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Commentary: Are alpha-2 agonist really effective in children with tics with comorbid ADHD? A commentary on Whittington et al. (2016) / Michael H. BLOCH in Journal of Child Psychology and Psychiatry, 57-9 (September 2016)
[article]
Titre : Commentary: Are alpha-2 agonist really effective in children with tics with comorbid ADHD? A commentary on Whittington et al. (2016) Type de document : Texte imprimé et/ou numérique Auteurs : Michael H. BLOCH, Auteur Article en page(s) : p.1005-1007 Langues : Anglais (eng) Mots-clés : tics attention deficit hyperactivity disorder clonidine guanfacine Index. décimale : PER Périodiques Résumé : In this issue, Whittington et al. (2016) present a systematic review that reports the efficacy of three primary treatments for children with Tourette syndrome (TS) – (a) ?2-adrenergic receptor agonists; (b) antipsychotic medications; and (c) habit reversal training/comprehensive behavioral intervention. In this commentary, we highlight the large degree of heterogeneity observed in the meta-analysis of trials involving alpha-2 agonist medications and present possible explanations for the observed heterogeneity. Among these possible explanations is the possibility that presence of comorbid ADHD may moderate the efficacy of alpha-2 agonists in the treatment of tic disorder with the medications being more effective in patients with both conditions. The commentary reviews the evidence supporting this possible moderating effect of ADHD and discusses the implications for such a relationship. En ligne : http://dx.doi.org/10.1111/jcpp.12592 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Journal of Child Psychology and Psychiatry > 57-9 (September 2016) . - p.1005-1007[article] Commentary: Are alpha-2 agonist really effective in children with tics with comorbid ADHD? A commentary on Whittington et al. (2016) [Texte imprimé et/ou numérique] / Michael H. BLOCH, Auteur . - p.1005-1007.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-9 (September 2016) . - p.1005-1007
Mots-clés : tics attention deficit hyperactivity disorder clonidine guanfacine Index. décimale : PER Périodiques Résumé : In this issue, Whittington et al. (2016) present a systematic review that reports the efficacy of three primary treatments for children with Tourette syndrome (TS) – (a) ?2-adrenergic receptor agonists; (b) antipsychotic medications; and (c) habit reversal training/comprehensive behavioral intervention. In this commentary, we highlight the large degree of heterogeneity observed in the meta-analysis of trials involving alpha-2 agonist medications and present possible explanations for the observed heterogeneity. Among these possible explanations is the possibility that presence of comorbid ADHD may moderate the efficacy of alpha-2 agonists in the treatment of tic disorder with the medications being more effective in patients with both conditions. The commentary reviews the evidence supporting this possible moderating effect of ADHD and discusses the implications for such a relationship. En ligne : http://dx.doi.org/10.1111/jcpp.12592 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 Practitioner Review: Treatments for Tourette syndrome in children and young people – a systematic review / Craig WHITTINGTON in Journal of Child Psychology and Psychiatry, 57-9 (September 2016)
[article]
Titre : Practitioner Review: Treatments for Tourette syndrome in children and young people – a systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Craig WHITTINGTON, Auteur ; Mary PENNANT, Auteur ; Tim KENDALL, Auteur ; Cristine GLAZEBROOK, Auteur ; Penny TRAYNER, Auteur ; Madeleine GROOM, Auteur ; Tammy HEDDERLY, Auteur ; Isobel HEYMAN, Auteur ; Georgina JACKSON, Auteur ; Stephen JACKSON, Auteur ; Tara MURPHY, Auteur ; Hugh RICKARDS, Auteur ; Mary ROBERTSON, Auteur ; Jeremy STERN, Auteur ; Chris HOLLIS, Auteur Article en page(s) : p.988-1004 Langues : Anglais (eng) Mots-clés : Paediatrics Tourette syndrome therapy tics Index. décimale : PER Périodiques Résumé : Background Tourette syndrome (TS) and chronic tic disorder (CTD) affect 1–2% of children and young people, but the most effective treatment is unclear. To establish the current evidence base, we conducted a systematic review of interventions for children and young people. Methods Databases were searched from inception to 1 October 2014 for placebo-controlled trials of pharmacological, behavioural, physical or alternative interventions for tics in children and young people with TS or CTD. Certainty in the evidence was assessed with the GRADE approach. Results Forty trials were included [pharmacological (32), behavioural (5), physical (2), dietary (1)]. For tics/global score there was evidence favouring the intervention from four trials of ?2-adrenergic receptor agonists [clonidine and guanfacine, standardised mean difference (SMD) = ?0.71; 95% CI ?1.03, ?0.40; N = 164] and two trials of habit reversal training (HRT)/comprehensive behavioural intervention (CBIT) (SMD = ?0.64; 95% CI ?0.99, ?0.29; N = 133). Certainty in the effect estimates was moderate. A post hoc analysis combining oral clonidine/guanfacine trials with a clonidine patch trial continued to demonstrate benefit (SMD = ?0.54; 95% CI ?0.92, ?0.16), but statistical heterogeneity was high. Evidence from four trials suggested that antipsychotic drugs improved tic scores (SMD = ?0.74; 95% CI ?1.08, ?0.40; N = 76), but certainty in the effect estimate was low. The evidence for other interventions was categorised as low or very low quality, or showed no conclusive benefit. Conclusions When medication is considered appropriate for the treatment of tics, the balance of clinical benefits to harm favours ?2-adrenergic receptor agonists (clonidine and guanfacine) as first-line agents. Antipsychotics are likely to be useful but carry the risk of harm and so should be reserved for when ?2-adrenergic receptor agonists are either ineffective or poorly tolerated. There is evidence that HRT/CBIT is effective, but there is no evidence for HRT/CBIT alone relative to combining medication and HRT/CBIT. There is currently no evidence to suggest that the physical and dietary interventions reviewed are sufficiently effective and safe to be considered as treatments. En ligne : http://dx.doi.org/10.1111/jcpp.12556 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Journal of Child Psychology and Psychiatry > 57-9 (September 2016) . - p.988-1004[article] Practitioner Review: Treatments for Tourette syndrome in children and young people – a systematic review [Texte imprimé et/ou numérique] / Craig WHITTINGTON, Auteur ; Mary PENNANT, Auteur ; Tim KENDALL, Auteur ; Cristine GLAZEBROOK, Auteur ; Penny TRAYNER, Auteur ; Madeleine GROOM, Auteur ; Tammy HEDDERLY, Auteur ; Isobel HEYMAN, Auteur ; Georgina JACKSON, Auteur ; Stephen JACKSON, Auteur ; Tara MURPHY, Auteur ; Hugh RICKARDS, Auteur ; Mary ROBERTSON, Auteur ; Jeremy STERN, Auteur ; Chris HOLLIS, Auteur . - p.988-1004.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-9 (September 2016) . - p.988-1004
Mots-clés : Paediatrics Tourette syndrome therapy tics Index. décimale : PER Périodiques Résumé : Background Tourette syndrome (TS) and chronic tic disorder (CTD) affect 1–2% of children and young people, but the most effective treatment is unclear. To establish the current evidence base, we conducted a systematic review of interventions for children and young people. Methods Databases were searched from inception to 1 October 2014 for placebo-controlled trials of pharmacological, behavioural, physical or alternative interventions for tics in children and young people with TS or CTD. Certainty in the evidence was assessed with the GRADE approach. Results Forty trials were included [pharmacological (32), behavioural (5), physical (2), dietary (1)]. For tics/global score there was evidence favouring the intervention from four trials of ?2-adrenergic receptor agonists [clonidine and guanfacine, standardised mean difference (SMD) = ?0.71; 95% CI ?1.03, ?0.40; N = 164] and two trials of habit reversal training (HRT)/comprehensive behavioural intervention (CBIT) (SMD = ?0.64; 95% CI ?0.99, ?0.29; N = 133). Certainty in the effect estimates was moderate. A post hoc analysis combining oral clonidine/guanfacine trials with a clonidine patch trial continued to demonstrate benefit (SMD = ?0.54; 95% CI ?0.92, ?0.16), but statistical heterogeneity was high. Evidence from four trials suggested that antipsychotic drugs improved tic scores (SMD = ?0.74; 95% CI ?1.08, ?0.40; N = 76), but certainty in the effect estimate was low. The evidence for other interventions was categorised as low or very low quality, or showed no conclusive benefit. Conclusions When medication is considered appropriate for the treatment of tics, the balance of clinical benefits to harm favours ?2-adrenergic receptor agonists (clonidine and guanfacine) as first-line agents. Antipsychotics are likely to be useful but carry the risk of harm and so should be reserved for when ?2-adrenergic receptor agonists are either ineffective or poorly tolerated. There is evidence that HRT/CBIT is effective, but there is no evidence for HRT/CBIT alone relative to combining medication and HRT/CBIT. There is currently no evidence to suggest that the physical and dietary interventions reviewed are sufficiently effective and safe to be considered as treatments. En ligne : http://dx.doi.org/10.1111/jcpp.12556 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 A proprietary herbal medicine (5-Ling Granule) for Tourette syndrome: a randomized controlled trial / Yi ZHENG in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)
[article]
Titre : A proprietary herbal medicine (5-Ling Granule) for Tourette syndrome: a randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Yi ZHENG, Auteur ; Zhang-Jin ZHANG, Auteur ; Xin-Min HAN, Auteur ; Ying DING, Auteur ; Yu-Yan CHEN, Auteur ; Xue-Feng WANG, Auteur ; Xiao-Wei WEI, Auteur ; Min-Jie WANG, Auteur ; Yan CHENG, Auteur ; Zhao-Hong NIE, Auteur ; Min ZHAO, Auteur ; Xi-Xi ZHENG, Auteur Article en page(s) : p.74-83 Langues : Anglais (eng) Mots-clés : Tourette syndrome tics herbal medicine tiapride 5-Ling Granule Index. décimale : PER Périodiques Résumé : Background Tourette syndrome (TS) is a common tic disorder in children and adolescents. There is preliminary evidence that herbal medicine may possess the potential to treat tics. The purpose of this study was to formally evaluate the efficacy and safety of 5-Ling Granule (5-LGr), a proprietary polyherbal product, for the treatment of patients with TS in comparison with tiapride and placebo. Methods In this multisite, double-blind, double-dummy, randomized, placebo-controlled trial, 603 patients with TS aged 5–18 years were randomly assigned to treatment with placebo (n = 117), tiapride (n = 123, 200–400 mg/day) or 5-LGr (n = 363, 15–22.5 g/day) for 8 weeks. The primary outcome was measured using the Yale Global Tic Severity Scale (YGTSS) and its subscales, total tic Score (TTS) and tic-related impairment. Incidence of adverse events was compared among the three groups. Results While tics of all patients were reduced over time, 5-LGr and tiapride treatment produced significantly greater improvement on the YGTSS overall scale and subscale for TTS and impairment at endpoint than the placebo. Seventy-four percentage of patients in the 5-LGr arm and 68.3% in the tiapride arm had clinical response and these rates of response were significantly higher than those on placebo (44.0%, p < .001). The incidence of overall adverse events was significantly fewer for patients on placebo and 5-LGr compared to tiapride (11.2% and 13.8% vs. 26.0%, p = .002); in particular physical tiredness, dizziness and sleep disturbance. Conclusions The clinical efficacy of 5-LGr is comparable to tiapride in reducing tics. Its safety profile is better than tiapride. 5-LGr can be considered a safe and effective therapy for TS (Trial registration: www.clinicaltrials.gov: NCT01501695). En ligne : http://dx.doi.org/10.1111/jcpp.12432 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273
in Journal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.74-83[article] A proprietary herbal medicine (5-Ling Granule) for Tourette syndrome: a randomized controlled trial [Texte imprimé et/ou numérique] / Yi ZHENG, Auteur ; Zhang-Jin ZHANG, Auteur ; Xin-Min HAN, Auteur ; Ying DING, Auteur ; Yu-Yan CHEN, Auteur ; Xue-Feng WANG, Auteur ; Xiao-Wei WEI, Auteur ; Min-Jie WANG, Auteur ; Yan CHENG, Auteur ; Zhao-Hong NIE, Auteur ; Min ZHAO, Auteur ; Xi-Xi ZHENG, Auteur . - p.74-83.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.74-83
Mots-clés : Tourette syndrome tics herbal medicine tiapride 5-Ling Granule Index. décimale : PER Périodiques Résumé : Background Tourette syndrome (TS) is a common tic disorder in children and adolescents. There is preliminary evidence that herbal medicine may possess the potential to treat tics. The purpose of this study was to formally evaluate the efficacy and safety of 5-Ling Granule (5-LGr), a proprietary polyherbal product, for the treatment of patients with TS in comparison with tiapride and placebo. Methods In this multisite, double-blind, double-dummy, randomized, placebo-controlled trial, 603 patients with TS aged 5–18 years were randomly assigned to treatment with placebo (n = 117), tiapride (n = 123, 200–400 mg/day) or 5-LGr (n = 363, 15–22.5 g/day) for 8 weeks. The primary outcome was measured using the Yale Global Tic Severity Scale (YGTSS) and its subscales, total tic Score (TTS) and tic-related impairment. Incidence of adverse events was compared among the three groups. Results While tics of all patients were reduced over time, 5-LGr and tiapride treatment produced significantly greater improvement on the YGTSS overall scale and subscale for TTS and impairment at endpoint than the placebo. Seventy-four percentage of patients in the 5-LGr arm and 68.3% in the tiapride arm had clinical response and these rates of response were significantly higher than those on placebo (44.0%, p < .001). The incidence of overall adverse events was significantly fewer for patients on placebo and 5-LGr compared to tiapride (11.2% and 13.8% vs. 26.0%, p = .002); in particular physical tiredness, dizziness and sleep disturbance. Conclusions The clinical efficacy of 5-LGr is comparable to tiapride in reducing tics. Its safety profile is better than tiapride. 5-LGr can be considered a safe and effective therapy for TS (Trial registration: www.clinicaltrials.gov: NCT01501695). En ligne : http://dx.doi.org/10.1111/jcpp.12432 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome / J. C. HUSTON in Journal of Autism and Developmental Disorders, 52-2 (February 2022)
[article]
Titre : Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : J. C. HUSTON, Auteur ; R. P. THOM, Auteur ; C. T. RAVICHANDRAN, Auteur ; J. E. MULLETT, Auteur ; C. MORAN, Auteur ; Jessica L. WAXLER, Auteur ; B. R. POBER, Auteur ; C. J. MCDOUGLE, Auteur Article en page(s) : p.852-862 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Child Female Humans Male Obsessive Behavior/diagnosis Obsessive-Compulsive Disorder/diagnosis/epidemiology Psychiatric Status Rating Scales Severity of Illness Index Tics Williams Syndrome Compulsion Obsession Repetitive Stereotypy Tic Williams syndrome Index. décimale : PER Périodiques Résumé : The purpose of the study was to characterize repetitive phenomena in Williams syndrome (WS). The parents of 60 subjects with WS completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) or Children's Y-BOCS, the Yale Global Tic Severity Scale, the Stereotyped Behavior Scale, and the Spence Children's Anxiety Scale-Parent Version. Nineteen males and 41 females participated in the study. Six subjects (10%) had obsessions only, six (10%) had compulsions only, and eleven (18%) had at least one obsession and at least one compulsion. None of the subjects had tics. Fifty subjects (83.3%) endorsed at least one stereotypy. Increased anxiety was associated with increased severity of obsessions, but not severity of compulsions or stereotypies. En ligne : http://dx.doi.org/10.1007/s10803-021-04979-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.852-862[article] Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome [Texte imprimé et/ou numérique] / J. C. HUSTON, Auteur ; R. P. THOM, Auteur ; C. T. RAVICHANDRAN, Auteur ; J. E. MULLETT, Auteur ; C. MORAN, Auteur ; Jessica L. WAXLER, Auteur ; B. R. POBER, Auteur ; C. J. MCDOUGLE, Auteur . - p.852-862.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.852-862
Mots-clés : Autism Spectrum Disorder Child Female Humans Male Obsessive Behavior/diagnosis Obsessive-Compulsive Disorder/diagnosis/epidemiology Psychiatric Status Rating Scales Severity of Illness Index Tics Williams Syndrome Compulsion Obsession Repetitive Stereotypy Tic Williams syndrome Index. décimale : PER Périodiques Résumé : The purpose of the study was to characterize repetitive phenomena in Williams syndrome (WS). The parents of 60 subjects with WS completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) or Children's Y-BOCS, the Yale Global Tic Severity Scale, the Stereotyped Behavior Scale, and the Spence Children's Anxiety Scale-Parent Version. Nineteen males and 41 females participated in the study. Six subjects (10%) had obsessions only, six (10%) had compulsions only, and eleven (18%) had at least one obsession and at least one compulsion. None of the subjects had tics. Fifty subjects (83.3%) endorsed at least one stereotypy. Increased anxiety was associated with increased severity of obsessions, but not severity of compulsions or stereotypies. En ligne : http://dx.doi.org/10.1007/s10803-021-04979-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 Syndrome de Gilles de la Tourette: une revue narrative des symptômes, conditions associées et interventions / Simon MORAND-BEAULIEU in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., 183 (Mai 2023)
[article]
Titre : Syndrome de Gilles de la Tourette: une revue narrative des symptômes, conditions associées et interventions Type de document : Texte imprimé et/ou numérique Auteurs : Simon MORAND-BEAULIEU, Auteur ; Annie VEILLEUX, Auteur ; J.B. LECLERC, Auteur Année de publication : 2023 Article en page(s) : p.153-160 Langues : Français (fre) Mots-clés : Syndrome de Gilles de la Tourette Tics Symptômes Conditions associées Traitement Index. décimale : PER Périodiques Résumé : Le syndrome de Gilles de la Tourette (SGT) est un trouble neurodéveloppemental dont les principales manifestations sont des tics moteurs et phoniques. Ce trouble est plus souvent qu’autrement accompagné de diverses conditions associées, ce qui vient diversifier les possibles présentations cliniques du SGT. D’autres conditions peuvent également avoir des symptômes qui s’apparentent aux tics qu’on peut voir chez les gens atteints du SGT. Lors de l’évaluation diagnostique, il importe d’identifier quels symptômes sont issus du SGT pour être en mesure d’intervenir correctement pour aider la personne qui présente des tics. Cette revue narrative de la littérature présente d’abord un survol des principaux symptômes du SGT et des conditions fréquemment associées. Nous abordons ensuite les différentes options de traitement qui s’offrent aux gens atteints du SGT, notamment sur le plan de la pharmacothérapie, des thérapies cognitives et comportementales, et de la stimulation cérébrale. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=506
in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E. > 183 (Mai 2023) . - p.153-160[article] Syndrome de Gilles de la Tourette: une revue narrative des symptômes, conditions associées et interventions [Texte imprimé et/ou numérique] / Simon MORAND-BEAULIEU, Auteur ; Annie VEILLEUX, Auteur ; J.B. LECLERC, Auteur . - 2023 . - p.153-160.
Langues : Français (fre)
in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E. > 183 (Mai 2023) . - p.153-160
Mots-clés : Syndrome de Gilles de la Tourette Tics Symptômes Conditions associées Traitement Index. décimale : PER Périodiques Résumé : Le syndrome de Gilles de la Tourette (SGT) est un trouble neurodéveloppemental dont les principales manifestations sont des tics moteurs et phoniques. Ce trouble est plus souvent qu’autrement accompagné de diverses conditions associées, ce qui vient diversifier les possibles présentations cliniques du SGT. D’autres conditions peuvent également avoir des symptômes qui s’apparentent aux tics qu’on peut voir chez les gens atteints du SGT. Lors de l’évaluation diagnostique, il importe d’identifier quels symptômes sont issus du SGT pour être en mesure d’intervenir correctement pour aider la personne qui présente des tics. Cette revue narrative de la littérature présente d’abord un survol des principaux symptômes du SGT et des conditions fréquemment associées. Nous abordons ensuite les différentes options de traitement qui s’offrent aux gens atteints du SGT, notamment sur le plan de la pharmacothérapie, des thérapies cognitives et comportementales, et de la stimulation cérébrale. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=506