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The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques / Simona SPINELLI in Development and Psychopathology, 24-1 (January 2012)
[article]
Titre : The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques Type de document : Texte imprimé et/ou numérique Auteurs : Simona SPINELLI, Auteur ; Melanie L. SCHWANDT, Auteur ; Stephen G. LINDELL, Auteur ; Markus HEILIG, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; David GOLDMAN, Auteur ; Christina S. BARR, Auteur Année de publication : 2012 Article en page(s) : p.157-165 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The short allele of the serotonin transporter linked polymorphic region (5-HTTLPR) moderates the effects of stress on vulnerability to mood and anxiety disorders. The mechanism by which this occurs may relate to differential sensitivity to stressful life events. Here we explored whether 5-HTTLPR and sex affected behavioral responses to repeated maternal separation in infant rhesus macaques. Behaviors were collected during the acute (Day 1) and the chronic (Days 2–4) phases of the separation, and the effects of duration of separation (acute vs. chronic), genotype (long/long vs. short allele), and sex (male vs. female) on behavioral responses were analyzed across four successive separations. Males increased their levels of locomotion with repeated maternal separation, whereas females exhibited an increase in frequency of self-directed behavior, a measure of “depression-like” behavior. The short-allele predicted increased environmental exploration, particularly during the chronic phase of social separation, indicative of higher arousal. In addition, the short-allele carriers were more likely to increase their levels of self-directed behavior during the chronic phase of separation, as a function of repeated exposures. These findings suggest that the short allele may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable. En ligne : http://dx.doi.org/10.1017/S0954579411000745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151
in Development and Psychopathology > 24-1 (January 2012) . - p.157-165[article] The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques [Texte imprimé et/ou numérique] / Simona SPINELLI, Auteur ; Melanie L. SCHWANDT, Auteur ; Stephen G. LINDELL, Auteur ; Markus HEILIG, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; David GOLDMAN, Auteur ; Christina S. BARR, Auteur . - 2012 . - p.157-165.
Langues : Anglais (eng)
in Development and Psychopathology > 24-1 (January 2012) . - p.157-165
Index. décimale : PER Périodiques Résumé : The short allele of the serotonin transporter linked polymorphic region (5-HTTLPR) moderates the effects of stress on vulnerability to mood and anxiety disorders. The mechanism by which this occurs may relate to differential sensitivity to stressful life events. Here we explored whether 5-HTTLPR and sex affected behavioral responses to repeated maternal separation in infant rhesus macaques. Behaviors were collected during the acute (Day 1) and the chronic (Days 2–4) phases of the separation, and the effects of duration of separation (acute vs. chronic), genotype (long/long vs. short allele), and sex (male vs. female) on behavioral responses were analyzed across four successive separations. Males increased their levels of locomotion with repeated maternal separation, whereas females exhibited an increase in frequency of self-directed behavior, a measure of “depression-like” behavior. The short-allele predicted increased environmental exploration, particularly during the chronic phase of social separation, indicative of higher arousal. In addition, the short-allele carriers were more likely to increase their levels of self-directed behavior during the chronic phase of separation, as a function of repeated exposures. These findings suggest that the short allele may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable. En ligne : http://dx.doi.org/10.1017/S0954579411000745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder / Dennis VAN DER MEER in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)
[article]
Titre : The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Dennis VAN DER MEER, Auteur ; Catharina A. HARTMAN, Auteur ; Jennifer RICHARDS, Auteur ; Janita B. BRALTEN, Auteur ; Barbara FRANKE, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Stephen V. FARAONE, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur Article en page(s) : p.1363-1371 Langues : Anglais (eng) Mots-clés : ADHD gene–environment interaction (GxE) stress serotonin transporter (5-HTTLPR) Index. décimale : PER Périodiques Résumé : Introduction The role of the serotonin transporter gene polymorphism 5-HTTLPR in attention-deficit/hyperactivity disorder (ADHD) is unclear. Heterogeneity of findings may be explained by gene–environment interactions (GxE), as it has been suggested that S-allele carriers are more reactive to psychosocial stress than L-allele homozygotes. This study aimed to investigate whether 5-HTTLPR genotype moderates the effects of stress on ADHD in a multisite prospective ADHD cohort study. Methods 5-HTTLPR genotype, as well as the number of stressful life events in the past 5 years and ongoing long-term difficulties, was determined in 671 adolescents and young adults with ADHD, their siblings, and healthy controls (57.4% male, average age 17.3 years). Linear mixed models, accounting for family relatedness, were applied to investigate the effects of genotype, experienced stress, and their interaction on ADHD severity at time point T2, while controlling for ADHD severity at T1 (mean follow-up time 5.9 years) and for comorbid internalizing problems at T2. Results The interaction between genotype and stress significantly predicted ADHD severity at T2 (p = .006), which was driven by the effect on hyperactivity–impulsivity (p = .004). Probing of the interaction effect made clear that S-allele carriers had a significantly more positive correlation between stress and ADHD severity than L-allele homozygotes. Conclusion The results show that the interaction between 5-HTTLPR and stress is a mechanism involved particularly in the hyperactivity/impulsivity dimension of ADHD, and that this is independent of comorbid internalizing problems. Further research into the neurobiological mechanisms underlying this interaction effect is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1363-1371[article] The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Dennis VAN DER MEER, Auteur ; Catharina A. HARTMAN, Auteur ; Jennifer RICHARDS, Auteur ; Janita B. BRALTEN, Auteur ; Barbara FRANKE, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Stephen V. FARAONE, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur . - p.1363-1371.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1363-1371
Mots-clés : ADHD gene–environment interaction (GxE) stress serotonin transporter (5-HTTLPR) Index. décimale : PER Périodiques Résumé : Introduction The role of the serotonin transporter gene polymorphism 5-HTTLPR in attention-deficit/hyperactivity disorder (ADHD) is unclear. Heterogeneity of findings may be explained by gene–environment interactions (GxE), as it has been suggested that S-allele carriers are more reactive to psychosocial stress than L-allele homozygotes. This study aimed to investigate whether 5-HTTLPR genotype moderates the effects of stress on ADHD in a multisite prospective ADHD cohort study. Methods 5-HTTLPR genotype, as well as the number of stressful life events in the past 5 years and ongoing long-term difficulties, was determined in 671 adolescents and young adults with ADHD, their siblings, and healthy controls (57.4% male, average age 17.3 years). Linear mixed models, accounting for family relatedness, were applied to investigate the effects of genotype, experienced stress, and their interaction on ADHD severity at time point T2, while controlling for ADHD severity at T1 (mean follow-up time 5.9 years) and for comorbid internalizing problems at T2. Results The interaction between genotype and stress significantly predicted ADHD severity at T2 (p = .006), which was driven by the effect on hyperactivity–impulsivity (p = .004). Probing of the interaction effect made clear that S-allele carriers had a significantly more positive correlation between stress and ADHD severity than L-allele homozygotes. Conclusion The results show that the interaction between 5-HTTLPR and stress is a mechanism involved particularly in the hyperactivity/impulsivity dimension of ADHD, and that this is independent of comorbid internalizing problems. Further research into the neurobiological mechanisms underlying this interaction effect is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood / Elizabeth P. HAYDEN in Development and Psychopathology, 25-3 (August 2013)
[article]
Titre : The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth P. HAYDEN, Auteur ; Thomas M. OLINO, Auteur ; Sara J. BUFFERD, Auteur ; Anna MILLER, Auteur ; Lea R. DOUGHERTY, Auteur ; Haroon I. SHEIKH, Auteur ; Shiva M. SINGH, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.587-598 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Preliminary work indicates that cognitive vulnerability to depression may be associated with variants of the serotonin transporter promoter polymorphism (5-HTTLPR) and the valine to methionine at position 66 (val66met) polymorphism of the brain-derived neurotrophic factor (BDNF) gene; however, existing reports come from small samples. The present study sought to replicate and extend this research in a sample of 375 community-dwelling children and their parents. Following a negative mood induction, children completed a self-referent encoding task tapping memory for positive and negative self-descriptive traits. Consistent with previous work, we found that children with at least one short variant of the 5-HTTLPR had enhanced memory for negative self-descriptive traits. The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history. The findings provide further support for the notion that the 5-HTTLPR is associated with cognitive markers of depression vulnerability and that the BDNF methionine allele moderates children's sensitivity to contextual factors. En ligne : http://dx.doi.org/10.1017/S0954579413000035 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210
in Development and Psychopathology > 25-3 (August 2013) . - p.587-598[article] The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood [Texte imprimé et/ou numérique] / Elizabeth P. HAYDEN, Auteur ; Thomas M. OLINO, Auteur ; Sara J. BUFFERD, Auteur ; Anna MILLER, Auteur ; Lea R. DOUGHERTY, Auteur ; Haroon I. SHEIKH, Auteur ; Shiva M. SINGH, Auteur ; Daniel N. KLEIN, Auteur . - p.587-598.
Langues : Anglais (eng)
in Development and Psychopathology > 25-3 (August 2013) . - p.587-598
Index. décimale : PER Périodiques Résumé : Preliminary work indicates that cognitive vulnerability to depression may be associated with variants of the serotonin transporter promoter polymorphism (5-HTTLPR) and the valine to methionine at position 66 (val66met) polymorphism of the brain-derived neurotrophic factor (BDNF) gene; however, existing reports come from small samples. The present study sought to replicate and extend this research in a sample of 375 community-dwelling children and their parents. Following a negative mood induction, children completed a self-referent encoding task tapping memory for positive and negative self-descriptive traits. Consistent with previous work, we found that children with at least one short variant of the 5-HTTLPR had enhanced memory for negative self-descriptive traits. The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history. The findings provide further support for the notion that the 5-HTTLPR is associated with cognitive markers of depression vulnerability and that the BDNF methionine allele moderates children's sensitivity to contextual factors. En ligne : http://dx.doi.org/10.1017/S0954579413000035 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 The serotonin transporter promoter polymorphism moderates the continuity of behavioral inhibition in early childhood / Victoria C. JOHNSON in Development and Psychopathology, 28-4 pt1 (November 2016)
[article]
Titre : The serotonin transporter promoter polymorphism moderates the continuity of behavioral inhibition in early childhood Type de document : Texte imprimé et/ou numérique Auteurs : Victoria C. JOHNSON, Auteur ; Katie R. KRYSKI, Auteur ; Haroon I. SHEIKH, Auteur ; Heather J. SMITH, Auteur ; Shiva M. SINGH, Auteur ; Elizabeth P. HAYDEN, Auteur Article en page(s) : p.1103-1116 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Persistently elevated behavioral inhibition (BI) in children is a marker of vulnerability to psychopathology. However, little research has considered the joint influences of caregiver and child factors that may moderate the continuity of BI in early childhood, particularly genetic variants that may serve as markers of biological plasticity, such as the serotonin transporter linked polymorphic region (5-HTTLPR). We explored this issue in 371 preschoolers and their caregivers, examining whether parent characteristics (i.e., overinvolvement or anxiety disorder) and child 5-HTTLPR influenced the continuity of BI between ages 3 and 5. Measures were observational ratings of child BI, observational and questionnaire measures of parenting, and parent interviews for anxiety disorder history, and children were genotyped for the 5-HTTLPR. Parent factors did not moderate the association between age 3 and age 5 BI; however, child BI at age 3 interacted with children's 5-HTTLPR variants to predict age 5 BI, such that children with at least one copy of the short allele exhibited less continuity of BI over time relative to children without this putative plasticity variant. Findings are consistent with previous work indicating the 5-HTTLPR short variant increases plasticity to contextual influences, thereby serving to decrease the continuity of BI in early childhood. En ligne : http://dx.doi.org/10.1017/s0954579416000729 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt1 (November 2016) . - p.1103-1116[article] The serotonin transporter promoter polymorphism moderates the continuity of behavioral inhibition in early childhood [Texte imprimé et/ou numérique] / Victoria C. JOHNSON, Auteur ; Katie R. KRYSKI, Auteur ; Haroon I. SHEIKH, Auteur ; Heather J. SMITH, Auteur ; Shiva M. SINGH, Auteur ; Elizabeth P. HAYDEN, Auteur . - p.1103-1116.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt1 (November 2016) . - p.1103-1116
Index. décimale : PER Périodiques Résumé : Persistently elevated behavioral inhibition (BI) in children is a marker of vulnerability to psychopathology. However, little research has considered the joint influences of caregiver and child factors that may moderate the continuity of BI in early childhood, particularly genetic variants that may serve as markers of biological plasticity, such as the serotonin transporter linked polymorphic region (5-HTTLPR). We explored this issue in 371 preschoolers and their caregivers, examining whether parent characteristics (i.e., overinvolvement or anxiety disorder) and child 5-HTTLPR influenced the continuity of BI between ages 3 and 5. Measures were observational ratings of child BI, observational and questionnaire measures of parenting, and parent interviews for anxiety disorder history, and children were genotyped for the 5-HTTLPR. Parent factors did not moderate the association between age 3 and age 5 BI; however, child BI at age 3 interacted with children's 5-HTTLPR variants to predict age 5 BI, such that children with at least one copy of the short allele exhibited less continuity of BI over time relative to children without this putative plasticity variant. Findings are consistent with previous work indicating the 5-HTTLPR short variant increases plasticity to contextual influences, thereby serving to decrease the continuity of BI in early childhood. En ligne : http://dx.doi.org/10.1017/s0954579416000729 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 The setting-sun eye phenomenon in infancy / Lars CERNERUD in Developmental Medicine & Child Neurology, 17-4 (August 1975)
[article]
Titre : The setting-sun eye phenomenon in infancy Type de document : Texte imprimé et/ou numérique Auteurs : Lars CERNERUD, Auteur Année de publication : 1975 Article en page(s) : p.447-455 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440
in Developmental Medicine & Child Neurology > 17-4 (August 1975) . - p.447-455[article] The setting-sun eye phenomenon in infancy [Texte imprimé et/ou numérique] / Lars CERNERUD, Auteur . - 1975 . - p.447-455.
Langues : Anglais (eng)
in Developmental Medicine & Child Neurology > 17-4 (August 1975) . - p.447-455
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 The Severe End of the Spectrum: Insights and Opportunities from the Autism Inpatient Collection (AIC) / M. SIEGEL in Journal of Autism and Developmental Disorders, 48-11 (November 2018)
PermalinkThe sex ratios of anencephalics born to anencephalic-prone women / William H. JAMES in Developmental Medicine & Child Neurology, 22-5 (October 1980)
PermalinkThe Sex Ratios of Dyslexic Children and their Sibs / William H. JAMES in Developmental Medicine & Child Neurology, 34-6 (June 1992)
PermalinkThe sexual health, orientation, and activity of autistic adolescents and adults / E. WEIR in Autism Research, 14-11 (November 2021)
PermalinkThe significance of childhood competence and problems for adult success in work: A developmental cascade analysis / Ann S. MASTEN in Development and Psychopathology, 22-3 (August 2010)
PermalinkThe significance of motor handicap in the prognosis of childhood epilepsy / Matti SILLANPAA in Developmental Medicine & Child Neurology, 17-1 (February 1975)
PermalinkThe Sisters' Advantage? Broader Autism Phenotype Characteristics and Young Adults' Sibling Support / A. C. JENSEN in Journal of Autism and Developmental Disorders, 49-10 (October 2019)
PermalinkThe Situation Specificity of Youth Responses to Peer Provocation / Melanie A. DIRKS in Journal of Clinical Child & Adolescent Psychology, 36-4 (October-December 2007)
PermalinkThe sleeper effect of intimate partner violence exposure: long-term consequences on young children's aggressive behavior / Megan R. HOLMES in Journal of Child Psychology and Psychiatry, 54-9 (September 2013)
PermalinkThe Smiling Age of Preterm Babies / Barbara M. CROW in Developmental Medicine & Child Neurology, 21-2 (April 1979)
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