An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure / Melissa KIRKOVSKI in Journal of Autism and Developmental Disorders, 54-6 (June 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2198-2210 Titre : An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure Type de document : Texte imprimé et/ou numérique Auteurs : Melissa KIRKOVSKI, Auteur ; Mervyn SINGH, Auteur ; Thijs DHOLLANDER, Auteur ; Ian FUELSCHER, Auteur ; Christian HYDE, Auteur ; Natalia ALBEIN-URIOS, Auteur ; Peter H. DONALDSON, Auteur ; Peter G. ENTICOTT, Auteur Article en page(s) : p.2198-2210 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared to age-matched controls, young adolescents with ASD (11.19?+?7.54 years) showed reduced macroscopic fiber cross-section (logFC) and combined fiber-density and cross-section (FDC). Reduced fiber-density (FD) and FDC was noted in a marginally older (13.87?+?3.15 years) ASD cohort. Among the oldest ASD cohort (17.07?+?3.56 years), a non-significant trend indicative of reduced FD was noted. White matter aberration appears greatest and most widespread among younger ASD cohorts. This supports the suggestion that some early neuropathophysiological indicators in ASD may dissipate with age. En ligne : https://doi.org/10.1007/s10803-023-05980-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530 [article] An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure [Texte imprimé et/ou numérique] / Melissa KIRKOVSKI, Auteur ; Mervyn SINGH, Auteur ; Thijs DHOLLANDER, Auteur ; Ian FUELSCHER, Auteur ; Christian HYDE, Auteur ; Natalia ALBEIN-URIOS, Auteur ; Peter H. DONALDSON, Auteur ; Peter G. ENTICOTT, Auteur . - p.2198-2210. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2198-2210 Index. décimale : PER Périodiques Résumé : Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared to age-matched controls, young adolescents with ASD (11.19?+?7.54 years) showed reduced macroscopic fiber cross-section (logFC) and combined fiber-density and cross-section (FDC). Reduced fiber-density (FD) and FDC was noted in a marginally older (13.87?+?3.15 years) ASD cohort. Among the oldest ASD cohort (17.07?+?3.56 years), a non-significant trend indicative of reduced FD was noted. White matter aberration appears greatest and most widespread among younger ASD cohorts. This supports the suggestion that some early neuropathophysiological indicators in ASD may dissipate with age. En ligne : https://doi.org/10.1007/s10803-023-05980-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530

Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder / Melissa KIRKOVSKI in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.954-963 Titre : Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur ; Matthew E. HUGHES, Auteur ; Susan L. ROSSELL, Auteur ; Paul B. FITZGERALD, Auteur Article en page(s) : p.954-963 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Theory of mind  Mentalizing network  Sex differences  Medial prefrontal cortex  Temporo-parietal junction  Superior temporal sulcus  Functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : The medial prefrontal cortex (mPFC) and the right temporo-parietal junction (rTPj) are highly involved in social understanding, a core area of impairment in autism spectrum disorder (ASD). We used fMRI to investigate sex differences in the neural correlates of social understanding in 27 high-functioning adults with ASD and 23 matched controls. There were no differences in neural activity in the mPFC or rTPj between groups during social processing. Whole brain analysis revealed decreased activity in the posterior superior temporal sulcus in males with ASD compared to control males while processing social information. This pattern was not observed in the female sub-sample. The current study indicates that sex mediates the neurobiology of ASD, particularly with respect to processing social information. En ligne : http://dx.doi.org/10.1007/s10803-015-2639-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 [article] Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur ; Matthew E. HUGHES, Auteur ; Susan L. ROSSELL, Auteur ; Paul B. FITZGERALD, Auteur . - p.954-963. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.954-963 Mots-clés : Autism spectrum disorder  Theory of mind  Mentalizing network  Sex differences  Medial prefrontal cortex  Temporo-parietal junction  Superior temporal sulcus  Functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : The medial prefrontal cortex (mPFC) and the right temporo-parietal junction (rTPj) are highly involved in social understanding, a core area of impairment in autism spectrum disorder (ASD). We used fMRI to investigate sex differences in the neural correlates of social understanding in 27 high-functioning adults with ASD and 23 matched controls. There were no differences in neural activity in the mPFC or rTPj between groups during social processing. Whole brain analysis revealed decreased activity in the posterior superior temporal sulcus in males with ASD compared to control males while processing social information. This pattern was not observed in the female sub-sample. The current study indicates that sex mediates the neurobiology of ASD, particularly with respect to processing social information. En ligne : http://dx.doi.org/10.1007/s10803-015-2639-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281

Brief Report: Executive Functioning in Autism Spectrum Disorders: A Gender Comparison of Response Inhibition / Janine M. LEMON in Journal of Autism and Developmental Disorders, 41-3 (March 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.352-356 Titre : Brief Report: Executive Functioning in Autism Spectrum Disorders: A Gender Comparison of Response Inhibition Type de document : Texte imprimé et/ou numérique Auteurs : Janine M. LEMON, Auteur ; Belinda GARGARO, Auteur ; Peter G. ENTICOTT, Auteur ; Nicole J. RINEHART, Auteur Année de publication : 2011 Article en page(s) : p.352-356 Langues : Anglais (eng) Mots-clés : Response inhibition  Stop task  Executive function  Gender Index. décimale : PER Périodiques Résumé : Although autism spectrum disorders (ASD) affect more males than females, it is not clear whether neurobehavioural correlates of ASD are equivalent across genders. This study examined gender differences in neurobehavioural functioning in boys and girls with ASD. Participants were males with ASD (n = 10), females with ASD (n = 13), typically developing males (n = 8), and typically developing females (n = 14). Each completed the stop task, a common measure of response inhibition. Females with ASD demonstrated a significant increase in stopping time (indicating poorer inhibition). By contrast, no response inhibition impairments were evident among males with ASD. Females with ASD may have a different neurobehavioural profile, and therefore different clinical needs, when compared with males with ASD. En ligne : http://dx.doi.org/10.1007/s10803-010-1039-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Brief Report: Executive Functioning in Autism Spectrum Disorders: A Gender Comparison of Response Inhibition [Texte imprimé et/ou numérique] / Janine M. LEMON, Auteur ; Belinda GARGARO, Auteur ; Peter G. ENTICOTT, Auteur ; Nicole J. RINEHART, Auteur . - 2011 . - p.352-356. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.352-356 Mots-clés : Response inhibition  Stop task  Executive function  Gender Index. décimale : PER Périodiques Résumé : Although autism spectrum disorders (ASD) affect more males than females, it is not clear whether neurobehavioural correlates of ASD are equivalent across genders. This study examined gender differences in neurobehavioural functioning in boys and girls with ASD. Participants were males with ASD (n = 10), females with ASD (n = 13), typically developing males (n = 8), and typically developing females (n = 14). Each completed the stop task, a common measure of response inhibition. Females with ASD demonstrated a significant increase in stopping time (indicating poorer inhibition). By contrast, no response inhibition impairments were evident among males with ASD. Females with ASD may have a different neurobehavioural profile, and therefore different clinical needs, when compared with males with ASD. En ligne : http://dx.doi.org/10.1007/s10803-010-1039-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Differential Olfactory Identification in Children with Autism and Asperger’s Disorder: A Comparative and Longitudinal Study / Tamara MAY in Journal of Autism and Developmental Disorders, 41-7 (July 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-7 (July 2011) . - p.837-847 Titre : Differential Olfactory Identification in Children with Autism and Asperger’s Disorder: A Comparative and Longitudinal Study Type de document : Texte imprimé et/ou numérique Auteurs : Tamara MAY, Auteur ; Warrick J. BREWER, Auteur ; Nicole J. RINEHART, Auteur ; Peter G. ENTICOTT, Auteur ; Avril V. BRERETON, Auteur ; Bruce J. TONGE, Auteur Année de publication : 2011 Article en page(s) : p.837-847 Langues : Anglais (eng) Mots-clés : High-functioning autism  Asperger’s disorder  Olfactory identification  UPSIT Index. décimale : PER Périodiques Résumé : Key theories of autism implicate orbitofrontal cortex (OFC) compromise, while olfactory identification (OI) deficits are associated with OFC dysfunction. This study aimed to complete a 5-year follow-up of children with high-functioning autism (HFA) who previously lacked the normal age-OI association; and compare unirhinal-OI in children with HFA, Asperger’s disorder (ASP), and controls. While both HFA and controls had improved birhinal-OI at follow-up, reduced OI in some HFA participants suggested OFC deterioration and heterogeneous OFC development. Unirhinal-OI was impaired in HFA but not ASP relative to controls, suggesting orbitofrontal compromise in HFA but integrity in ASP. Differing IQ-OI relationships existed between HFA and ASP. Findings support the hypothesis of separate neurobiological underpinnings in ASP and HFA, specifically differential orbitofrontal functioning. En ligne : http://dx.doi.org/10.1007/s10803-010-1101-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130 [article] Differential Olfactory Identification in Children with Autism and Asperger’s Disorder: A Comparative and Longitudinal Study [Texte imprimé et/ou numérique] / Tamara MAY, Auteur ; Warrick J. BREWER, Auteur ; Nicole J. RINEHART, Auteur ; Peter G. ENTICOTT, Auteur ; Avril V. BRERETON, Auteur ; Bruce J. TONGE, Auteur . - 2011 . - p.837-847. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-7 (July 2011) . - p.837-847 Mots-clés : High-functioning autism  Asperger’s disorder  Olfactory identification  UPSIT Index. décimale : PER Périodiques Résumé : Key theories of autism implicate orbitofrontal cortex (OFC) compromise, while olfactory identification (OI) deficits are associated with OFC dysfunction. This study aimed to complete a 5-year follow-up of children with high-functioning autism (HFA) who previously lacked the normal age-OI association; and compare unirhinal-OI in children with HFA, Asperger’s disorder (ASP), and controls. While both HFA and controls had improved birhinal-OI at follow-up, reduced OI in some HFA participants suggested OFC deterioration and heterogeneous OFC development. Unirhinal-OI was impaired in HFA but not ASP relative to controls, suggesting orbitofrontal compromise in HFA but integrity in ASP. Differing IQ-OI relationships existed between HFA and ASP. Findings support the hypothesis of separate neurobiological underpinnings in ASP and HFA, specifically differential orbitofrontal functioning. En ligne : http://dx.doi.org/10.1007/s10803-010-1101-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130

Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta-analysis / Jacqueline A. RIDDIFORD in Autism Research, 15-8 (August 2022)  

Public ISBD [article]  inAutism Research > 15-8 (August 2022) . - p.1380-1446 Titre : Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Jacqueline A. RIDDIFORD, Auteur ; Peter G. ENTICOTT, Auteur ; Alex LAVALE, Auteur ; Caroline GURVICH, Auteur Article en page(s) : p.1380-1446 Langues : Anglais (eng) Mots-clés : Attention  Autism Spectrum Disorder  Fixation, Ocular  Humans  Social Interaction  Visual Perception  autism spectrum disorder  cognition  eye gaze  motivation  social functioning  visual processing Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by significant social functioning impairments, including (but not limited to) emotion recognition, mentalizing, and joint attention. Despite extensive investigation into the correlates of social functioning in ASD, only recently has there been focus on the role of low-level sensory input, particularly visual processing. Extensive gaze deficits have been described in ASD, from basic saccadic function through to social attention and the processing of complex biological motion. Given that social functioning often relies on accurately processing visual information, inefficient visual processing may contribute to the emergence and sustainment of social functioning difficulties in ASD. To explore the association between measures of gaze and social functioning in ASD, a systematic review and meta-analysis was conducted. A total of 95 studies were identified from a search of CINAHL Plus, Embase, OVID Medline, and psycINFO databases in July 2021. Findings support associations between increased gaze to the face/head and eye regions with improved social functioning and reduced autism symptom severity. However, gaze allocation to the mouth appears dependent on social and emotional content of scenes and the cognitive profile of participants. This review supports the investigation of gaze variables as potential biomarkers of ASD, although future longitudinal studies are required to investigate the developmental progression of this relationship and to explore the influence of heterogeneity in ASD clinical characteristics. LAY SUMMARY: This review explored how eye gaze (e.g., where a person looks when watching a movie) is associated with social functioning in autism spectrum disorder (ASD). We found evidence that better social functioning in ASD was associated with increased eye gaze toward faces/head and eye regions. Individual characteristics (e.g., intelligence) and the complexity of the social scene also influenced eye gaze. Future research including large longitudinal studies and studies investigating the influence of differing presentations of ASD are recommended. En ligne : http://dx.doi.org/10.1002/aur.2729 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / Jacqueline A. RIDDIFORD, Auteur ; Peter G. ENTICOTT, Auteur ; Alex LAVALE, Auteur ; Caroline GURVICH, Auteur . - p.1380-1446. Langues : Anglais (eng) in Autism Research > 15-8 (August 2022) . - p.1380-1446 Mots-clés : Attention  Autism Spectrum Disorder  Fixation, Ocular  Humans  Social Interaction  Visual Perception  autism spectrum disorder  cognition  eye gaze  motivation  social functioning  visual processing Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by significant social functioning impairments, including (but not limited to) emotion recognition, mentalizing, and joint attention. Despite extensive investigation into the correlates of social functioning in ASD, only recently has there been focus on the role of low-level sensory input, particularly visual processing. Extensive gaze deficits have been described in ASD, from basic saccadic function through to social attention and the processing of complex biological motion. Given that social functioning often relies on accurately processing visual information, inefficient visual processing may contribute to the emergence and sustainment of social functioning difficulties in ASD. To explore the association between measures of gaze and social functioning in ASD, a systematic review and meta-analysis was conducted. A total of 95 studies were identified from a search of CINAHL Plus, Embase, OVID Medline, and psycINFO databases in July 2021. Findings support associations between increased gaze to the face/head and eye regions with improved social functioning and reduced autism symptom severity. However, gaze allocation to the mouth appears dependent on social and emotional content of scenes and the cognitive profile of participants. This review supports the investigation of gaze variables as potential biomarkers of ASD, although future longitudinal studies are required to investigate the developmental progression of this relationship and to explore the influence of heterogeneity in ASD clinical characteristics. LAY SUMMARY: This review explored how eye gaze (e.g., where a person looks when watching a movie) is associated with social functioning in autism spectrum disorder (ASD). We found evidence that better social functioning in ASD was associated with increased eye gaze toward faces/head and eye regions. Individual characteristics (e.g., intelligence) and the complexity of the social scene also influenced eye gaze. Future research including large longitudinal studies and studies investigating the influence of differing presentations of ASD are recommended. En ligne : http://dx.doi.org/10.1002/aur.2729 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

Research and Treatment Applications of Transcranial Direct Current Stimulation (tDCS) in Autism Spectrum Disorder / Dinisha PARMAR

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A Review of the Role of Female Gender in Autism Spectrum Disorders / Melissa KIRKOVSKI in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

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‘Subtypes’ in the Presentation of Autistic Traits in the General Adult Population / Colin J. PALMER in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

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The Rubber Hand Illusion Reveals Proprioceptive and Sensorimotor Differences in Autism Spectrum Disorders / Bryan PATON in Journal of Autism and Developmental Disorders, 42-9 (September 2012)  

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Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research / Lindsay M. OBERMAN in Autism Research, 9-2 (February 2016)  

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