Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents / Justine Nienke PANNEKOEK in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1317-1327 Titre : Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents Type de document : texte imprimé Auteurs : Justine Nienke PANNEKOEK, Auteur ; S.J.A. VAN DER WERFF, Auteur ; Paul H.F. MEENS, Auteur ; Bianca G. VAN DEN BULK, Auteur ; Dietsje D. JOLLES, Auteur ; Ilya M. VEER, Auteur ; Natasja D.J. VAN LANG, Auteur ; Serge A.R.B. ROMBOUTS, Auteur ; Nic J.A. VAN DER WEE, Auteur ; Robert R.J.M. VERMEIREN, Auteur Article en page(s) : p.1317-1327 Langues : Anglais (eng) Mots-clés : Resting-state  adolescents  depression  anxiety Index. décimale : PER Périodiques Résumé : Background Depression is prevalent and typically has its onset in adolescence. Resting-state fMRI could help create a better understanding of the underlying neurobiological mechanisms during this critical period. In this study, resting-state functional connectivity (RSFC) is examined using seed regions-of-interest (ROIs) associated with three networks: the limbic network, the default mode network (DMN) and the salience network. Methods Twenty-six treatment-naïve, clinically depressed adolescents of whom 18 had comorbid anxiety, and 26 pair-wise matched healthy controls underwent resting-state fMRI. The three networks were investigated using a seed-based ROI approach with seeds in the bilateral amygdala (limbic network), bilateral dorsal anterior cingulate cortex (dACC; salience network) and bilateral posterior cingulate cortex (default mode network). Results Compared to healthy controls, clinically depressed adolescents showed increased RSFC of the left amygdala with right parietal cortical areas, and decreased right amygdala RSFC with left frontal cortical areas including the ACC, as well as with right occipito-parietal areas. The bilateral dACC showed decreased RSFC with the right middle frontal gyrus, frontal pole, and inferior frontal gyrus in clinically depressed adolescents. No abnormalities in DMN RSFC were found, and differences in RSFC did not correlate with clinical measures. Conclusions The aberrant RSFC of the amygdala network and the dACC network may be related to altered emotion processing and regulation in depressed adolescents. Our results provide new insights into RSFC in clinically depressed adolescents and future models on adolescent depression may include abnormalities in the connectivity of salience network. En ligne : http://dx.doi.org/10.1111/jcpp.12266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents [texte imprimé] / Justine Nienke PANNEKOEK, Auteur ; S.J.A. VAN DER WERFF, Auteur ; Paul H.F. MEENS, Auteur ; Bianca G. VAN DEN BULK, Auteur ; Dietsje D. JOLLES, Auteur ; Ilya M. VEER, Auteur ; Natasja D.J. VAN LANG, Auteur ; Serge A.R.B. ROMBOUTS, Auteur ; Nic J.A. VAN DER WEE, Auteur ; Robert R.J.M. VERMEIREN, Auteur . - p.1317-1327. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1317-1327 Mots-clés : Resting-state  adolescents  depression  anxiety Index. décimale : PER Périodiques Résumé : Background Depression is prevalent and typically has its onset in adolescence. Resting-state fMRI could help create a better understanding of the underlying neurobiological mechanisms during this critical period. In this study, resting-state functional connectivity (RSFC) is examined using seed regions-of-interest (ROIs) associated with three networks: the limbic network, the default mode network (DMN) and the salience network. Methods Twenty-six treatment-naïve, clinically depressed adolescents of whom 18 had comorbid anxiety, and 26 pair-wise matched healthy controls underwent resting-state fMRI. The three networks were investigated using a seed-based ROI approach with seeds in the bilateral amygdala (limbic network), bilateral dorsal anterior cingulate cortex (dACC; salience network) and bilateral posterior cingulate cortex (default mode network). Results Compared to healthy controls, clinically depressed adolescents showed increased RSFC of the left amygdala with right parietal cortical areas, and decreased right amygdala RSFC with left frontal cortical areas including the ACC, as well as with right occipito-parietal areas. The bilateral dACC showed decreased RSFC with the right middle frontal gyrus, frontal pole, and inferior frontal gyrus in clinically depressed adolescents. No abnormalities in DMN RSFC were found, and differences in RSFC did not correlate with clinical measures. Conclusions The aberrant RSFC of the amygdala network and the dACC network may be related to altered emotion processing and regulation in depressed adolescents. Our results provide new insights into RSFC in clinically depressed adolescents and future models on adolescent depression may include abnormalities in the connectivity of salience network. En ligne : http://dx.doi.org/10.1111/jcpp.12266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Developmental trajectories of depressive symptoms from early childhood to late adolescence: gender differences and adult outcome / Marielle C. DEKKER in Journal of Child Psychology and Psychiatry, 48-7 (July 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-7 (July 2007) . - p.657–666 Titre : Developmental trajectories of depressive symptoms from early childhood to late adolescence: gender differences and adult outcome Type de document : texte imprimé Auteurs : Marielle C. DEKKER, Auteur ; Natasja D.J. VAN LANG, Auteur ; Frank C. VERHULST, Auteur ; Jan VAN DER ENDE, Auteur ; Robert F. FERDINAND, Auteur ; Ilja L. BONGERS, Auteur Année de publication : 2007 Article en page(s) : p.657–666 Langues : Anglais (eng) Mots-clés : Depressive-symptoms growth-mixture-model developmental-trajectories depression child-development sex-differences longitudinal-studies Child-Behavioral-Checklist-(CBCL)adolescence adult-outcome Index. décimale : PER Périodiques Résumé : Background: Limited information is available on gender differences and young-adult poor outcome in children and adolescents following distinct developmental trajectories of depressive symptoms. Methods: Parent information on depressive symptoms of 4- to 18-year-olds from an ongoing Dutch community-based longitudinal multiple-cohort study (N = 2,076) was used to estimate trajectories from semi-parametric mixture models. The identified trajectories were used to predict depressive problems, general mental health problems, referral to mental health care, and educational attainment in young adulthood. Results: In both genders six distinct developmental trajectories were identified. Gender differences existed not only in level, but also in shape and timing of onset of depressive problems. Only in girls was a chronic trajectory of early childhood-onset depression identified. In both boys and girls a group with increasing levels of depressive symptoms was identified that reached a high level around adolescence, although boys showed an earlier onset. Two decreasing trajectories were found in boys, one reaching normative levels of depressive symptoms around late childhood and one around mid-adolescence, while none was found for girls. Individuals who followed elevated trajectories during their whole childhood or starting at adolescence had significantly more depressive and other mental health problems in young adulthood compared to those who followed normative trajectories. Boys in these elevated trajectories showed lower educational attainment, while girls were more likely to have been referred to mental health care. Conclusions: This study shows the value of estimating growth-mixture models separately for boys and girls. Girls with early childhood or adolescence-onset depressive problems and boys with depressive problems during childhood or starting in adolescence are especially at risk for poor outcome as young adults and should be considered candidates for intervention. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01742.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Developmental trajectories of depressive symptoms from early childhood to late adolescence: gender differences and adult outcome [texte imprimé] / Marielle C. DEKKER, Auteur ; Natasja D.J. VAN LANG, Auteur ; Frank C. VERHULST, Auteur ; Jan VAN DER ENDE, Auteur ; Robert F. FERDINAND, Auteur ; Ilja L. BONGERS, Auteur . - 2007 . - p.657–666. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-7 (July 2007) . - p.657–666 Mots-clés : Depressive-symptoms growth-mixture-model developmental-trajectories depression child-development sex-differences longitudinal-studies Child-Behavioral-Checklist-(CBCL)adolescence adult-outcome Index. décimale : PER Périodiques Résumé : Background: Limited information is available on gender differences and young-adult poor outcome in children and adolescents following distinct developmental trajectories of depressive symptoms. Methods: Parent information on depressive symptoms of 4- to 18-year-olds from an ongoing Dutch community-based longitudinal multiple-cohort study (N = 2,076) was used to estimate trajectories from semi-parametric mixture models. The identified trajectories were used to predict depressive problems, general mental health problems, referral to mental health care, and educational attainment in young adulthood. Results: In both genders six distinct developmental trajectories were identified. Gender differences existed not only in level, but also in shape and timing of onset of depressive problems. Only in girls was a chronic trajectory of early childhood-onset depression identified. In both boys and girls a group with increasing levels of depressive symptoms was identified that reached a high level around adolescence, although boys showed an earlier onset. Two decreasing trajectories were found in boys, one reaching normative levels of depressive symptoms around late childhood and one around mid-adolescence, while none was found for girls. Individuals who followed elevated trajectories during their whole childhood or starting at adolescence had significantly more depressive and other mental health problems in young adulthood compared to those who followed normative trajectories. Boys in these elevated trajectories showed lower educational attainment, while girls were more likely to have been referred to mental health care. Conclusions: This study shows the value of estimating growth-mixture models separately for boys and girls. Girls with early childhood or adolescence-onset depressive problems and boys with depressive problems during childhood or starting in adolescence are especially at risk for poor outcome as young adults and should be considered candidates for intervention. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01742.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

Different brain responses during empathy in autism spectrum disorders versus conduct disorder and callous-unemotional traits / Eduard T. KLAPWIJK in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.737-747 Titre : Different brain responses during empathy in autism spectrum disorders versus conduct disorder and callous-unemotional traits Type de document : texte imprimé Auteurs : Eduard T. KLAPWIJK, Auteur ; Moji AGHAJANI, Auteur ; Olivier F. COLINS, Auteur ; Godfried M. MARIJNISSEN, Auteur ; Arne POPMA, Auteur ; Natasja D.J. VAN LANG, Auteur ; Nic J.A. VAN DER WEE, Auteur ; Robert R.J.M. VERMEIREN, Auteur Article en page(s) : p.737-747 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  callous-unemotional  conduct disorder  emotions  empathy  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Background Deficits in empathy are reported in autism spectrum disorders (ASD) and also underlie antisocial behavior of individuals with conduct disorder and callous-unemotional traits (CD/CU+). Many studies suggest that individuals with ASD are typically impaired in cognitive aspects of empathy, and individuals with CD/CU+ typically in affective aspects. In the current study, we compared the neural correlates of cognitive and affective aspects of empathy between youth with ASD and youth with CD/CU+. Methods Functional magnetic resonance imaging (fMRI) was used to assess boys with ASD (N = 23), boys with CD/CU+ (N = 23), and typically developing (TD) boys (N = 33), aged 15–19 years. Angry and fearful faces were presented and participants were asked to either infer the emotional state from the face (other-task; emotion recognition) or to judge their own emotional response to the face (self-task; emotional resonance). Results During emotion recognition, boys with ASD showed reduced responses compared to the other groups in the ventromedial prefrontal cortex (vmPFC). During emotional resonance, the CD/CU+ and ASD groups showed reduced amygdala responses compared to the TD controls, boys with ASD showed reduced responses in bilateral hippocampus, and the CD/CU+ boys showed reduced responses in the inferior frontal gyrus (IFG) and anterior insula (AI). Conclusion Results suggest differential abnormal brain responses associated with specific aspects of empathic functioning in ASD and CD/CU+. Decreased amygdala responses in ASD and CD/CU+ might point to impaired emotion processing in both disorders, whereas reduced vmPFC responses suggest problems in processing cognitive aspects of empathy in ASD. Reduced IFG/AI responses, finally, suggest decreased emotional resonance in CD/CU+. En ligne : http://dx.doi.org/10.1111/jcpp.12498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Different brain responses during empathy in autism spectrum disorders versus conduct disorder and callous-unemotional traits [texte imprimé] / Eduard T. KLAPWIJK, Auteur ; Moji AGHAJANI, Auteur ; Olivier F. COLINS, Auteur ; Godfried M. MARIJNISSEN, Auteur ; Arne POPMA, Auteur ; Natasja D.J. VAN LANG, Auteur ; Nic J.A. VAN DER WEE, Auteur ; Robert R.J.M. VERMEIREN, Auteur . - p.737-747. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.737-747 Mots-clés : Autism spectrum disorders  callous-unemotional  conduct disorder  emotions  empathy  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Background Deficits in empathy are reported in autism spectrum disorders (ASD) and also underlie antisocial behavior of individuals with conduct disorder and callous-unemotional traits (CD/CU+). Many studies suggest that individuals with ASD are typically impaired in cognitive aspects of empathy, and individuals with CD/CU+ typically in affective aspects. In the current study, we compared the neural correlates of cognitive and affective aspects of empathy between youth with ASD and youth with CD/CU+. Methods Functional magnetic resonance imaging (fMRI) was used to assess boys with ASD (N = 23), boys with CD/CU+ (N = 23), and typically developing (TD) boys (N = 33), aged 15–19 years. Angry and fearful faces were presented and participants were asked to either infer the emotional state from the face (other-task; emotion recognition) or to judge their own emotional response to the face (self-task; emotional resonance). Results During emotion recognition, boys with ASD showed reduced responses compared to the other groups in the ventromedial prefrontal cortex (vmPFC). During emotional resonance, the CD/CU+ and ASD groups showed reduced amygdala responses compared to the TD controls, boys with ASD showed reduced responses in bilateral hippocampus, and the CD/CU+ boys showed reduced responses in the inferior frontal gyrus (IFG) and anterior insula (AI). Conclusion Results suggest differential abnormal brain responses associated with specific aspects of empathic functioning in ASD and CD/CU+. Decreased amygdala responses in ASD and CD/CU+ might point to impaired emotion processing in both disorders, whereas reduced vmPFC responses suggest problems in processing cognitive aspects of empathy in ASD. Reduced IFG/AI responses, finally, suggest decreased emotional resonance in CD/CU+. En ligne : http://dx.doi.org/10.1111/jcpp.12498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Differential Fairness Decisions and Brain Responses After Expressed Emotions of Others in Boys with Autism Spectrum Disorders / Eduard T. KLAPWIJK in Journal of Autism and Developmental Disorders, 47-8 (August 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-8 (August 2017) . - p.2390-2400 Titre : Differential Fairness Decisions and Brain Responses After Expressed Emotions of Others in Boys with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Eduard T. KLAPWIJK, Auteur ; Moji AGHAJANI, Auteur ; Gert-Jan LELIEVELD, Auteur ; Natasja D.J. VAN LANG, Auteur ; Arne POPMA, Auteur ; Nic J.A. VAN DER WEE, Auteur ; Olivier F. COLINS, Auteur ; Robert R.J.M. VERMEIREN, Auteur Article en page(s) : p.2390-2400 Langues : Anglais (eng) Mots-clés : Social decision-making  Autism spectrum disorders  Interpersonal effects of emotions  Dictator game  fMRI Index. décimale : PER Périodiques Résumé : Little is known about how emotions expressed by others influence social decisions and associated brain responses in autism spectrum disorders (ASD). We investigated the neural mechanisms underlying fairness decisions in response to explicitly expressed emotions of others in boys with ASD and typically developing (TD) boys. Participants with ASD adjusted their allocation behavior in response to the emotions but reacted less unfair than TD controls in response to happiness. We also found reduced brain responses in the precental gyrus in the ASD versus TD group when receiving happy versus angry reactions and autistic traits were positively associated with activity in the postcentral gyrus. These results provide indications for a role of precentral and postcentral gyrus in social-affective difficulties in ASD. En ligne : https://doi.org/10.1007/s10803-017-3159-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314 [article] Differential Fairness Decisions and Brain Responses After Expressed Emotions of Others in Boys with Autism Spectrum Disorders [texte imprimé] / Eduard T. KLAPWIJK, Auteur ; Moji AGHAJANI, Auteur ; Gert-Jan LELIEVELD, Auteur ; Natasja D.J. VAN LANG, Auteur ; Arne POPMA, Auteur ; Nic J.A. VAN DER WEE, Auteur ; Olivier F. COLINS, Auteur ; Robert R.J.M. VERMEIREN, Auteur . - p.2390-2400. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-8 (August 2017) . - p.2390-2400 Mots-clés : Social decision-making  Autism spectrum disorders  Interpersonal effects of emotions  Dictator game  fMRI Index. décimale : PER Périodiques Résumé : Little is known about how emotions expressed by others influence social decisions and associated brain responses in autism spectrum disorders (ASD). We investigated the neural mechanisms underlying fairness decisions in response to explicitly expressed emotions of others in boys with ASD and typically developing (TD) boys. Participants with ASD adjusted their allocation behavior in response to the emotions but reacted less unfair than TD controls in response to happiness. We also found reduced brain responses in the precental gyrus in the ASD versus TD group when receiving happy versus angry reactions and autistic traits were positively associated with activity in the postcentral gyrus. These results provide indications for a role of precentral and postcentral gyrus in social-affective difficulties in ASD. En ligne : https://doi.org/10.1007/s10803-017-3159-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314

Evaluation of the ADOS Revised Algorithm: The Applicability in 558 Dutch Children and Adolescents / Annelies A. DE BILDT in Journal of Autism and Developmental Disorders, 39-9 (September 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-9 (September 2009) . - p.1350-1358 Titre : Evaluation of the ADOS Revised Algorithm: The Applicability in 558 Dutch Children and Adolescents Type de document : texte imprimé Auteurs : Annelies A. DE BILDT, Auteur ; Natasja D.J. VAN LANG, Auteur ; Sjoerd SYTEMA, Auteur ; Ruud B. MINDERAA, Auteur ; Herman VAN ENGELAND, Auteur ; Maretha V. DE JONGE, Auteur Année de publication : 2009 Article en page(s) : p.1350-1358 Note générale : Open Access Langues : Anglais (eng) Mots-clés : ADOS Autism ASD Diagnosis Index. décimale : PER Périodiques Résumé : The revised ADOS algorithms, proposed by Gotham et al. (J Autism Dev Disord 37:613–627, 2007), were investigated in an independent sample of 558 Dutch children (modules 1, 2 and 3). The revised algorithms lead to better balanced sensitivity and specificity for modules 2 and 3, without losing efficiency of the classification. Including the restricted repetitive behaviour domain in the algorithm contributes to a clinical ASD classification in modules 2 and 3. For module 1, the results indicate less improvement, probably due to the low-functioning population. In most groups, the advantages of the revised algorithms are achieved without losing the strength of the original algorithm. En ligne : http://dx.doi.org/10.1007/s10803-009-0749-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=815 [article] Evaluation of the ADOS Revised Algorithm: The Applicability in 558 Dutch Children and Adolescents [texte imprimé] / Annelies A. DE BILDT, Auteur ; Natasja D.J. VAN LANG, Auteur ; Sjoerd SYTEMA, Auteur ; Ruud B. MINDERAA, Auteur ; Herman VAN ENGELAND, Auteur ; Maretha V. DE JONGE, Auteur . - 2009 . - p.1350-1358. Open Access Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-9 (September 2009) . - p.1350-1358 Mots-clés : ADOS Autism ASD Diagnosis Index. décimale : PER Périodiques Résumé : The revised ADOS algorithms, proposed by Gotham et al. (J Autism Dev Disord 37:613–627, 2007), were investigated in an independent sample of 558 Dutch children (modules 1, 2 and 3). The revised algorithms lead to better balanced sensitivity and specificity for modules 2 and 3, without losing efficiency of the classification. Including the restricted repetitive behaviour domain in the algorithm contributes to a clinical ASD classification in modules 2 and 3. For module 1, the results indicate less improvement, probably due to the low-functioning population. In most groups, the advantages of the revised algorithms are achieved without losing the strength of the original algorithm. En ligne : http://dx.doi.org/10.1007/s10803-009-0749-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=815

A new symptom model for autism cross-validated in an independent sample / Anne BOOMSMA in Journal of Child Psychology and Psychiatry, 49-8 (August 2008)  

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Standardized ADOS Scores: Measuring Severity of Autism Spectrum Disorders in a Dutch Sample / Annelies A. DE BILDT in Journal of Autism and Developmental Disorders, 41-3 (March 2011)  

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Structural equation analysis of a hypothesised symptom model in the autism spectrum / Natasja D.J. VAN LANG in Journal of Child Psychology and Psychiatry, 47-1 (January 2006)  

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The visual rooting reflex in individuals with autism spectrum disorders and co-occurring intellectual disability / Annelies A. DE BILDT in Autism Research, 5-1 (February 2012)  

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Validity of the Children’s Social Behavior Questionnaire (CSBQ) in Children with Intellectual Disability: Comparing the CSBQ with ADI-R, ADOS, and Clinical DSM-IV-TR Classification / Annelies A. DE BILDT in Journal of Autism and Developmental Disorders, 39-10 (October 2009)  

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