistical word learning ability was not correlated with the modulation of the N400 on either task for either group. CONCLUSION: The behavioral data suggests intact semantic conceptual knowledge, but impaired lexical phonological processing for the adolescents with SLI, consistent with the PDH. The pattern of cortical activation in response to semantic congruency and word frequency suggests, however, that the processing of lexical-semantic and lexical-phonological information by adolescents with a history of SLI may be supported by both overlapping and nonoverlapping neural generators to those of CA controls, and a greater reliance on declarative memory strategies. Taken together, the findings from this study suggest that the underlying representations of words in the lexicons of adolescents with a history of SLI may differ qualitatively from those of their typical peers, but these differences may only be evident when behavioral data and neural cortical patterns of activation are examined together. En ligne : https://dx.doi.org/10.1186/s11689-022-09419-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 In the Eye of the Beholder: Rapid Visual Perception of Real-Life Scenes by Young Adults with and Without ASD / Steven VANMARCKE in Journal of Autism and Developmental Disorders, 46-8 (August 2016)
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PermalinkVisual and Verbal Narrative Comprehension in Children and Adolescents with Autism Spectrum Disorders: An ERP Study / Mirella MANFREDI in Journal of Autism and Developmental Disorders, 50-8 (August 2020)
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PermalinkExplaining metaphors in high-functioning Autism Spectrum Disorder children: A brief report / Sergio MELOGNO in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)
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