An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure / Melissa KIRKOVSKI in Journal of Autism and Developmental Disorders, 54-6 (June 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2198-2210 Titre : An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure Type de document : texte imprimé Auteurs : Melissa KIRKOVSKI, Auteur ; Mervyn SINGH, Auteur ; Thijs DHOLLANDER, Auteur ; Ian FUELSCHER, Auteur ; Christian HYDE, Auteur ; Natalia ALBEIN-URIOS, Auteur ; Peter H. DONALDSON, Auteur ; Peter G. ENTICOTT, Auteur Article en page(s) : p.2198-2210 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared to age-matched controls, young adolescents with ASD (11.19+7.54 years) showed reduced macroscopic fiber cross-section (logFC) and combined fiber-density and cross-section (FDC). Reduced fiber-density (FD) and FDC was noted in a marginally older (13.87+3.15 years) ASD cohort. Among the oldest ASD cohort (17.07+3.56 years), a non-significant trend indicative of reduced FD was noted. White matter aberration appears greatest and most widespread among younger ASD cohorts. This supports the suggestion that some early neuropathophysiological indicators in ASD may dissipate with age. En ligne : https://doi.org/10.1007/s10803-023-05980-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530 [article] An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure [texte imprimé] / Melissa KIRKOVSKI, Auteur ; Mervyn SINGH, Auteur ; Thijs DHOLLANDER, Auteur ; Ian FUELSCHER, Auteur ; Christian HYDE, Auteur ; Natalia ALBEIN-URIOS, Auteur ; Peter H. DONALDSON, Auteur ; Peter G. ENTICOTT, Auteur . - p.2198-2210. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2198-2210 Index. décimale : PER Périodiques Résumé : Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared to age-matched controls, young adolescents with ASD (11.19+7.54 years) showed reduced macroscopic fiber cross-section (logFC) and combined fiber-density and cross-section (FDC). Reduced fiber-density (FD) and FDC was noted in a marginally older (13.87+3.15 years) ASD cohort. Among the oldest ASD cohort (17.07+3.56 years), a non-significant trend indicative of reduced FD was noted. White matter aberration appears greatest and most widespread among younger ASD cohorts. This supports the suggestion that some early neuropathophysiological indicators in ASD may dissipate with age. En ligne : https://doi.org/10.1007/s10803-023-05980-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530

Associations Between Limbic System White Matter Structure and Socio-Emotional Functioning in Children with ADHD + ASD / Kate STEPHENS in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2663-2672 Titre : Associations Between Limbic System White Matter Structure and Socio-Emotional Functioning in Children with ADHD + ASD Type de document : texte imprimé Auteurs : Kate STEPHENS, Auteur ; Tim J. SILK, Auteur ; Vicki ANDERSON, Auteur ; Philip L. HAZELL, Auteur ; Peter G. ENTICOTT, Auteur ; Emma SCIBERRAS, Auteur Article en page(s) : p.2663-2672 Langues : Anglais (eng) Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/psychology  Autism Spectrum Disorder/psychology  Child  Comorbidity  Emotions/physiology  Humans  Limbic System/physiopathology  Male  Nerve Net  Surveys and Questionnaires  White Matter  Attention deficit/hyperactivity disorder  Autism spectrum disorder  Brain imaging Index. décimale : PER Périodiques Résumé : Children with attention deficit/hyperactivity disorder (ADHD) combined with autism spectrum disorder (ASD) symptoms (ADHD + ASD) have poorer social and emotional functioning than those with ADHD alone. However, no studies have specifically examined the associations between ASD symptoms, measures of social and emotional functioning and limbic system white matter microstructure. Tractography on the cingulum, uncinate fasciculus and fornix were performed for 151 children with (N = 78) and without (N = 73) ADHD. Participants in the ADHD group who scored 11 or above on the Social Communication Questionnaire were classified as the ADHD + ASD group (N = 16). Significant differences in mean cingulum FA were present between the control group and the ADHD (all) group, however, no significant differences were seen between the ADHD and ADHD + ASD groups. Despite this, significant associations were seen between mean FA of the left cingulum and emotional problems for the ADHD + ASD group. Results give greater insights into the specific biological basis of emotional problems in the ADHD + ASD group, indicating that the cingulum may play a role. En ligne : http://dx.doi.org/10.1007/s10803-020-04738-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Associations Between Limbic System White Matter Structure and Socio-Emotional Functioning in Children with ADHD + ASD [texte imprimé] / Kate STEPHENS, Auteur ; Tim J. SILK, Auteur ; Vicki ANDERSON, Auteur ; Philip L. HAZELL, Auteur ; Peter G. ENTICOTT, Auteur ; Emma SCIBERRAS, Auteur . - p.2663-2672. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2663-2672 Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/psychology  Autism Spectrum Disorder/psychology  Child  Comorbidity  Emotions/physiology  Humans  Limbic System/physiopathology  Male  Nerve Net  Surveys and Questionnaires  White Matter  Attention deficit/hyperactivity disorder  Autism spectrum disorder  Brain imaging Index. décimale : PER Périodiques Résumé : Children with attention deficit/hyperactivity disorder (ADHD) combined with autism spectrum disorder (ASD) symptoms (ADHD + ASD) have poorer social and emotional functioning than those with ADHD alone. However, no studies have specifically examined the associations between ASD symptoms, measures of social and emotional functioning and limbic system white matter microstructure. Tractography on the cingulum, uncinate fasciculus and fornix were performed for 151 children with (N = 78) and without (N = 73) ADHD. Participants in the ADHD group who scored 11 or above on the Social Communication Questionnaire were classified as the ADHD + ASD group (N = 16). Significant differences in mean cingulum FA were present between the control group and the ADHD (all) group, however, no significant differences were seen between the ADHD and ADHD + ASD groups. Despite this, significant associations were seen between mean FA of the left cingulum and emotional problems for the ADHD + ASD group. Results give greater insights into the specific biological basis of emotional problems in the ADHD + ASD group, indicating that the cingulum may play a role. En ligne : http://dx.doi.org/10.1007/s10803-020-04738-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder / Melissa KIRKOVSKI in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.954-963 Titre : Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur ; Matthew E. HUGHES, Auteur ; Susan L. ROSSELL, Auteur ; Paul B. FITZGERALD, Auteur Article en page(s) : p.954-963 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Theory of mind  Mentalizing network  Sex differences  Medial prefrontal cortex  Temporo-parietal junction  Superior temporal sulcus  Functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : The medial prefrontal cortex (mPFC) and the right temporo-parietal junction (rTPj) are highly involved in social understanding, a core area of impairment in autism spectrum disorder (ASD). We used fMRI to investigate sex differences in the neural correlates of social understanding in 27 high-functioning adults with ASD and 23 matched controls. There were no differences in neural activity in the mPFC or rTPj between groups during social processing. Whole brain analysis revealed decreased activity in the posterior superior temporal sulcus in males with ASD compared to control males while processing social information. This pattern was not observed in the female sub-sample. The current study indicates that sex mediates the neurobiology of ASD, particularly with respect to processing social information. En ligne : http://dx.doi.org/10.1007/s10803-015-2639-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 [article] Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder [texte imprimé] / Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur ; Matthew E. HUGHES, Auteur ; Susan L. ROSSELL, Auteur ; Paul B. FITZGERALD, Auteur . - p.954-963. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.954-963 Mots-clés : Autism spectrum disorder  Theory of mind  Mentalizing network  Sex differences  Medial prefrontal cortex  Temporo-parietal junction  Superior temporal sulcus  Functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : The medial prefrontal cortex (mPFC) and the right temporo-parietal junction (rTPj) are highly involved in social understanding, a core area of impairment in autism spectrum disorder (ASD). We used fMRI to investigate sex differences in the neural correlates of social understanding in 27 high-functioning adults with ASD and 23 matched controls. There were no differences in neural activity in the mPFC or rTPj between groups during social processing. Whole brain analysis revealed decreased activity in the posterior superior temporal sulcus in males with ASD compared to control males while processing social information. This pattern was not observed in the female sub-sample. The current study indicates that sex mediates the neurobiology of ASD, particularly with respect to processing social information. En ligne : http://dx.doi.org/10.1007/s10803-015-2639-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281

Autism Spectrum Traits Linked with Reduced Performance on Self-Report Behavioural Measures of Cognitive Flexibility / Natalia ALBEIN-URIOS in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2506-2515 Titre : Autism Spectrum Traits Linked with Reduced Performance on Self-Report Behavioural Measures of Cognitive Flexibility Type de document : texte imprimé Auteurs : Natalia ALBEIN-URIOS, Auteur ; George J. YOUSSEF, Auteur ; Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur Article en page(s) : p.2506-2515 Langues : Anglais (eng) Mots-clés : Autism quotient  Autism spectrum disorder traits  Behavioural self-report  Cognitive flexibility  Lab-based measures Index. décimale : PER Périodiques Résumé : Deficits in cognitive flexibility are thought to underpin the core symptom of repetitive and restricted patterns of behaviour in autism spectrum disorder (ASD). Studies investigating this relationship, however, report inconsistent results. This is partly due to the variable nature of measures used to assess the construct of flexibility. The main purpose of this study was to investigate whether ASD traits differentially predict cognitive flexibility performance on lab-based neurocognitive measures relative to behavioural self-reports in a non-clinical sample of young adults. Our results indicate that ASD traits exclusively predict performance on behavioural self-reports of cognitive flexibility. These findings highlight the possibility that behavioural self-reports are a better index than lab-based neurocognitive measures to capture cognitive flexibility impairments in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3503-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Autism Spectrum Traits Linked with Reduced Performance on Self-Report Behavioural Measures of Cognitive Flexibility [texte imprimé] / Natalia ALBEIN-URIOS, Auteur ; George J. YOUSSEF, Auteur ; Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur . - p.2506-2515. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2506-2515 Mots-clés : Autism quotient  Autism spectrum disorder traits  Behavioural self-report  Cognitive flexibility  Lab-based measures Index. décimale : PER Périodiques Résumé : Deficits in cognitive flexibility are thought to underpin the core symptom of repetitive and restricted patterns of behaviour in autism spectrum disorder (ASD). Studies investigating this relationship, however, report inconsistent results. This is partly due to the variable nature of measures used to assess the construct of flexibility. The main purpose of this study was to investigate whether ASD traits differentially predict cognitive flexibility performance on lab-based neurocognitive measures relative to behavioural self-reports in a non-clinical sample of young adults. Our results indicate that ASD traits exclusively predict performance on behavioural self-reports of cognitive flexibility. These findings highlight the possibility that behavioural self-reports are a better index than lab-based neurocognitive measures to capture cognitive flexibility impairments in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3503-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Brief Report: Executive Functioning in Autism Spectrum Disorders: A Gender Comparison of Response Inhibition / Janine M. LEMON in Journal of Autism and Developmental Disorders, 41-3 (March 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.352-356 Titre : Brief Report: Executive Functioning in Autism Spectrum Disorders: A Gender Comparison of Response Inhibition Type de document : texte imprimé Auteurs : Janine M. LEMON, Auteur ; Belinda GARGARO, Auteur ; Peter G. ENTICOTT, Auteur ; Nicole J. RINEHART, Auteur Année de publication : 2011 Article en page(s) : p.352-356 Langues : Anglais (eng) Mots-clés : Response inhibition  Stop task  Executive function  Gender Index. décimale : PER Périodiques Résumé : Although autism spectrum disorders (ASD) affect more males than females, it is not clear whether neurobehavioural correlates of ASD are equivalent across genders. This study examined gender differences in neurobehavioural functioning in boys and girls with ASD. Participants were males with ASD (n = 10), females with ASD (n = 13), typically developing males (n = 8), and typically developing females (n = 14). Each completed the stop task, a common measure of response inhibition. Females with ASD demonstrated a significant increase in stopping time (indicating poorer inhibition). By contrast, no response inhibition impairments were evident among males with ASD. Females with ASD may have a different neurobehavioural profile, and therefore different clinical needs, when compared with males with ASD. En ligne : http://dx.doi.org/10.1007/s10803-010-1039-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Brief Report: Executive Functioning in Autism Spectrum Disorders: A Gender Comparison of Response Inhibition [texte imprimé] / Janine M. LEMON, Auteur ; Belinda GARGARO, Auteur ; Peter G. ENTICOTT, Auteur ; Nicole J. RINEHART, Auteur . - 2011 . - p.352-356. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.352-356 Mots-clés : Response inhibition  Stop task  Executive function  Gender Index. décimale : PER Périodiques Résumé : Although autism spectrum disorders (ASD) affect more males than females, it is not clear whether neurobehavioural correlates of ASD are equivalent across genders. This study examined gender differences in neurobehavioural functioning in boys and girls with ASD. Participants were males with ASD (n = 10), females with ASD (n = 13), typically developing males (n = 8), and typically developing females (n = 14). Each completed the stop task, a common measure of response inhibition. Females with ASD demonstrated a significant increase in stopping time (indicating poorer inhibition). By contrast, no response inhibition impairments were evident among males with ASD. Females with ASD may have a different neurobehavioural profile, and therefore different clinical needs, when compared with males with ASD. En ligne : http://dx.doi.org/10.1007/s10803-010-1039-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Differential Olfactory Identification in Children with Autism and Asperger’s Disorder: A Comparative and Longitudinal Study / Tamara MAY in Journal of Autism and Developmental Disorders, 41-7 (July 2011)  

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Do children with ASD have difficulty handwriting under time pressure? / N. GRACE in Research in Autism Spectrum Disorders, 37 (May 2017)  

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Do Handwriting Difficulties Correlate with Core Symptomology, Motor Proficiency and Attentional Behaviours? / Nicci GRACE in Journal of Autism and Developmental Disorders, 47-4 (April 2017)  

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Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta-analysis / Jacqueline A. RIDDIFORD in Autism Research, 15-8 (August 2022)  

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Head circumference trends in autism between 0 and 100 months / Joel CRUCITTI in Autism, 24-7 (October 2020)  

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Inner Speech Moderates the Relationship Between Autism Spectrum Traits and Emotion Regulation / Natalia ALBEIN-URIOS in Journal of Autism and Developmental Disorders, 51-9 (September 2021)  

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Investigating Mirror System (MS) Activity in Adults with ASD When Inferring Others' Intentions Using Both TMS and EEG / Eleanor J. COLE in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

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Research and Treatment Applications of Transcranial Direct Current Stimulation (tDCS) in Autism Spectrum Disorder / Dinisha PARMAR

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A Review of the Role of Female Gender in Autism Spectrum Disorders / Melissa KIRKOVSKI in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

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‘Subtypes’ in the Presentation of Autistic Traits in the General Adult Population / Colin J. PALMER in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

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