Caregiver perspectives on interventions for behavior challenges in autistic children / Jessica E. TSCHIDA in Research in Autism Spectrum Disorders, 81 (March 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 81 (March 2021) . - 101714 Titre : Caregiver perspectives on interventions for behavior challenges in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Jessica E. TSCHIDA, Auteur ; Brenna B. MADDOX, Auteur ; Jennifer R. BERTOLLO, Auteur ; Emily S. KUSCHNER, Auteur ; Judith S. MILLER, Auteur ; Thomas H. OLLENDICK, Auteur ; Ross W. GREENE, Auteur ; Benjamin E. YERYS, Auteur Article en page(s) : 101714 Langues : Anglais (eng) Mots-clés : Aggression  Autism  Intervention  Parent  School-age Index. décimale : PER Périodiques Résumé : Background Children with an autism spectrum disorder (ASD) diagnosis have high rates of behaviors such as aggression, oppositional behaviors, and tantrums. Despite effectiveness of interventions for these behavior challenges in a considerable number of autistic children, there is little information on stakeholder perspectives about available interventions. The present study preliminarily characterized caregiver perspectives on intervention for behavior challenges in school-age autistic children. Method 321 caregivers of autistic children completed a survey about interventions used to address behavior challenges. Kruskal-Wallis rank-sum tests and subsequent pairwise comparisons using a Wilcoxon rank-sum test with False-Discovery Rate-adjusted p-values (q<0.05) were conducted for caregiver ratings of interventions. Thematic analysis was conducted for caregivers’ open-ended suggestions for improving interventions. Results Caregivers indicated limited approval of attempted interventions. For children with an IQ ? 70, the omnibus test was significant for caregiver ratings of intervention helpfulness (?2(8) = 38.707, q<0.001, ?2 = 0.017) with medications and Collaborative & Proactive Solutions (CPS; Greene, 2010) therapy rated highest, and was significant for caregiver ratings of amount of improvement maintained over time (?2(8) = 46.013, q<0.001, ?2 = 0.020) with medications, CPS, applied behavioral analysis (ABA), and “other interventions” rated highest. For children with an IQ < 70, pairwise tests revealed no significant differences. Caregivers suggested improvements at the systems, provider, caregiver/family, and child/intervention levels. Conclusions Caregivers’ limited approval of interventions used to address behavior challenges suggests the need for improved intervention options. While medications and ABA are standard-of-care interventions, CPS may be a caregiver-preferred and efficacious option that is underutilized among autistic children with an IQ ? 70. En ligne : https://doi.org/10.1016/j.rasd.2020.101714 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] Caregiver perspectives on interventions for behavior challenges in autistic children [Texte imprimé et/ou numérique] / Jessica E. TSCHIDA, Auteur ; Brenna B. MADDOX, Auteur ; Jennifer R. BERTOLLO, Auteur ; Emily S. KUSCHNER, Auteur ; Judith S. MILLER, Auteur ; Thomas H. OLLENDICK, Auteur ; Ross W. GREENE, Auteur ; Benjamin E. YERYS, Auteur . - 101714. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 81 (March 2021) . - 101714 Mots-clés : Aggression  Autism  Intervention  Parent  School-age Index. décimale : PER Périodiques Résumé : Background Children with an autism spectrum disorder (ASD) diagnosis have high rates of behaviors such as aggression, oppositional behaviors, and tantrums. Despite effectiveness of interventions for these behavior challenges in a considerable number of autistic children, there is little information on stakeholder perspectives about available interventions. The present study preliminarily characterized caregiver perspectives on intervention for behavior challenges in school-age autistic children. Method 321 caregivers of autistic children completed a survey about interventions used to address behavior challenges. Kruskal-Wallis rank-sum tests and subsequent pairwise comparisons using a Wilcoxon rank-sum test with False-Discovery Rate-adjusted p-values (q<0.05) were conducted for caregiver ratings of interventions. Thematic analysis was conducted for caregivers’ open-ended suggestions for improving interventions. Results Caregivers indicated limited approval of attempted interventions. For children with an IQ ? 70, the omnibus test was significant for caregiver ratings of intervention helpfulness (?2(8) = 38.707, q<0.001, ?2 = 0.017) with medications and Collaborative & Proactive Solutions (CPS; Greene, 2010) therapy rated highest, and was significant for caregiver ratings of amount of improvement maintained over time (?2(8) = 46.013, q<0.001, ?2 = 0.020) with medications, CPS, applied behavioral analysis (ABA), and “other interventions” rated highest. For children with an IQ < 70, pairwise tests revealed no significant differences. Caregivers suggested improvements at the systems, provider, caregiver/family, and child/intervention levels. Conclusions Caregivers’ limited approval of interventions used to address behavior challenges suggests the need for improved intervention options. While medications and ABA are standard-of-care interventions, CPS may be a caregiver-preferred and efficacious option that is underutilized among autistic children with an IQ ? 70. En ligne : https://doi.org/10.1016/j.rasd.2020.101714 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development / Heather L. GREEN in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.4076-4089 Titre : Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development Type de document : Texte imprimé et/ou numérique Auteurs : Heather L. GREEN, Auteur ; Guannan SHEN, Auteur ; Rose E. FRANZEN, Auteur ; Marybeth MCNAMEE, Auteur ; Jeffrey I. BERMAN, Auteur ; Theresa G. MOWAD, Auteur ; Matthew KU, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Yu-Han CHEN, Auteur ; Megan AIREY, Auteur ; Emma MCBRIDE, Auteur ; Sophia GOLDIN, Auteur ; Marissa A. DIPIERO, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Timothy P. L. ROBERTS, Auteur ; J. Christopher EDGAR, Auteur Article en page(s) : p.4076-4089 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Maturation of auditory cortex neural encoding processes was assessed in children with typical development (TD) and autism. Children 6-9 years old were enrolled at Time 1 (T1), with follow-up data obtained?~?18 months later at Time 2 (T2), and?~?36 months later at Time 3 (T3). Findings suggested an initial period of rapid auditory cortex maturation in autism, earlier than TD (prior to and surrounding the T1 exam), followed by a period of faster maturation in TD than autism (T1-T3). As a result of group maturation differences, post-stimulus group differences were observed at T1 but not T3. In contrast, stronger pre-stimulus activity in autism than TD was found at all time points, indicating this brain measure is stable across time. En ligne : https://doi.org/10.1007/s10803-022-05696-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development [Texte imprimé et/ou numérique] / Heather L. GREEN, Auteur ; Guannan SHEN, Auteur ; Rose E. FRANZEN, Auteur ; Marybeth MCNAMEE, Auteur ; Jeffrey I. BERMAN, Auteur ; Theresa G. MOWAD, Auteur ; Matthew KU, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Yu-Han CHEN, Auteur ; Megan AIREY, Auteur ; Emma MCBRIDE, Auteur ; Sophia GOLDIN, Auteur ; Marissa A. DIPIERO, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Timothy P. L. ROBERTS, Auteur ; J. Christopher EDGAR, Auteur . - p.4076-4089. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.4076-4089 Index. décimale : PER Périodiques Résumé : Maturation of auditory cortex neural encoding processes was assessed in children with typical development (TD) and autism. Children 6-9 years old were enrolled at Time 1 (T1), with follow-up data obtained?~?18 months later at Time 2 (T2), and?~?36 months later at Time 3 (T3). Findings suggested an initial period of rapid auditory cortex maturation in autism, earlier than TD (prior to and surrounding the T1 exam), followed by a period of faster maturation in TD than autism (T1-T3). As a result of group maturation differences, post-stimulus group differences were observed at T1 but not T3. In contrast, stronger pre-stimulus activity in autism than TD was found at all time points, indicating this brain measure is stable across time. En ligne : https://doi.org/10.1007/s10803-022-05696-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD / Russell G. PORT in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.593-607 Titre : Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Russell G. PORT, Auteur ; William GAETZ, Auteur ; Luke BLOY, Auteur ; Dah-Jyuu WANG, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Susan E. LEVY, Auteur ; Edward S. BRODKIN, Auteur ; Timothy P. L. ROBERTS, Auteur Article en page(s) : p.593-607 Langues : Anglais (eng) Mots-clés : magnetoencephalography  gamma-band  GABA  MEGA-PRESS  magnetic resonance spectroscopy  auditory  autism spectrum disorder  excitatory/inhibitory Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is hypothesized to arise from imbalances between excitatory and inhibitory neurotransmission (E/I imbalance). Studies have demonstrated E/I imbalance in individuals with ASD and also corresponding rodent models. One neural process thought to be reliant on E/I balance is gamma-band activity (Gamma), with support arising from observed correlations between motor, as well as visual, Gamma and underlying GABA concentrations in healthy adults. Additionally, decreased Gamma has been observed in ASD individuals and relevant animal models, though the direct relationship between Gamma and GABA concentrations in ASD remains unexplored. This study combined magnetoencephalography (MEG) and edited magnetic resonance spectroscopy (MRS) in 27 typically developing individuals (TD) and 30 individuals with ASD. Auditory cortex localized phase-locked Gamma was compared to resting Superior Temporal Gyrus relative cortical GABA concentrations for both children/adolescents and adults. Children/adolescents with ASD exhibited significantly decreased GABA+/Creatine (Cr) levels, though typical Gamma. Additionally, these children/adolescents lacked the typical maturation of GABA+/Cr concentrations and gamma-band coherence. Furthermore, children/adolescents with ASD additionally failed to exhibit the typical GABA+/Cr to gamma-band coherence association. This altered coupling during childhood/adolescence may result in Gamma decreases observed in the adults with ASD. Therefore, individuals with ASD exhibit improper local neuronal circuitry maturation during a childhood/adolescence critical period, when GABA is involved in configuring of such circuit functioning. Provocatively a novel line of treatment is suggested (with a critical time window); by increasing neural GABA levels in children/adolescents with ASD, proper local circuitry maturation may be restored resulting in typical Gamma in adulthood. En ligne : http://dx.doi.org/10.1002/aur.1686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD [Texte imprimé et/ou numérique] / Russell G. PORT, Auteur ; William GAETZ, Auteur ; Luke BLOY, Auteur ; Dah-Jyuu WANG, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Susan E. LEVY, Auteur ; Edward S. BRODKIN, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.593-607. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.593-607 Mots-clés : magnetoencephalography  gamma-band  GABA  MEGA-PRESS  magnetic resonance spectroscopy  auditory  autism spectrum disorder  excitatory/inhibitory Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is hypothesized to arise from imbalances between excitatory and inhibitory neurotransmission (E/I imbalance). Studies have demonstrated E/I imbalance in individuals with ASD and also corresponding rodent models. One neural process thought to be reliant on E/I balance is gamma-band activity (Gamma), with support arising from observed correlations between motor, as well as visual, Gamma and underlying GABA concentrations in healthy adults. Additionally, decreased Gamma has been observed in ASD individuals and relevant animal models, though the direct relationship between Gamma and GABA concentrations in ASD remains unexplored. This study combined magnetoencephalography (MEG) and edited magnetic resonance spectroscopy (MRS) in 27 typically developing individuals (TD) and 30 individuals with ASD. Auditory cortex localized phase-locked Gamma was compared to resting Superior Temporal Gyrus relative cortical GABA concentrations for both children/adolescents and adults. Children/adolescents with ASD exhibited significantly decreased GABA+/Creatine (Cr) levels, though typical Gamma. Additionally, these children/adolescents lacked the typical maturation of GABA+/Cr concentrations and gamma-band coherence. Furthermore, children/adolescents with ASD additionally failed to exhibit the typical GABA+/Cr to gamma-band coherence association. This altered coupling during childhood/adolescence may result in Gamma decreases observed in the adults with ASD. Therefore, individuals with ASD exhibit improper local neuronal circuitry maturation during a childhood/adolescence critical period, when GABA is involved in configuring of such circuit functioning. Provocatively a novel line of treatment is suggested (with a critical time window); by increasing neural GABA levels in children/adolescents with ASD, proper local circuitry maturation may be restored resulting in typical Gamma in adulthood. En ligne : http://dx.doi.org/10.1002/aur.1686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Local vs. global approaches to reproducing the Rey Osterrieth complex figure by children, adolescents, and adults with high-functioning autism / Emily S. KUSCHNER in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.348-358 Titre : Local vs. global approaches to reproducing the Rey Osterrieth complex figure by children, adolescents, and adults with high-functioning autism Type de document : Texte imprimé et/ou numérique Auteurs : Emily S. KUSCHNER, Auteur ; Nancy J. MINSHEW, Auteur ; Kimberly E. BODNER, Auteur Année de publication : 2009 Article en page(s) : p.348-358 Langues : Anglais (eng) Mots-clés : autism visual-processing visuo-spatial-abilities local-processing global-processing strategic-planning problem-solving neural-connectivity Index. décimale : PER Périodiques Résumé : Individuals with autism have an atypical pattern of visual processing. Various studies have provided evidence that individuals with autism perceive the details of stimuli before the gestalt, the reverse of the typical pattern of visual processing. This study used the Rey Osterreith Complex Figure (ROCF) task and an objective scoring system to examine local/global processing approaches to its reproduction in 37 individuals diagnosed with high-functioning autism (HFA) compared to 49 age-, IQ-, and gender-matched typically developing controls (TD). The sample was divided into children (aged 8-14 years) and adolescents/adults (aged 15-47 years) to assess age effects. Results showed no difference in overall performance on the ROCF between HFA and TD children. TD participants displayed improved organizational and planning skills with age and a shift to global processing approaches, but there were no differences in performance between children and adolescents/adults with HFA. There was no evidence of enhanced local processing in either HFA group. These findings suggest that HFA individuals with average IQ scores do not have the clinically demonstrable evidence of the enhanced local processing thought to reflect increased local brain connectivity in more severely autistic individuals. The deficient global processing of the HFA adults reflects dependence of performance on impaired strategic problem-solving abilities, which has been demonstrated to result from under development of neural connectivity between visuo-spatial and frontal brain regions in HFA adults. En ligne : http://dx.doi.org/10.1002/aur.101 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Local vs. global approaches to reproducing the Rey Osterrieth complex figure by children, adolescents, and adults with high-functioning autism [Texte imprimé et/ou numérique] / Emily S. KUSCHNER, Auteur ; Nancy J. MINSHEW, Auteur ; Kimberly E. BODNER, Auteur . - 2009 . - p.348-358. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.348-358 Mots-clés : autism visual-processing visuo-spatial-abilities local-processing global-processing strategic-planning problem-solving neural-connectivity Index. décimale : PER Périodiques Résumé : Individuals with autism have an atypical pattern of visual processing. Various studies have provided evidence that individuals with autism perceive the details of stimuli before the gestalt, the reverse of the typical pattern of visual processing. This study used the Rey Osterreith Complex Figure (ROCF) task and an objective scoring system to examine local/global processing approaches to its reproduction in 37 individuals diagnosed with high-functioning autism (HFA) compared to 49 age-, IQ-, and gender-matched typically developing controls (TD). The sample was divided into children (aged 8-14 years) and adolescents/adults (aged 15-47 years) to assess age effects. Results showed no difference in overall performance on the ROCF between HFA and TD children. TD participants displayed improved organizational and planning skills with age and a shift to global processing approaches, but there were no differences in performance between children and adolescents/adults with HFA. There was no evidence of enhanced local processing in either HFA group. These findings suggest that HFA individuals with average IQ scores do not have the clinically demonstrable evidence of the enhanced local processing thought to reflect increased local brain connectivity in more severely autistic individuals. The deficient global processing of the HFA adults reflects dependence of performance on impaired strategic problem-solving abilities, which has been demonstrated to result from under development of neural connectivity between visuo-spatial and frontal brain regions in HFA adults. En ligne : http://dx.doi.org/10.1002/aur.101 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

Patterns of Nonverbal Cognitive Functioning in Young Children with Autism Spectrum Disorders / Emily S. KUSCHNER in Journal of Autism and Developmental Disorders, 37-5 (May 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.795-807 Titre : Patterns of Nonverbal Cognitive Functioning in Young Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Emily S. KUSCHNER, Auteur ; Loisa BENNETTO, Auteur ; Kelley YOST, Auteur Année de publication : 2007 Article en page(s) : p.795-807 Langues : Anglais (eng) Mots-clés : Autism Nonverbal Cognitive-functioning Preschool Leiter-R Index. décimale : PER Périodiques Résumé : Previous research demonstrates an uneven pattern of cognitive abilities in children with autism spectrum disorders (ASDs). This study examined whether this uneven pattern exists within the nonverbal domain in young children. We hypothesized relative strengths in perceptual abilities and weaknesses in nonverbal conceptual abilities in preschoolers with ASDs compared to groups with non-autism developmental delays and typical development. Profiles were examined using the Leiter International Performance Scale-Revised. The ASD group displayed clear relative strengths in visuospatial disembedding and detail-focused processing, with relative weaknesses in abstraction and concept formation. This contrasted with patterns of roughly equivalent abilities in both comparison groups. These findings have implications for subsequent development and may represent key features of the cognitive profile of autism. En ligne : http://dx.doi.org/10.1007/s10803-006-0209-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 [article] Patterns of Nonverbal Cognitive Functioning in Young Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Emily S. KUSCHNER, Auteur ; Loisa BENNETTO, Auteur ; Kelley YOST, Auteur . - 2007 . - p.795-807. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.795-807 Mots-clés : Autism Nonverbal Cognitive-functioning Preschool Leiter-R Index. décimale : PER Périodiques Résumé : Previous research demonstrates an uneven pattern of cognitive abilities in children with autism spectrum disorders (ASDs). This study examined whether this uneven pattern exists within the nonverbal domain in young children. We hypothesized relative strengths in perceptual abilities and weaknesses in nonverbal conceptual abilities in preschoolers with ASDs compared to groups with non-autism developmental delays and typical development. Profiles were examined using the Leiter International Performance Scale-Revised. The ASD group displayed clear relative strengths in visuospatial disembedding and detail-focused processing, with relative weaknesses in abstraction and concept formation. This contrasted with patterns of roughly equivalent abilities in both comparison groups. These findings have implications for subsequent development and may represent key features of the cognitive profile of autism. En ligne : http://dx.doi.org/10.1007/s10803-006-0209-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

A preliminary study of self-reported food selectivity in adolescents and young adults with autism spectrum disorder / Emily S. KUSCHNER in Research in Autism Spectrum Disorders, 15-16 (July 2015)  

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Resting-State Activity in Children: Replicating and Extending Findings of Early Maturation of Alpha Rhythms in Autism Spectrum Disorder / Guannan SHEN in Journal of Autism and Developmental Disorders, 54-5 (May 2024)  

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