Adverse family life events during pregnancy and ADHD symptoms in five-year-old offspring / Mina A. ROSENQVIST in Journal of Child Psychology and Psychiatry, 60-6 (June 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.665-675 Titre : Adverse family life events during pregnancy and ADHD symptoms in five-year-old offspring Type de document : texte imprimé Auteurs : Mina A. ROSENQVIST, Auteur ; A. SJOLANDER, Auteur ; Eivind YSTRØM, Auteur ; Henrik LARSSON, Auteur ; Ted REICHBORN-KJENNERUD, Auteur Article en page(s) : p.665-675 Langues : Anglais (eng) Mots-clés : Adhd  MoBa  adverse life events  antenatal stress  delayed effects  prenatal exposures  the Norwegian Mother and Child Cohort Study Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to maternal adverse life events has been associated with offspring ADHD, but the role of familial confounding is unclear. We aimed to clarify if adverse life events during pregnancy are related to ADHD symptoms in offspring, taking shared familial factors into account. METHOD: Data were collected on 34,751 children (including 6,427 siblings) participating in the population-based Norwegian Mother and Child Cohort Study. During pregnancy, mothers reported whether they had experienced specific life events. We assessed ADHD symptoms in five-year-old children with the Conners' Parent Rating Scale-Revised: short form. We modeled the associations between life events and mean ADHD scores with ordinary linear regression in the full cohort, and with fixed-effect linear regression in sibling comparisons to adjust for familial confounding. RESULTS: Children exposed to adverse life events had higher ADHD scores at age 5, with the strongest effect observed for financial problems (mean differences 0.10 [95% CI: 0.09, 0.11] in adjusted model), and the weakest for having lost someone close (0.02 [95% CI 0.01, 0.04] in adjusted model). Comparing exposure-discordant siblings resulted in attenuated estimates that were no longer statistically significant (e.g. mean difference for financial problems -0.03 [95% CI -0.07, 0.02]). ADHD scores increased if the mother had experienced the event as painful or difficult, and with the number of events, whereas sibling-comparison analyses resulted in estimates attenuated toward the null. CONCLUSIONS: These results suggest that the association between adverse life events during pregnancy and offspring ADHD symptoms is largely explained by familial factors. En ligne : http://dx.doi.org/10.1111/jcpp.12990 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Adverse family life events during pregnancy and ADHD symptoms in five-year-old offspring [texte imprimé] / Mina A. ROSENQVIST, Auteur ; A. SJOLANDER, Auteur ; Eivind YSTRØM, Auteur ; Henrik LARSSON, Auteur ; Ted REICHBORN-KJENNERUD, Auteur . - p.665-675. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.665-675 Mots-clés : Adhd  MoBa  adverse life events  antenatal stress  delayed effects  prenatal exposures  the Norwegian Mother and Child Cohort Study Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to maternal adverse life events has been associated with offspring ADHD, but the role of familial confounding is unclear. We aimed to clarify if adverse life events during pregnancy are related to ADHD symptoms in offspring, taking shared familial factors into account. METHOD: Data were collected on 34,751 children (including 6,427 siblings) participating in the population-based Norwegian Mother and Child Cohort Study. During pregnancy, mothers reported whether they had experienced specific life events. We assessed ADHD symptoms in five-year-old children with the Conners' Parent Rating Scale-Revised: short form. We modeled the associations between life events and mean ADHD scores with ordinary linear regression in the full cohort, and with fixed-effect linear regression in sibling comparisons to adjust for familial confounding. RESULTS: Children exposed to adverse life events had higher ADHD scores at age 5, with the strongest effect observed for financial problems (mean differences 0.10 [95% CI: 0.09, 0.11] in adjusted model), and the weakest for having lost someone close (0.02 [95% CI 0.01, 0.04] in adjusted model). Comparing exposure-discordant siblings resulted in attenuated estimates that were no longer statistically significant (e.g. mean difference for financial problems -0.03 [95% CI -0.07, 0.02]). ADHD scores increased if the mother had experienced the event as painful or difficult, and with the number of events, whereas sibling-comparison analyses resulted in estimates attenuated toward the null. CONCLUSIONS: These results suggest that the association between adverse life events during pregnancy and offspring ADHD symptoms is largely explained by familial factors. En ligne : http://dx.doi.org/10.1111/jcpp.12990 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Age effects on autism heritability and etiological stability of autistic traits / Agnieszka BUTWICKA ; Ebba DU RIETZ ; Aleksandra KANINA ; Mina A. ROSENQVIST ; Henrik LARSSON ; Paul LICHTENSTEIN ; Mark J. TAYLOR in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1135-1144 Titre : Age effects on autism heritability and etiological stability of autistic traits Type de document : texte imprimé Auteurs : Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Mina A. ROSENQVIST, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Mark J. TAYLOR, Auteur Article en page(s) : p.1135-1144 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Autism and autistic traits onset in childhood but persist into adulthood. Little is known about how genetic and environmental factors influence autism and autistic traits into adulthood. We aimed to determine age effects on the heritability of clinically diagnosed autism and the etiological stability of autistic traits from childhood to adulthood using twin methods. Methods From 23,849 twin pairs in the Swedish Twin Register born between 1959 and 2010, we identified 485 individuals (1.01%, 31.5% female) with a clinical autism diagnosis. We estimated and compared the relative contribution of genetic, shared, and nonshared environmental influences to autism in childhood and adulthood. We further used multivariate twin analysis with four measurement points among 1,348 twin pairs in the longitudinal Twin Study of Child and Adolescent Development to assess the phenotypic and etiological stability of autistic traits - measured with three scales from the Child Behavior Checklist - from childhood to adulthood. Results Autism heritability was comparable from childhood, (96% [95% CI, 76-99%]) to adulthood (87% [67-96%]). Autistic traits were moderately stable (phenotypic correlation = 0.35-0.61) from childhood to adulthood, and their heritability varied between 52 and 71%. We observed stable as well as newly emerging genetic influences on autistic traits from ages 8-9 to 19-20, and unique nonshared environmental influences at each age. Conclusions Genetic factors are important for autism and autistic traits in adulthood and separate genetic studies in adults are warranted. En ligne : https://doi.org/10.1111/jcpp.13949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Age effects on autism heritability and etiological stability of autistic traits [texte imprimé] / Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Mina A. ROSENQVIST, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Mark J. TAYLOR, Auteur . - p.1135-1144. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1135-1144 Index. décimale : PER Périodiques Résumé : Background Autism and autistic traits onset in childhood but persist into adulthood. Little is known about how genetic and environmental factors influence autism and autistic traits into adulthood. We aimed to determine age effects on the heritability of clinically diagnosed autism and the etiological stability of autistic traits from childhood to adulthood using twin methods. Methods From 23,849 twin pairs in the Swedish Twin Register born between 1959 and 2010, we identified 485 individuals (1.01%, 31.5% female) with a clinical autism diagnosis. We estimated and compared the relative contribution of genetic, shared, and nonshared environmental influences to autism in childhood and adulthood. We further used multivariate twin analysis with four measurement points among 1,348 twin pairs in the longitudinal Twin Study of Child and Adolescent Development to assess the phenotypic and etiological stability of autistic traits - measured with three scales from the Child Behavior Checklist - from childhood to adulthood. Results Autism heritability was comparable from childhood, (96% [95% CI, 76-99%]) to adulthood (87% [67-96%]). Autistic traits were moderately stable (phenotypic correlation = 0.35-0.61) from childhood to adulthood, and their heritability varied between 52 and 71%. We observed stable as well as newly emerging genetic influences on autistic traits from ages 8-9 to 19-20, and unique nonshared environmental influences at each age. Conclusions Genetic factors are important for autism and autistic traits in adulthood and separate genetic studies in adults are warranted. En ligne : https://doi.org/10.1111/jcpp.13949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort / Paul LICHTENSTEIN in Journal of Child Psychology and Psychiatry, 61-7 (July 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-7 (July 2020) . - p.798-806 Titre : Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort Type de document : texte imprimé Auteurs : Paul LICHTENSTEIN, Auteur ; Martin CEDERLÖF, Auteur ; Sebastian LUNDSTROM, Auteur ; Brian M. D'ONOFRIO, Auteur ; Henrik ANCKARSATER, Auteur ; Henrik LARSSON, Auteur ; Erik PETTERSSON, Auteur Article en page(s) : p.798-806 Langues : Anglais (eng) Mots-clés : Twins  comorbidity  conduct disorder  externalizing disorder  internalizing disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: We examined whether childhood conduct problems predicted a wide range of adverse outcomes in emerging adulthood and whether the association with internalizing problems remained after adjusting for general comorbidity and externalizing problems. METHODS: Participants were 18,649 twins from the Child and Adolescent Twin Study in Sweden. At age 9/12, parents rated their children on eight conduct problems. Adverse outcomes were retrieved from national registers in emerging adulthood (median follow-up time = 9.2 years), including diagnoses of six psychiatric disorders, prescriptions of antidepressants, suicide attempts, criminality, high school ineligibility, and social welfare recipiency. We estimated risk for the separate outcomes and examined if conduct problems predicted an internalizing factor above and beyond a general comorbidity and an externalizing factor. We used twin analyses to estimate genetic and environmental contributions to these associations. RESULTS: On the average, each additional conduct symptom in childhood was associated with a 32% increased risk of the adverse outcomes in emerging adulthood (mean hazard ratio = 1.32; range = 1.16, 1.56). A latent childhood conduct problems factor predicted the internalizing factor in emerging adulthood (β(boys) = .24, standard error, SE = 0.03; β(girls) = .17, SE = 0.03), above and beyond its association with the externalizing (β(boys) = 0.21, SE = 0.04; β(girls) = 0.17, SE = 0.05) and general factors (β(boys) = 0.45, SE = 0.03; β(girls) = 0.34, SE = 0.04). These associations were differentially influenced by genetic and environmental factors. CONCLUSIONS: It is important to monitor boys and girls with conduct problems not only for future externalizing problems, but also for future internalizing problems. Prevention of specific outcomes, however, might require interventions at different levels. En ligne : http://dx.doi.org/10.1111/jcpp.13169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort [texte imprimé] / Paul LICHTENSTEIN, Auteur ; Martin CEDERLÖF, Auteur ; Sebastian LUNDSTROM, Auteur ; Brian M. D'ONOFRIO, Auteur ; Henrik ANCKARSATER, Auteur ; Henrik LARSSON, Auteur ; Erik PETTERSSON, Auteur . - p.798-806. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-7 (July 2020) . - p.798-806 Mots-clés : Twins  comorbidity  conduct disorder  externalizing disorder  internalizing disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: We examined whether childhood conduct problems predicted a wide range of adverse outcomes in emerging adulthood and whether the association with internalizing problems remained after adjusting for general comorbidity and externalizing problems. METHODS: Participants were 18,649 twins from the Child and Adolescent Twin Study in Sweden. At age 9/12, parents rated their children on eight conduct problems. Adverse outcomes were retrieved from national registers in emerging adulthood (median follow-up time = 9.2 years), including diagnoses of six psychiatric disorders, prescriptions of antidepressants, suicide attempts, criminality, high school ineligibility, and social welfare recipiency. We estimated risk for the separate outcomes and examined if conduct problems predicted an internalizing factor above and beyond a general comorbidity and an externalizing factor. We used twin analyses to estimate genetic and environmental contributions to these associations. RESULTS: On the average, each additional conduct symptom in childhood was associated with a 32% increased risk of the adverse outcomes in emerging adulthood (mean hazard ratio = 1.32; range = 1.16, 1.56). A latent childhood conduct problems factor predicted the internalizing factor in emerging adulthood (β(boys) = .24, standard error, SE = 0.03; β(girls) = .17, SE = 0.03), above and beyond its association with the externalizing (β(boys) = 0.21, SE = 0.04; β(girls) = 0.17, SE = 0.05) and general factors (β(boys) = 0.45, SE = 0.03; β(girls) = 0.34, SE = 0.04). These associations were differentially influenced by genetic and environmental factors. CONCLUSIONS: It is important to monitor boys and girls with conduct problems not only for future externalizing problems, but also for future internalizing problems. Prevention of specific outcomes, however, might require interventions at different levels. En ligne : http://dx.doi.org/10.1111/jcpp.13169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs / Cen CHEN in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1513-1522 Titre : Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs Type de document : texte imprimé Auteurs : Cen CHEN, Auteur ; Yi LU, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Erik PETTERSSON, Auteur Article en page(s) : p.1513-1522 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Twins, Dizygotic  Longitudinal Studies  Psychopathology  Mental Disorders/epidemiology/genetics  Risk Factors  Attention Deficit Disorder with Hyperactivity/epidemiology  General factor of psychopathology  genetic nurture  multi-polygenic score  polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. METHODS: The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n=2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (ÃŽ2) and then within DZ twin pairs (ÃŽ2(w) ), which controls for indirect pathways. RESULTS: In childhood, the PRS for ADHD predicted general psychopathology (ÃŽ2=0.09, 95% CI: [0.06, 0.12]; ÃŽ2(w) =0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (ÃŽ2=0.04 [0.00, 0.08]; ÃŽ2(w) =0.09 [0.01, 0.17]) and specific hyperactivity (ÃŽ2=0.07 [0.04, 0.11]; ÃŽ2(w) =0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (ÃŽ2=0.08 [0.03, 0.13]; ÃŽ2(w) =0.19 [0.08, 0.30]) and specific inattention problems (ÃŽ2=0.05 [0.01, 0.09]; ÃŽ2(w) =0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (ÃŽ2=0.06 [0.02, 0.10]; ÃŽ2(w) =0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. CONCLUSIONS: This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology. En ligne : http://dx.doi.org/10.1111/jcpp.13605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs [texte imprimé] / Cen CHEN, Auteur ; Yi LU, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Erik PETTERSSON, Auteur . - p.1513-1522. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1513-1522 Mots-clés : Adolescent  Humans  Twins, Dizygotic  Longitudinal Studies  Psychopathology  Mental Disorders/epidemiology/genetics  Risk Factors  Attention Deficit Disorder with Hyperactivity/epidemiology  General factor of psychopathology  genetic nurture  multi-polygenic score  polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. METHODS: The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n=2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (ÃŽ2) and then within DZ twin pairs (ÃŽ2(w) ), which controls for indirect pathways. RESULTS: In childhood, the PRS for ADHD predicted general psychopathology (ÃŽ2=0.09, 95% CI: [0.06, 0.12]; ÃŽ2(w) =0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (ÃŽ2=0.04 [0.00, 0.08]; ÃŽ2(w) =0.09 [0.01, 0.17]) and specific hyperactivity (ÃŽ2=0.07 [0.04, 0.11]; ÃŽ2(w) =0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (ÃŽ2=0.08 [0.03, 0.13]; ÃŽ2(w) =0.19 [0.08, 0.30]) and specific inattention problems (ÃŽ2=0.05 [0.01, 0.09]; ÃŽ2(w) =0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (ÃŽ2=0.06 [0.02, 0.10]; ÃŽ2(w) =0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. CONCLUSIONS: This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology. En ligne : http://dx.doi.org/10.1111/jcpp.13605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Bidirectional relationship between eating disorders and autoimmune diseases / Anna HEDMAN in Journal of Child Psychology and Psychiatry, 60-7 (July 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.803-812 Titre : Bidirectional relationship between eating disorders and autoimmune diseases Type de document : texte imprimé Auteurs : Anna HEDMAN, Auteur ; Lauren BREITHAUPT, Auteur ; C. HUBEL, Auteur ; Laura M. THORNTON, Auteur ; Annika TILLANDER, Auteur ; Claes NORRING, Auteur ; A. BIRGEGARD, Auteur ; Henrik LARSSON, Auteur ; Jonas F. LUDVIGSSON, Auteur ; L. SAVENDAHL, Auteur ; Catarina ALMQVIST, Auteur ; Cynthia M. BULIK, Auteur Article en page(s) : p.803-812 Langues : Anglais (eng) Mots-clés : anorexia nervosa  autoimmunity  bulimia nervosa  cox regression  hazard  immune system  risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Immune system dysfunction may be associated with eating disorders (ED) and could have implications for detection, risk assessment, and treatment of both autoimmune diseases and EDs. However, questions regarding the nature of the relationship between these two disease entities remain. We evaluated the strength of associations for the bidirectional relationships between EDs and autoimmune diseases. METHODS: In this nationwide population-based study, Swedish registers were linked to establish a cohort of more than 2.5 million individuals born in Sweden between January 1, 1979 and December 31, 2005 and followed up until December 2013. Cox proportional hazard regression models were used to investigate: (a) subsequent risk of EDs in individuals with autoimmune diseases; and (b) subsequent risk of autoimmune diseases in individuals with EDs. RESULTS: We observed a strong, bidirectional relationship between the two illness classes indicating that diagnosis in one illness class increased the risk of the other. In women, the diagnoses of autoimmune disease increased subsequent hazards of anorexia nervosa (AN), bulimia nervosa (BN), and other eating disorders (OED). Similarly, AN, BN, and OED increased subsequent hazards of autoimmune diseases.Gastrointestinal-related autoimmune diseases such as, celiac disease and Crohn's disease showed a bidirectional relationship with AN and OED. Psoriasis showed a bidirectional relationship with OED. The previous occurence of type 1 diabetes increased the risk for AN, BN, and OED. In men, we did not observe a bidirectional pattern, but prior autoimmune arthritis increased the risk for OED. CONCLUSIONS: The interactions between EDs and autoimmune diseases support the previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.12958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Bidirectional relationship between eating disorders and autoimmune diseases [texte imprimé] / Anna HEDMAN, Auteur ; Lauren BREITHAUPT, Auteur ; C. HUBEL, Auteur ; Laura M. THORNTON, Auteur ; Annika TILLANDER, Auteur ; Claes NORRING, Auteur ; A. BIRGEGARD, Auteur ; Henrik LARSSON, Auteur ; Jonas F. LUDVIGSSON, Auteur ; L. SAVENDAHL, Auteur ; Catarina ALMQVIST, Auteur ; Cynthia M. BULIK, Auteur . - p.803-812. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.803-812 Mots-clés : anorexia nervosa  autoimmunity  bulimia nervosa  cox regression  hazard  immune system  risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Immune system dysfunction may be associated with eating disorders (ED) and could have implications for detection, risk assessment, and treatment of both autoimmune diseases and EDs. However, questions regarding the nature of the relationship between these two disease entities remain. We evaluated the strength of associations for the bidirectional relationships between EDs and autoimmune diseases. METHODS: In this nationwide population-based study, Swedish registers were linked to establish a cohort of more than 2.5 million individuals born in Sweden between January 1, 1979 and December 31, 2005 and followed up until December 2013. Cox proportional hazard regression models were used to investigate: (a) subsequent risk of EDs in individuals with autoimmune diseases; and (b) subsequent risk of autoimmune diseases in individuals with EDs. RESULTS: We observed a strong, bidirectional relationship between the two illness classes indicating that diagnosis in one illness class increased the risk of the other. In women, the diagnoses of autoimmune disease increased subsequent hazards of anorexia nervosa (AN), bulimia nervosa (BN), and other eating disorders (OED). Similarly, AN, BN, and OED increased subsequent hazards of autoimmune diseases.Gastrointestinal-related autoimmune diseases such as, celiac disease and Crohn's disease showed a bidirectional relationship with AN and OED. Psoriasis showed a bidirectional relationship with OED. The previous occurence of type 1 diabetes increased the risk for AN, BN, and OED. In men, we did not observe a bidirectional pattern, but prior autoimmune arthritis increased the risk for OED. CONCLUSIONS: The interactions between EDs and autoimmune diseases support the previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.12958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

Birth weight as an independent predictor of ADHD symptoms: a within-twin pair analysis / Erik PETTERSSON in Journal of Child Psychology and Psychiatry, 56-4 (April 2015)  

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Childhood and adolescence outcomes in offspring to parents with bipolar disorder: the impact of lifetime parental comorbidity, parental sex, and bipolar subtype / Mengping ZHOU ; Marcus BOMAN ; Arvid SJÖLANDER ; Henrik LARSSON ; Brian M. D'ONOFRIO ; Erik PETTERSSON ; Paul LICHTENSTEIN ; Mikael LANDÉN in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

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Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 53-1 (January 2012)  

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Childhood Neurodevelopmental Disorders and Violent Criminality: A Sibling Control Study / Sebastian LUNDSTROM in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

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Codevelopment of ADHD and externalizing behavior from childhood to adulthood / Ralf KUJA-HALKOLA in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

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Commentary: How can family-based quasi-experimental designs and national registers be used to address confounding in risk factor studies of psychopathology? A reflection on Obel et al. (2016) / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)  

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Commentary: Important design features to consider in observational research on the long-term outcomes of ADHD – reflections on Sibley et al. (2017) and Swanson et al. (2017) / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)  

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Commentary: Psychopathic traits enhance adolescents’ influence on others and make them less easily influenced by others? – reflections on Kerr et al. (2012) / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 53-8 (August 2012)  

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Developmental trajectories of DSM-IV symptoms of attention-deficit/hyperactivity disorder: genetic effects, family risk and associated psychopathology / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 52-9 (September 2011)  

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Etiological links between autism and difficulties in initiating and maintaining sleep: a familial co-aggregation and twin study / Margot J. TAYLOR in Journal of Child Psychology and Psychiatry, 63-3 (March 2022)  

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