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Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder / Xiaonan GUO in Molecular Autism, 13 (2022)
[article]
Titre : Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Xiaonan GUO, Auteur ; Guangjin ZHAI, Auteur ; Junfeng LIU, Auteur ; Yabo CAO, Auteur ; Xia ZHANG, Auteur ; Dong CUI, Auteur ; Le GAO, Auteur Article en page(s) : 52 p. Langues : Anglais (eng) Mots-clés : Humans Male Child Autism Spectrum Disorder/diagnostic imaging Brain Mapping/methods Magnetic Resonance Imaging/methods Brain/diagnostic imaging Autistic Disorder Neural Pathways/diagnostic imaging Autism spectrum disorder Functional connectivity Functional magnetic resonance imaging Subtype k-means clustering Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical heterogeneity. This study aimed to explore the heterogeneity of ASD based on inter-individual heterogeneity of functional brain networks. METHODS: Resting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange database were used in this study for 105 children with ASD and 102 demographically matched typical controls (TC) children. Functional connectivity (FC) networks were first obtained for ASD and TC groups, and inter-individual deviation of functional connectivity (IDFC) from the TC group was then calculated for each individual with ASD. A k-means clustering algorithm was used to obtain ASD subtypes based on IDFC patterns. The FC patterns were further compared between ASD subtypes and the TC group from the brain region, network, and whole-brain levels. The relationship between IDFC and the severity of clinical symptoms of ASD for ASD subtypes was also analyzed using a support vector regression model. RESULTS: Two ASD subtypes were identified based on the IDFC patterns. Compared with the TC group, the ASD subtype 1 group exhibited a hypoconnectivity pattern and the ASD subtype 2 group exhibited a hyperconnectivity pattern. IDFC for ASD subtype 1 and subtype 2 was found to predict the severity of social communication impairments and the severity of restricted and repetitive behaviors in ASD, respectively. LIMITATIONS: Only male children were selected for this study, which limits the ability to study the effects of gender and development on ASD heterogeneity. CONCLUSIONS: These results suggest the existence of subtypes with different FC patterns in ASD and provide insight into the complex pathophysiological mechanism of clinical manifestations of ASD. En ligne : http://dx.doi.org/10.1186/s13229-022-00535-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Molecular Autism > 13 (2022) . - 52 p.[article] Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Xiaonan GUO, Auteur ; Guangjin ZHAI, Auteur ; Junfeng LIU, Auteur ; Yabo CAO, Auteur ; Xia ZHANG, Auteur ; Dong CUI, Auteur ; Le GAO, Auteur . - 52 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 52 p.
Mots-clés : Humans Male Child Autism Spectrum Disorder/diagnostic imaging Brain Mapping/methods Magnetic Resonance Imaging/methods Brain/diagnostic imaging Autistic Disorder Neural Pathways/diagnostic imaging Autism spectrum disorder Functional connectivity Functional magnetic resonance imaging Subtype k-means clustering Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical heterogeneity. This study aimed to explore the heterogeneity of ASD based on inter-individual heterogeneity of functional brain networks. METHODS: Resting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange database were used in this study for 105 children with ASD and 102 demographically matched typical controls (TC) children. Functional connectivity (FC) networks were first obtained for ASD and TC groups, and inter-individual deviation of functional connectivity (IDFC) from the TC group was then calculated for each individual with ASD. A k-means clustering algorithm was used to obtain ASD subtypes based on IDFC patterns. The FC patterns were further compared between ASD subtypes and the TC group from the brain region, network, and whole-brain levels. The relationship between IDFC and the severity of clinical symptoms of ASD for ASD subtypes was also analyzed using a support vector regression model. RESULTS: Two ASD subtypes were identified based on the IDFC patterns. Compared with the TC group, the ASD subtype 1 group exhibited a hypoconnectivity pattern and the ASD subtype 2 group exhibited a hyperconnectivity pattern. IDFC for ASD subtype 1 and subtype 2 was found to predict the severity of social communication impairments and the severity of restricted and repetitive behaviors in ASD, respectively. LIMITATIONS: Only male children were selected for this study, which limits the ability to study the effects of gender and development on ASD heterogeneity. CONCLUSIONS: These results suggest the existence of subtypes with different FC patterns in ASD and provide insight into the complex pathophysiological mechanism of clinical manifestations of ASD. En ligne : http://dx.doi.org/10.1186/s13229-022-00535-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Adaptive behavior profiles in young children with autism spectrum disorder diagnosed under DSM-5 criteria / Rose E. NEVILL in Research in Autism Spectrum Disorders, 43-44 (November 2017)
[article]
Titre : Adaptive behavior profiles in young children with autism spectrum disorder diagnosed under DSM-5 criteria Type de document : Texte imprimé et/ou numérique Auteurs : Rose E. NEVILL, Auteur ; Darren HEDLEY, Auteur ; Mirko ULJAREVIC, Auteur ; Eric BUTTER, Auteur ; James A. MULICK, Auteur Article en page(s) : p.53-66 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Vineland-II Adaptive behavior Subtype Severity Toddlers Early childhood Cluster analysis Index. décimale : PER Périodiques Résumé : AbstractBackground This study explored adaptive behavior profiles in a clinical sample of well-characterized children aged one to three years with ASD. Method Profiles were compared to a sample of children with non-ASD developmental delays. Cluster analyses were performed to determine whether differences in adaptive skills effectively distinguished children with ASD from other young children presenting for assessment due to behavioral or other concerns, but who received other non-ASD diagnoses. Results A profile of motor > daily living > socialization > communication skills was found in both children with ASD and children with non-spectrum diagnoses, showing that this profile is not unique to young children with ASD. A two-group cluster solution was found which differentiated children by developmental functioning level rather than by diagnosis. Discussion The results of this study provide support for two developmental profiles for adaptive functioning in children with ASD: an average to borderline delayed profile and a borderline to more severely delayed profile that may remain stable or worsen over time. They additionally highlight the importance of delivering early targeted interventions to children with ASD who have greater deficits in adaptive functioning due to their association with poorer long-term outcomes. En ligne : https://doi.org/10.1016/j.rasd.2017.09.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327
in Research in Autism Spectrum Disorders > 43-44 (November 2017) . - p.53-66[article] Adaptive behavior profiles in young children with autism spectrum disorder diagnosed under DSM-5 criteria [Texte imprimé et/ou numérique] / Rose E. NEVILL, Auteur ; Darren HEDLEY, Auteur ; Mirko ULJAREVIC, Auteur ; Eric BUTTER, Auteur ; James A. MULICK, Auteur . - p.53-66.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 43-44 (November 2017) . - p.53-66
Mots-clés : Autism spectrum disorder Vineland-II Adaptive behavior Subtype Severity Toddlers Early childhood Cluster analysis Index. décimale : PER Périodiques Résumé : AbstractBackground This study explored adaptive behavior profiles in a clinical sample of well-characterized children aged one to three years with ASD. Method Profiles were compared to a sample of children with non-ASD developmental delays. Cluster analyses were performed to determine whether differences in adaptive skills effectively distinguished children with ASD from other young children presenting for assessment due to behavioral or other concerns, but who received other non-ASD diagnoses. Results A profile of motor > daily living > socialization > communication skills was found in both children with ASD and children with non-spectrum diagnoses, showing that this profile is not unique to young children with ASD. A two-group cluster solution was found which differentiated children by developmental functioning level rather than by diagnosis. Discussion The results of this study provide support for two developmental profiles for adaptive functioning in children with ASD: an average to borderline delayed profile and a borderline to more severely delayed profile that may remain stable or worsen over time. They additionally highlight the importance of delivering early targeted interventions to children with ASD who have greater deficits in adaptive functioning due to their association with poorer long-term outcomes. En ligne : https://doi.org/10.1016/j.rasd.2017.09.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327