Brain function distinguishes female carriers and non-carriers of familial risk for autism / Adam T. EGGEBRECHT in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 82 p. Titre : Brain function distinguishes female carriers and non-carriers of familial risk for autism Type de document : texte imprimé Auteurs : Adam T. EGGEBRECHT, Auteur ; Ally DWORETSKY, Auteur ; Zoe HAWKS, Auteur ; Rebecca COALSON, Auteur ; Babatunde ADEYEMO, Auteur ; Savannah DAVIS, Auteur ; Daniel GRAY, Auteur ; Alana MCMICHAEL, Auteur ; Steven E. PETERSEN, Auteur ; John N. CONSTANTINO, Auteur ; John R. PRUETT, Auteur Année de publication : 2020 Article en page(s) : 82 p. Langues : Anglais (eng) Mots-clés : Biological motion  Endophenotype  Familial risk  Sex ratio  Silent transmission  Responsiveness Scale-2 (SRS-2), a quantitative measure of autistic traits used in  this study—no royalties were generated from the implementation of the SRS-2 in this  program of research. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by high population-level heritability and a three-to-one male-to-female ratio that occurs independent of sex linkage. Prior research in a mixed-sex pediatric sample identified neural signatures of familial risk elicited by passive viewing of point light motion displays, suggesting the possibility that both resilience and risk of autism might be associated with brain responses to biological motion. To confirm a relationship between these signatures and inherited risk of autism, we tested them in families enriched for genetic loading through undiagnosed ("carrier") females. METHODS: Using functional magnetic resonance imaging, we examined brain responses to passive viewing of point light displays-depicting biological versus non-biological motion-in a sample of undiagnosed adult females enriched for inherited susceptibility to ASD on the basis of affectation in their respective family pedigrees. Brain responses in carrier females were compared to responses in age-, SRS-, and IQ-matched non-carrier-females-i.e., females unrelated to individuals with ASD. We conducted a hypothesis-driven analysis focused on previously published regions of interest as well as exploratory, brain-wide analyses designed to characterize more fully the rich responses to this paradigm. RESULTS: We observed robust responses to biological motion. Notwithstanding, the 12 regions implicated by prior research did not exhibit the hypothesized interaction between group (carriers vs. controls) and point light displays (biological vs. non-biological motion). Exploratory, brain-wide analyses identified this interaction in three novel regions. Post hoc analyses additionally revealed significant variations in the time course of brain activation in 20 regions spanning occipital and temporal cortex, indicating group differences in response to point light displays (irrespective of the nature of motion) for exploration in future studies. LIMITATIONS: We were unable to successfully eye-track all participants, which prevented us from being able to control for potential differences in eye gaze position. CONCLUSIONS: These methods confirmed pronounced neural signatures that differentiate brain responses to biological and scrambled motion. Our sample of undiagnosed females enriched for family genetic loading enabled discovery of numerous contrasts between carriers and non-carriers of risk of ASD that may index variations in visual attention and motion processing related to genetic susceptibility and inform our understanding of mechanisms incurred by inherited liability for ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00381-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Brain function distinguishes female carriers and non-carriers of familial risk for autism [texte imprimé] / Adam T. EGGEBRECHT, Auteur ; Ally DWORETSKY, Auteur ; Zoe HAWKS, Auteur ; Rebecca COALSON, Auteur ; Babatunde ADEYEMO, Auteur ; Savannah DAVIS, Auteur ; Daniel GRAY, Auteur ; Alana MCMICHAEL, Auteur ; Steven E. PETERSEN, Auteur ; John N. CONSTANTINO, Auteur ; John R. PRUETT, Auteur . - 2020 . - 82 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 82 p. Mots-clés : Biological motion  Endophenotype  Familial risk  Sex ratio  Silent transmission  Responsiveness Scale-2 (SRS-2), a quantitative measure of autistic traits used in  this study—no royalties were generated from the implementation of the SRS-2 in this  program of research. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by high population-level heritability and a three-to-one male-to-female ratio that occurs independent of sex linkage. Prior research in a mixed-sex pediatric sample identified neural signatures of familial risk elicited by passive viewing of point light motion displays, suggesting the possibility that both resilience and risk of autism might be associated with brain responses to biological motion. To confirm a relationship between these signatures and inherited risk of autism, we tested them in families enriched for genetic loading through undiagnosed ("carrier") females. METHODS: Using functional magnetic resonance imaging, we examined brain responses to passive viewing of point light displays-depicting biological versus non-biological motion-in a sample of undiagnosed adult females enriched for inherited susceptibility to ASD on the basis of affectation in their respective family pedigrees. Brain responses in carrier females were compared to responses in age-, SRS-, and IQ-matched non-carrier-females-i.e., females unrelated to individuals with ASD. We conducted a hypothesis-driven analysis focused on previously published regions of interest as well as exploratory, brain-wide analyses designed to characterize more fully the rich responses to this paradigm. RESULTS: We observed robust responses to biological motion. Notwithstanding, the 12 regions implicated by prior research did not exhibit the hypothesized interaction between group (carriers vs. controls) and point light displays (biological vs. non-biological motion). Exploratory, brain-wide analyses identified this interaction in three novel regions. Post hoc analyses additionally revealed significant variations in the time course of brain activation in 20 regions spanning occipital and temporal cortex, indicating group differences in response to point light displays (irrespective of the nature of motion) for exploration in future studies. LIMITATIONS: We were unable to successfully eye-track all participants, which prevented us from being able to control for potential differences in eye gaze position. CONCLUSIONS: These methods confirmed pronounced neural signatures that differentiate brain responses to biological and scrambled motion. Our sample of undiagnosed females enriched for family genetic loading enabled discovery of numerous contrasts between carriers and non-carriers of risk of ASD that may index variations in visual attention and motion processing related to genetic susceptibility and inform our understanding of mechanisms incurred by inherited liability for ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00381-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees / Carley FAUGHN in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1483-1488 Titre : Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees Type de document : texte imprimé Auteurs : Carley FAUGHN, Auteur ; Natasha M. MARRUS, Auteur ; Jeremy SHUMAN, Auteur ; Stephen R. ROSS, Auteur ; John N. CONSTANTINO, Auteur ; John R. PRUETT, Auteur ; Daniel J. POVINELLI, Auteur Article en page(s) : p.1483-1488 Langues : Anglais (eng) Mots-clés : Comparative cognition  Autism  Social Responsiveness Scale  Chimpanzee  Nonhuman primate Index. décimale : PER Périodiques Résumé : Comparative studies of social responsiveness, a core impairment in autism spectrum disorder (ASD), will enhance our understanding of typical and atypical social behavior. We previously reported a quantitative, cross-species (human–chimpanzee) social responsiveness measure, which included the development of the Chimpanzee Social Responsiveness Scale (CSRS). Here, we augment our prior CSRS sample with 25 zoo chimpanzees at three sites: combined N = 54. The CSRS demonstrated strong interrater reliability, and low-ranked chimpanzees, on average, displayed higher CSRS scores. The CSRS continues to discriminate variation in chimpanzee social responsiveness, and the association of higher scores with lower chimpanzee social standing has implications for the relationship between autistic traits and human social status. Continued comparative investigations of social responsiveness will enhance our understanding of underlying impairments in ASD, improve early diagnosis, and inform future therapies. En ligne : http://dx.doi.org/10.1007/s10803-014-2273-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees [texte imprimé] / Carley FAUGHN, Auteur ; Natasha M. MARRUS, Auteur ; Jeremy SHUMAN, Auteur ; Stephen R. ROSS, Auteur ; John N. CONSTANTINO, Auteur ; John R. PRUETT, Auteur ; Daniel J. POVINELLI, Auteur . - p.1483-1488. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1483-1488 Mots-clés : Comparative cognition  Autism  Social Responsiveness Scale  Chimpanzee  Nonhuman primate Index. décimale : PER Périodiques Résumé : Comparative studies of social responsiveness, a core impairment in autism spectrum disorder (ASD), will enhance our understanding of typical and atypical social behavior. We previously reported a quantitative, cross-species (human–chimpanzee) social responsiveness measure, which included the development of the Chimpanzee Social Responsiveness Scale (CSRS). Here, we augment our prior CSRS sample with 25 zoo chimpanzees at three sites: combined N = 54. The CSRS demonstrated strong interrater reliability, and low-ranked chimpanzees, on average, displayed higher CSRS scores. The CSRS continues to discriminate variation in chimpanzee social responsiveness, and the association of higher scores with lower chimpanzee social standing has implications for the relationship between autistic traits and human social status. Continued comparative investigations of social responsiveness will enhance our understanding of underlying impairments in ASD, improve early diagnosis, and inform future therapies. En ligne : http://dx.doi.org/10.1007/s10803-014-2273-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

Brief Report: Theory of Mind, Relational Reasoning, and Social Responsiveness in Children With and Without Autism: Demonstration of Feasibility for a Larger-Scale Study / John R. PRUETT in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2243-2251 Titre : Brief Report: Theory of Mind, Relational Reasoning, and Social Responsiveness in Children With and Without Autism: Demonstration of Feasibility for a Larger-Scale Study Type de document : texte imprimé Auteurs : John R. PRUETT, Auteur ; Sridhar KANDALA, Auteur ; Steven E. PETERSEN, Auteur ; Daniel J. POVINELLI, Auteur Année de publication : 2015 Article en page(s) : p.2243-2251 Langues : Anglais (eng) Mots-clés : Theory of mind  Relational reasoning  Analogical reasoning  Social responsiveness  Autism  Cognition Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-015-2357-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 [article] Brief Report: Theory of Mind, Relational Reasoning, and Social Responsiveness in Children With and Without Autism: Demonstration of Feasibility for a Larger-Scale Study [texte imprimé] / John R. PRUETT, Auteur ; Sridhar KANDALA, Auteur ; Steven E. PETERSEN, Auteur ; Daniel J. POVINELLI, Auteur . - 2015 . - p.2243-2251. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2243-2251 Mots-clés : Theory of mind  Relational reasoning  Analogical reasoning  Social responsiveness  Autism  Cognition Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-015-2357-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261

Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD / Catherine A. BURROWS in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1710-1723 Titre : Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD Type de document : texte imprimé Auteurs : Catherine A. BURROWS, Auteur ; James W. BODFISH, Auteur ; Jason J. WOLFF, Auteur ; Elayne P. VOLLMAN, Auteur ; Melody R. ALTSCHULER, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Annette M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; John R. PRUETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Joseph PIVEN, Auteur ; Jed T. ELISON, Auteur Article en page(s) : p.1710-1723 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child, Preschool  Family  Humans  Infant  Male  Phenotype  Risk  Siblings  attention  intense interests  problem behavior  restricted interests  toddlers Index. décimale : PER Périodiques Résumé : Intense interests are common in children with and without autism spectrum disorder (ASD), and little research has characterized aspects of interests that are unique to or shared among children with and without ASD. We aimed to characterize interests in a sample of infants at high-familial-risk (HR) and low-familial-risk (LR) for ASD using a novel interview. Participants included HR siblings who were diagnosed with ASD at 24 months (HR-ASD, n = 56), HR siblings who did not receive an ASD diagnosis at 24 months (HR-Neg, n = 187), and a LR comparison group (n = 109). We developed and collected data with the Intense Interests Inventory at 18- and 24-months of age, a semi-structured interview that measures intensity and peculiarity of interests in toddlers and preschool-aged children. Intensity of interests differed by familial risk at 24 months, with HR-ASD and HR-Neg groups demonstrating equivalent intensity of interests that were higher than the LR group. By contrast, peculiarity of interest differed by ASD diagnosis, with the HR-ASD group showing more peculiar interests than the HR-Neg and LR groups at 24 months. At 18 months the HR-ASD group had more peculiar interests than the LR group, though no differences emerged in intensity of interests. This measure may be useful in identifying clinically-relevant features of interests in young children with ASD. We also replicated previous findings of males showing more intense interests at 18 months in our non-ASD sample. These results reveal new information about the nature of interests and preoccupations in the early autism phenotype. LAY SUMMARY: Intense interests are common in young children with autism and their family members. Intense interests are also prevalent among typically-developing children, and especially boys. Here we catalog interests and features of these interests in a large sample of toddlers enriched for autism risk. Children who had family members with autism had more intense interests, and those who developed autism themselves had more unusual interests at 24 months. These results highlight the importance of different aspects of interest in autism. En ligne : http://dx.doi.org/10.1002/aur.2543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD [texte imprimé] / Catherine A. BURROWS, Auteur ; James W. BODFISH, Auteur ; Jason J. WOLFF, Auteur ; Elayne P. VOLLMAN, Auteur ; Melody R. ALTSCHULER, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Annette M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; John R. PRUETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Joseph PIVEN, Auteur ; Jed T. ELISON, Auteur . - p.1710-1723. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1710-1723 Mots-clés : Autism Spectrum Disorder  Child, Preschool  Family  Humans  Infant  Male  Phenotype  Risk  Siblings  attention  intense interests  problem behavior  restricted interests  toddlers Index. décimale : PER Périodiques Résumé : Intense interests are common in children with and without autism spectrum disorder (ASD), and little research has characterized aspects of interests that are unique to or shared among children with and without ASD. We aimed to characterize interests in a sample of infants at high-familial-risk (HR) and low-familial-risk (LR) for ASD using a novel interview. Participants included HR siblings who were diagnosed with ASD at 24 months (HR-ASD, n = 56), HR siblings who did not receive an ASD diagnosis at 24 months (HR-Neg, n = 187), and a LR comparison group (n = 109). We developed and collected data with the Intense Interests Inventory at 18- and 24-months of age, a semi-structured interview that measures intensity and peculiarity of interests in toddlers and preschool-aged children. Intensity of interests differed by familial risk at 24 months, with HR-ASD and HR-Neg groups demonstrating equivalent intensity of interests that were higher than the LR group. By contrast, peculiarity of interest differed by ASD diagnosis, with the HR-ASD group showing more peculiar interests than the HR-Neg and LR groups at 24 months. At 18 months the HR-ASD group had more peculiar interests than the LR group, though no differences emerged in intensity of interests. This measure may be useful in identifying clinically-relevant features of interests in young children with ASD. We also replicated previous findings of males showing more intense interests at 18 months in our non-ASD sample. These results reveal new information about the nature of interests and preoccupations in the early autism phenotype. LAY SUMMARY: Intense interests are common in young children with autism and their family members. Intense interests are also prevalent among typically-developing children, and especially boys. Here we catalog interests and features of these interests in a large sample of toddlers enriched for autism risk. Children who had family members with autism had more intense interests, and those who developed autism themselves had more unusual interests at 24 months. These results highlight the importance of different aspects of interest in autism. En ligne : http://dx.doi.org/10.1002/aur.2543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Commentary – Autism Spectrum Disorder: Spectrum or Cluster? / John R. PRUETT in Autism Research, 9-12 (December 2016)  

Public ISBD [article]  inAutism Research > 9-12 (December 2016) . - p.1237-1240 Titre : Commentary – Autism Spectrum Disorder: Spectrum or Cluster? Type de document : texte imprimé Auteurs : John R. PRUETT, Auteur ; Daniel J. POVINELLI, Auteur Article en page(s) : p.1237-1240 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Commentary – Autism Spectrum Disorder: Spectrum or Cluster? [texte imprimé] / John R. PRUETT, Auteur ; Daniel J. POVINELLI, Auteur . - p.1237-1240. Langues : Anglais (eng) in Autism Research > 9-12 (December 2016) . - p.1237-1240 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Diagnostic shifts in autism spectrum disorder can be linked to the fuzzy nature of the diagnostic boundary: a data-driven approach / B. TUNC in Journal of Child Psychology and Psychiatry, 62-10 (October 2021)  

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Infants later diagnosed with autism have lower canonical babbling ratios in the first year of life / Lisa D. YANKOWITZ in Molecular Autism, 13 (2022)  

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Language delay aggregates in toddler siblings of children with autism spectrum disorder / Natasha M. MARRUS in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

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Mapping neural correlates of biological motion perception in autistic children using high-density diffuse optical tomography / Dalin YANG in Molecular Autism, 15 (2024)  

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Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism / Jason J. WOLFF in Molecular Autism, 8 (2017)  

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Potential Risk Factors for the Development of Self-Injurious Behavior among Infants at Risk for Autism Spectrum Disorder / Adele F. DIMIAN in Journal of Autism and Developmental Disorders, 47-5 (May 2017)  

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Sleep in Infants with Down Syndrome or Familial Likelihood of Autism in the First Year of Life / Emma R. COCO in Journal of Autism and Developmental Disorders, 55-12 (December 2025)  

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Social and Non-Social Cueing of Visuospatial Attention in Autism and Typical Development / John R. PRUETT in Journal of Autism and Developmental Disorders, 41-6 (June 2011)  

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Social motivation in infancy is associated with familial recurrence of ASD / Natasha M. MARRUS in Development and Psychopathology, 36-1 (February 2024)  

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Training of child and adolescent psychiatry fellows in autism and intellectual disability / Natasha M. MARRUS in Autism, 18-4 (May 2014)  

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