Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention / Devon N. GANGI in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1142-1150 Titre : Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention Type de document : texte imprimé Auteurs : Devon N. GANGI, Auteur ; Daniel S. MESSINGER, Auteur ; Eden R. MARTIN, Auteur ; Michael L. CUCCARO, Auteur Article en page(s) : p.1142-1150 Langues : Anglais (eng) Mots-clés : high-risk siblings  initiating joint attention  dopamine  differential susceptibility  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) exhibit lower levels of initiating joint attention (IJA; sharing an object or experience with a social partner through gaze and/or gesture) than low-risk siblings of children without ASD. However, high-risk siblings also exhibit substantial variability in this domain. The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants have been associated with attention difficulties. We examined whether these common dopaminergic variants, DRD4 and DRD2, explain variability in IJA in high-risk (n = 55) and low-risk (n = 38) siblings. IJA was assessed in the first year during a semi-structured interaction with an examiner. DRD4 and DRD2 genotypes were coded according to associated dopaminergic functioning to create a gene score, with higher scores indicating more genotypes associated with less efficient dopaminergic functioning. Higher dopamine gene scores (indicative of less efficient dopaminergic functioning) were associated with lower levels of IJA in the first year for high-risk siblings, while the opposite pattern emerged in low-risk siblings. Findings suggest differential susceptibility—IJA was differentially associated with dopaminergic functioning depending on familial ASD risk. Understanding genes linked to ASD-relevant behaviors in high-risk siblings will aid in early identification of children at greatest risk for difficulties in these behavioral domains, facilitating targeted prevention and intervention. En ligne : http://dx.doi.org/10.1002/aur.1623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention [texte imprimé] / Devon N. GANGI, Auteur ; Daniel S. MESSINGER, Auteur ; Eden R. MARTIN, Auteur ; Michael L. CUCCARO, Auteur . - p.1142-1150. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1142-1150 Mots-clés : high-risk siblings  initiating joint attention  dopamine  differential susceptibility  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) exhibit lower levels of initiating joint attention (IJA; sharing an object or experience with a social partner through gaze and/or gesture) than low-risk siblings of children without ASD. However, high-risk siblings also exhibit substantial variability in this domain. The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants have been associated with attention difficulties. We examined whether these common dopaminergic variants, DRD4 and DRD2, explain variability in IJA in high-risk (n = 55) and low-risk (n = 38) siblings. IJA was assessed in the first year during a semi-structured interaction with an examiner. DRD4 and DRD2 genotypes were coded according to associated dopaminergic functioning to create a gene score, with higher scores indicating more genotypes associated with less efficient dopaminergic functioning. Higher dopamine gene scores (indicative of less efficient dopaminergic functioning) were associated with lower levels of IJA in the first year for high-risk siblings, while the opposite pattern emerged in low-risk siblings. Findings suggest differential susceptibility—IJA was differentially associated with dopaminergic functioning depending on familial ASD risk. Understanding genes linked to ASD-relevant behaviors in high-risk siblings will aid in early identification of children at greatest risk for difficulties in these behavioral domains, facilitating targeted prevention and intervention. En ligne : http://dx.doi.org/10.1002/aur.1623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Gaze to faces across interactive contexts in infants at heightened risk for autism / Devon N. GANGI in Autism, 22-6 (August 2018)  

Public ISBD [article]  inAutism > 22-6 (August 2018) . - p.763-768 Titre : Gaze to faces across interactive contexts in infants at heightened risk for autism Type de document : texte imprimé Auteurs : Devon N. GANGI, Auteur ; A. J. SCHWICHTENBERG, Auteur ; A. M. IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; F. BAGUIO, Auteur ; S. OZONOFF, Auteur Article en page(s) : p.763-768 Langues : Anglais (eng) Mots-clés : context  eye gaze  high-risk siblings  social partner Index. décimale : PER Périodiques Résumé : Infant social-communicative behavior, such as gaze to the face of an interactive partner, is an important early developmental skill. Children with autism spectrum disorder exhibit atypicalities in social-communicative behavior, including gaze and eye contact. Behavioral differences in infancy may serve as early markers of autism spectrum disorder and help identify individuals at highest risk for developing the disorder. Researchers often assess social-communicative behavior in a single interactive context, such as during assessment with an unfamiliar examiner or play with a parent. Understanding whether infant behavior is consistent across such contexts is important for evaluating the validity of experimental paradigms and the generalizability of findings from one interactive context/partner to another. We examined infant gaze to the face of a social partner at 6, 9, and 12 months of age in infants who were later diagnosed with autism spectrum disorder, as well as low- and high-risk infants without autism spectrum disorder outcomes, across two interactive contexts: structured testing with an unfamiliar examiner and semi-structured play with a parent. By 9 months, infant gaze behavior was significantly associated between the two contexts. By 12 months, infants without autism spectrum disorder outcomes exhibited higher mean rates of gaze to faces during parent-child play than Mullen testing, while the gaze behavior of the autism spectrum disorder group did not differ by context-suggesting that infants developing autism spectrum disorder may be less sensitive to context or interactive partner. Findings support the validity of assessing infant social-communicative behavior during structured laboratory settings and suggest that infant behavior exhibits consistency across settings and interactive partners. En ligne : http://dx.doi.org/10.1177/1362361317704421 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Gaze to faces across interactive contexts in infants at heightened risk for autism [texte imprimé] / Devon N. GANGI, Auteur ; A. J. SCHWICHTENBERG, Auteur ; A. M. IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; F. BAGUIO, Auteur ; S. OZONOFF, Auteur . - p.763-768. Langues : Anglais (eng) in Autism > 22-6 (August 2018) . - p.763-768 Mots-clés : context  eye gaze  high-risk siblings  social partner Index. décimale : PER Périodiques Résumé : Infant social-communicative behavior, such as gaze to the face of an interactive partner, is an important early developmental skill. Children with autism spectrum disorder exhibit atypicalities in social-communicative behavior, including gaze and eye contact. Behavioral differences in infancy may serve as early markers of autism spectrum disorder and help identify individuals at highest risk for developing the disorder. Researchers often assess social-communicative behavior in a single interactive context, such as during assessment with an unfamiliar examiner or play with a parent. Understanding whether infant behavior is consistent across such contexts is important for evaluating the validity of experimental paradigms and the generalizability of findings from one interactive context/partner to another. We examined infant gaze to the face of a social partner at 6, 9, and 12 months of age in infants who were later diagnosed with autism spectrum disorder, as well as low- and high-risk infants without autism spectrum disorder outcomes, across two interactive contexts: structured testing with an unfamiliar examiner and semi-structured play with a parent. By 9 months, infant gaze behavior was significantly associated between the two contexts. By 12 months, infants without autism spectrum disorder outcomes exhibited higher mean rates of gaze to faces during parent-child play than Mullen testing, while the gaze behavior of the autism spectrum disorder group did not differ by context-suggesting that infants developing autism spectrum disorder may be less sensitive to context or interactive partner. Findings support the validity of assessing infant social-communicative behavior during structured laboratory settings and suggest that infant behavior exhibits consistency across settings and interactive partners. En ligne : http://dx.doi.org/10.1177/1362361317704421 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Joint Attention Initiation With and Without Positive Affect: Risk Group Differences and Associations with ASD Symptoms / Devon N. GANGI in Journal of Autism and Developmental Disorders, 44-6 (June 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1414-1424 Titre : Joint Attention Initiation With and Without Positive Affect: Risk Group Differences and Associations with ASD Symptoms Type de document : texte imprimé Auteurs : Devon N. GANGI, Auteur ; Lisa V. IBANEZ, Auteur ; Daniel S. MESSINGER, Auteur Article en page(s) : p.1414-1424 Langues : Anglais (eng) Mots-clés : Anticipatory smiling  High-risk siblings  Autism spectrum disorders  Initiating joint attention Index. décimale : PER Périodiques Résumé : Infants at risk for autism spectrum disorders (ASD) may have difficulty integrating smiles into initiating joint attention (IJA) bids. A specific IJA pattern, anticipatory smiling, may communicate preexisting positive affect when an infant smiles at an object and then turns the smile toward the social partner. We compared the development of anticipatory smiling at 8, 10, and 12 months in infant siblings of children with ASD (high-risk siblings) and without ASD (low-risk siblings). High-risk siblings produced less anticipatory smiling than low-risk siblings, suggesting early differences in communicating preexisting positive affect. While early anticipatory smiling distinguished the risk groups, IJA not accompanied by smiling best predicted later severity of ASD-related behavioral characteristics among high-risk siblings. High-risk infants appear to show lower levels of motivation to share positive affect with others. However, facility with initiating joint attention in the absence of a clear index of positive affective motivation appears to be central to the prediction of ASD symptoms. En ligne : http://dx.doi.org/10.1007/s10803-013-2002-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 [article] Joint Attention Initiation With and Without Positive Affect: Risk Group Differences and Associations with ASD Symptoms [texte imprimé] / Devon N. GANGI, Auteur ; Lisa V. IBANEZ, Auteur ; Daniel S. MESSINGER, Auteur . - p.1414-1424. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1414-1424 Mots-clés : Anticipatory smiling  High-risk siblings  Autism spectrum disorders  Initiating joint attention Index. décimale : PER Périodiques Résumé : Infants at risk for autism spectrum disorders (ASD) may have difficulty integrating smiles into initiating joint attention (IJA) bids. A specific IJA pattern, anticipatory smiling, may communicate preexisting positive affect when an infant smiles at an object and then turns the smile toward the social partner. We compared the development of anticipatory smiling at 8, 10, and 12 months in infant siblings of children with ASD (high-risk siblings) and without ASD (low-risk siblings). High-risk siblings produced less anticipatory smiling than low-risk siblings, suggesting early differences in communicating preexisting positive affect. While early anticipatory smiling distinguished the risk groups, IJA not accompanied by smiling best predicted later severity of ASD-related behavioral characteristics among high-risk siblings. High-risk infants appear to show lower levels of motivation to share positive affect with others. However, facility with initiating joint attention in the absence of a clear index of positive affective motivation appears to be central to the prediction of ASD symptoms. En ligne : http://dx.doi.org/10.1007/s10803-013-2002-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233

Measuring social-communication difficulties in school-age siblings of children with autism spectrum disorder: Standardized versus naturalistic assessment / Devon N. GANGI in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.1913-1922 Titre : Measuring social-communication difficulties in school-age siblings of children with autism spectrum disorder: Standardized versus naturalistic assessment Type de document : texte imprimé Auteurs : Devon N. GANGI, Auteur ; M. M. HILL, Auteur ; S. MAQBOOL, Auteur ; Gregory S. YOUNG, Auteur ; S. OZONOFF, Auteur Article en page(s) : p.1913-1922 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Communication  Humans  Schools  Siblings  broader autism phenotype  high-risk siblings  measurement  social communication Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) are at elevated risk for developing the broader autism phenotype (BAP), which consists of subclinical features of ASD. We examined conversational skills in a naturalistic context and standardized assessments of pragmatic language and communication skills in high-risk and low-risk school-age children with BAP (n = 22) and ASD (n = 18) outcomes, as well as comparison children without ASD or BAP (n = 135). Children with BAP characteristics exhibited lower conversational skills than comparison children, but did not differ on any of three standardized measures. Only the conversational ratings significantly predicted membership in the BAP versus Comparison group. This suggests that naturalistic tasks are crucial when assessing social-communication difficulties in children with a family history of ASD. LAY SUMMARY: The broader autism phenotype (BAP) consists of subclinical features of autism spectrum disorder (ASD) and is more common among family members of those with ASD. School-age children with BAP characteristics exhibited lower conversational skills than comparison children, but did not differ on standardized language measures tapping similar abilities. This suggests that naturalistic tasks may be more sensitive to the social-communication difficulties seen in some children with a family history of ASD than the standardized language tests used in most evaluations. En ligne : http://dx.doi.org/10.1002/aur.2531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Measuring social-communication difficulties in school-age siblings of children with autism spectrum disorder: Standardized versus naturalistic assessment [texte imprimé] / Devon N. GANGI, Auteur ; M. M. HILL, Auteur ; S. MAQBOOL, Auteur ; Gregory S. YOUNG, Auteur ; S. OZONOFF, Auteur . - p.1913-1922. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.1913-1922 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Communication  Humans  Schools  Siblings  broader autism phenotype  high-risk siblings  measurement  social communication Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) are at elevated risk for developing the broader autism phenotype (BAP), which consists of subclinical features of ASD. We examined conversational skills in a naturalistic context and standardized assessments of pragmatic language and communication skills in high-risk and low-risk school-age children with BAP (n = 22) and ASD (n = 18) outcomes, as well as comparison children without ASD or BAP (n = 135). Children with BAP characteristics exhibited lower conversational skills than comparison children, but did not differ on any of three standardized measures. Only the conversational ratings significantly predicted membership in the BAP versus Comparison group. This suggests that naturalistic tasks are crucial when assessing social-communication difficulties in children with a family history of ASD. LAY SUMMARY: The broader autism phenotype (BAP) consists of subclinical features of autism spectrum disorder (ASD) and is more common among family members of those with ASD. School-age children with BAP characteristics exhibited lower conversational skills than comparison children, but did not differ on standardized language measures tapping similar abilities. This suggests that naturalistic tasks may be more sensitive to the social-communication difficulties seen in some children with a family history of ASD than the standardized language tests used in most evaluations. En ligne : http://dx.doi.org/10.1002/aur.2531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Onset patterns in autism: Variation across informants, methods, and timing / Sally OZONOFF in Autism Research, 11-5 (May 2018)  

Public ISBD [article]  inAutism Research > 11-5 (May 2018) . - p.788-797 Titre : Onset patterns in autism: Variation across informants, methods, and timing Type de document : texte imprimé Auteurs : Sally OZONOFF, Auteur ; Devon N. GANGI, Auteur ; P. HANZEL ELISE, Auteur ; Alesha HILL, Auteur ; M. HILL MONIQUE, Auteur ; Meghan MILLER, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Beth STEINFELD MARY, Auteur ; Chandni PARIKH, Auteur ; Ana‐Maria IOSIF, Auteur Article en page(s) : p.788-797 Langues : Anglais (eng) Mots-clés : early signs  infants  regression Index. décimale : PER Périodiques Résumé : While previous studies suggested that regressive forms of onset were not common in autism spectrum disorder (ASD), more recent investigations suggest that the rates are quite high and may be under?reported using certain methods. The current study undertook a systematic investigation of how rates of regression differed by measurement method. Infants with (n=147) and without a family history of ASD (n=83) were seen prospectively for up to 7 visits in the first three years of life. Reports of symptom onset were collected using four measures that systematically varied the informant (examiner vs. parent), the decision type (categorical [regression absent or present] vs. dimensional [frequency of social behaviors]), and the timing of the assessment (retrospective vs. prospective). Latent class growth models were used to classify individual trajectories to see whether regressive onset patterns were infrequent or widespread within the ASD group. A majority of the sample was classified as having a regressive onset using either examiner (88%) or parent (69%) prospective dimensional ratings. Rates of regression were much lower using retrospective or categorical measures (from 29 to 47%). Agreement among different measurement methods was low. Declining trajectories of development, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The accuracy of widely used methods of measuring onset is questionable and the present findings argue against their widespread use. Autism Res 2018, 11: 788 797. ? 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This study examines different ways of measuring the onset of symptoms in autism spectrum disorder (ASD). The present findings suggest that declining developmental skills, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The results question the accuracy of widely used methods of measuring symptom onset and argue against their widespread use. En ligne : https://doi.org/10.1002/aur.1943 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Onset patterns in autism: Variation across informants, methods, and timing [texte imprimé] / Sally OZONOFF, Auteur ; Devon N. GANGI, Auteur ; P. HANZEL ELISE, Auteur ; Alesha HILL, Auteur ; M. HILL MONIQUE, Auteur ; Meghan MILLER, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Beth STEINFELD MARY, Auteur ; Chandni PARIKH, Auteur ; Ana‐Maria IOSIF, Auteur . - p.788-797. Langues : Anglais (eng) in Autism Research > 11-5 (May 2018) . - p.788-797 Mots-clés : early signs  infants  regression Index. décimale : PER Périodiques Résumé : While previous studies suggested that regressive forms of onset were not common in autism spectrum disorder (ASD), more recent investigations suggest that the rates are quite high and may be under?reported using certain methods. The current study undertook a systematic investigation of how rates of regression differed by measurement method. Infants with (n=147) and without a family history of ASD (n=83) were seen prospectively for up to 7 visits in the first three years of life. Reports of symptom onset were collected using four measures that systematically varied the informant (examiner vs. parent), the decision type (categorical [regression absent or present] vs. dimensional [frequency of social behaviors]), and the timing of the assessment (retrospective vs. prospective). Latent class growth models were used to classify individual trajectories to see whether regressive onset patterns were infrequent or widespread within the ASD group. A majority of the sample was classified as having a regressive onset using either examiner (88%) or parent (69%) prospective dimensional ratings. Rates of regression were much lower using retrospective or categorical measures (from 29 to 47%). Agreement among different measurement methods was low. Declining trajectories of development, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The accuracy of widely used methods of measuring onset is questionable and the present findings argue against their widespread use. Autism Res 2018, 11: 788 797. ? 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This study examines different ways of measuring the onset of symptoms in autism spectrum disorder (ASD). The present findings suggest that declining developmental skills, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The results question the accuracy of widely used methods of measuring symptom onset and argue against their widespread use. En ligne : https://doi.org/10.1002/aur.1943 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

A video-based measure to identify autism risk in infancy / Gregory S. YOUNG in Journal of Child Psychology and Psychiatry, 61-1 (January 2020)  

Permalink

---

1 (1 - 6 / 6) Par page : 25 50 100 200