11 recherche sur le mot-clé 'mediation analysis'

Stunting and lead: using causal mediation analysis to better understand how environmental lead exposure affects cognitive outcomes in children / Kelsey M. GLEASON in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Stunting and lead: using causal mediation analysis to better understand how environmental lead exposure affects cognitive outcomes in children Type de document : texte imprimé Auteurs : Kelsey M. GLEASON, Auteur ; Linda VALERI, Auteur ; Anuraj H. SHANKAR, Auteur ; John F. OBRYCKI, Auteur ; Md Omar Sharif IBNE HASAN, Auteur ; Golam MOSTOFA, Auteur ; Quazi QUAMRUZZAMAN, Auteur ; Robert O. WRIGHT, Auteur ; David C. CHRISTIANI, Auteur ; David C. BELLINGER, Auteur ; Maitreyi MAZUMDAR, Auteur Langues : Anglais (eng) Mots-clés : Bangladesh  Child, Preschool  Cognition  Female  Growth Disorders/chemically induced  Humans  Infant  Infant, Newborn  Lead/adverse effects  Mediation Analysis  Pregnancy  Bayley Scales of Infant Development  Blood lead  Cognitive development  Mediation analysis  Stunting Index. décimale : PER Périodiques Résumé : BACKGROUND: Many children in Bangladesh experience poor nutritional status and environmental lead exposure, both of which are associated with lower scores on neurodevelopmental assessments. Recent studies have suggested that part of lead's adverse effects on neurodevelopment are caused in part by lead's effect on growth. New statistical methods are now available to evaluate potential causal pathways in observational studies. This study used a novel statistical method to test the hypothesis that stunting, a measure of linear growth related to poor nutrition, is a mediator and/or an effect modifier of the lead exposure's adverse effect on cognitive development. METHODS: Participants were 734 children from a longitudinal birth cohort established in rural Bangladesh to study the health effects of prenatal and early childhood environmental metal exposures. Lead exposure was estimated using umbilical cord blood samples obtained at birth and blood obtained via venipuncture at age 20-40 months. Stunting was determined using the World Health Organization's standards. Neurodevelopment was assessed at age 20-40 months years using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). We evaluated the effect of lead on stunting and whether the effect of lead on cognitive scores is modified by stunting status in multivariable regression analyses. We then conducted a novel 4-way mediation analysis that allows for exposure-mediator interaction to assess how much of the effect of lead on cognitive scores is explained by the pathway through stunting (mediation) and how much is explained by the interaction between lead and stunt (effect modification). RESULTS: Stunting was not a mediator of the effect of lead in our analyses. Results suggested effect modification by stunting. In an area of Bangladesh with lower lead exposures (median umbilical cord blood lead concentration, 1.7 μg/dL), stunting modified the relationship between prenatal blood lead concentrations and cognitive score at age 2-3 years. A 1-unit increase in natural log cord blood lead concentration in the presence of stunting was associated with a 2.1-unit decrease in cognitive scores (β = - 2.10, SE = 0.71, P = 0.003). This interaction was not found in a second study site where lead exposures were higher (median umbilical cord blood lead concentration, 6.1 μg/dL, β = - 0.45, SE = 0.49, P = 0.360). CONCLUSIONS: We used a novel method of mediation analysis to test whether stunting mediated the adverse effect of prenatal lead exposure on cognitive outcomes in Bangladesh. While we did not find that stunting acted as mediator of lead's effect on cognitive development, we found significant effect modification by stunting. Our results suggest that children with stunting are more vulnerable to the adverse effects of low-level lead exposure. En ligne : https://dx.doi.org/10.1186/s11689-020-09346-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Stunting and lead: using causal mediation analysis to better understand how environmental lead exposure affects cognitive outcomes in children [texte imprimé] / Kelsey M. GLEASON, Auteur ; Linda VALERI, Auteur ; Anuraj H. SHANKAR, Auteur ; John F. OBRYCKI, Auteur ; Md Omar Sharif IBNE HASAN, Auteur ; Golam MOSTOFA, Auteur ; Quazi QUAMRUZZAMAN, Auteur ; Robert O. WRIGHT, Auteur ; David C. CHRISTIANI, Auteur ; David C. BELLINGER, Auteur ; Maitreyi MAZUMDAR, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Bangladesh  Child, Preschool  Cognition  Female  Growth Disorders/chemically induced  Humans  Infant  Infant, Newborn  Lead/adverse effects  Mediation Analysis  Pregnancy  Bayley Scales of Infant Development  Blood lead  Cognitive development  Mediation analysis  Stunting Index. décimale : PER Périodiques Résumé : BACKGROUND: Many children in Bangladesh experience poor nutritional status and environmental lead exposure, both of which are associated with lower scores on neurodevelopmental assessments. Recent studies have suggested that part of lead's adverse effects on neurodevelopment are caused in part by lead's effect on growth. New statistical methods are now available to evaluate potential causal pathways in observational studies. This study used a novel statistical method to test the hypothesis that stunting, a measure of linear growth related to poor nutrition, is a mediator and/or an effect modifier of the lead exposure's adverse effect on cognitive development. METHODS: Participants were 734 children from a longitudinal birth cohort established in rural Bangladesh to study the health effects of prenatal and early childhood environmental metal exposures. Lead exposure was estimated using umbilical cord blood samples obtained at birth and blood obtained via venipuncture at age 20-40 months. Stunting was determined using the World Health Organization's standards. Neurodevelopment was assessed at age 20-40 months years using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). We evaluated the effect of lead on stunting and whether the effect of lead on cognitive scores is modified by stunting status in multivariable regression analyses. We then conducted a novel 4-way mediation analysis that allows for exposure-mediator interaction to assess how much of the effect of lead on cognitive scores is explained by the pathway through stunting (mediation) and how much is explained by the interaction between lead and stunt (effect modification). RESULTS: Stunting was not a mediator of the effect of lead in our analyses. Results suggested effect modification by stunting. In an area of Bangladesh with lower lead exposures (median umbilical cord blood lead concentration, 1.7 μg/dL), stunting modified the relationship between prenatal blood lead concentrations and cognitive score at age 2-3 years. A 1-unit increase in natural log cord blood lead concentration in the presence of stunting was associated with a 2.1-unit decrease in cognitive scores (β = - 2.10, SE = 0.71, P = 0.003). This interaction was not found in a second study site where lead exposures were higher (median umbilical cord blood lead concentration, 6.1 μg/dL, β = - 0.45, SE = 0.49, P = 0.360). CONCLUSIONS: We used a novel method of mediation analysis to test whether stunting mediated the adverse effect of prenatal lead exposure on cognitive outcomes in Bangladesh. While we did not find that stunting acted as mediator of lead's effect on cognitive development, we found significant effect modification by stunting. Our results suggest that children with stunting are more vulnerable to the adverse effects of low-level lead exposure. En ligne : https://dx.doi.org/10.1186/s11689-020-09346-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Effects of micronutrients on neurodevelopmental disorders through the mediation of brain structure and function: A two-step Mendelian randomization analysis / Jiatong DENG ; Weiyan HUANG ; Wanling CHEN ; Lijuan WEI ; Guanghui RAN ; Lili LIU ; Zhongyi LI ; Meiliang LIU ; Dongping HUANG ; Shun LIU ; Xiaoyun ZENG ; Lijun WANG in Autism, 29-7 (July 2025)  

Public ISBD [article]  inAutism > 29-7 (July 2025) . - p.1795-1806 Titre : Effects of micronutrients on neurodevelopmental disorders through the mediation of brain structure and function: A two-step Mendelian randomization analysis Type de document : texte imprimé Auteurs : Jiatong DENG, Auteur ; Weiyan HUANG, Auteur ; Wanling CHEN, Auteur ; Lijuan WEI, Auteur ; Guanghui RAN, Auteur ; Lili LIU, Auteur ; Zhongyi LI, Auteur ; Meiliang LIU, Auteur ; Dongping HUANG, Auteur ; Shun LIU, Auteur ; Xiaoyun ZENG, Auteur ; Lijun WANG, Auteur Article en page(s) : p.1795-1806 Langues : Anglais (eng) Mots-clés : brain imaging-derived phenotypes  mediation analysis  Mendelian randomization  micronutrients  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : The physiological functions of micronutrients in neurodevelopment are well documented, but their protective effects on neurodevelopmental disorders remain controversial. We assessed the associations between micronutrients and three main neurodevelopmental disorders, that is, autism spectrum disorder (18,381 cases), attention-deficit/hyperactivity disorder (38,691 cases), and Tourette?s syndrome (4,819 cases), using two-sample Mendelian randomization analyses. In addition, we estimated the mediation role of brain imaging-derived phenotypes (n = 33,224) in these associations. Each 1 SD (0.08 mmol/L) increase in serum magnesium concentration was associated with a 16% reduced risk of autism spectrum disorder (odds ratio 0.84, 95% confidence interval 0.72-0.98). Each 1 SD (65 ?mol/L) increase in blood erythrocyte zinc concentration was associated with an 8% reduced risk of attention-deficit/hyperactivity disorder (0.92, 0.86-0.98). Each 1 SD (173 pmol/L) increase in serum vitamin B12 concentration was associated with a 19% reduced risk of Tourette?s syndrome (0.81, 0.68-0.97). These effects were partly mediated by alterations in multiple brain imaging-derived phenotypes, with mediated proportions ranging from 5.84% to 32.66%. Our results suggested that interventions targeting micronutrient deficiencies could be a practical and effective strategy for preventing neurodevelopmental disorders, especially in populations at high risk of malnutrition.Lay abstract Increasing evidence highlights the critical role of micronutrients in neurodevelopment. However, the causal relationship between micronutrients and neurodevelopmental disorders remains unclear. Using genetic variants associated with micronutrient levels and neurodevelopmental disorders, our study revealed the protective effects of magnesium on autism spectrum disorders, zinc on attention-deficit/hyperactivity disorder, and vitamin B12 on Tourette?s syndrome. These protective effects were partially mediated through alterations in brain structure, function, and connectivity. Our findings emphasize the importance of adequate micronutrient intake for healthy neurodevelopment and may support the development of intervention strategies aimed at preventing neurodevelopmental disorders by addressing micronutrient deficiencies. En ligne : https://dx.doi.org/10.1177/13623613251326702 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Effects of micronutrients on neurodevelopmental disorders through the mediation of brain structure and function: A two-step Mendelian randomization analysis [texte imprimé] / Jiatong DENG, Auteur ; Weiyan HUANG, Auteur ; Wanling CHEN, Auteur ; Lijuan WEI, Auteur ; Guanghui RAN, Auteur ; Lili LIU, Auteur ; Zhongyi LI, Auteur ; Meiliang LIU, Auteur ; Dongping HUANG, Auteur ; Shun LIU, Auteur ; Xiaoyun ZENG, Auteur ; Lijun WANG, Auteur . - p.1795-1806. Langues : Anglais (eng) in Autism > 29-7 (July 2025) . - p.1795-1806 Mots-clés : brain imaging-derived phenotypes  mediation analysis  Mendelian randomization  micronutrients  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : The physiological functions of micronutrients in neurodevelopment are well documented, but their protective effects on neurodevelopmental disorders remain controversial. We assessed the associations between micronutrients and three main neurodevelopmental disorders, that is, autism spectrum disorder (18,381 cases), attention-deficit/hyperactivity disorder (38,691 cases), and Tourette?s syndrome (4,819 cases), using two-sample Mendelian randomization analyses. In addition, we estimated the mediation role of brain imaging-derived phenotypes (n = 33,224) in these associations. Each 1 SD (0.08 mmol/L) increase in serum magnesium concentration was associated with a 16% reduced risk of autism spectrum disorder (odds ratio 0.84, 95% confidence interval 0.72-0.98). Each 1 SD (65 ?mol/L) increase in blood erythrocyte zinc concentration was associated with an 8% reduced risk of attention-deficit/hyperactivity disorder (0.92, 0.86-0.98). Each 1 SD (173 pmol/L) increase in serum vitamin B12 concentration was associated with a 19% reduced risk of Tourette?s syndrome (0.81, 0.68-0.97). These effects were partly mediated by alterations in multiple brain imaging-derived phenotypes, with mediated proportions ranging from 5.84% to 32.66%. Our results suggested that interventions targeting micronutrient deficiencies could be a practical and effective strategy for preventing neurodevelopmental disorders, especially in populations at high risk of malnutrition.Lay abstract Increasing evidence highlights the critical role of micronutrients in neurodevelopment. However, the causal relationship between micronutrients and neurodevelopmental disorders remains unclear. Using genetic variants associated with micronutrient levels and neurodevelopmental disorders, our study revealed the protective effects of magnesium on autism spectrum disorders, zinc on attention-deficit/hyperactivity disorder, and vitamin B12 on Tourette?s syndrome. These protective effects were partially mediated through alterations in brain structure, function, and connectivity. Our findings emphasize the importance of adequate micronutrient intake for healthy neurodevelopment and may support the development of intervention strategies aimed at preventing neurodevelopmental disorders by addressing micronutrient deficiencies. En ligne : https://dx.doi.org/10.1177/13623613251326702 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

The Role of Theory of Mind on Social Information Processing in Children With Autism Spectrum Disorders: A Mediation Analysis / Monica MAZZA in Journal of Autism and Developmental Disorders, 47-5 (May 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1369-1379 Titre : The Role of Theory of Mind on Social Information Processing in Children With Autism Spectrum Disorders: A Mediation Analysis Type de document : texte imprimé Auteurs : Monica MAZZA, Auteur ; Melania MARIANO, Auteur ; Sara PERETTI, Auteur ; Francesco MASEDU, Auteur ; Maria Chiara PINO, Auteur ; Marco VALENTI, Auteur Article en page(s) : p.1369-1379 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders (ASD)  Mediation analysis  Theory of mind (ToM)  Social cognition  Social information processing Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) show significant impairments in social skills and theory of mind (ToM). The aim of this study was to evaluate ToM and social information processing abilities in 52 children with ASD compared to 55 typically developing (TD) children. A mediation analysis evaluated whether social information processing abilities can be mediated by ToM competences. In our results, children with autism showed a deficit in social skills and ToM components. The innovative results of our study applying mediation analysis demonstrate that ToM plays a key role in the development of social abilities, and the lack of ToM competences in children with autism impairs their competent social behavior. En ligne : http://dx.doi.org/10.1007/s10803-017-3069-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] The Role of Theory of Mind on Social Information Processing in Children With Autism Spectrum Disorders: A Mediation Analysis [texte imprimé] / Monica MAZZA, Auteur ; Melania MARIANO, Auteur ; Sara PERETTI, Auteur ; Francesco MASEDU, Auteur ; Maria Chiara PINO, Auteur ; Marco VALENTI, Auteur . - p.1369-1379. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1369-1379 Mots-clés : Autism spectrum disorders (ASD)  Mediation analysis  Theory of mind (ToM)  Social cognition  Social information processing Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) show significant impairments in social skills and theory of mind (ToM). The aim of this study was to evaluate ToM and social information processing abilities in 52 children with ASD compared to 55 typically developing (TD) children. A mediation analysis evaluated whether social information processing abilities can be mediated by ToM competences. In our results, children with autism showed a deficit in social skills and ToM components. The innovative results of our study applying mediation analysis demonstrate that ToM plays a key role in the development of social abilities, and the lack of ToM competences in children with autism impairs their competent social behavior. En ligne : http://dx.doi.org/10.1007/s10803-017-3069-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Mediators of focused psychosocial support interventions for children in low-resource humanitarian settings: analysis from an Individual Participant Dataset with 3,143 participants / Marianna PURGATO in Journal of Child Psychology and Psychiatry, 61-5 (May 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.584-593 Titre : Mediators of focused psychosocial support interventions for children in low-resource humanitarian settings: analysis from an Individual Participant Dataset with 3,143 participants Type de document : texte imprimé Auteurs : Marianna PURGATO, Auteur ; Federico TEDESCHI, Auteur ; Theresa S. BETANCOURT, Auteur ; Paul BOLTON, Auteur ; Chiara BONETTO, Auteur ; Chiara GASTALDON, Auteur ; James GORDON, Auteur ; Paul O'CALLAGHAN, Auteur ; Davide PAPOLA, Auteur ; Kirsi PELTONEN, Auteur ; Raija-Leena PUNAMAKI, Auteur ; Justin RICHARDS, Auteur ; Julie K. STAPLES, Auteur ; Johanna UNTERHITZENBERGER, Auteur ; Joop DE JONG, Auteur ; Mark J.D. JORDANS, Auteur ; Alden L. GROSS, Auteur ; Wietse A. TOL, Auteur ; Corrado BARBUI, Auteur Article en page(s) : p.584-593 Langues : Anglais (eng) Mots-clés : Mediation analysis  children  humanitarian setting  individual participant data  trauma Index. décimale : PER Périodiques Résumé : BACKGROUND: Research on psychosocial interventions has been focused on the effectiveness of psychosocial interventions on mental health outcomes, without exploring how interventions achieve beneficial effects. Identifying the potential pathways through which interventions work would potentially allow further strengthening of interventions by emphasizing specific components connected with such pathways. METHODS: We conducted a preplanned mediation analysis using individual participant data from a dataset of 11 randomized controlled trials (RCTs) which compared focused psychosocial support interventions versus control conditions for children living in low- and middle-income countries (LMICs) affected by humanitarian crises. Based on an ecological resilience framework, we hypothesized that (a) coping, (b) hope, (c) social support, and (d) functional impairment mediate the relationship between intervention and outcome PTSD symptoms. A systematic search on the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PubMed, PyscARTICLES, Web of Science, and the main local LMICs databases was conducted up to August 2018. The hypotheses were tested by using individual participant data obtained from study authors of all the studies included in the systematic review. RESULTS: We included 3,143 children from 11 studies (100% of data from included studies), of which 1,877 from six studies contributed to the mediation analysis. Functional impairment was the strongest mediator for focused psychosocial interventions on PTSD (mediation coefficient -0.087, standard error 0.040). The estimated proportion of effect mediated by functional impairment, and adjusted for confounders, was 31%. CONCLUSIONS: Findings did not support the proposed mediation hypotheses for coping, hope, and social support. The mediation through functional impairment may represent unmeasured proxy measures or point to a broader mechanism that impacts self-efficacy and agency. En ligne : http://dx.doi.org/10.1111/jcpp.13151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Mediators of focused psychosocial support interventions for children in low-resource humanitarian settings: analysis from an Individual Participant Dataset with 3,143 participants [texte imprimé] / Marianna PURGATO, Auteur ; Federico TEDESCHI, Auteur ; Theresa S. BETANCOURT, Auteur ; Paul BOLTON, Auteur ; Chiara BONETTO, Auteur ; Chiara GASTALDON, Auteur ; James GORDON, Auteur ; Paul O'CALLAGHAN, Auteur ; Davide PAPOLA, Auteur ; Kirsi PELTONEN, Auteur ; Raija-Leena PUNAMAKI, Auteur ; Justin RICHARDS, Auteur ; Julie K. STAPLES, Auteur ; Johanna UNTERHITZENBERGER, Auteur ; Joop DE JONG, Auteur ; Mark J.D. JORDANS, Auteur ; Alden L. GROSS, Auteur ; Wietse A. TOL, Auteur ; Corrado BARBUI, Auteur . - p.584-593. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.584-593 Mots-clés : Mediation analysis  children  humanitarian setting  individual participant data  trauma Index. décimale : PER Périodiques Résumé : BACKGROUND: Research on psychosocial interventions has been focused on the effectiveness of psychosocial interventions on mental health outcomes, without exploring how interventions achieve beneficial effects. Identifying the potential pathways through which interventions work would potentially allow further strengthening of interventions by emphasizing specific components connected with such pathways. METHODS: We conducted a preplanned mediation analysis using individual participant data from a dataset of 11 randomized controlled trials (RCTs) which compared focused psychosocial support interventions versus control conditions for children living in low- and middle-income countries (LMICs) affected by humanitarian crises. Based on an ecological resilience framework, we hypothesized that (a) coping, (b) hope, (c) social support, and (d) functional impairment mediate the relationship between intervention and outcome PTSD symptoms. A systematic search on the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PubMed, PyscARTICLES, Web of Science, and the main local LMICs databases was conducted up to August 2018. The hypotheses were tested by using individual participant data obtained from study authors of all the studies included in the systematic review. RESULTS: We included 3,143 children from 11 studies (100% of data from included studies), of which 1,877 from six studies contributed to the mediation analysis. Functional impairment was the strongest mediator for focused psychosocial interventions on PTSD (mediation coefficient -0.087, standard error 0.040). The estimated proportion of effect mediated by functional impairment, and adjusted for confounders, was 31%. CONCLUSIONS: Findings did not support the proposed mediation hypotheses for coping, hope, and social support. The mediation through functional impairment may represent unmeasured proxy measures or point to a broader mechanism that impacts self-efficacy and agency. En ligne : http://dx.doi.org/10.1111/jcpp.13151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Mindfulness and parenting stress among parents of autistic children: The mediation of resilience and psychological flexibility / Dali LU ; Tsz Ying Christine NG ; Pui Hing CHAU ; Lily Man Lee CHAN ; Jojo Yan Yan KWOK in Autism, 29-7 (July 2025)  

Public ISBD [article]  inAutism > 29-7 (July 2025) . - p.1849-1863 Titre : Mindfulness and parenting stress among parents of autistic children: The mediation of resilience and psychological flexibility Type de document : texte imprimé Auteurs : Dali LU, Auteur ; Tsz Ying Christine NG, Auteur ; Pui Hing CHAU, Auteur ; Lily Man Lee CHAN, Auteur ; Jojo Yan Yan KWOK, Auteur Article en page(s) : p.1849-1863 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  mediation analysis  mindfulness  parenting stress  psychological flexibility  resilience Index. décimale : PER Périodiques Résumé : High parenting stress is associated with diminished quality of life in parents and more problem behaviors in autistic children. Mindfulness-based interventions have demonstrated efficacy in mitigating parenting stress. Psychological flexibility and resilience have been recognized as protective factors against psychological distress. However, the extent to which psychological flexibility and resilience mediate the effect of mindfulness on parenting stress among parents of autistic children remains unclear. This cross-sectional study examined the mediating roles of psychological flexibility and resilience in the relationship between mindfulness and parenting stress. We recruited a convenience sample of 181 Chinese parents of autistic children from Shenzhen Longhua Maternity and Child Healthcare Hospital in Shenzhen, China. This study assessed characteristics, parents" mindfulness, psychological flexibility, resilience, and parenting stress. Results indicated that parents experienced considerable parenting stress. Correlation analysis found that higher mindfulness, psychological flexibility, and resilience were associated with lower parenting stress. After controlling for children s age, gender, core symptom severity, parents" age, gender, marital status, and education levels, psychological flexibility and resilience completely mediated the relationship between mindfulness and parenting stress. These findings suggest that multicomponent psychological interventions may enhance the mental health of parents of children with autism, warranting further investigation.Lay Abstract Raising a child with autism spectrum disorder can be very stressful for parents, and this stress can lead to serious problems, like diminished quality of life in parents and more challenging behaviors in autistic children. But there?s something called mindfulness that can help parents feel less stressed. Mindfulness is like training your mind to stay calm and focused. It?s like learning to take a deep breath and find calm in a busy day. Our study in China investigated 181 parents of children with autism from Shenzhen Longhua Maternity and Child Healthcare Hospital in Shenzhen, China. We wanted to see if two things-being able to bounce back from hard times (resilience) and being flexible in how you think and act (psychological flexibility)-help mindfulness work its magic in easing stress. We found that more mindful parents also felt less stressed. Moreover, having psychological flexibility and resilience seemed to be the reason why mindfulness was so helpful. After controlling for covariates including children s age, gender, core symptom severity, parents" age, gender, marital status, occupational status, and education levels, the effects of mindfulness on stress still existed. This tells us that programs that teach mindfulness, along with how to build resilience and be more flexible in thinking, could make a difference for parents of children with autism. It could help them feel less stressed and more at peace. En ligne : https://dx.doi.org/10.1177/13623613251328465 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Mindfulness and parenting stress among parents of autistic children: The mediation of resilience and psychological flexibility [texte imprimé] / Dali LU, Auteur ; Tsz Ying Christine NG, Auteur ; Pui Hing CHAU, Auteur ; Lily Man Lee CHAN, Auteur ; Jojo Yan Yan KWOK, Auteur . - p.1849-1863. Langues : Anglais (eng) in Autism > 29-7 (July 2025) . - p.1849-1863 Mots-clés : Autism spectrum disorder  mediation analysis  mindfulness  parenting stress  psychological flexibility  resilience Index. décimale : PER Périodiques Résumé : High parenting stress is associated with diminished quality of life in parents and more problem behaviors in autistic children. Mindfulness-based interventions have demonstrated efficacy in mitigating parenting stress. Psychological flexibility and resilience have been recognized as protective factors against psychological distress. However, the extent to which psychological flexibility and resilience mediate the effect of mindfulness on parenting stress among parents of autistic children remains unclear. This cross-sectional study examined the mediating roles of psychological flexibility and resilience in the relationship between mindfulness and parenting stress. We recruited a convenience sample of 181 Chinese parents of autistic children from Shenzhen Longhua Maternity and Child Healthcare Hospital in Shenzhen, China. This study assessed characteristics, parents" mindfulness, psychological flexibility, resilience, and parenting stress. Results indicated that parents experienced considerable parenting stress. Correlation analysis found that higher mindfulness, psychological flexibility, and resilience were associated with lower parenting stress. After controlling for children s age, gender, core symptom severity, parents" age, gender, marital status, and education levels, psychological flexibility and resilience completely mediated the relationship between mindfulness and parenting stress. These findings suggest that multicomponent psychological interventions may enhance the mental health of parents of children with autism, warranting further investigation.Lay Abstract Raising a child with autism spectrum disorder can be very stressful for parents, and this stress can lead to serious problems, like diminished quality of life in parents and more challenging behaviors in autistic children. But there?s something called mindfulness that can help parents feel less stressed. Mindfulness is like training your mind to stay calm and focused. It?s like learning to take a deep breath and find calm in a busy day. Our study in China investigated 181 parents of children with autism from Shenzhen Longhua Maternity and Child Healthcare Hospital in Shenzhen, China. We wanted to see if two things-being able to bounce back from hard times (resilience) and being flexible in how you think and act (psychological flexibility)-help mindfulness work its magic in easing stress. We found that more mindful parents also felt less stressed. Moreover, having psychological flexibility and resilience seemed to be the reason why mindfulness was so helpful. After controlling for covariates including children s age, gender, core symptom severity, parents" age, gender, marital status, occupational status, and education levels, the effects of mindfulness on stress still existed. This tells us that programs that teach mindfulness, along with how to build resilience and be more flexible in thinking, could make a difference for parents of children with autism. It could help them feel less stressed and more at peace. En ligne : https://dx.doi.org/10.1177/13623613251328465 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Childhood psychopathology mediates associations between childhood adversities and multiple health risk behaviours in adolescence: analysis using the ALSPAC birth cohort / David TROY in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

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Longitudinal associations across vocabulary modalities in children with autism and typical development / Kristen BOTTEMA-BEUTEL in Autism, 23-2 (February 2019)  

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Mechanisms of Altered Imitation in Autism Spectrum Disorders / Ata KOLDAY ; Ericka L. WODKA ; Stewart H. MOSTOFSKY ; Brian S. CAFFO ; Joshua B. EWEN in Autism Research, 18-7 (July 2025)  

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The developmental phenotype of motor delay in extremely preterm infants following early-life respiratory adversity is influenced by brain dysmaturation in the parietal lobe / Wen-Hao YU in Journal of Neurodevelopmental Disorders, 16 (2024)  

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Internalizing Symptoms Mediate the Relation Between Acute Pain and Autism in Adults / Domingo GARCIA-VILLAMISAR in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

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