Dépouillements

Post-school needs of young people with high-functioning Autism Spectrum Disorder / Philippa NEARY in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.1-11 Titre : Post-school needs of young people with high-functioning Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Philippa NEARY, Auteur ; Linda GILMORE, Auteur ; Jill ASHBURNER, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  High-functioning ASD  Post-school outcomes  Adults  Service needs Index. décimale : PER Périodiques Résumé : Abstract This study describes the post-school circumstances and service needs of older teenagers and adults with high-functioning Autism Spectrum Disorder, living in Queensland, Australia. The respondents were 95 parents. Results indicated that the majority of the young people lived in the family home and were unemployed. Of those who worked, 56% had unskilled jobs. They were estimated to spend a significant proportion of their time engaged in solitary, technology-based activities, and comparatively little time in employment or socialising. Parents rated employment support as the greatest service priority for their sons and daughters, followed by specialised support to assist with completing post-school education and training, assistance to support the transition from high school to adulthood, and social skills training. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.06.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Post-school needs of young people with high-functioning Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Philippa NEARY, Auteur ; Linda GILMORE, Auteur ; Jill ASHBURNER, Auteur . - p.1-11. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.1-11 Mots-clés : Autism Spectrum Disorder  High-functioning ASD  Post-school outcomes  Adults  Service needs Index. décimale : PER Périodiques Résumé : Abstract This study describes the post-school circumstances and service needs of older teenagers and adults with high-functioning Autism Spectrum Disorder, living in Queensland, Australia. The respondents were 95 parents. Results indicated that the majority of the young people lived in the family home and were unemployed. Of those who worked, 56% had unskilled jobs. They were estimated to spend a significant proportion of their time engaged in solitary, technology-based activities, and comparatively little time in employment or socialising. Parents rated employment support as the greatest service priority for their sons and daughters, followed by specialised support to assist with completing post-school education and training, assistance to support the transition from high school to adulthood, and social skills training. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.06.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder / Chang-Jiang YANG in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.12-20 Titre : The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; He-Ping WANG, Auteur ; Chun-Ling LIU, Auteur ; Hui-Zhong HE, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur Article en page(s) : p.12-20 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Repetitive behaviors  Cortisol  Serotonin  Oxytocin Index. décimale : PER Périodiques Résumé : Abstract Repetitive behaviors (RBs) are a core feature of autism spectrum disorders (ASD). They constitute a major barrier to learning and social adaptation. Research on potential causes of RBs is still at an early stage. However, promising new ideas and evidence are emerging from neurobiology. Instead of testing single neurotransmitter or hormone, the present study examined the associations of cortisol, serotonin, and oxytocin on subscales of repetitive behavior scales-revised (RBS-R). The results demonstrated that the individuals with ASD showed higher levels of cortisol areas under curve (cortisol AUC), higher levels of serotonin, and lower level of oxytocin compared with the typically developing (TD) individuals. For individuals with ASD, the levels of cortisol AUC, serotonin and oxytocin were all significantly associated with total scores measured by RBS-R. In addition, the cortisol AUC was positively associated with the stereotyped and restricted behavior subscales scores. The level of serotonin was positively associated with the stereotyped and self-injurious behavior subscales scores. The level of oxytocin was negatively associated with compulsive, sameness and restricted behavior subscales scores. Therefore, cortisol, serotonin and oxytocin may all be involved in the occurrence of RBs in ASD. The occurrence of RBs in ASD may due to a variety of pathological factors, not just one factor. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder [Texte imprimé et/ou numérique] / Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; He-Ping WANG, Auteur ; Chun-Ling LIU, Auteur ; Hui-Zhong HE, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur . - p.12-20. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.12-20 Mots-clés : Autism spectrum disorders  Repetitive behaviors  Cortisol  Serotonin  Oxytocin Index. décimale : PER Périodiques Résumé : Abstract Repetitive behaviors (RBs) are a core feature of autism spectrum disorders (ASD). They constitute a major barrier to learning and social adaptation. Research on potential causes of RBs is still at an early stage. However, promising new ideas and evidence are emerging from neurobiology. Instead of testing single neurotransmitter or hormone, the present study examined the associations of cortisol, serotonin, and oxytocin on subscales of repetitive behavior scales-revised (RBS-R). The results demonstrated that the individuals with ASD showed higher levels of cortisol areas under curve (cortisol AUC), higher levels of serotonin, and lower level of oxytocin compared with the typically developing (TD) individuals. For individuals with ASD, the levels of cortisol AUC, serotonin and oxytocin were all significantly associated with total scores measured by RBS-R. In addition, the cortisol AUC was positively associated with the stereotyped and restricted behavior subscales scores. The level of serotonin was positively associated with the stereotyped and self-injurious behavior subscales scores. The level of oxytocin was negatively associated with compulsive, sameness and restricted behavior subscales scores. Therefore, cortisol, serotonin and oxytocin may all be involved in the occurrence of RBs in ASD. The occurrence of RBs in ASD may due to a variety of pathological factors, not just one factor. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Autism spectrum disorders: An historical synthesis and a multidimensional assessment toward a tailored therapeutic program / Jean XAVIER in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.21-33 Titre : Autism spectrum disorders: An historical synthesis and a multidimensional assessment toward a tailored therapeutic program Type de document : Texte imprimé et/ou numérique Auteurs : Jean XAVIER, Auteur ; Claude BURSZTEJN, Auteur ; Maitri STISKIN, Auteur ; Roberto CANITANO, Auteur ; David COHEN, Auteur Article en page(s) : p.21-33 Langues : Anglais (eng) Mots-clés : Categorical  Developmental  Multidimensional assessment  Integrative perspective  Tailored therapeutic proposal Index. décimale : PER Périodiques Résumé : Abstract Autism is a large group of disorders. From the first description in 1943 until know, attempts to propose nosological boundaries, through successive redefinitions of diagnostic criteria, have not succeeded in constraining the extensiveness nor in explaining the heterogeneity of autism. The failure of the categorical approach is revealed by several indices, including excessive comorbidity, the frequent use of Not Otherwise Specified categories and diagnostic uncertainty in borderline cases. Several proposals have been formulated to categorize subgroups of children with complex severe developmental disorders but less severe trajectories than typical autism. The diversity and overlap in their clinical expression emphasize the importance of using a multidimensional assessment inscribed in a developmental perspective. In this way, clinicians could encompass the issues of the categorical approach, address the child holistically and then achieve a functional diagnosis enabling the elaboration of a tailored therapeutic proposal. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.06.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Autism spectrum disorders: An historical synthesis and a multidimensional assessment toward a tailored therapeutic program [Texte imprimé et/ou numérique] / Jean XAVIER, Auteur ; Claude BURSZTEJN, Auteur ; Maitri STISKIN, Auteur ; Roberto CANITANO, Auteur ; David COHEN, Auteur . - p.21-33. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.21-33 Mots-clés : Categorical  Developmental  Multidimensional assessment  Integrative perspective  Tailored therapeutic proposal Index. décimale : PER Périodiques Résumé : Abstract Autism is a large group of disorders. From the first description in 1943 until know, attempts to propose nosological boundaries, through successive redefinitions of diagnostic criteria, have not succeeded in constraining the extensiveness nor in explaining the heterogeneity of autism. The failure of the categorical approach is revealed by several indices, including excessive comorbidity, the frequent use of Not Otherwise Specified categories and diagnostic uncertainty in borderline cases. Several proposals have been formulated to categorize subgroups of children with complex severe developmental disorders but less severe trajectories than typical autism. The diversity and overlap in their clinical expression emphasize the importance of using a multidimensional assessment inscribed in a developmental perspective. In this way, clinicians could encompass the issues of the categorical approach, address the child holistically and then achieve a functional diagnosis enabling the elaboration of a tailored therapeutic proposal. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.06.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

The effectiveness of self-management interventions for children with autism—A literature review / Elian ALJADEFF-ABERGEL in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.34-50 Titre : The effectiveness of self-management interventions for children with autism—A literature review Type de document : Texte imprimé et/ou numérique Auteurs : Elian ALJADEFF-ABERGEL, Auteur ; Yannick SCHENK, Auteur ; Christopher WALMSLEY, Auteur ; Stephanie M. PETERSON, Auteur ; Jessica E. FRIEDER, Auteur ; Nicholas ACKER, Auteur Article en page(s) : p.34-50 Langues : Anglais (eng) Mots-clés : Autism  Self-management  Effective treatments  Literature review Index. décimale : PER Périodiques Résumé : Abstract In 2009 the National Autism Center published its initial National Standards Project (NSP) report detailing a list of existing treatments for individuals with autism. Recently, the report was updated and was made available to the public in April 2015. The 2015 report divided treatments into three categories: established, emerging, and unestablished. Among the 11 treatments identified as established, self-management interventions for children with autism were included. Although self-management was found to be effective, the NSP did not evaluate the extent to which this treatment has been studied in natural settings versus clinical/laboratory and mixed settings, nor the social validity of the treatments. Having knowledge on the effectiveness of a treatment in the natural setting and its social validity can assist teachers and parents in making better decisions regarding the adoption of a treatment. The purpose of this review is to extend the NSP report by evaluating the social validity of self-management interventions for individuals with autism, evaluate the extent to which these interventions have been conducted in the natural setting (as opposed to a clinical setting), and to provide a second evaluation of the methodological quality of these studies. Results of this review suggest that, self-management interventions for children with autism are effective in natural, clinical, and mixed settings. However, few studies have provided a formal evaluation of social validity. There are also some limitations to the methodological quality of the studies that should be considered for future research. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] The effectiveness of self-management interventions for children with autism—A literature review [Texte imprimé et/ou numérique] / Elian ALJADEFF-ABERGEL, Auteur ; Yannick SCHENK, Auteur ; Christopher WALMSLEY, Auteur ; Stephanie M. PETERSON, Auteur ; Jessica E. FRIEDER, Auteur ; Nicholas ACKER, Auteur . - p.34-50. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.34-50 Mots-clés : Autism  Self-management  Effective treatments  Literature review Index. décimale : PER Périodiques Résumé : Abstract In 2009 the National Autism Center published its initial National Standards Project (NSP) report detailing a list of existing treatments for individuals with autism. Recently, the report was updated and was made available to the public in April 2015. The 2015 report divided treatments into three categories: established, emerging, and unestablished. Among the 11 treatments identified as established, self-management interventions for children with autism were included. Although self-management was found to be effective, the NSP did not evaluate the extent to which this treatment has been studied in natural settings versus clinical/laboratory and mixed settings, nor the social validity of the treatments. Having knowledge on the effectiveness of a treatment in the natural setting and its social validity can assist teachers and parents in making better decisions regarding the adoption of a treatment. The purpose of this review is to extend the NSP report by evaluating the social validity of self-management interventions for individuals with autism, evaluate the extent to which these interventions have been conducted in the natural setting (as opposed to a clinical setting), and to provide a second evaluation of the methodological quality of these studies. Results of this review suggest that, self-management interventions for children with autism are effective in natural, clinical, and mixed settings. However, few studies have provided a formal evaluation of social validity. There are also some limitations to the methodological quality of the studies that should be considered for future research. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

A comparison of the effects of rhythm and robotic interventions on repetitive behaviors and affective states of children with Autism Spectrum Disorder (ASD) / Sudha M. SRINIVASAN in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.51-63 Titre : A comparison of the effects of rhythm and robotic interventions on repetitive behaviors and affective states of children with Autism Spectrum Disorder (ASD) Type de document : Texte imprimé et/ou numérique Auteurs : Sudha M. SRINIVASAN, Auteur ; Isabel K. PARK, Auteur ; Linda B. NEELLY, Auteur ; Anjana N. BHAT, Auteur Article en page(s) : p.51-63 Langues : Anglais (eng) Mots-clés : Music  Rhythm  Robots  Autism  Repetitive behaviors  Affective states  Multisystem interventions Index. décimale : PER Périodiques Résumé : Abstract Repetitive behaviors and poor affect regulation are commonly seen in children with Autism Spectrum Disorder (ASD). We compared the effects of two novel interventions—rhythm and robotic therapies, with those of a standard-of-care intervention, on the repetitive behaviors and affective states of 36 children with ASD between 5 and 12 years using a randomized controlled trial design. We coded for frequencies of sensory, negative, and stereotyped behaviors and the duration of positive, negative, and interested affective states in children during early, mid, and late training sessions. In terms of repetitive behaviors, in the early session, the rhythm and robot groups engaged in greater negative behaviors, whereas the comparison group engaged in greater sensory behaviors. With training, the rhythm group reduced negative behaviors whereas there were no training-related changes in the other groups. In terms of affective states, the rhythm and robot groups showed greater negative affect, whereas the comparison group demonstrated greater interested affect across all sessions. With training, the rhythm group showed a reduction in negative affect and an increase in interested affect whereas the robot group showed a reduction in positive affect. Overall, it appears that rhythm-based interventions are socially engaging treatment tools to target core impairments in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] A comparison of the effects of rhythm and robotic interventions on repetitive behaviors and affective states of children with Autism Spectrum Disorder (ASD) [Texte imprimé et/ou numérique] / Sudha M. SRINIVASAN, Auteur ; Isabel K. PARK, Auteur ; Linda B. NEELLY, Auteur ; Anjana N. BHAT, Auteur . - p.51-63. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.51-63 Mots-clés : Music  Rhythm  Robots  Autism  Repetitive behaviors  Affective states  Multisystem interventions Index. décimale : PER Périodiques Résumé : Abstract Repetitive behaviors and poor affect regulation are commonly seen in children with Autism Spectrum Disorder (ASD). We compared the effects of two novel interventions—rhythm and robotic therapies, with those of a standard-of-care intervention, on the repetitive behaviors and affective states of 36 children with ASD between 5 and 12 years using a randomized controlled trial design. We coded for frequencies of sensory, negative, and stereotyped behaviors and the duration of positive, negative, and interested affective states in children during early, mid, and late training sessions. In terms of repetitive behaviors, in the early session, the rhythm and robot groups engaged in greater negative behaviors, whereas the comparison group engaged in greater sensory behaviors. With training, the rhythm group reduced negative behaviors whereas there were no training-related changes in the other groups. In terms of affective states, the rhythm and robot groups showed greater negative affect, whereas the comparison group demonstrated greater interested affect across all sessions. With training, the rhythm group showed a reduction in negative affect and an increase in interested affect whereas the robot group showed a reduction in positive affect. Overall, it appears that rhythm-based interventions are socially engaging treatment tools to target core impairments in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Disruptive mood dysregulation disorder (DMDD) symptoms in children with autism, ADHD, and neurotypical development and impact of co-occurring ODD, depression, and anxiety / S. D. MAYES in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.64-72 Titre : Disruptive mood dysregulation disorder (DMDD) symptoms in children with autism, ADHD, and neurotypical development and impact of co-occurring ODD, depression, and anxiety Type de document : Texte imprimé et/ou numérique Auteurs : S. D. MAYES, Auteur ; J. WAXMONSKY, Auteur ; Susan L. CALHOUN, Auteur ; C. KOKOTOVICH, Auteur ; C. MATHIOWETZ, Auteur ; R. BAWEJA, Auteur Article en page(s) : p.64-72 Langues : Anglais (eng) Mots-clés : Disruptive mood dysregulation disorder  Autism  ADHD  ODD  Neurotypical Index. décimale : PER Périodiques Résumé : Abstract Disruptive mood dysregulation disorder (DMDD) is a controversial diagnosis introduced in the DSM-5 that is particularly relevant to autism and other disorders in which DMDD symptoms (irritable-angry mood and temper outbursts) are common. Mothers rated DMDD symptoms in 1593 children with autism, ADHD, and neurotypical development (6–16 years, IQ ? 80). Percentages with DMDD symptoms (often or very often) were autism 45%, ADHD-Combined type 39%, ADHD-Inattentive type 12%, and neurotypical 3%. Almost all (91%) with DMDD symptoms met DSM-5 criteria for ODD, and 79% with ODD had DMDD symptoms. Only 5% without ODD had DMDD symptoms, and most of these had autism. Children with autism had significantly higher DMDD scores than all other groups, even when the oppositional behavior score (excluding the two DMDD symptoms) was controlled. The findings suggest that DMDD and ODD are not meaningfully differentiated based on their symptoms and that DMDD symptoms are particularly common in autism, more so than expected by comorbid ODD alone. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Disruptive mood dysregulation disorder (DMDD) symptoms in children with autism, ADHD, and neurotypical development and impact of co-occurring ODD, depression, and anxiety [Texte imprimé et/ou numérique] / S. D. MAYES, Auteur ; J. WAXMONSKY, Auteur ; Susan L. CALHOUN, Auteur ; C. KOKOTOVICH, Auteur ; C. MATHIOWETZ, Auteur ; R. BAWEJA, Auteur . - p.64-72. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.64-72 Mots-clés : Disruptive mood dysregulation disorder  Autism  ADHD  ODD  Neurotypical Index. décimale : PER Périodiques Résumé : Abstract Disruptive mood dysregulation disorder (DMDD) is a controversial diagnosis introduced in the DSM-5 that is particularly relevant to autism and other disorders in which DMDD symptoms (irritable-angry mood and temper outbursts) are common. Mothers rated DMDD symptoms in 1593 children with autism, ADHD, and neurotypical development (6–16 years, IQ ? 80). Percentages with DMDD symptoms (often or very often) were autism 45%, ADHD-Combined type 39%, ADHD-Inattentive type 12%, and neurotypical 3%. Almost all (91%) with DMDD symptoms met DSM-5 criteria for ODD, and 79% with ODD had DMDD symptoms. Only 5% without ODD had DMDD symptoms, and most of these had autism. Children with autism had significantly higher DMDD scores than all other groups, even when the oppositional behavior score (excluding the two DMDD symptoms) was controlled. The findings suggest that DMDD and ODD are not meaningfully differentiated based on their symptoms and that DMDD symptoms are particularly common in autism, more so than expected by comorbid ODD alone. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.73-82 Titre : Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Aisha S. DICKERSON, Auteur ; Manouchehr HESSABI, Auteur ; Katherine A. LOVELAND, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.73-82 Langues : Anglais (eng) Mots-clés : Manganese  Autism Spectrum Disorder (ASD)  Glutathione-S-transferase (GST) genes  Oxidative stress  Interactions  Jamaica Index. décimale : PER Périodiques Résumé : Abstract We used data from 100 age- and sex-matched case-control pairs (age 2–8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ? 12 ?g/L had about 4 times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ? 12 ?g/L had about six times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.08.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Aisha S. DICKERSON, Auteur ; Manouchehr HESSABI, Auteur ; Katherine A. LOVELAND, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur . - p.73-82. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.73-82 Mots-clés : Manganese  Autism Spectrum Disorder (ASD)  Glutathione-S-transferase (GST) genes  Oxidative stress  Interactions  Jamaica Index. décimale : PER Périodiques Résumé : Abstract We used data from 100 age- and sex-matched case-control pairs (age 2–8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ? 12 ?g/L had about 4 times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ? 12 ?g/L had about six times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.08.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Language-related abilities in ‘unaffected’ school-aged siblings of children with ASD / Ellen DRUMM in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.83-96 Titre : Language-related abilities in ‘unaffected’ school-aged siblings of children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Ellen DRUMM, Auteur ; Susan E. BRYSON, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur Article en page(s) : p.83-96 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  High-risk siblings  Language  Pragmatics  Phonological processing  Reading Index. décimale : PER Périodiques Résumé : Abstract Siblings of children with autism spectrum disorder (ASD) who do not have ASD outcomes are more likely than their peers to experience delays in language acquisition as preschoolers. However, less is known about how these siblings are faring when they are school-aged. We examined language-related abilities of 18 siblings with non-ASD outcomes, aged 8–11. On average, siblings performed more poorly than the normative sample in phonological memory and phonological awareness. In contrast, word-level reading was unimpaired. No deficits relative to norms were found on a direct child assessment and parent-report measure of pragmatic language; however, recommendations for further research in this area are made. Comparing two direct child assessments, this sample performed more poorly in pragmatics than receptive/expressive language. Language abilities in siblings of children with ASD is an area ripe for further investigation with larger sample sizes and appropriate comparison groups. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Language-related abilities in ‘unaffected’ school-aged siblings of children with ASD [Texte imprimé et/ou numérique] / Ellen DRUMM, Auteur ; Susan E. BRYSON, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur . - p.83-96. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.83-96 Mots-clés : Autism spectrum disorder  High-risk siblings  Language  Pragmatics  Phonological processing  Reading Index. décimale : PER Périodiques Résumé : Abstract Siblings of children with autism spectrum disorder (ASD) who do not have ASD outcomes are more likely than their peers to experience delays in language acquisition as preschoolers. However, less is known about how these siblings are faring when they are school-aged. We examined language-related abilities of 18 siblings with non-ASD outcomes, aged 8–11. On average, siblings performed more poorly than the normative sample in phonological memory and phonological awareness. In contrast, word-level reading was unimpaired. No deficits relative to norms were found on a direct child assessment and parent-report measure of pragmatic language; however, recommendations for further research in this area are made. Comparing two direct child assessments, this sample performed more poorly in pragmatics than receptive/expressive language. Language abilities in siblings of children with ASD is an area ripe for further investigation with larger sample sizes and appropriate comparison groups. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Anxiety and aggression in adolescents with autism spectrum disorders attending mainstream schools / Pamela Gaye AMBLER in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.97-109 Titre : Anxiety and aggression in adolescents with autism spectrum disorders attending mainstream schools Type de document : Texte imprimé et/ou numérique Auteurs : Pamela Gaye AMBLER, Auteur ; Ami EIDELS, Auteur ; Christopher GREGORY, Auteur Article en page(s) : p.97-109 Langues : Anglais (eng) Mots-clés : Autism  Anxiety  Anger  Aggression  Adolescents Index. décimale : PER Périodiques Résumé : Abstract This study investigated the link between anxiety and aggression in adolescents with autism spectrum disorders (ASDs) using self-report measures of anxiety and anger and teacher ratings of behaviour. Participants were 104 high school students aged 12–18: 52 students with ASDs, without intellectual disability, and their typically developing peers matched for age and gender. Students with ASDs who attend mainstream high schools reported higher levels of anxiety and reactive anger than their peers, were reported by their teachers to engage in more aggressive behaviours, and were at higher risk of being suspended from school. The results further suggested that social anxiety is a significant moderator of the relationship between autism and physical aggression. For ASD students, but not for the control students, there was a strong, positive relationship: higher levels of anxiety were associated with higher levels of physical aggression. However, ASD students with high anger control did not display physical aggression. Our results have implications for screening students for anxiety, the provision of interventions for managing anxiety and the development of anger management skills, and for the appropriateness of suspension as a mandatory response to incidents of physical aggression in schools. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Anxiety and aggression in adolescents with autism spectrum disorders attending mainstream schools [Texte imprimé et/ou numérique] / Pamela Gaye AMBLER, Auteur ; Ami EIDELS, Auteur ; Christopher GREGORY, Auteur . - p.97-109. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.97-109 Mots-clés : Autism  Anxiety  Anger  Aggression  Adolescents Index. décimale : PER Périodiques Résumé : Abstract This study investigated the link between anxiety and aggression in adolescents with autism spectrum disorders (ASDs) using self-report measures of anxiety and anger and teacher ratings of behaviour. Participants were 104 high school students aged 12–18: 52 students with ASDs, without intellectual disability, and their typically developing peers matched for age and gender. Students with ASDs who attend mainstream high schools reported higher levels of anxiety and reactive anger than their peers, were reported by their teachers to engage in more aggressive behaviours, and were at higher risk of being suspended from school. The results further suggested that social anxiety is a significant moderator of the relationship between autism and physical aggression. For ASD students, but not for the control students, there was a strong, positive relationship: higher levels of anxiety were associated with higher levels of physical aggression. However, ASD students with high anger control did not display physical aggression. Our results have implications for screening students for anxiety, the provision of interventions for managing anxiety and the development of anger management skills, and for the appropriateness of suspension as a mandatory response to incidents of physical aggression in schools. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268