Brief Report: Prevalence of Autistic Spectrum Disorders in the Sultanate of Oman / Yahya M. AL-FARSI in Journal of Autism and Developmental Disorders, 41-6 (June 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-6 (June 2011) . - p.821-825 Titre : Brief Report: Prevalence of Autistic Spectrum Disorders in the Sultanate of Oman Type de document : Texte imprimé et/ou numérique Auteurs : Yahya M. AL-FARSI, Auteur ; Marwan M. AL-SHARBATI, Auteur ; Omar A. AL-FARSI, Auteur ; Mohammed A. AL SHAFAEE, Auteur ; Daniel R. BROOKS, Auteur ; Mostafa WALY, Auteur Année de publication : 2011 Article en page(s) : p.821-825 Langues : Anglais (eng) Mots-clés : Autism  ASD  Prevalence  Symptoms  Oman Index. décimale : PER Périodiques Résumé : Prevalence of autistic spectrum disorders (ASD) in Oman is unknown. We conducted a cross-sectional study to estimate the prevalence of ASD among 0–14 year old children. Diagnoses were made as per DSM-IV-TR criteria and supplemented with information collected with the standard Childhood Autism Rating Scale (CARS) questionnaire. A total 113 cases of ASD were enumerated nationwide, indicating an overall prevalence of 1.4 (95% CI 1.2, 1.7) cases per 10,000 children aged 0–14 years. More prevalent cases were among boys (75%) and among low-income families. Ritualistic interests were more common among girls as an onset-symptom compared to boys (p = 0.03). The reported low prevalence of ASD in Oman is likely due to under-diagnosis and under-reporting. En ligne : http://dx.doi.org/10.1007/s10803-010-1094-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=127 [article] Brief Report: Prevalence of Autistic Spectrum Disorders in the Sultanate of Oman [Texte imprimé et/ou numérique] / Yahya M. AL-FARSI, Auteur ; Marwan M. AL-SHARBATI, Auteur ; Omar A. AL-FARSI, Auteur ; Mohammed A. AL SHAFAEE, Auteur ; Daniel R. BROOKS, Auteur ; Mostafa WALY, Auteur . - 2011 . - p.821-825. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-6 (June 2011) . - p.821-825 Mots-clés : Autism  ASD  Prevalence  Symptoms  Oman Index. décimale : PER Périodiques Résumé : Prevalence of autistic spectrum disorders (ASD) in Oman is unknown. We conducted a cross-sectional study to estimate the prevalence of ASD among 0–14 year old children. Diagnoses were made as per DSM-IV-TR criteria and supplemented with information collected with the standard Childhood Autism Rating Scale (CARS) questionnaire. A total 113 cases of ASD were enumerated nationwide, indicating an overall prevalence of 1.4 (95% CI 1.2, 1.7) cases per 10,000 children aged 0–14 years. More prevalent cases were among boys (75%) and among low-income families. Ritualistic interests were more common among girls as an onset-symptom compared to boys (p = 0.03). The reported low prevalence of ASD in Oman is likely due to under-diagnosis and under-reporting. En ligne : http://dx.doi.org/10.1007/s10803-010-1094-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=127

Malnutrition among preschool-aged autistic children in Oman / Yahya M. AL-FARSI in Research in Autism Spectrum Disorders, 5-4 (October-December 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-4 (October-December 2011) . - p.1549-1552 Titre : Malnutrition among preschool-aged autistic children in Oman Type de document : Texte imprimé et/ou numérique Auteurs : Yahya M. AL-FARSI, Auteur ; Marwan M. AL-SHARBATI, Auteur ; Mostafa WALY, Auteur ; Omar A. AL-FARSI, Auteur ; Mohammed A. AL SHAFAEE, Auteur ; Richard DETH, Auteur Année de publication : 2011 Article en page(s) : p.1549-1552 Langues : Anglais (eng) Mots-clés : Malnutrition  Stunting  Underweight  Wasting  Autism  Oman Index. décimale : PER Périodiques Résumé : To assess prevalence of malnutrition indicators among preschool children with autism spectrum disorder (ASD) a cross-sectional study was conducted among 128 Omani autistic children 3–5 years of age. Based on standardized z-scores, the overall prevalence of malnutrition was 9.2 per 100 preschool ASD children (95% CI 4.1, 11.6). The most common type of malnutrition was underweight (3.9; 95% CI 0.5, 7.3), followed by wasting (3.1; 95% CI 0.1, 6.1) and stunting (2.3; 95% CI 0.3, 5.0). Among boys, underweight and stunting were significantly higher than in girls, while wasting was more prevalent among girls. None of the participants showed evidence of overweight or obesity. The study indicates an overall tendency among autistic Omani children towards being malnourished. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.02.018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126 [article] Malnutrition among preschool-aged autistic children in Oman [Texte imprimé et/ou numérique] / Yahya M. AL-FARSI, Auteur ; Marwan M. AL-SHARBATI, Auteur ; Mostafa WALY, Auteur ; Omar A. AL-FARSI, Auteur ; Mohammed A. AL SHAFAEE, Auteur ; Richard DETH, Auteur . - 2011 . - p.1549-1552. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-4 (October-December 2011) . - p.1549-1552 Mots-clés : Malnutrition  Stunting  Underweight  Wasting  Autism  Oman Index. décimale : PER Périodiques Résumé : To assess prevalence of malnutrition indicators among preschool children with autism spectrum disorder (ASD) a cross-sectional study was conducted among 128 Omani autistic children 3–5 years of age. Based on standardized z-scores, the overall prevalence of malnutrition was 9.2 per 100 preschool ASD children (95% CI 4.1, 11.6). The most common type of malnutrition was underweight (3.9; 95% CI 0.5, 7.3), followed by wasting (3.1; 95% CI 0.1, 6.1) and stunting (2.3; 95% CI 0.3, 5.0). Among boys, underweight and stunting were significantly higher than in girls, while wasting was more prevalent among girls. None of the participants showed evidence of overweight or obesity. The study indicates an overall tendency among autistic Omani children towards being malnourished. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.02.018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126

Oxidative Stress in Autism and Its Implications for Dopamine-Stimulated Phospholipid Methylation / Richard DETH

Public ISBD contenu dans The Neurochemical Basis of Autism / Gene J. BLATT Titre : Oxidative Stress in Autism and Its Implications for Dopamine-Stimulated Phospholipid Methylation Type de document : Texte imprimé et/ou numérique Auteurs : Richard DETH, Auteur ; Christina MURATORE, Auteur ; Mostafa WALY, Auteur Année de publication : 2010 Importance : p.185-199 Langues : Anglais (eng) Mots-clés : Réaction d'oxydoréduction  Dopamine  Neuroinflammation  Vaccination Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=109 contenu dans The Neurochemical Basis of Autism / Gene J. BLATT Oxidative Stress in Autism and Its Implications for Dopamine-Stimulated Phospholipid Methylation [Texte imprimé et/ou numérique] / Richard DETH, Auteur ; Christina MURATORE, Auteur ; Mostafa WALY, Auteur . - 2010 . - p.185-199. Langues : Anglais (eng) Mots-clés : Réaction d'oxydoréduction  Dopamine  Neuroinflammation  Vaccination Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=109

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Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism / Mostafa WALY in Autism Research and Treatment, (May 2012)  

Public ISBD [article]  inAutism Research and Treatment > (May 2012) . - 13 p. Titre : Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Mostafa WALY, Auteur ; Mady HORNIG, Auteur ; Malav TRIVEDI, Auteur ; Nathaniel HODGSON, Auteur ; Radhika KINI, Auteur ; Akio OHTA, Auteur ; Richard DETH, Auteur Année de publication : 2012 Article en page(s) : 13 p. Langues : Anglais (eng) Mots-clés : Maladie gastro-intestinale Index. décimale : PER Périodiques Résumé : Although autism is first and foremost a disorder of the central nervous system, comorbid dysfunction of the gastrointestinal (GI) and immune systems is common, suggesting that all three systems may be affected by common molecular mechanisms. Substantial systemic deficits in the antioxidant glutathione and its precursor, cysteine, have been documented in autism in association with oxidative stress and impaired methylation. DNA and histone methylation provide epigenetic regulation of gene expression during prenatal and postnatal development. Prenatal epigenetic programming (PrEP) can be affected by the maternal metabolic and nutritional environment, whereas postnatal epigenetic programming (PEP) importantly depends upon nutritional support provided through the GI tract. Cysteine absorption from the GI tract is a crucial determinant of antioxidant capacity, and systemic deficits of glutathione and cysteine in autism are likely to reflect impaired cysteine absorption. Excitatory amino acid transporter 3 (EAAT3) provides cysteine uptake for GI epithelial, neuronal, and immune cells, and its activity is decreased during oxidative stress. Based upon these observations, we propose that neurodevelopmental, GI, and immune aspects of autism each reflect manifestations of inadequate antioxidant capacity, secondary to impaired cysteine uptake by the GI tract. Genetic and environmental factors that adversely affect antioxidant capacity can disrupt PrEP and/or PEP, increasing vulnerability to autism. En ligne : http://dx.doi.org/10.1155/2012/190930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism [Texte imprimé et/ou numérique] / Mostafa WALY, Auteur ; Mady HORNIG, Auteur ; Malav TRIVEDI, Auteur ; Nathaniel HODGSON, Auteur ; Radhika KINI, Auteur ; Akio OHTA, Auteur ; Richard DETH, Auteur . - 2012 . - 13 p. Langues : Anglais (eng) in Autism Research and Treatment > (May 2012) . - 13 p. Mots-clés : Maladie gastro-intestinale Index. décimale : PER Périodiques Résumé : Although autism is first and foremost a disorder of the central nervous system, comorbid dysfunction of the gastrointestinal (GI) and immune systems is common, suggesting that all three systems may be affected by common molecular mechanisms. Substantial systemic deficits in the antioxidant glutathione and its precursor, cysteine, have been documented in autism in association with oxidative stress and impaired methylation. DNA and histone methylation provide epigenetic regulation of gene expression during prenatal and postnatal development. Prenatal epigenetic programming (PrEP) can be affected by the maternal metabolic and nutritional environment, whereas postnatal epigenetic programming (PEP) importantly depends upon nutritional support provided through the GI tract. Cysteine absorption from the GI tract is a crucial determinant of antioxidant capacity, and systemic deficits of glutathione and cysteine in autism are likely to reflect impaired cysteine absorption. Excitatory amino acid transporter 3 (EAAT3) provides cysteine uptake for GI epithelial, neuronal, and immune cells, and its activity is decreased during oxidative stress. Based upon these observations, we propose that neurodevelopmental, GI, and immune aspects of autism each reflect manifestations of inadequate antioxidant capacity, secondary to impaired cysteine uptake by the GI tract. Genetic and environmental factors that adversely affect antioxidant capacity can disrupt PrEP and/or PEP, increasing vulnerability to autism. En ligne : http://dx.doi.org/10.1155/2012/190930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Variation in Socio-Economic Burden for Caring of Children with Autism Spectrum Disorder in Oman: Caregiver Perspectives / Yahya M. AL-FARSI in Journal of Autism and Developmental Disorders, 43-5 (May 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1214-1221 Titre : Variation in Socio-Economic Burden for Caring of Children with Autism Spectrum Disorder in Oman: Caregiver Perspectives Type de document : Texte imprimé et/ou numérique Auteurs : Yahya M. AL-FARSI, Auteur ; Mostafa WALY, Auteur ; Marwan M. AL-SHARBATI, Auteur ; Mohamed AL-SHAFAEE, Auteur ; Omar A. AL-FARSI, Auteur ; Samiya AL-FAHDI, Auteur ; Allal OUHTIT, Auteur ; Maha AL-KHADURI, Auteur ; Samir AL-ADAWI, Auteur Article en page(s) : p.1214-1221 Langues : Anglais (eng) Mots-clés : Socio-economic burden  Autism  ASD  Caregiver  Oman Index. décimale : PER Périodiques Résumé : A cross-sectional study was conducted to investigate whether caregiver’s variations in socioeconomic status (SES) has direct bearing on challenges of nurturing children with autism spectrum disorder (ASD) in Oman. A cadre of caregivers (n = 150) from two types of SES (low-income and middle-high income) were compared based on four domains: (1) accessing and perception of remedial services, (2) utilization and perception of psychiatric services, (3) constraints for being a caregiver of children with ASD and (4) financial expenses of taking care of children with ASD. There is little indication that any particular SES fare well on these domains. Factors to mitigate such predicaments are therefore imperative in order to improve quality of life for caregivers among children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1667-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195 [article] Variation in Socio-Economic Burden for Caring of Children with Autism Spectrum Disorder in Oman: Caregiver Perspectives [Texte imprimé et/ou numérique] / Yahya M. AL-FARSI, Auteur ; Mostafa WALY, Auteur ; Marwan M. AL-SHARBATI, Auteur ; Mohamed AL-SHAFAEE, Auteur ; Omar A. AL-FARSI, Auteur ; Samiya AL-FAHDI, Auteur ; Allal OUHTIT, Auteur ; Maha AL-KHADURI, Auteur ; Samir AL-ADAWI, Auteur . - p.1214-1221. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1214-1221 Mots-clés : Socio-economic burden  Autism  ASD  Caregiver  Oman Index. décimale : PER Périodiques Résumé : A cross-sectional study was conducted to investigate whether caregiver’s variations in socioeconomic status (SES) has direct bearing on challenges of nurturing children with autism spectrum disorder (ASD) in Oman. A cadre of caregivers (n = 150) from two types of SES (low-income and middle-high income) were compared based on four domains: (1) accessing and perception of remedial services, (2) utilization and perception of psychiatric services, (3) constraints for being a caregiver of children with ASD and (4) financial expenses of taking care of children with ASD. There is little indication that any particular SES fare well on these domains. Factors to mitigate such predicaments are therefore imperative in order to improve quality of life for caregivers among children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1667-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195

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