Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees / Carley FAUGHN in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1483-1488 Titre : Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees Type de document : Texte imprimé et/ou numérique Auteurs : Carley FAUGHN, Auteur ; Natasha MARRUS, Auteur ; Jeremy SHUMAN, Auteur ; Stephen R. ROSS, Auteur ; John N. CONSTANTINO, Auteur ; John R. PRUETT, Auteur ; Daniel J. POVINELLI, Auteur Article en page(s) : p.1483-1488 Langues : Anglais (eng) Mots-clés : Comparative cognition  Autism  Social Responsiveness Scale  Chimpanzee  Nonhuman primate Index. décimale : PER Périodiques Résumé : Comparative studies of social responsiveness, a core impairment in autism spectrum disorder (ASD), will enhance our understanding of typical and atypical social behavior. We previously reported a quantitative, cross-species (human–chimpanzee) social responsiveness measure, which included the development of the Chimpanzee Social Responsiveness Scale (CSRS). Here, we augment our prior CSRS sample with 25 zoo chimpanzees at three sites: combined N = 54. The CSRS demonstrated strong interrater reliability, and low-ranked chimpanzees, on average, displayed higher CSRS scores. The CSRS continues to discriminate variation in chimpanzee social responsiveness, and the association of higher scores with lower chimpanzee social standing has implications for the relationship between autistic traits and human social status. Continued comparative investigations of social responsiveness will enhance our understanding of underlying impairments in ASD, improve early diagnosis, and inform future therapies. En ligne : http://dx.doi.org/10.1007/s10803-014-2273-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees [Texte imprimé et/ou numérique] / Carley FAUGHN, Auteur ; Natasha MARRUS, Auteur ; Jeremy SHUMAN, Auteur ; Stephen R. ROSS, Auteur ; John N. CONSTANTINO, Auteur ; John R. PRUETT, Auteur ; Daniel J. POVINELLI, Auteur . - p.1483-1488. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1483-1488 Mots-clés : Comparative cognition  Autism  Social Responsiveness Scale  Chimpanzee  Nonhuman primate Index. décimale : PER Périodiques Résumé : Comparative studies of social responsiveness, a core impairment in autism spectrum disorder (ASD), will enhance our understanding of typical and atypical social behavior. We previously reported a quantitative, cross-species (human–chimpanzee) social responsiveness measure, which included the development of the Chimpanzee Social Responsiveness Scale (CSRS). Here, we augment our prior CSRS sample with 25 zoo chimpanzees at three sites: combined N = 54. The CSRS demonstrated strong interrater reliability, and low-ranked chimpanzees, on average, displayed higher CSRS scores. The CSRS continues to discriminate variation in chimpanzee social responsiveness, and the association of higher scores with lower chimpanzee social standing has implications for the relationship between autistic traits and human social status. Continued comparative investigations of social responsiveness will enhance our understanding of underlying impairments in ASD, improve early diagnosis, and inform future therapies. En ligne : http://dx.doi.org/10.1007/s10803-014-2273-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

Commentary – Autism Spectrum Disorder: Spectrum or Cluster? / John R. PRUETT in Autism Research, 9-12 (December 2016)  

Public ISBD [article]  inAutism Research > 9-12 (December 2016) . - p.1237-1240 Titre : Commentary – Autism Spectrum Disorder: Spectrum or Cluster? Type de document : Texte imprimé et/ou numérique Auteurs : John R. PRUETT, Auteur ; Daniel J. POVINELLI, Auteur Article en page(s) : p.1237-1240 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Commentary – Autism Spectrum Disorder: Spectrum or Cluster? [Texte imprimé et/ou numérique] / John R. PRUETT, Auteur ; Daniel J. POVINELLI, Auteur . - p.1237-1240. Langues : Anglais (eng) in Autism Research > 9-12 (December 2016) . - p.1237-1240 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Mapping neural correlates of biological motion perception in autistic children using high-density diffuse optical tomography / Dalin YANG in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 35p. Titre : Mapping neural correlates of biological motion perception in autistic children using high-density diffuse optical tomography Type de document : Texte imprimé et/ou numérique Auteurs : Dalin YANG, Auteur ; Alexandra M. SVOBODA, Auteur ; Tessa G. GEORGE, Auteur ; Patricia K. MANSFIELD, Auteur ; Muriah D. WHEELOCK, Auteur ; Mariel L. SCHROEDER, Auteur ; Sean M. RAFFERTY, Auteur ; Arefeh SHERAFATI, Auteur ; Kalyan TRIPATHY, Auteur ; Tracy BURNS-YOCUM, Auteur ; Elizabeth FORSEN, Auteur ; John R. PRUETT, Auteur ; Natasha M. MARRUS, Auteur ; Joseph P CULVER, Auteur ; John N. CONSTANTINO, Auteur ; Adam T. EGGEBRECHT, Auteur Article en page(s) : 35p. Langues : Anglais (eng) Mots-clés : Humans  Tomography, Optical/methods  Male  Child  Female  Motion Perception/physiology  Brain Mapping/methods  Autism Spectrum Disorder/diagnostic imaging/physiopathology  Brain/diagnostic imaging/physiopathology  Autistic Disorder/physiopathology/diagnostic imaging  Magnetic Resonance Imaging/methods  Adolescent  Autism spectrum disorder  Biological motion  High-density diffuse optical tomography  Neuroimaging  Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD), a neurodevelopmental disorder defined by social communication deficits plus repetitive behaviors and restricted interests, currently affects 1/36 children in the general population. Recent advances in functional brain imaging show promise to provide useful biomarkers of ASD diagnostic likelihood, behavioral trait severity, and even response to therapeutic intervention. However, current gold-standard neuroimaging methods (e.g., functional magnetic resonance imaging, fMRI) are limited in naturalistic studies of brain function underlying ASD-associated behaviors due to the constrained imaging environment. Compared to fMRI, high-density diffuse optical tomography (HD-DOT), a non-invasive and minimally constraining optical neuroimaging modality, can overcome these limitations. Herein, we aimed to establish HD-DOT to evaluate brain function in autistic and non-autistic school-age children as they performed a biological motion perception task previously shown to yield results related to both ASD diagnosis and behavioral traits. METHODS: We used HD-DOT to image brain function in 46 ASD school-age participants and 49 non-autistic individuals (NAI) as they viewed dynamic point-light displays of coherent biological and scrambled motion. We assessed group-level cortical brain function with statistical parametric mapping. Additionally, we tested for brain-behavior associations with dimensional metrics of autism traits, as measured with the Social Responsiveness Scale-2, with hierarchical regression models. RESULTS: We found that NAI participants presented stronger brain activity contrast (coherent > scrambled) than ASD children in cortical regions related to visual, motor, and social processing. Additionally, regression models revealed multiple cortical regions in autistic participants where brain function is significantly associated with dimensional measures of ASD traits. LIMITATIONS: Optical imaging methods are limited in depth sensitivity and so cannot measure brain activity within deep subcortical regions. However, the field of view of this HD-DOT system includes multiple brain regions previously implicated in both task-based and task-free studies on autism. CONCLUSIONS: This study demonstrates that HD-DOT is sensitive to brain function that both differentiates between NAI and ASD groups and correlates with dimensional measures of ASD traits. These findings establish HD-DOT as an effective tool for investigating brain function in autistic and non-autistic children. Moreover, this study established neural correlates related to biological motion perception and its association with dimensional measures of ASD traits. En ligne : https://dx.doi.org/10.1186/s13229-024-00614-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Mapping neural correlates of biological motion perception in autistic children using high-density diffuse optical tomography [Texte imprimé et/ou numérique] / Dalin YANG, Auteur ; Alexandra M. SVOBODA, Auteur ; Tessa G. GEORGE, Auteur ; Patricia K. MANSFIELD, Auteur ; Muriah D. WHEELOCK, Auteur ; Mariel L. SCHROEDER, Auteur ; Sean M. RAFFERTY, Auteur ; Arefeh SHERAFATI, Auteur ; Kalyan TRIPATHY, Auteur ; Tracy BURNS-YOCUM, Auteur ; Elizabeth FORSEN, Auteur ; John R. PRUETT, Auteur ; Natasha M. MARRUS, Auteur ; Joseph P CULVER, Auteur ; John N. CONSTANTINO, Auteur ; Adam T. EGGEBRECHT, Auteur . - 35p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 35p. Mots-clés : Humans  Tomography, Optical/methods  Male  Child  Female  Motion Perception/physiology  Brain Mapping/methods  Autism Spectrum Disorder/diagnostic imaging/physiopathology  Brain/diagnostic imaging/physiopathology  Autistic Disorder/physiopathology/diagnostic imaging  Magnetic Resonance Imaging/methods  Adolescent  Autism spectrum disorder  Biological motion  High-density diffuse optical tomography  Neuroimaging  Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD), a neurodevelopmental disorder defined by social communication deficits plus repetitive behaviors and restricted interests, currently affects 1/36 children in the general population. Recent advances in functional brain imaging show promise to provide useful biomarkers of ASD diagnostic likelihood, behavioral trait severity, and even response to therapeutic intervention. However, current gold-standard neuroimaging methods (e.g., functional magnetic resonance imaging, fMRI) are limited in naturalistic studies of brain function underlying ASD-associated behaviors due to the constrained imaging environment. Compared to fMRI, high-density diffuse optical tomography (HD-DOT), a non-invasive and minimally constraining optical neuroimaging modality, can overcome these limitations. Herein, we aimed to establish HD-DOT to evaluate brain function in autistic and non-autistic school-age children as they performed a biological motion perception task previously shown to yield results related to both ASD diagnosis and behavioral traits. METHODS: We used HD-DOT to image brain function in 46 ASD school-age participants and 49 non-autistic individuals (NAI) as they viewed dynamic point-light displays of coherent biological and scrambled motion. We assessed group-level cortical brain function with statistical parametric mapping. Additionally, we tested for brain-behavior associations with dimensional metrics of autism traits, as measured with the Social Responsiveness Scale-2, with hierarchical regression models. RESULTS: We found that NAI participants presented stronger brain activity contrast (coherent > scrambled) than ASD children in cortical regions related to visual, motor, and social processing. Additionally, regression models revealed multiple cortical regions in autistic participants where brain function is significantly associated with dimensional measures of ASD traits. LIMITATIONS: Optical imaging methods are limited in depth sensitivity and so cannot measure brain activity within deep subcortical regions. However, the field of view of this HD-DOT system includes multiple brain regions previously implicated in both task-based and task-free studies on autism. CONCLUSIONS: This study demonstrates that HD-DOT is sensitive to brain function that both differentiates between NAI and ASD groups and correlates with dimensional measures of ASD traits. These findings establish HD-DOT as an effective tool for investigating brain function in autistic and non-autistic children. Moreover, this study established neural correlates related to biological motion perception and its association with dimensional measures of ASD traits. En ligne : https://dx.doi.org/10.1186/s13229-024-00614-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Potential Risk Factors for the Development of Self-Injurious Behavior among Infants at Risk for Autism Spectrum Disorder / Adele F. DIMIAN in Journal of Autism and Developmental Disorders, 47-5 (May 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1403-1415 Titre : Potential Risk Factors for the Development of Self-Injurious Behavior among Infants at Risk for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Adele F. DIMIAN, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Jed T. ELISON, Auteur ; Annette M. ESTES, Auteur ; John R. PRUETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Joseph PIVEN, Auteur ; Jason J. WOLFF, Auteur Article en page(s) : p.1403-1415 Langues : Anglais (eng) Mots-clés : Self-injurious behavior  Repetitive behavior  Autism spectrum disorder  Risk factors  Infants Index. décimale : PER Périodiques Résumé : Prevalence of self-injurious behavior (SIB) is as high as 50% among children with autism spectrum disorder (ASD). Identification of risk factors for the development of SIB is critical to early intervention and prevention. However, there is little empirical research utilizing a prospective design to identify early risk factors for SIB. The purpose of this study was to evaluate behavioral characteristics predicting SIB at age 2 years among 235 infants at high familial risk for ASD. Logistic regression results indicated that presence of SIB or proto-SIB and lower developmental functioning at age 12 months significantly predicted SIB at 24 months. A pattern of persistent SIB over this period was associated with a diagnosis of autism and poorer cognitive and adaptive outcomes. En ligne : http://dx.doi.org/10.1007/s10803-017-3057-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Potential Risk Factors for the Development of Self-Injurious Behavior among Infants at Risk for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Adele F. DIMIAN, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Jed T. ELISON, Auteur ; Annette M. ESTES, Auteur ; John R. PRUETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Joseph PIVEN, Auteur ; Jason J. WOLFF, Auteur . - p.1403-1415. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1403-1415 Mots-clés : Self-injurious behavior  Repetitive behavior  Autism spectrum disorder  Risk factors  Infants Index. décimale : PER Périodiques Résumé : Prevalence of self-injurious behavior (SIB) is as high as 50% among children with autism spectrum disorder (ASD). Identification of risk factors for the development of SIB is critical to early intervention and prevention. However, there is little empirical research utilizing a prospective design to identify early risk factors for SIB. The purpose of this study was to evaluate behavioral characteristics predicting SIB at age 2 years among 235 infants at high familial risk for ASD. Logistic regression results indicated that presence of SIB or proto-SIB and lower developmental functioning at age 12 months significantly predicted SIB at 24 months. A pattern of persistent SIB over this period was associated with a diagnosis of autism and poorer cognitive and adaptive outcomes. En ligne : http://dx.doi.org/10.1007/s10803-017-3057-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Social and Non-Social Cueing of Visuospatial Attention in Autism and Typical Development / John R. PRUETT in Journal of Autism and Developmental Disorders, 41-6 (June 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-6 (June 2011) . - p.715-731 Titre : Social and Non-Social Cueing of Visuospatial Attention in Autism and Typical Development Type de document : Texte imprimé et/ou numérique Auteurs : John R. PRUETT, Auteur ; Angela LAMACCHIA, Auteur ; Sarah HOERTEL, Auteur ; Emma SQUIRE, Auteur ; Kelly MCVEY, Auteur ; Richard D. TODD, Auteur ; John N. CONSTANTINO, Auteur ; Steven E. PETERSEN, Auteur Année de publication : 2011 Article en page(s) : p.715-731 Langues : Anglais (eng) Mots-clés : Gaze  Box  Arrow  Vision  Oculomotor  Child Index. décimale : PER Périodiques Résumé : Three experiments explored attention to eye gaze, which is incompletely understood in typical development and is hypothesized to be disrupted in autism. Experiment 1 (n = 26 typical adults) involved covert orienting to box, arrow, and gaze cues at two probabilities and cue-target times to test whether reorienting for gaze is endogenous, exogenous, or unique; experiment 2 (total n = 80: male and female children and adults) studied age and sex effects on gaze cueing. Gaze cueing appears endogenous and may strengthen in typical development. Experiment 3 tested exogenous, endogenous, and gaze-based orienting in 25 typical and 27 Autistic Spectrum Disorder (ASD) children. ASD children made more saccades, slowing their reaction times; however, exogenous and endogenous orienting, including gaze cueing, appear intact in ASD. En ligne : http://dx.doi.org/10.1007/s10803-010-1090-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=127 [article] Social and Non-Social Cueing of Visuospatial Attention in Autism and Typical Development [Texte imprimé et/ou numérique] / John R. PRUETT, Auteur ; Angela LAMACCHIA, Auteur ; Sarah HOERTEL, Auteur ; Emma SQUIRE, Auteur ; Kelly MCVEY, Auteur ; Richard D. TODD, Auteur ; John N. CONSTANTINO, Auteur ; Steven E. PETERSEN, Auteur . - 2011 . - p.715-731. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-6 (June 2011) . - p.715-731 Mots-clés : Gaze  Box  Arrow  Vision  Oculomotor  Child Index. décimale : PER Périodiques Résumé : Three experiments explored attention to eye gaze, which is incompletely understood in typical development and is hypothesized to be disrupted in autism. Experiment 1 (n = 26 typical adults) involved covert orienting to box, arrow, and gaze cues at two probabilities and cue-target times to test whether reorienting for gaze is endogenous, exogenous, or unique; experiment 2 (total n = 80: male and female children and adults) studied age and sex effects on gaze cueing. Gaze cueing appears endogenous and may strengthen in typical development. Experiment 3 tested exogenous, endogenous, and gaze-based orienting in 25 typical and 27 Autistic Spectrum Disorder (ASD) children. ASD children made more saccades, slowing their reaction times; however, exogenous and endogenous orienting, including gaze cueing, appear intact in ASD. En ligne : http://dx.doi.org/10.1007/s10803-010-1090-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=127

Social motivation in infancy is associated with familial recurrence of ASD / Natasha MARRUS in Development and Psychopathology, 36-1 (February 2024)  

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Training of child and adolescent psychiatry fellows in autism and intellectual disability / Natasha MARRUS in Autism, 18-4 (May 2014)  

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