Abstract Analogical Reasoning in High-Functioning Children with Autism Spectrum Disorders / Adam E. GREEN in Autism Research, 7-6 (December 2014)  

Public ISBD [article]  inAutism Research > 7-6 (December 2014) . - p.677-686 Titre : Abstract Analogical Reasoning in High-Functioning Children with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Adam E. GREEN, Auteur ; Lauren KENWORTHY, Auteur ; Maya G. MOSNER, Auteur ; Natalie M. GALLAGHER, Auteur ; Edward W. FEARON, Auteur ; Carlos D. BALHANA, Auteur ; Benjamin E. YERYS, Auteur Article en page(s) : p.677-686 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  analogical reasoning  development  social cognition Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) exhibit a deficit in spontaneously recognizing abstract similarities that are crucial for generalizing learning to new situations. This may contribute to deficits in the development of appropriate schemas for navigating novel situations, including social interactions. Analogical reasoning is the central cognitive mechanism that enables typically developing children to understand abstract similarities between different situations. Intriguingly, studies of high-functioning children with ASD point to a relative cognitive strength in basic, nonabstract forms of analogical reasoning. If this analogical reasoning ability extends to abstract analogical reasoning (i.e., between superficially dissimilar situations), it may provide a bridge between a cognitive capability and core ASD deficits in areas such as generalization and categorization. This study tested whether preserved analogical reasoning abilities in ASD can be extended to abstract analogical reasoning, using photographs of real-world items and situations. Abstractness of the analogies was determined via a quantitative measure of semantic distance derived from latent semantic analysis. Children with ASD performed as well as typically developing children at identifying abstract analogical similarities when explicitly instructed to apply analogical reasoning. Individual differences in abstract analogical reasoning ability predicted individual differences in a measure of social function in the ASD group. Preliminary analyses indicated that children with ASD, but not typically developing children, showed an effect of age on abstract analogical reasoning. These results provide new evidence that children with ASD are capable of identifying abstract similarities through analogical reasoning, pointing to abstract analogical reasoning as a potential lever for improving generalization skills and social function in ASD. En ligne : http://dx.doi.org/10.1002/aur.1411 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Abstract Analogical Reasoning in High-Functioning Children with Autism Spectrum Disorders [texte imprimé] / Adam E. GREEN, Auteur ; Lauren KENWORTHY, Auteur ; Maya G. MOSNER, Auteur ; Natalie M. GALLAGHER, Auteur ; Edward W. FEARON, Auteur ; Carlos D. BALHANA, Auteur ; Benjamin E. YERYS, Auteur . - p.677-686. Langues : Anglais (eng) in Autism Research > 7-6 (December 2014) . - p.677-686 Mots-clés : autism spectrum disorders  analogical reasoning  development  social cognition Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) exhibit a deficit in spontaneously recognizing abstract similarities that are crucial for generalizing learning to new situations. This may contribute to deficits in the development of appropriate schemas for navigating novel situations, including social interactions. Analogical reasoning is the central cognitive mechanism that enables typically developing children to understand abstract similarities between different situations. Intriguingly, studies of high-functioning children with ASD point to a relative cognitive strength in basic, nonabstract forms of analogical reasoning. If this analogical reasoning ability extends to abstract analogical reasoning (i.e., between superficially dissimilar situations), it may provide a bridge between a cognitive capability and core ASD deficits in areas such as generalization and categorization. This study tested whether preserved analogical reasoning abilities in ASD can be extended to abstract analogical reasoning, using photographs of real-world items and situations. Abstractness of the analogies was determined via a quantitative measure of semantic distance derived from latent semantic analysis. Children with ASD performed as well as typically developing children at identifying abstract analogical similarities when explicitly instructed to apply analogical reasoning. Individual differences in abstract analogical reasoning ability predicted individual differences in a measure of social function in the ASD group. Preliminary analyses indicated that children with ASD, but not typically developing children, showed an effect of age on abstract analogical reasoning. These results provide new evidence that children with ASD are capable of identifying abstract similarities through analogical reasoning, pointing to abstract analogical reasoning as a potential lever for improving generalization skills and social function in ASD. En ligne : http://dx.doi.org/10.1002/aur.1411 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Altered reward system reactivity for personalized circumscribed interests in autism / Gregor KOHLS in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 9p. Titre : Altered reward system reactivity for personalized circumscribed interests in autism Type de document : texte imprimé Auteurs : Gregor KOHLS, Auteur ; Ligia ANTEZANA, Auteur ; Maya G. MOSNER, Auteur ; Robert T. SCHULTZ, Auteur ; Benjamin E. YERYS, Auteur Article en page(s) : 9p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Caudate nucleus  Circumscribed interests  Functional magnetic resonance imaging  Motivation  Restricted and repetitive behaviors and interests  Reward  Reward system  Striatum Index. décimale : PER Périodiques Résumé : Background: Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain's reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study's central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i.e., social approval), in youth with ASD relative to typically developing controls (TDCs). Methods: We conducted a 3T functional magnetic resonance imaging (fMRI) study to investigate the blood-oxygenation-level-dependent effect of personalized circumscribed interest rewards versus social rewards in 39 youth with ASD relative to 22 TDC. To probe the reward system, we employed short video clips as reinforcement in an instrumental incentive delay task. This optimization increased the task's ecological validity compared to still pictures that are often used in this line of research. Results: Compared to TDCs, youth with ASD had stronger reward system responses for CIs mostly within the non-social realm (e.g., video games) than social rewards (e.g., approval). Additionally, this imbalance within the caudate nucleus' responsiveness was related to greater social impairment. Conclusions: The current data support the idea of reward system dysfunction that may contribute to enhanced motivation for RRBIs in ASD, accompanied by diminished motivation for social engagement. If a dysregulated reward system indeed supports the emergence and maintenance of social and non-social symptoms of ASD, then strategically targeting the reward system in future treatment endeavors may allow for more efficacious treatment practices that help improve outcomes for individuals with ASD and their families. En ligne : http://dx.doi.org/10.1186/s13229-018-0195-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Altered reward system reactivity for personalized circumscribed interests in autism [texte imprimé] / Gregor KOHLS, Auteur ; Ligia ANTEZANA, Auteur ; Maya G. MOSNER, Auteur ; Robert T. SCHULTZ, Auteur ; Benjamin E. YERYS, Auteur . - 9p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 9p. Mots-clés : Autism spectrum disorders  Caudate nucleus  Circumscribed interests  Functional magnetic resonance imaging  Motivation  Restricted and repetitive behaviors and interests  Reward  Reward system  Striatum Index. décimale : PER Périodiques Résumé : Background: Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain's reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study's central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i.e., social approval), in youth with ASD relative to typically developing controls (TDCs). Methods: We conducted a 3T functional magnetic resonance imaging (fMRI) study to investigate the blood-oxygenation-level-dependent effect of personalized circumscribed interest rewards versus social rewards in 39 youth with ASD relative to 22 TDC. To probe the reward system, we employed short video clips as reinforcement in an instrumental incentive delay task. This optimization increased the task's ecological validity compared to still pictures that are often used in this line of research. Results: Compared to TDCs, youth with ASD had stronger reward system responses for CIs mostly within the non-social realm (e.g., video games) than social rewards (e.g., approval). Additionally, this imbalance within the caudate nucleus' responsiveness was related to greater social impairment. Conclusions: The current data support the idea of reward system dysfunction that may contribute to enhanced motivation for RRBIs in ASD, accompanied by diminished motivation for social engagement. If a dysregulated reward system indeed supports the emergence and maintenance of social and non-social symptoms of ASD, then strategically targeting the reward system in future treatment endeavors may allow for more efficacious treatment practices that help improve outcomes for individuals with ASD and their families. En ligne : http://dx.doi.org/10.1186/s13229-018-0195-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards / Cara R. DAMIANO in Molecular Autism, (January 2014)  

Public ISBD [article]  inMolecular Autism > (January 2014) Titre : Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards Type de document : texte imprimé Auteurs : Cara R. DAMIANO, Auteur ; Joseph ALOI, Auteur ; Kaitlyn DUNLAP, Auteur ; Caley BURRUS, Auteur ; Maya G. MOSNER, Auteur ; Rachel KOZINK, Auteur ; Ralph MCLAURIN, Auteur ; O'Dhaniel MULLETTE-GILLMAN, Auteur ; Ronald CARTER, Auteur ; Scott A. HUETTEL, Auteur ; Francis MCCLERNON, Auteur ; Allison ASHLEY-KOCH, Auteur ; Gabriel S. DICHTER, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There has been significant progress in identifying genes that confer risk for autism spectrum disorders (ASDs). However, the heterogeneity of symptom presentation in ASDs impedes the detection of ASD risk genes. One approach to understanding genetic influences on ASD symptom expression is to evaluate relations between variants of ASD candidate genes and neural endophenotypes in unaffected samples. Allelic variations in the oxytocin receptor (OXTR) gene confer small but significant risk for ASDs for which the underlying mechanisms may involve associations between variability in oxytocin signaling pathways and neural response to rewards. The purpose of this preliminary study was to investigate the influence of allelic variability in the OXTR gene on neural responses to monetary rewards in healthy adults using functional magnetic resonance imaging (fMRI). The moderating effects of three single nucleotide polymorphisms (SNPs) (rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task. T homozygotes of the rs2268493 SNP demonstrated relatively decreased activation in mesolimbic reward circuitry (including the nucleus accumbens, amygdala, insula, thalamus and prefrontal cortical regions) during the anticipation of rewards but not during the outcome phase of the task. Allelic variation of the rs1042778 and rs237887 SNPs did not moderate mesolimbic activation during either reward anticipation or outcomes. This preliminary study suggests that the OXTR SNP rs2268493, which has been previously identified as an ASD risk gene, moderates mesolimbic responses during reward anticipation. Given previous findings of decreased mesolimbic activation during reward anticipation in ASD, the present results suggest that OXTR may confer ASD risk via influences on the neural systems that support reward anticipation. En ligne : http://dx.doi.org/10.1186/2040-2392-5-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards [texte imprimé] / Cara R. DAMIANO, Auteur ; Joseph ALOI, Auteur ; Kaitlyn DUNLAP, Auteur ; Caley BURRUS, Auteur ; Maya G. MOSNER, Auteur ; Rachel KOZINK, Auteur ; Ralph MCLAURIN, Auteur ; O'Dhaniel MULLETTE-GILLMAN, Auteur ; Ronald CARTER, Auteur ; Scott A. HUETTEL, Auteur ; Francis MCCLERNON, Auteur ; Allison ASHLEY-KOCH, Auteur ; Gabriel S. DICHTER, Auteur. Langues : Anglais (eng) in Molecular Autism > (January 2014) Index. décimale : PER Périodiques Résumé : There has been significant progress in identifying genes that confer risk for autism spectrum disorders (ASDs). However, the heterogeneity of symptom presentation in ASDs impedes the detection of ASD risk genes. One approach to understanding genetic influences on ASD symptom expression is to evaluate relations between variants of ASD candidate genes and neural endophenotypes in unaffected samples. Allelic variations in the oxytocin receptor (OXTR) gene confer small but significant risk for ASDs for which the underlying mechanisms may involve associations between variability in oxytocin signaling pathways and neural response to rewards. The purpose of this preliminary study was to investigate the influence of allelic variability in the OXTR gene on neural responses to monetary rewards in healthy adults using functional magnetic resonance imaging (fMRI). The moderating effects of three single nucleotide polymorphisms (SNPs) (rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task. T homozygotes of the rs2268493 SNP demonstrated relatively decreased activation in mesolimbic reward circuitry (including the nucleus accumbens, amygdala, insula, thalamus and prefrontal cortical regions) during the anticipation of rewards but not during the outcome phase of the task. Allelic variation of the rs1042778 and rs237887 SNPs did not moderate mesolimbic activation during either reward anticipation or outcomes. This preliminary study suggests that the OXTR SNP rs2268493, which has been previously identified as an ASD risk gene, moderates mesolimbic responses during reward anticipation. Given previous findings of decreased mesolimbic activation during reward anticipation in ASD, the present results suggest that OXTR may confer ASD risk via influences on the neural systems that support reward anticipation. En ligne : http://dx.doi.org/10.1186/2040-2392-5-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Dynamic Eye Tracking as a Predictor and Outcome Measure of Social Skills Intervention in Adolescents and Adults with Autism Spectrum Disorder / Rachel K. GREENE in Journal of Autism and Developmental Disorders, 51-4 (April 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-4 (April 2021) . - p.1173-1187 Titre : Dynamic Eye Tracking as a Predictor and Outcome Measure of Social Skills Intervention in Adolescents and Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Rachel K. GREENE, Auteur ; Julia PARISH-MORRIS, Auteur ; Miranda SULLIVAN, Auteur ; Jessica L. KINARD, Auteur ; Maya G. MOSNER, Auteur ; Lauren M. TURNER-BROWN, Auteur ; David L. PENN, Auteur ; Christopher A. WIESEN, Auteur ; Ashley A. PALLATHRA, Auteur ; Edward S. BRODKIN, Auteur ; Robert T. SCHULTZ, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : p.1173-1187 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Eye tracking  Social skills intervention  Treatment outcome Index. décimale : PER Périodiques Résumé : To evaluate an eye tracking task as a predictor and outcome measure of treatment response for autism spectrum disorder (ASD) social skills interventions, adolescents and young adults with ASD completed the eye tracking task before, immediately after, and two months after completing Social Cognition and Interaction Training for Autism (SCIT-A). The study compared SCIT-A participants (n = 20) to participants with ASD who received treatment as usual (TAU; n = 21). Overall, increased visual attention to faces and background objects and decreased attention to hands playing with toys at baseline were associated with improved social functioning immediately following intervention, suggesting this eye tracking task may reliably predict ASD social intervention outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04594-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Dynamic Eye Tracking as a Predictor and Outcome Measure of Social Skills Intervention in Adolescents and Adults with Autism Spectrum Disorder [texte imprimé] / Rachel K. GREENE, Auteur ; Julia PARISH-MORRIS, Auteur ; Miranda SULLIVAN, Auteur ; Jessica L. KINARD, Auteur ; Maya G. MOSNER, Auteur ; Lauren M. TURNER-BROWN, Auteur ; David L. PENN, Auteur ; Christopher A. WIESEN, Auteur ; Ashley A. PALLATHRA, Auteur ; Edward S. BRODKIN, Auteur ; Robert T. SCHULTZ, Auteur ; Gabriel S. DICHTER, Auteur . - p.1173-1187. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-4 (April 2021) . - p.1173-1187 Mots-clés : Autism spectrum disorder  Eye tracking  Social skills intervention  Treatment outcome Index. décimale : PER Périodiques Résumé : To evaluate an eye tracking task as a predictor and outcome measure of treatment response for autism spectrum disorder (ASD) social skills interventions, adolescents and young adults with ASD completed the eye tracking task before, immediately after, and two months after completing Social Cognition and Interaction Training for Autism (SCIT-A). The study compared SCIT-A participants (n = 20) to participants with ASD who received treatment as usual (TAU; n = 21). Overall, increased visual attention to faces and background objects and decreased attention to hands playing with toys at baseline were associated with improved social functioning immediately following intervention, suggesting this eye tracking task may reliably predict ASD social intervention outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04594-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Experience sampling of positive affect in adolescents with autism: Feasibility and preliminary findings / Megan KOVAC in Research in Autism Spectrum Disorders, 29-30 (September–October 2016)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 29-30 (September–October 2016) . - p.57-65 Titre : Experience sampling of positive affect in adolescents with autism: Feasibility and preliminary findings Type de document : texte imprimé Auteurs : Megan KOVAC, Auteur ; Maya G. MOSNER, Auteur ; Stephanie MILLER, Auteur ; Eleanor K. HANNA, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : p.57-65 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Experience sampling  Positive affect  Restricted interests Index. décimale : PER Périodiques Résumé : AbstractBackground Experience sampling is a powerful method for obtaining ecologically valid data from research participants in real-world contexts. Given the urgent need for innovative and sensitive outcome measures in autism spectrum disorder (ASD) research, the present study sought to examine the feasibility of using experience sampling of positive affect and behavior in adolescents with ASD. Method Nineteen high functioning adolescents with ASD and 20 sex and age matched controls completed smartphone- and Qualtrics® −based experience sampling of positive affect and behavior six times over four days. Results Adherence was excellent: adolescents with ASD completed 85% of the assessments, compared to 93% in controls, and response rates were not impacted by age or IQ. Groups did not differ in positive affect overall or as a function of activities, nor did groups differ in the proportion of assessments completed during social or nonsocial activities. However, groups did differ in the proportion of assessments completed during preferred activities. Conclusions Results suggest that smartphone- and Qualtrics® −based experience sampling with high functioning adolescents with ASD is feasible and captures real-world behaviors that would not be possible using laboratory-based measures. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.06.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 [article] Experience sampling of positive affect in adolescents with autism: Feasibility and preliminary findings [texte imprimé] / Megan KOVAC, Auteur ; Maya G. MOSNER, Auteur ; Stephanie MILLER, Auteur ; Eleanor K. HANNA, Auteur ; Gabriel S. DICHTER, Auteur . - p.57-65. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 29-30 (September–October 2016) . - p.57-65 Mots-clés : Autism spectrum disorder  Experience sampling  Positive affect  Restricted interests Index. décimale : PER Périodiques Résumé : AbstractBackground Experience sampling is a powerful method for obtaining ecologically valid data from research participants in real-world contexts. Given the urgent need for innovative and sensitive outcome measures in autism spectrum disorder (ASD) research, the present study sought to examine the feasibility of using experience sampling of positive affect and behavior in adolescents with ASD. Method Nineteen high functioning adolescents with ASD and 20 sex and age matched controls completed smartphone- and Qualtrics® −based experience sampling of positive affect and behavior six times over four days. Results Adherence was excellent: adolescents with ASD completed 85% of the assessments, compared to 93% in controls, and response rates were not impacted by age or IQ. Groups did not differ in positive affect overall or as a function of activities, nor did groups differ in the proportion of assessments completed during social or nonsocial activities. However, groups did differ in the proportion of assessments completed during preferred activities. Conclusions Results suggest that smartphone- and Qualtrics® −based experience sampling with high functioning adolescents with ASD is feasible and captures real-world behaviors that would not be possible using laboratory-based measures. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.06.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292

Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder / Maya G. MOSNER in Autism Research and Treatment, 2019 (2019)  

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Neural Mechanisms of Social and Nonsocial Reward Prediction Errors in Adolescents with Autism Spectrum Disorder / Jessica L. KINARD in Autism Research, 13-5 (May 2020)  

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Rates of Co-occurring Psychiatric Disorders in Autism Spectrum Disorder Using the Mini International Neuropsychiatric Interview / Maya G. MOSNER in Journal of Autism and Developmental Disorders, 49-9 (September 2019)  

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Social analogical reasoning in school-aged children with autism spectrum disorder and typically developing peers / Adam E. GREEN in Autism, 21-4 (May 2017)  

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Social and nonsocial visual prediction errors in autism spectrum disorder / Rachel K. GREENE in Autism Research, 12-6 (June 2019)  

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Social-Emotional Inhibition of Return in Children with Autism Spectrum Disorder Versus Typical Development / Ligia ANTEZANA in Journal of Autism and Developmental Disorders, 46-4 (April 2016)  

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The effects of intranasal oxytocin on reward circuitry responses in children with autism spectrum disorder / Rachel K. GREENE in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

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Vicarious Effort-Based Decision-Making in Autism Spectrum Disorders / Maya G. MOSNER in Journal of Autism and Developmental Disorders, 47-10 (October 2017)  

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