Altered Medial Frontal and Superior Temporal Response to Implicit Processing of Emotions in Autism / Rajesh K. KANA in Autism Research, 9-1 (January 2016)  

Public ISBD [article]  inAutism Research > 9-1 (January 2016) . - p.55-66 Titre : Altered Medial Frontal and Superior Temporal Response to Implicit Processing of Emotions in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Rajesh K. KANA, Auteur ; Michelle A. PATRIQUIN, Auteur ; Briley S. BLACK, Auteur ; Marie M. CHANNELL, Auteur ; Bruno WICKER, Auteur Article en page(s) : p.55-66 Langues : Anglais (eng) Mots-clés : implicit emotion  explicit emotion  fMRI  functional connectivity  autism Index. décimale : PER Périodiques Résumé : Interpreting emotional expressions appropriately poses a challenge for individuals with autism spectrum disorder (ASD). In particular, difficulties with emotional processing in ASD are more pronounced in contexts where emotional expressions are subtle, automatic, and reflexive—that is, implicit. In contrast, explicit emotional processing, which requires the cognitive evaluation of an emotional experience, appears to be relatively intact in individuals with ASD. In the present study, we examined the brain activation and functional connectivity differences underlying explicit and implicit emotional processing in age- and IQ-matched adults with (n?=?17) and without (n?=?15) ASD. Results indicated: (1) significantly reduced levels of brain activation in participants with ASD in medial prefrontal cortex (MPFC) and superior temporal gyrus (STG) during implicit emotion processing; (2) significantly weaker functional connectivity in the ASD group in connections of the MPFC with the amygdala, temporal lobe, parietal lobe, and fusiform gyrus; (3) No group difference in performance accuracy or reaction time; and (4) Significant positive relationship between empathizing ability and STG activity in ASD but not in typically developing participants. These findings suggest that the neural mechanisms underlying implicit, but not explicit, emotion processing may be altered at multiple levels in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Altered Medial Frontal and Superior Temporal Response to Implicit Processing of Emotions in Autism [Texte imprimé et/ou numérique] / Rajesh K. KANA, Auteur ; Michelle A. PATRIQUIN, Auteur ; Briley S. BLACK, Auteur ; Marie M. CHANNELL, Auteur ; Bruno WICKER, Auteur . - p.55-66. Langues : Anglais (eng) in Autism Research > 9-1 (January 2016) . - p.55-66 Mots-clés : implicit emotion  explicit emotion  fMRI  functional connectivity  autism Index. décimale : PER Périodiques Résumé : Interpreting emotional expressions appropriately poses a challenge for individuals with autism spectrum disorder (ASD). In particular, difficulties with emotional processing in ASD are more pronounced in contexts where emotional expressions are subtle, automatic, and reflexive—that is, implicit. In contrast, explicit emotional processing, which requires the cognitive evaluation of an emotional experience, appears to be relatively intact in individuals with ASD. In the present study, we examined the brain activation and functional connectivity differences underlying explicit and implicit emotional processing in age- and IQ-matched adults with (n?=?17) and without (n?=?15) ASD. Results indicated: (1) significantly reduced levels of brain activation in participants with ASD in medial prefrontal cortex (MPFC) and superior temporal gyrus (STG) during implicit emotion processing; (2) significantly weaker functional connectivity in the ASD group in connections of the MPFC with the amygdala, temporal lobe, parietal lobe, and fusiform gyrus; (3) No group difference in performance accuracy or reaction time; and (4) Significant positive relationship between empathizing ability and STG activity in ASD but not in typically developing participants. These findings suggest that the neural mechanisms underlying implicit, but not explicit, emotion processing may be altered at multiple levels in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Identifying diagnostically-relevant resting state brain functional connectivity in the ventral posterior complex via genetic data mining in autism spectrum disorder / Philip R. BALDWIN in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.553-562 Titre : Identifying diagnostically-relevant resting state brain functional connectivity in the ventral posterior complex via genetic data mining in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Philip R. BALDWIN, Auteur ; Kaylah N. CURTIS, Auteur ; Michelle A. PATRIQUIN, Auteur ; Varina WOLF, Auteur ; Humsini VISWANATH, Auteur ; Chad SHAW, Auteur ; Yasunari SAKAI, Auteur ; Ramiro SALAS, Auteur Article en page(s) : p.553-562 Langues : Anglais (eng) Mots-clés : autism  brain  connectivity  genes  genetic data mining  neuroimaging  resting state  restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Exome sequencing and copy number variation analyses continue to provide novel insight to the biological bases of autism spectrum disorder (ASD). The growing speed at which massive genetic data are produced causes serious lags in analysis and interpretation of the data. Thus, there is a need to develop systematic genetic data mining processes that facilitate efficient analysis of large datasets. We report a new genetic data mining system, ProcessGeneLists and integrated a list of ASD-related genes with currently available resources in gene expression and functional connectivity of the human brain. Our data-mining program successfully identified three primary regions of interest (ROIs) in the mouse brain: inferior colliculus, ventral posterior complex of the thalamus (VPC), and parafascicular nucleus (PFn). To understand its pathogenic relevance in ASD, we examined the resting state functional connectivity (RSFC) of the homologous ROIs in human brain with other brain regions that were previously implicated in the neuro-psychiatric features of ASD. Among them, the RSFC of the VPC with the medial frontal gyrus (MFG) was significantly more anticorrelated, whereas the RSFC of the PN with the globus pallidus was significantly increased in children with ASD compared with healthy children. Moreover, greater values of RSFC between VPC and MFG were correlated with severity index and repetitive behaviors in children with ASD. No significant RSFC differences were detected in adults with ASD. Together, these data demonstrate the utility of our data-mining program through identifying the aberrant connectivity of thalamo-cortical circuits in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Identifying diagnostically-relevant resting state brain functional connectivity in the ventral posterior complex via genetic data mining in autism spectrum disorder [Texte imprimé et/ou numérique] / Philip R. BALDWIN, Auteur ; Kaylah N. CURTIS, Auteur ; Michelle A. PATRIQUIN, Auteur ; Varina WOLF, Auteur ; Humsini VISWANATH, Auteur ; Chad SHAW, Auteur ; Yasunari SAKAI, Auteur ; Ramiro SALAS, Auteur . - p.553-562. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.553-562 Mots-clés : autism  brain  connectivity  genes  genetic data mining  neuroimaging  resting state  restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Exome sequencing and copy number variation analyses continue to provide novel insight to the biological bases of autism spectrum disorder (ASD). The growing speed at which massive genetic data are produced causes serious lags in analysis and interpretation of the data. Thus, there is a need to develop systematic genetic data mining processes that facilitate efficient analysis of large datasets. We report a new genetic data mining system, ProcessGeneLists and integrated a list of ASD-related genes with currently available resources in gene expression and functional connectivity of the human brain. Our data-mining program successfully identified three primary regions of interest (ROIs) in the mouse brain: inferior colliculus, ventral posterior complex of the thalamus (VPC), and parafascicular nucleus (PFn). To understand its pathogenic relevance in ASD, we examined the resting state functional connectivity (RSFC) of the homologous ROIs in human brain with other brain regions that were previously implicated in the neuro-psychiatric features of ASD. Among them, the RSFC of the VPC with the medial frontal gyrus (MFG) was significantly more anticorrelated, whereas the RSFC of the PN with the globus pallidus was significantly increased in children with ASD compared with healthy children. Moreover, greater values of RSFC between VPC and MFG were correlated with severity index and repetitive behaviors in children with ASD. No significant RSFC differences were detected in adults with ASD. Together, these data demonstrate the utility of our data-mining program through identifying the aberrant connectivity of thalamo-cortical circuits in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Parent-reported problematic sleep behaviors in children with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder / Katharine C. REYNOLDS in Research in Autism Spectrum Disorders, 39 (July 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 39 (July 2017) . - p.20-32 Titre : Parent-reported problematic sleep behaviors in children with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Katharine C. REYNOLDS, Auteur ; Michelle A. PATRIQUIN, Auteur ; Candice A. ALFANO, Auteur ; Katherine A. LOVELAND, Auteur ; Deborah A. PEARSON, Auteur Article en page(s) : p.20-32 Langues : Anglais (eng) Mots-clés : Sleep  Autism spectrum disorder  Attention-deficit/hyperactivity disorder  Child  Psychopathology Index. décimale : PER Périodiques Résumé : AbstractBackground Sleep problems are frequent and well documented in children with Autism Spectrum Disorders (ASD), children with Attention Deficit/Hyperactivity Disorder (ADHD) and children with internalizing problems, however limited work has examined sleep problems in children presenting with comorbid ASD/ADHD. In healthy children, sleep problems negatively impact social, emotional, and academic functioning. The current study sought to examine diagnostic severity as predictors of sleep problems in children with comorbid ASD/ADHD. Additionally, the association between sleep and “real-life” functional domains (i.e., intellectual functioning, academic achievement, and executive functioning) were assessed. Method Sleep, internalizing difficulties, intellectual functioning, academic achievement and executive functioning were assessed in 85 children with who carried the dual diagnoses of ASD and ADHD. Results Internalizing difficulties, rather than ASD or ADHD symptom severity, was the most consistent predictor of problematic sleep behaviors (i.e., nightmares overtiredness, sleeping less than other children, trouble sleeping, and Total Problematic Sleep Behaviors) in this sample. Further, parent report of problematic sleep behaviors was significantly associated with functional domains after controlling for ASD, ADHD, and internalizing symptoms. Conclusions Results suggest that internalizing symptoms are associated with problematic sleep behaviors in children with comorbid ASD/ADHD and may have implications for the “real-life” functioning among children with comorbid ASD/ADHD. En ligne : https://doi.org/10.1016/j.rasd.2017.04.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Parent-reported problematic sleep behaviors in children with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Katharine C. REYNOLDS, Auteur ; Michelle A. PATRIQUIN, Auteur ; Candice A. ALFANO, Auteur ; Katherine A. LOVELAND, Auteur ; Deborah A. PEARSON, Auteur . - p.20-32. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 39 (July 2017) . - p.20-32 Mots-clés : Sleep  Autism spectrum disorder  Attention-deficit/hyperactivity disorder  Child  Psychopathology Index. décimale : PER Périodiques Résumé : AbstractBackground Sleep problems are frequent and well documented in children with Autism Spectrum Disorders (ASD), children with Attention Deficit/Hyperactivity Disorder (ADHD) and children with internalizing problems, however limited work has examined sleep problems in children presenting with comorbid ASD/ADHD. In healthy children, sleep problems negatively impact social, emotional, and academic functioning. The current study sought to examine diagnostic severity as predictors of sleep problems in children with comorbid ASD/ADHD. Additionally, the association between sleep and “real-life” functional domains (i.e., intellectual functioning, academic achievement, and executive functioning) were assessed. Method Sleep, internalizing difficulties, intellectual functioning, academic achievement and executive functioning were assessed in 85 children with who carried the dual diagnoses of ASD and ADHD. Results Internalizing difficulties, rather than ASD or ADHD symptom severity, was the most consistent predictor of problematic sleep behaviors (i.e., nightmares overtiredness, sleeping less than other children, trouble sleeping, and Total Problematic Sleep Behaviors) in this sample. Further, parent report of problematic sleep behaviors was significantly associated with functional domains after controlling for ASD, ADHD, and internalizing symptoms. Conclusions Results suggest that internalizing symptoms are associated with problematic sleep behaviors in children with comorbid ASD/ADHD and may have implications for the “real-life” functioning among children with comorbid ASD/ADHD. En ligne : https://doi.org/10.1016/j.rasd.2017.04.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

The Modified Checklist for Autism in Toddlers: Reliability in a Diverse Rural American Sample / Angela SCARPA in Journal of Autism and Developmental Disorders, 43-10 (October 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-10 (October 2013) . - p.2269-2279 Titre : The Modified Checklist for Autism in Toddlers: Reliability in a Diverse Rural American Sample Type de document : Texte imprimé et/ou numérique Auteurs : Angela SCARPA, Auteur ; Nuri M. REYES, Auteur ; Michelle A. PATRIQUIN, Auteur ; Jill LORENZI, Auteur ; Tyler A. HASSENFELDT, Auteur ; Varsha J. DESAI, Auteur ; Kathryn W. KERKERING, Auteur Article en page(s) : p.2269-2279 Langues : Anglais (eng) Mots-clés : M-CHAT  Autism screening  Reliability  Diverse populations Index. décimale : PER Périodiques Résumé : This study investigated the psychometric properties of the modified checklist for autism in toddlers (M-CHAT) in a diverse rural American low-socioeconomic status (SES) sample. Four hundred and forty-seven English (n = 335) and Spanish (n = 112) speaking caregivers completed the M-CHAT during their toddler’s 18- or 24-month well visit in a Southwest Virginia pediatric clinic. The M-CHAT did not show acceptable internal consistency in groups with low maternal education or minority status. Caregivers reporting low maternal education and minority status were more likely to endorse items suggestive of autism. These results indicate that the M-CHAT may require modifications to be more internally consistent and accurate across ethnic and educational groups in rural areas with low levels of SES. Recommendations to increase the utility of the M-CHAT are discussed. En ligne : http://dx.doi.org/10.1007/s10803-013-1779-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215 [article] The Modified Checklist for Autism in Toddlers: Reliability in a Diverse Rural American Sample [Texte imprimé et/ou numérique] / Angela SCARPA, Auteur ; Nuri M. REYES, Auteur ; Michelle A. PATRIQUIN, Auteur ; Jill LORENZI, Auteur ; Tyler A. HASSENFELDT, Auteur ; Varsha J. DESAI, Auteur ; Kathryn W. KERKERING, Auteur . - p.2269-2279. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-10 (October 2013) . - p.2269-2279 Mots-clés : M-CHAT  Autism screening  Reliability  Diverse populations Index. décimale : PER Périodiques Résumé : This study investigated the psychometric properties of the modified checklist for autism in toddlers (M-CHAT) in a diverse rural American low-socioeconomic status (SES) sample. Four hundred and forty-seven English (n = 335) and Spanish (n = 112) speaking caregivers completed the M-CHAT during their toddler’s 18- or 24-month well visit in a Southwest Virginia pediatric clinic. The M-CHAT did not show acceptable internal consistency in groups with low maternal education or minority status. Caregivers reporting low maternal education and minority status were more likely to endorse items suggestive of autism. These results indicate that the M-CHAT may require modifications to be more internally consistent and accurate across ethnic and educational groups in rural areas with low levels of SES. Recommendations to increase the utility of the M-CHAT are discussed. En ligne : http://dx.doi.org/10.1007/s10803-013-1779-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215

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