[article]
| Titre : |
Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses |
| Type de document : |
texte imprimé |
| Auteurs : |
Amirhossein MODABBERNIA, Auteur ; Eva VELTHORST, Auteur ; Abraham REICHENBERG, Auteur |
| Article en page(s) : |
13p. |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Spectrum Disorder/*etiology Delivery, Obstetric/*adverse effects Environmental Exposure/*adverse effects Female Humans Metals, Heavy/*toxicity Parents Pregnancy Prospective Studies Risk Factors *Autism spectrum disorders *Environment *Epigenetics *Gene-environment interaction *Metals *Nutrition *Pregnancy prenatal *Toxin *Vaccine |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: According to recent evidence, up to 40-50% of variance in autism spectrum disorder (ASD) liability might be determined by environmental factors. In the present paper, we conducted a review of systematic reviews and meta-analyses of environmental risk factors for ASD. We assessed each review for quality of evidence and provided a brief overview of putative mechanisms of environmental risk factors for ASD. FINDINGS: Current evidence suggests that several environmental factors including vaccination, maternal smoking, thimerosal exposure, and most likely assisted reproductive technologies are unrelated to risk of ASD. On the contrary, advanced parental age is associated with higher risk of ASD. Birth complications that are associated with trauma or ischemia and hypoxia have also shown strong links to ASD, whereas other pregnancy-related factors such as maternal obesity, maternal diabetes, and caesarian section have shown a less strong (but significant) association with risk of ASD. The reviews on nutritional elements have been inconclusive about the detrimental effects of deficiency in folic acid and omega 3, but vitamin D seems to be deficient in patients with ASD. The studies on toxic elements have been largely limited by their design, but there is enough evidence for the association between some heavy metals (most important inorganic mercury and lead) and ASD that warrants further investigation. Mechanisms of the association between environmental factors and ASD are debated but might include non-causative association (including confounding), gene-related effect, oxidative stress, inflammation, hypoxia/ischemia, endocrine disruption, neurotransmitter alterations, and interference with signaling pathways. CONCLUSIONS: Compared to genetic studies of ASD, studies of environmental risk factors are in their infancy and have significant methodological limitations. Future studies of ASD risk factors would benefit from a developmental psychopathology approach, prospective design, precise exposure measurement, reliable timing of exposure in relation to critical developmental periods and should take into account the dynamic interplay between gene and environment by using genetically informed designs. |
| En ligne : |
http://dx.doi.org/10.1186/s13229-017-0121-4 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 |
in Molecular Autism > 8 (2017) . - 13p.
[article] Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses [texte imprimé] / Amirhossein MODABBERNIA, Auteur ; Eva VELTHORST, Auteur ; Abraham REICHENBERG, Auteur . - 13p. Langues : Anglais ( eng) in Molecular Autism > 8 (2017) . - 13p.
| Mots-clés : |
Autism Spectrum Disorder/*etiology Delivery, Obstetric/*adverse effects Environmental Exposure/*adverse effects Female Humans Metals, Heavy/*toxicity Parents Pregnancy Prospective Studies Risk Factors *Autism spectrum disorders *Environment *Epigenetics *Gene-environment interaction *Metals *Nutrition *Pregnancy prenatal *Toxin *Vaccine |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: According to recent evidence, up to 40-50% of variance in autism spectrum disorder (ASD) liability might be determined by environmental factors. In the present paper, we conducted a review of systematic reviews and meta-analyses of environmental risk factors for ASD. We assessed each review for quality of evidence and provided a brief overview of putative mechanisms of environmental risk factors for ASD. FINDINGS: Current evidence suggests that several environmental factors including vaccination, maternal smoking, thimerosal exposure, and most likely assisted reproductive technologies are unrelated to risk of ASD. On the contrary, advanced parental age is associated with higher risk of ASD. Birth complications that are associated with trauma or ischemia and hypoxia have also shown strong links to ASD, whereas other pregnancy-related factors such as maternal obesity, maternal diabetes, and caesarian section have shown a less strong (but significant) association with risk of ASD. The reviews on nutritional elements have been inconclusive about the detrimental effects of deficiency in folic acid and omega 3, but vitamin D seems to be deficient in patients with ASD. The studies on toxic elements have been largely limited by their design, but there is enough evidence for the association between some heavy metals (most important inorganic mercury and lead) and ASD that warrants further investigation. Mechanisms of the association between environmental factors and ASD are debated but might include non-causative association (including confounding), gene-related effect, oxidative stress, inflammation, hypoxia/ischemia, endocrine disruption, neurotransmitter alterations, and interference with signaling pathways. CONCLUSIONS: Compared to genetic studies of ASD, studies of environmental risk factors are in their infancy and have significant methodological limitations. Future studies of ASD risk factors would benefit from a developmental psychopathology approach, prospective design, precise exposure measurement, reliable timing of exposure in relation to critical developmental periods and should take into account the dynamic interplay between gene and environment by using genetically informed designs. |
| En ligne : |
http://dx.doi.org/10.1186/s13229-017-0121-4 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 |
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Faire une suggestion Affiner la rechercheAcide folique, multivitamines et nutriments pendant la grossesse et autisme in Bulletin Scientifique de l'arapi (Le), 40 (Hiver 2017)
Parental and Perinatal Risk Factors for Autism: Epidemiological Findings and Potential Mechanisms
