Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder / Junko MATSUZAKI in Autism Research, 12-8 (August 2019)  

Public ISBD [article]  inAutism Research > 12-8 (August 2019) . - p.1225-1235 Titre : Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder Type de document : texte imprimé Auteurs : Junko MATSUZAKI, Auteur ; Emily S. KUSCHNER, Auteur ; Lisa BLASKEY, Auteur ; Luke BLOY, Auteur ; Mina KIM, Auteur ; Matthew KU, Auteur ; J. Christopher EDGAR, Auteur ; David EMBICK, Auteur ; Timothy P.L. ROBERTS, Auteur Article en page(s) : p.1225-1235 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  language and communication skill  magnetoencephalography  minimally verbal/non-verbal children  vowel mismatch fields Index. décimale : PER Périodiques Résumé : Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded by magnetoencephalography (MEG), have been reported in verbal children with ASD. Association with clinical measures indicates that delayed MMF components are associated with poorer language and communication performance. At present, little is known about neural correlates of language and communication skills in extremely language impaired (minimally-verbal/non-verbal) children who have ASD: ASD-MVNV. It is hypothesized that MMF delays observed in language-impaired but nonetheless verbal children with ASD will be exacerbated in ASD-MVNV. The present study investigated this hypothesis, examining MMF responses bilaterally during an auditory oddball paradigm with vowel stimuli in ASD-MVNV, in a verbal ASD cohort without cognitive impairment and in typically developing (TD) children. The verbal ASD cohort without cognitive impairment was split into those demonstrating considerable language impairment (CELF core language index <85; "ASD-LI") versus those with less or no language impairment (CELF CLI >85; "ASD-V"). Eighty-four participants (8-12 years) were included in final analysis: ASD-MVNV: n = 9, 9.67 +/- 1.41 years, ASD: n = 48, (ASD-V: n = 27, 10.55 +/- 1.21 years, ASD-LI: n = 21, 10.67 +/- 1.20 years) and TD: n = 27, 10.14 +/- 1.38 years. Delayed MMF latencies were found bilaterally in ASD-MVNV compared to verbal ASD (both ASD-V and ASD-LI) and TD children. Delayed MMF responses were associated with diminished language and communication skills. Furthermore, whereas the TD children showed leftward lateralization of MMF amplitude, ASD-MVNV and verbal ASD (ASD-V and ASD-LI) showed abnormal rightward lateralization. Findings suggest delayed auditory discrimination processes and abnormal rightward laterality as objective markers of language/communication skills in both verbal and MVNV children who have ASD. Autism Res 2019, 12: 1225-1235. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Brain imaging showed abnormal auditory discrimination processes in minimally-verbal/non-verbal children (MVNV) who have autism spectrum disorder (ASD). Delays in auditory discrimination were associated with impaired language and communication skills. Findings suggest these auditory neural measures may be objective markers of language and communication skills in both verbal and, previously-understudied, MVNV children who have ASD. En ligne : http://dx.doi.org/10.1002/aur.2136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder [texte imprimé] / Junko MATSUZAKI, Auteur ; Emily S. KUSCHNER, Auteur ; Lisa BLASKEY, Auteur ; Luke BLOY, Auteur ; Mina KIM, Auteur ; Matthew KU, Auteur ; J. Christopher EDGAR, Auteur ; David EMBICK, Auteur ; Timothy P.L. ROBERTS, Auteur . - p.1225-1235. Langues : Anglais (eng) in Autism Research > 12-8 (August 2019) . - p.1225-1235 Mots-clés : autism spectrum disorder  language and communication skill  magnetoencephalography  minimally verbal/non-verbal children  vowel mismatch fields Index. décimale : PER Périodiques Résumé : Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded by magnetoencephalography (MEG), have been reported in verbal children with ASD. Association with clinical measures indicates that delayed MMF components are associated with poorer language and communication performance. At present, little is known about neural correlates of language and communication skills in extremely language impaired (minimally-verbal/non-verbal) children who have ASD: ASD-MVNV. It is hypothesized that MMF delays observed in language-impaired but nonetheless verbal children with ASD will be exacerbated in ASD-MVNV. The present study investigated this hypothesis, examining MMF responses bilaterally during an auditory oddball paradigm with vowel stimuli in ASD-MVNV, in a verbal ASD cohort without cognitive impairment and in typically developing (TD) children. The verbal ASD cohort without cognitive impairment was split into those demonstrating considerable language impairment (CELF core language index <85; "ASD-LI") versus those with less or no language impairment (CELF CLI >85; "ASD-V"). Eighty-four participants (8-12 years) were included in final analysis: ASD-MVNV: n = 9, 9.67 +/- 1.41 years, ASD: n = 48, (ASD-V: n = 27, 10.55 +/- 1.21 years, ASD-LI: n = 21, 10.67 +/- 1.20 years) and TD: n = 27, 10.14 +/- 1.38 years. Delayed MMF latencies were found bilaterally in ASD-MVNV compared to verbal ASD (both ASD-V and ASD-LI) and TD children. Delayed MMF responses were associated with diminished language and communication skills. Furthermore, whereas the TD children showed leftward lateralization of MMF amplitude, ASD-MVNV and verbal ASD (ASD-V and ASD-LI) showed abnormal rightward lateralization. Findings suggest delayed auditory discrimination processes and abnormal rightward laterality as objective markers of language/communication skills in both verbal and MVNV children who have ASD. Autism Res 2019, 12: 1225-1235. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Brain imaging showed abnormal auditory discrimination processes in minimally-verbal/non-verbal children (MVNV) who have autism spectrum disorder (ASD). Delays in auditory discrimination were associated with impaired language and communication skills. Findings suggest these auditory neural measures may be objective markers of language and communication skills in both verbal and, previously-understudied, MVNV children who have ASD. En ligne : http://dx.doi.org/10.1002/aur.2136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Delayed M50/M100 evoked response component latency in minimally verbal/nonverbal children who have autism spectrum disorder / Timothy P.L. ROBERTS in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 34 p. Titre : Delayed M50/M100 evoked response component latency in minimally verbal/nonverbal children who have autism spectrum disorder Type de document : texte imprimé Auteurs : Timothy P.L. ROBERTS, Auteur ; Junko MATSUZAKI, Auteur ; Lisa BLASKEY, Auteur ; Luke BLOY, Auteur ; J. Christopher EDGAR, Auteur ; Mina KIM, Auteur ; Matthew KU, Auteur ; Emily S. KUSCHNER, Auteur ; David EMBICK, Auteur Article en page(s) : 34 p. Langues : Anglais (eng) Mots-clés : Auditory cortex  Autism spectrum disorder  M50/M100 responses and language impairment  Magnetoencephalography  Minimally verbal/non-verbal children  Nonverbal Index. décimale : PER Périodiques Résumé : Abnormal auditory neuromagnetic M50 and M100 responses, reflecting primary/secondary auditory cortex processing, have been reported in children who have autism spectrum disorder (ASD). Some studies have reported an association between delays in these responses and language impairment. However, as most prior research has focused on verbal individuals with ASD without cognitive impairment, rather little is known about neural activity during auditory processing in minimally verbal or nonverbal children who have ASD (ASD-MVNV)-children with little or no speech and often significant cognitive impairment. To understand the neurophysiological mechanisms underlying auditory processing in ASD-MVNV children, magnetoencephalography (MEG) measured M50 and M100 responses arising from left and right superior temporal gyri during tone stimuli in three cohorts: (1) MVNV children who have ASD (ASD-MVNV), (2) verbal children who have ASD and no intellectual disability (ASD-V), and (3) typically developing (TD) children. One hundred and five participants (8-12 years) were included in the final analyses (ASD-MVNV: n = 16, 9.85 +/- 1.32 years; ASD-V: n = 55, 10.64 +/- 1.31 years; TD: n = 34, 10.18 +/- 1.36 years). ASD-MVNV children showed significantly delayed M50 and M100 latencies compared to TD. These delays tended to be greater than the corresponding delays in verbal children with ASD. Across cohorts, delayed latencies were associated with language and communication skills, assessed by the Vineland Adaptive Behavior Scale Communication Domain. Findings suggest that auditory cortex neural activity measures could be dimensional objective indices of language impairment in ASD for either diagnostic (e.g., via threshold or cutoff) or prognostic (considering the continuous variable) use. En ligne : https://dx.doi.org/10.1186/s13229-019-0283-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Delayed M50/M100 evoked response component latency in minimally verbal/nonverbal children who have autism spectrum disorder [texte imprimé] / Timothy P.L. ROBERTS, Auteur ; Junko MATSUZAKI, Auteur ; Lisa BLASKEY, Auteur ; Luke BLOY, Auteur ; J. Christopher EDGAR, Auteur ; Mina KIM, Auteur ; Matthew KU, Auteur ; Emily S. KUSCHNER, Auteur ; David EMBICK, Auteur . - 34 p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 34 p. Mots-clés : Auditory cortex  Autism spectrum disorder  M50/M100 responses and language impairment  Magnetoencephalography  Minimally verbal/non-verbal children  Nonverbal Index. décimale : PER Périodiques Résumé : Abnormal auditory neuromagnetic M50 and M100 responses, reflecting primary/secondary auditory cortex processing, have been reported in children who have autism spectrum disorder (ASD). Some studies have reported an association between delays in these responses and language impairment. However, as most prior research has focused on verbal individuals with ASD without cognitive impairment, rather little is known about neural activity during auditory processing in minimally verbal or nonverbal children who have ASD (ASD-MVNV)-children with little or no speech and often significant cognitive impairment. To understand the neurophysiological mechanisms underlying auditory processing in ASD-MVNV children, magnetoencephalography (MEG) measured M50 and M100 responses arising from left and right superior temporal gyri during tone stimuli in three cohorts: (1) MVNV children who have ASD (ASD-MVNV), (2) verbal children who have ASD and no intellectual disability (ASD-V), and (3) typically developing (TD) children. One hundred and five participants (8-12 years) were included in the final analyses (ASD-MVNV: n = 16, 9.85 +/- 1.32 years; ASD-V: n = 55, 10.64 +/- 1.31 years; TD: n = 34, 10.18 +/- 1.36 years). ASD-MVNV children showed significantly delayed M50 and M100 latencies compared to TD. These delays tended to be greater than the corresponding delays in verbal children with ASD. Across cohorts, delayed latencies were associated with language and communication skills, assessed by the Vineland Adaptive Behavior Scale Communication Domain. Findings suggest that auditory cortex neural activity measures could be dimensional objective indices of language impairment in ASD for either diagnostic (e.g., via threshold or cutoff) or prognostic (considering the continuous variable) use. En ligne : https://dx.doi.org/10.1186/s13229-019-0283-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development / Heather L. GREEN in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.4076-4089 Titre : Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development Type de document : texte imprimé Auteurs : Heather L. GREEN, Auteur ; Guannan SHEN, Auteur ; Rose E. FRANZEN, Auteur ; Marybeth MCNAMEE, Auteur ; Jeffrey I. BERMAN, Auteur ; Theresa G. MOWAD, Auteur ; Matthew KU, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Yu-Han CHEN, Auteur ; Megan AIREY, Auteur ; Emma MCBRIDE, Auteur ; Sophia GOLDIN, Auteur ; Marissa A. DIPIERO, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Timothy P.L. ROBERTS, Auteur ; J. Christopher EDGAR, Auteur Article en page(s) : p.4076-4089 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Maturation of auditory cortex neural encoding processes was assessed in children with typical development (TD) and autism. Children 6-9 years old were enrolled at Time 1 (T1), with follow-up data obtained?~ 18 months later at Time 2 (T2), and?~ 36 months later at Time 3 (T3). Findings suggested an initial period of rapid auditory cortex maturation in autism, earlier than TD (prior to and surrounding the T1 exam), followed by a period of faster maturation in TD than autism (T1-T3). As a result of group maturation differences, post-stimulus group differences were observed at T1 but not T3. In contrast, stronger pre-stimulus activity in autism than TD was found at all time points, indicating this brain measure is stable across time. En ligne : https://doi.org/10.1007/s10803-022-05696-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development [texte imprimé] / Heather L. GREEN, Auteur ; Guannan SHEN, Auteur ; Rose E. FRANZEN, Auteur ; Marybeth MCNAMEE, Auteur ; Jeffrey I. BERMAN, Auteur ; Theresa G. MOWAD, Auteur ; Matthew KU, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Yu-Han CHEN, Auteur ; Megan AIREY, Auteur ; Emma MCBRIDE, Auteur ; Sophia GOLDIN, Auteur ; Marissa A. DIPIERO, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Timothy P.L. ROBERTS, Auteur ; J. Christopher EDGAR, Auteur . - p.4076-4089. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.4076-4089 Index. décimale : PER Périodiques Résumé : Maturation of auditory cortex neural encoding processes was assessed in children with typical development (TD) and autism. Children 6-9 years old were enrolled at Time 1 (T1), with follow-up data obtained?~ 18 months later at Time 2 (T2), and?~ 36 months later at Time 3 (T3). Findings suggested an initial period of rapid auditory cortex maturation in autism, earlier than TD (prior to and surrounding the T1 exam), followed by a period of faster maturation in TD than autism (T1-T3). As a result of group maturation differences, post-stimulus group differences were observed at T1 but not T3. In contrast, stronger pre-stimulus activity in autism than TD was found at all time points, indicating this brain measure is stable across time. En ligne : https://doi.org/10.1007/s10803-022-05696-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

MEG-PLAN: a clinical and technical protocol for obtaining magnetoencephalography data in minimally verbal or nonverbal children who have autism spectrum disorder / Emily S. KUSCHNER in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : MEG-PLAN: a clinical and technical protocol for obtaining magnetoencephalography data in minimally verbal or nonverbal children who have autism spectrum disorder Type de document : texte imprimé Auteurs : Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Luke BLOY, Auteur ; Marissa DIPIERO, Auteur ; J. Christopher EDGAR, Auteur ; Timothy P.L. ROBERTS, Auteur Langues : Anglais (eng) Mots-clés : Aptitude  Autism Spectrum Disorder  Child  Female  Humans  Language  Magnetoencephalography  Male  Neuroimaging  Applied behavior analysis  Autism spectrum disorder  Compliance  Imaging methodology  Intellectual disability  Minimally verbal  Nonverbal  Imaging, AveXis, Spago Nanomedicine, and Acadia Pharmaceuticals. TR and JCE  disclose IP related to the use of MEG as a biomarker for ASD. No other authors  declare any financial disclosures. Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimaging research on individuals who have autism spectrum disorder (ASD) has historically been limited primarily to those with age-appropriate cognitive and language performance. Children with limited abilities are frequently excluded from such neuroscience research given anticipated barriers like tolerating the loud sounds associated with magnetic resonance imaging and remaining still during data collection. To better understand brain function across the full range of ASD there is a need to (1) include individuals with limited cognitive and language performance in neuroimaging research (non-sedated, awake) and (2) improve data quality across the performance range. The purpose of this study was to develop, implement, and test the feasibility of a clinical/behavioral and technical protocol for obtaining magnetoencephalography (MEG) data. Participants were 38 children with ASD (8-12 years) meeting the study definition of minimally verbal/nonverbal language. MEG data were obtained during a passive pure-tone auditory task. RESULTS: Based on stakeholder feedback, the MEG Protocol for Low-language/cognitive Ability Neuroimaging (MEG-PLAN) was developed, integrating clinical/behavioral and technical components to be implemented by an interdisciplinary team (clinicians, behavior specialists, scientists, and technologists). Using MEG-PLAN, a 74% success rate was achieved for acquiring MEG data, with a 71% success rate for evaluable and analyzable data. Exploratory analyses suggested nonverbal IQ and adaptive skills were related to reaching the point of acquirable data. No differences in group characteristics were observed between those with acquirable versus evaluable/analyzable data. Examination of data quality (evaluable trial count) was acceptable. Moreover, results were reproducible, with high intraclass correlation coefficients for pure-tone auditory latency. CONCLUSIONS: Children who have ASD who are minimally verbal/nonverbal, and often have co-occurring cognitive impairments, can be effectively and comfortably supported to complete an electrophysiological exam that yields valid and reproducible results. MEG-PLAN is a protocol that can be disseminated and implemented across research teams and adapted across technologies and neurodevelopmental disorders to collect electrophysiology and neuroimaging data in previously understudied groups of individuals. En ligne : https://dx.doi.org/10.1186/s11689-020-09350-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] MEG-PLAN: a clinical and technical protocol for obtaining magnetoencephalography data in minimally verbal or nonverbal children who have autism spectrum disorder [texte imprimé] / Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Luke BLOY, Auteur ; Marissa DIPIERO, Auteur ; J. Christopher EDGAR, Auteur ; Timothy P.L. ROBERTS, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Aptitude  Autism Spectrum Disorder  Child  Female  Humans  Language  Magnetoencephalography  Male  Neuroimaging  Applied behavior analysis  Autism spectrum disorder  Compliance  Imaging methodology  Intellectual disability  Minimally verbal  Nonverbal  Imaging, AveXis, Spago Nanomedicine, and Acadia Pharmaceuticals. TR and JCE  disclose IP related to the use of MEG as a biomarker for ASD. No other authors  declare any financial disclosures. Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimaging research on individuals who have autism spectrum disorder (ASD) has historically been limited primarily to those with age-appropriate cognitive and language performance. Children with limited abilities are frequently excluded from such neuroscience research given anticipated barriers like tolerating the loud sounds associated with magnetic resonance imaging and remaining still during data collection. To better understand brain function across the full range of ASD there is a need to (1) include individuals with limited cognitive and language performance in neuroimaging research (non-sedated, awake) and (2) improve data quality across the performance range. The purpose of this study was to develop, implement, and test the feasibility of a clinical/behavioral and technical protocol for obtaining magnetoencephalography (MEG) data. Participants were 38 children with ASD (8-12 years) meeting the study definition of minimally verbal/nonverbal language. MEG data were obtained during a passive pure-tone auditory task. RESULTS: Based on stakeholder feedback, the MEG Protocol for Low-language/cognitive Ability Neuroimaging (MEG-PLAN) was developed, integrating clinical/behavioral and technical components to be implemented by an interdisciplinary team (clinicians, behavior specialists, scientists, and technologists). Using MEG-PLAN, a 74% success rate was achieved for acquiring MEG data, with a 71% success rate for evaluable and analyzable data. Exploratory analyses suggested nonverbal IQ and adaptive skills were related to reaching the point of acquirable data. No differences in group characteristics were observed between those with acquirable versus evaluable/analyzable data. Examination of data quality (evaluable trial count) was acceptable. Moreover, results were reproducible, with high intraclass correlation coefficients for pure-tone auditory latency. CONCLUSIONS: Children who have ASD who are minimally verbal/nonverbal, and often have co-occurring cognitive impairments, can be effectively and comfortably supported to complete an electrophysiological exam that yields valid and reproducible results. MEG-PLAN is a protocol that can be disseminated and implemented across research teams and adapted across technologies and neurodevelopmental disorders to collect electrophysiology and neuroimaging data in previously understudied groups of individuals. En ligne : https://dx.doi.org/10.1186/s11689-020-09350-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Peak Alpha Frequency and Thalamic Structure in Children with Typical Development and Autism Spectrum Disorder / Heather L. GREEN in Journal of Autism and Developmental Disorders, 52-1 (January 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.103-112 Titre : Peak Alpha Frequency and Thalamic Structure in Children with Typical Development and Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Heather L. GREEN, Auteur ; Marissa A. DIPIERO, Auteur ; Simon KOPPERS, Auteur ; Jeffrey I. BERMAN, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Emma MCBRIDE, Auteur ; Matthew KU, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Megan AIREY, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Timothy P.L. ROBERTS, Auteur ; J. Christopher EDGAR, Auteur Article en page(s) : p.103-112 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Brain  Child  Humans  Magnetic Resonance Imaging  Male  Thalamus/diagnostic imaging  Alpha  Autism spectrum disorder  Magnetoencephalography  Maturation  Resting-state  Thalamic volume Index. décimale : PER Périodiques Résumé : Associations between age, resting-state (RS) peak-alpha-frequency (PAF = frequency showing largest amplitude alpha activity), and thalamic volume (thalamus thought to modulate alpha activity) were examined to understand differences in RS alpha activity between children with autism spectrum disorder (ASD) and typically-developing children (TDC) noted in prior studies. RS MEG and structural-MRI data were obtained from 51 ASD and 70 TDC 6- to 18-year-old males. PAF and thalamic volume maturation were observed in TDC but not ASD. Although PAF was associated with right thalamic volume in TDC (R(2) = 0.12, p = 0.01) but not ASD (R(2) = 0.01, p = 0.35), this group difference was not large enough to reach significance. Findings thus showed unusual maturation of brain function and structure in ASD as well as an across-group thalamic contribution to alpha rhythms. En ligne : http://dx.doi.org/10.1007/s10803-021-04926-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Peak Alpha Frequency and Thalamic Structure in Children with Typical Development and Autism Spectrum Disorder [texte imprimé] / Heather L. GREEN, Auteur ; Marissa A. DIPIERO, Auteur ; Simon KOPPERS, Auteur ; Jeffrey I. BERMAN, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Emma MCBRIDE, Auteur ; Matthew KU, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Megan AIREY, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Timothy P.L. ROBERTS, Auteur ; J. Christopher EDGAR, Auteur . - p.103-112. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.103-112 Mots-clés : Adolescent  Autism Spectrum Disorder  Brain  Child  Humans  Magnetic Resonance Imaging  Male  Thalamus/diagnostic imaging  Alpha  Autism spectrum disorder  Magnetoencephalography  Maturation  Resting-state  Thalamic volume Index. décimale : PER Périodiques Résumé : Associations between age, resting-state (RS) peak-alpha-frequency (PAF = frequency showing largest amplitude alpha activity), and thalamic volume (thalamus thought to modulate alpha activity) were examined to understand differences in RS alpha activity between children with autism spectrum disorder (ASD) and typically-developing children (TDC) noted in prior studies. RS MEG and structural-MRI data were obtained from 51 ASD and 70 TDC 6- to 18-year-old males. PAF and thalamic volume maturation were observed in TDC but not ASD. Although PAF was associated with right thalamic volume in TDC (R(2) = 0.12, p = 0.01) but not ASD (R(2) = 0.01, p = 0.35), this group difference was not large enough to reach significance. Findings thus showed unusual maturation of brain function and structure in ASD as well as an across-group thalamic contribution to alpha rhythms. En ligne : http://dx.doi.org/10.1007/s10803-021-04926-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Resting-State Activity in Children: Replicating and Extending Findings of Early Maturation of Alpha Rhythms in Autism Spectrum Disorder / Guannan SHEN in Journal of Autism and Developmental Disorders, 54-5 (May 2024)  

Permalink

Social Skills Assessments for Children with Autism Spectrum Disorders / Erin ROTHERAM-FULLER in Autism - Open Access, 3-3 (December 2013)  

Permalink

White matter microstructure as a potential contributor to differences in resting state alpha activity between neurotypical and autistic children: a longitudinal multimodal imaging study / Heather L. GREEN ; Marybeth MCNAMEE ; Rose E. FRANZEN ; Marissa A. DIPIERO ; Jeffrey I. BERMAN ; Matthew KU ; Luke BLOY ; Song LIU ; Megan AIREY ; Sophia GOLDIN ; Lisa BLASKEY ; Emily S. KUSCHNER ; Mina KIM ; Kimberly KONKA ; Gregory A. MILLER ; J. Christopher EDGAR in Molecular Autism, 16 (2025)  

Permalink

---

1 (1 - 8 / 8) Par page : 25 50 100 200