Dépouillements

Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology / Sakeena PANJU in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-10 Titre : Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology Type de document : Texte imprimé et/ou numérique Auteurs : Sakeena PANJU, Auteur ; Jessica BRIAN, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) has been associated with autonomic atypicalities, although the nature of these differences remains largely unknown. Moreover, existing literature suggests large variability in autonomic function in ASD, motivating the need to examine the existence of subgroups that exhibit more homogeneous autonomic features. En ligne : http://dx.doi.org/10.1186/s13229-015-0057-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology [Texte imprimé et/ou numérique] / Sakeena PANJU, Auteur ; Jessica BRIAN, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-10 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) has been associated with autonomic atypicalities, although the nature of these differences remains largely unknown. Moreover, existing literature suggests large variability in autonomic function in ASD, motivating the need to examine the existence of subgroups that exhibit more homogeneous autonomic features. En ligne : http://dx.doi.org/10.1186/s13229-015-0057-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder / Ulrika ROINE in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-11 Titre : Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Pekka TANI, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Karen CAEYENBERGHS, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Recent brain imaging findings suggest that there are widely distributed abnormalities affecting the brain connectivity in individuals with autism spectrum disorder (ASD). Using graph theoretical analysis, it is possible to investigate both global and local properties of brain’s wiring diagram, i.e., the connectome. En ligne : http://dx.doi.org/10.1186/s13229-015-0058-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Pekka TANI, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Karen CAEYENBERGHS, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur . - p.1-11. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-11 Index. décimale : PER Périodiques Résumé : Recent brain imaging findings suggest that there are widely distributed abnormalities affecting the brain connectivity in individuals with autism spectrum disorder (ASD). Using graph theoretical analysis, it is possible to investigate both global and local properties of brain’s wiring diagram, i.e., the connectome. En ligne : http://dx.doi.org/10.1186/s13229-015-0058-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Is impaired joint attention present in non-clinical individuals with high autistic traits? / Shuo ZHAO in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-9 Titre : Is impaired joint attention present in non-clinical individuals with high autistic traits? Type de document : Texte imprimé et/ou numérique Auteurs : Shuo ZHAO, Auteur ; Shota UONO, Auteur ; Sayaka YOSHIMURA, Auteur ; Motomi TOICHI, Auteur Article en page(s) : p.1-9 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Joint attention skills are impaired in individuals with autism spectrum disorder (ASD). Recently, varying degrees of autistic social attention deficit have been detected in the general population. We investigated gaze-triggered attention in individuals with high and low levels of autistic traits under visual–auditory cross-modal conditions, which are more sensitive to social attention deficits than unimodal paradigms. En ligne : http://dx.doi.org/10.1186/s13229-015-0059-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Is impaired joint attention present in non-clinical individuals with high autistic traits? [Texte imprimé et/ou numérique] / Shuo ZHAO, Auteur ; Shota UONO, Auteur ; Sayaka YOSHIMURA, Auteur ; Motomi TOICHI, Auteur . - p.1-9. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-9 Index. décimale : PER Périodiques Résumé : Joint attention skills are impaired in individuals with autism spectrum disorder (ASD). Recently, varying degrees of autistic social attention deficit have been detected in the general population. We investigated gaze-triggered attention in individuals with high and low levels of autistic traits under visual–auditory cross-modal conditions, which are more sensitive to social attention deficits than unimodal paradigms. En ligne : http://dx.doi.org/10.1186/s13229-015-0059-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures / Daria PRILUTSKY in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-14 Titre : Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures Type de document : Texte imprimé et/ou numérique Auteurs : Daria PRILUTSKY, Auteur ; Alvin T. KHO, Auteur ; Nathan P. PALMER, Auteur ; Asha L. BHAKAR, Auteur ; Niklas SMEDEMARK-MARGULIES, Auteur ; Sek Won KONG, Auteur ; David M. MARGULIES, Auteur ; Mark F. BEAR, Auteur ; Isaac S. KOHANE, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes in cultured neurons using standard morphological, functional, and chemical approaches have demonstrated considerable variability. Here, we study transcriptomes obtained in situ in the intact brain tissues of a murine model of FXS to see how they reflect the in vitro state. En ligne : http://dx.doi.org/10.1186/s13229-015-0061-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures [Texte imprimé et/ou numérique] / Daria PRILUTSKY, Auteur ; Alvin T. KHO, Auteur ; Nathan P. PALMER, Auteur ; Asha L. BHAKAR, Auteur ; Niklas SMEDEMARK-MARGULIES, Auteur ; Sek Won KONG, Auteur ; David M. MARGULIES, Auteur ; Mark F. BEAR, Auteur ; Isaac S. KOHANE, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes in cultured neurons using standard morphological, functional, and chemical approaches have demonstrated considerable variability. Here, we study transcriptomes obtained in situ in the intact brain tissues of a murine model of FXS to see how they reflect the in vitro state. En ligne : http://dx.doi.org/10.1186/s13229-015-0061-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Social communication and emotion difficulties and second to fourth digit ratio in a large community-based sample / Manuela BARONA in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-11 Titre : Social communication and emotion difficulties and second to fourth digit ratio in a large community-based sample Type de document : Texte imprimé et/ou numérique Auteurs : Manuela BARONA, Auteur ; Radha KOTHARI, Auteur ; David SKUSE, Auteur ; Nadia MICALI, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Recent research investigating the extreme male brain theory of autism spectrum disorders (ASD) has drawn attention to the possibility that autistic type social difficulties may be associated with high prenatal testosterone exposure. This study aims to investigate the association between social communication and emotion recognition difficulties and second to fourth digit ratio (2D:4D) and circulating maternal testosterone during pregnancy in a large community-based cohort: the Avon Longitudinal Study of Parents and Children (ALSPAC). A secondary aim is to investigate possible gender differences in the associations. En ligne : http://dx.doi.org/10.1186/s13229-015-0063-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Social communication and emotion difficulties and second to fourth digit ratio in a large community-based sample [Texte imprimé et/ou numérique] / Manuela BARONA, Auteur ; Radha KOTHARI, Auteur ; David SKUSE, Auteur ; Nadia MICALI, Auteur . - p.1-11. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-11 Index. décimale : PER Périodiques Résumé : Recent research investigating the extreme male brain theory of autism spectrum disorders (ASD) has drawn attention to the possibility that autistic type social difficulties may be associated with high prenatal testosterone exposure. This study aims to investigate the association between social communication and emotion recognition difficulties and second to fourth digit ratio (2D:4D) and circulating maternal testosterone during pregnancy in a large community-based cohort: the Avon Longitudinal Study of Parents and Children (ALSPAC). A secondary aim is to investigate possible gender differences in the associations. En ligne : http://dx.doi.org/10.1186/s13229-015-0063-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex / J. Christopher EDGAR in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-14 Titre : Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex Type de document : Texte imprimé et/ou numérique Auteurs : J. Christopher EDGAR, Auteur ; Charles L. FISK IV, Auteur ; Jeffrey I. BERMAN, Auteur ; Darina CHUDNOVSKAYA, Auteur ; Song LIU, Auteur ; Juhi PANDEY, Auteur ; John D. HERRINGTON, Auteur ; Russell G. PORT, Auteur ; Robert T. SCHULTZ, Auteur ; Timothy P. L. ROBERTS, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Findings of auditory abnormalities in children with autism spectrum disorder (ASD) include delayed superior temporal gyrus auditory responses, pre- and post-stimulus superior temporal gyrus (STG) auditory oscillatory abnormalities, and atypical hemispheric lateralization. These abnormalities are likely associated with abnormal brain maturation. To better understand changes in brain activity as a function of age, the present study investigated associations between age and STG auditory time-domain and time-frequency neural activity. En ligne : http://dx.doi.org/10.1186/s13229-015-0065-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex [Texte imprimé et/ou numérique] / J. Christopher EDGAR, Auteur ; Charles L. FISK IV, Auteur ; Jeffrey I. BERMAN, Auteur ; Darina CHUDNOVSKAYA, Auteur ; Song LIU, Auteur ; Juhi PANDEY, Auteur ; John D. HERRINGTON, Auteur ; Russell G. PORT, Auteur ; Robert T. SCHULTZ, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : Findings of auditory abnormalities in children with autism spectrum disorder (ASD) include delayed superior temporal gyrus auditory responses, pre- and post-stimulus superior temporal gyrus (STG) auditory oscillatory abnormalities, and atypical hemispheric lateralization. These abnormalities are likely associated with abnormal brain maturation. To better understand changes in brain activity as a function of age, the present study investigated associations between age and STG auditory time-domain and time-frequency neural activity. En ligne : http://dx.doi.org/10.1186/s13229-015-0065-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder / I. W. EISENBERG in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - 54p. Titre : Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : I. W. EISENBERG, Auteur ; Gregory L. WALLACE, Auteur ; L. KENWORTHY, Auteur ; S. J. GOTTS, Auteur ; A. MARTIN, Auteur Article en page(s) : 54p. Langues : Anglais (eng) Mots-clés : Autism  Insistence on sameness  Mri  Repetitive behavior  Structural covariance  Subcortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS. METHODS: We quantified the structural covariance of cortical and subcortical gray matter volume in 55 individuals with high-functioning ASD using 3T MRI. We then related these structural metrics to individual IS scores, as assessed by the Repetitive Behavior Scale-Revised (RBS-R). RESULTS: We found that increased coupling among subcortical regions and between subcortical and cortical regions related to greater IS symptom severity. Most pronounced, the striatum and amygdala participated in a plurality of identified relationships, indicating a central role for these structures in IS symptomatology. These structural associations were specific to IS and did not relate to any of the other RRB subcomponents measured by the RBS-R. CONCLUSIONS: This study indicates that behavioral dimensions in ASD can relate to the coordination of development across multiple brain regions, which might be otherwise obscured using typical brain-behavior correlations. It also expands the structures traditionally related to RRB in ASD and provides neuroanatomical evidence supportive of IS as a separate RRB dimension. TRIAL REGISTRATION: ClinicalTrials.gov NCT01031407. En ligne : http://dx.doi.org/10.1186/s13229-015-0047-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder [Texte imprimé et/ou numérique] / I. W. EISENBERG, Auteur ; Gregory L. WALLACE, Auteur ; L. KENWORTHY, Auteur ; S. J. GOTTS, Auteur ; A. MARTIN, Auteur . - 54p. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - 54p. Mots-clés : Autism  Insistence on sameness  Mri  Repetitive behavior  Structural covariance  Subcortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS. METHODS: We quantified the structural covariance of cortical and subcortical gray matter volume in 55 individuals with high-functioning ASD using 3T MRI. We then related these structural metrics to individual IS scores, as assessed by the Repetitive Behavior Scale-Revised (RBS-R). RESULTS: We found that increased coupling among subcortical regions and between subcortical and cortical regions related to greater IS symptom severity. Most pronounced, the striatum and amygdala participated in a plurality of identified relationships, indicating a central role for these structures in IS symptomatology. These structural associations were specific to IS and did not relate to any of the other RRB subcomponents measured by the RBS-R. CONCLUSIONS: This study indicates that behavioral dimensions in ASD can relate to the coordination of development across multiple brain regions, which might be otherwise obscured using typical brain-behavior correlations. It also expands the structures traditionally related to RRB in ASD and provides neuroanatomical evidence supportive of IS as a separate RRB dimension. TRIAL REGISTRATION: ClinicalTrials.gov NCT01031407. En ligne : http://dx.doi.org/10.1186/s13229-015-0047-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328