Autistic Traits and Emotion Dysregulation in 5-11-Year-Old Intellectually Able Children With Autism Spectrum Condition: Mediating Role of Emotion Regulation Strategies / Angana NANDY ; Hsing-Chang NI in Autism Research, 18-5 (May 2025)  

Public ISBD [article]  inAutism Research > 18-5 (May 2025) . - p.1050-1061 Titre : Autistic Traits and Emotion Dysregulation in 5-11-Year-Old Intellectually Able Children With Autism Spectrum Condition: Mediating Role of Emotion Regulation Strategies Type de document : Texte imprimé et/ou numérique Auteurs : Angana NANDY, Auteur ; Hsing-Chang NI, Auteur Article en page(s) : p.1050-1061 Langues : Anglais (eng) Mots-clés : cognitive reappraisal  ERS-focused intervention  expressive suppression  parental coregulation  parent-child dyad Index. décimale : PER Périodiques Résumé : ABSTRACT Emotion dysregulation (ED) is common among children with an autism spectrum condition (ASC). However, the mechanisms underlying emotion regulation strategies (ERSs) and their impacts on ED in this population remain unclear. The current study examined whether ED is directly related to autistic traits or mediated by deficits in ERSs after comorbidity is accounted for. A cohort of 110 intellectually able children aged 5?11?years with ASC participated in this study. Autistic traits and ED were assessed using the Autism Spectrum Quotient-Children and Child Behavior Checklist, respectively. Intrinsic ERSs, specifically cognitive reappraisal and expressive suppression, were evaluated using the Parent Emotion Regulation Questionnaire, alongside items measuring parental coregulation as an extrinsic ERS. After adjusting for comorbidities (i.e., other neurodevelopmental or neurological disorders), the findings revealed pronounced autistic traits in social skills, attention switching, communication, and imagination correlated with higher ED levels, with parental coregulation mediating this correlation. Notably, the effects of communication and imagination on ED were fully mediated by parental coregulation. Additionally, autistic traits related to imagination were demonstrated to impair the development of cognitive reappraisal, further exacerbating ED. These results provide a deeper understanding of the emotional challenges faced by intellectually able children with ASC. The findings of this study underscore the importance of interventions aimed at enhancing emotion regulation within the parent?child dyad and fostering the development of cognitive reappraisal through imitative tasks. Such ERS-focused interventions hold potential for mitigating the adverse effects of autistic traits on emotional functioning. En ligne : https://doi.org/10.1002/aur.70027 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Autistic Traits and Emotion Dysregulation in 5-11-Year-Old Intellectually Able Children With Autism Spectrum Condition: Mediating Role of Emotion Regulation Strategies [Texte imprimé et/ou numérique] / Angana NANDY, Auteur ; Hsing-Chang NI, Auteur . - p.1050-1061. Langues : Anglais (eng) in Autism Research > 18-5 (May 2025) . - p.1050-1061 Mots-clés : cognitive reappraisal  ERS-focused intervention  expressive suppression  parental coregulation  parent-child dyad Index. décimale : PER Périodiques Résumé : ABSTRACT Emotion dysregulation (ED) is common among children with an autism spectrum condition (ASC). However, the mechanisms underlying emotion regulation strategies (ERSs) and their impacts on ED in this population remain unclear. The current study examined whether ED is directly related to autistic traits or mediated by deficits in ERSs after comorbidity is accounted for. A cohort of 110 intellectually able children aged 5?11?years with ASC participated in this study. Autistic traits and ED were assessed using the Autism Spectrum Quotient-Children and Child Behavior Checklist, respectively. Intrinsic ERSs, specifically cognitive reappraisal and expressive suppression, were evaluated using the Parent Emotion Regulation Questionnaire, alongside items measuring parental coregulation as an extrinsic ERS. After adjusting for comorbidities (i.e., other neurodevelopmental or neurological disorders), the findings revealed pronounced autistic traits in social skills, attention switching, communication, and imagination correlated with higher ED levels, with parental coregulation mediating this correlation. Notably, the effects of communication and imagination on ED were fully mediated by parental coregulation. Additionally, autistic traits related to imagination were demonstrated to impair the development of cognitive reappraisal, further exacerbating ED. These results provide a deeper understanding of the emotional challenges faced by intellectually able children with ASC. The findings of this study underscore the importance of interventions aimed at enhancing emotion regulation within the parent?child dyad and fostering the development of cognitive reappraisal through imitative tasks. Such ERS-focused interventions hold potential for mitigating the adverse effects of autistic traits on emotional functioning. En ligne : https://doi.org/10.1002/aur.70027 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Characterizing intrinsic functional connectivity in relation to impaired self-regulation in intellectually able male youth with autism spectrum disorder / Hsiang-Yuan LIN in Autism, 24-5 (July 2020)  

Public ISBD [article]  inAutism > 24-5 (July 2020) . - p.1201-1216 Titre : Characterizing intrinsic functional connectivity in relation to impaired self-regulation in intellectually able male youth with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Hsiang-Yuan LIN, Auteur ; Hsing-Chang NI, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.1201-1216 Langues : Anglais (eng) Mots-clés : Child Behavior Checklist  autism spectrum disorder  connectivity  connectome-wide association study  dysregulation  resting-state fMRI Index. décimale : PER Périodiques Résumé : Impaired self-regulation (i.e., dysregulation in affective, behavioral, and cognitive control), is commonly present in young people with autism spectrum disorder (ASD). However, little is known about what is happening in people's brains when self-regulation is impaired in young people with ASD. We used a technique called functional MRI (which measures brain activity by detecting changes associated with blood flow) at a resting state (when participants are not asked to do anything) to research this in intellectually able young people with ASD. We found that brains with more connections, especially between regions involved in sensorimotor processing and regions involved in the processes that enable peoples to focus their attention on the most pertinent features from the sensory environment (salience processing), were related to more impaired self-regulation in young people with and without ASD. We also found that impaired self-regulation was related to increased communication within the brain system involved in voluntary orienting attention to a sensory cue (the dorsal attention network) in young people with ASD. These results highlight how different people have different degrees of dysregulation, which has been largely overlooked in the earlier brain imaging reports on ASD. This might contribute to understanding some of the inconsistencies in the existing published literature on this topic. En ligne : http://dx.doi.org/10.1177/1362361319888104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Characterizing intrinsic functional connectivity in relation to impaired self-regulation in intellectually able male youth with autism spectrum disorder [Texte imprimé et/ou numérique] / Hsiang-Yuan LIN, Auteur ; Hsing-Chang NI, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur . - p.1201-1216. Langues : Anglais (eng) in Autism > 24-5 (July 2020) . - p.1201-1216 Mots-clés : Child Behavior Checklist  autism spectrum disorder  connectivity  connectome-wide association study  dysregulation  resting-state fMRI Index. décimale : PER Périodiques Résumé : Impaired self-regulation (i.e., dysregulation in affective, behavioral, and cognitive control), is commonly present in young people with autism spectrum disorder (ASD). However, little is known about what is happening in people's brains when self-regulation is impaired in young people with ASD. We used a technique called functional MRI (which measures brain activity by detecting changes associated with blood flow) at a resting state (when participants are not asked to do anything) to research this in intellectually able young people with ASD. We found that brains with more connections, especially between regions involved in sensorimotor processing and regions involved in the processes that enable peoples to focus their attention on the most pertinent features from the sensory environment (salience processing), were related to more impaired self-regulation in young people with and without ASD. We also found that impaired self-regulation was related to increased communication within the brain system involved in voluntary orienting attention to a sensory cue (the dorsal attention network) in young people with ASD. These results highlight how different people have different degrees of dysregulation, which has been largely overlooked in the earlier brain imaging reports on ASD. This might contribute to understanding some of the inconsistencies in the existing published literature on this topic. En ligne : http://dx.doi.org/10.1177/1362361319888104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Exploring camouflaging by the Chinese version Camouflaging Autistic Traits Questionnaire in Taiwanese autistic and non-autistic adolescents: An initial development / Chun-Hao LIU in Autism, 28-3 (March 2024)  

Public ISBD [article]  inAutism > 28-3 (March 2024) . - p.690-704 Titre : Exploring camouflaging by the Chinese version Camouflaging Autistic Traits Questionnaire in Taiwanese autistic and non-autistic adolescents: An initial development Type de document : Texte imprimé et/ou numérique Auteurs : Chun-Hao LIU, Auteur ; Yi-Lung CHEN, Auteur ; Pei-Jung CHEN, Auteur ; Hsing-Chang NI, Auteur ; Meng-Chuan LAI, Auteur Article en page(s) : p.690-704 Langues : Anglais (eng) Mots-clés : adolescent  autism  camouflaging  psychometrics  reliability Index. décimale : PER Périodiques Résumé : Camouflaging is a strategy adopted by neurodivergent individuals to cope in neurotypical social contexts, likely related to perceived stress. Despite increasing research in autistic adults, studies of camouflaging in adolescents remain sparse. The self-reported Camouflaging Autistic Traits Questionnaire has been validated in adults in some Western societies, but not in non-Western populations. We examined the psychometric properties of the self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire in Taiwanese adolescents. We enrolled 100 autistic and 105 non-autistic adolescents (aged 12-18?years) and their caregivers. As an initial development, we found a two-factor structure ("compensation-masking" and "assimilation") via exploratory factor analysis, alongside good internal consistency and test-retest reliability, for both the self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire. Self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire scores were moderately to highly correlated. Autistic adolescents showed higher total Chinese version Camouflaging Autistic Traits Questionnaire and assimilation scores than non-autistic adolescents in both males and females. Female autistic adolescents showed higher assimilation than male autistic adolescents, but there was no significant difference between sex assigned at birth on compensation-masking in either autistic or non-autistic adolescents. Assimilation correlated with higher self-perceived stress for both autistic and non-autistic adolescents. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were reliable and offered meaningful information to understand social coping of Taiwanese autistic and non-autistic adolescents. Lay abstract Camouflaging is a coping strategy used by some autistic and other neurodivergent people to fit in neurotypical social contexts. The self-reported Camouflaging Autistic Traits Questionnaire has been validated for use in research with adults in some Western societies, but not in non-Western cultural-ethnic groups. We translated Camouflaging Autistic Traits Questionnaire into traditional Chinese and examined the use of this measure in Taiwanese adolescents via both self-report and caregiver-report in 100 autistic and 105 non-autistic adolescents. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were composed of two factors (i.e. a "compensation-masking" subscale and an "assimilation" subscale). Both adolescent self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire total score and subscales were reliable in measurement, and they highly correlated with each other. Taiwanese autistic adolescents were more likely to camouflage than non-autistic adolescents, especially on assimilation. Female autistic adolescents showed higher assimilation than male autistic adolescents. Higher camouflaging, especially assimilation, was associated with higher stress in autistic and non-autistic adolescents alike. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were reliable and offered meaningful information to help us understand the social coping experiences of autistic and non-autistic adolescents. En ligne : https://dx.doi.org/10.1177/13623613231181732 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Exploring camouflaging by the Chinese version Camouflaging Autistic Traits Questionnaire in Taiwanese autistic and non-autistic adolescents: An initial development [Texte imprimé et/ou numérique] / Chun-Hao LIU, Auteur ; Yi-Lung CHEN, Auteur ; Pei-Jung CHEN, Auteur ; Hsing-Chang NI, Auteur ; Meng-Chuan LAI, Auteur . - p.690-704. Langues : Anglais (eng) in Autism > 28-3 (March 2024) . - p.690-704 Mots-clés : adolescent  autism  camouflaging  psychometrics  reliability Index. décimale : PER Périodiques Résumé : Camouflaging is a strategy adopted by neurodivergent individuals to cope in neurotypical social contexts, likely related to perceived stress. Despite increasing research in autistic adults, studies of camouflaging in adolescents remain sparse. The self-reported Camouflaging Autistic Traits Questionnaire has been validated in adults in some Western societies, but not in non-Western populations. We examined the psychometric properties of the self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire in Taiwanese adolescents. We enrolled 100 autistic and 105 non-autistic adolescents (aged 12-18?years) and their caregivers. As an initial development, we found a two-factor structure ("compensation-masking" and "assimilation") via exploratory factor analysis, alongside good internal consistency and test-retest reliability, for both the self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire. Self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire scores were moderately to highly correlated. Autistic adolescents showed higher total Chinese version Camouflaging Autistic Traits Questionnaire and assimilation scores than non-autistic adolescents in both males and females. Female autistic adolescents showed higher assimilation than male autistic adolescents, but there was no significant difference between sex assigned at birth on compensation-masking in either autistic or non-autistic adolescents. Assimilation correlated with higher self-perceived stress for both autistic and non-autistic adolescents. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were reliable and offered meaningful information to understand social coping of Taiwanese autistic and non-autistic adolescents. Lay abstract Camouflaging is a coping strategy used by some autistic and other neurodivergent people to fit in neurotypical social contexts. The self-reported Camouflaging Autistic Traits Questionnaire has been validated for use in research with adults in some Western societies, but not in non-Western cultural-ethnic groups. We translated Camouflaging Autistic Traits Questionnaire into traditional Chinese and examined the use of this measure in Taiwanese adolescents via both self-report and caregiver-report in 100 autistic and 105 non-autistic adolescents. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were composed of two factors (i.e. a "compensation-masking" subscale and an "assimilation" subscale). Both adolescent self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire total score and subscales were reliable in measurement, and they highly correlated with each other. Taiwanese autistic adolescents were more likely to camouflage than non-autistic adolescents, especially on assimilation. Female autistic adolescents showed higher assimilation than male autistic adolescents. Higher camouflaging, especially assimilation, was associated with higher stress in autistic and non-autistic adolescents alike. Both self-reported and caregiver-reported Chinese version Camouflaging Autistic Traits Questionnaire were reliable and offered meaningful information to help us understand the social coping experiences of autistic and non-autistic adolescents. En ligne : https://dx.doi.org/10.1177/13623613231181732 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention / Hsing-Chang NI in Autism, 25-5 (July 2021)  

Public ISBD [article]  inAutism > 25-5 (July 2021) . - p.1279-1294 Titre : Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention Type de document : Texte imprimé et/ou numérique Auteurs : Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : p.1279-1294 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy  Child  Double-Blind Method  Humans  Single-Blind Method  Temporal Lobe  Transcranial Magnetic Stimulation  Treatment Outcome  autism spectrum disorder  children and adolescents  intervention  posterior superior temporal sulcus  theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8?weeks. Those in the sham group received two-session/week sham stimulations in the first 4?weeks and then active intervention for the following 4?weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention [Texte imprimé et/ou numérique] / Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur . - p.1279-1294. Langues : Anglais (eng) in Autism > 25-5 (July 2021) . - p.1279-1294 Mots-clés : Autism Spectrum Disorder/therapy  Child  Double-Blind Method  Humans  Single-Blind Method  Temporal Lobe  Transcranial Magnetic Stimulation  Treatment Outcome  autism spectrum disorder  children and adolescents  intervention  posterior superior temporal sulcus  theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8?weeks. Those in the sham group received two-session/week sham stimulations in the first 4?weeks and then active intervention for the following 4?weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention / Hsing-Chang NI in Autism, 26-5 (July 2022)  

Public ISBD [article]  inAutism > 26-5 (July 2022) . - p.1279-1294 Titre : Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention Type de document : Texte imprimé et/ou numérique Auteurs : Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : p.1279-1294 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy  Child  Double-Blind Method  Humans  Single-Blind Method  Temporal Lobe  Transcranial Magnetic Stimulation  Treatment Outcome  autism spectrum disorder  children and adolescents  intervention  posterior superior temporal sulcus  theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8weeks. Those in the sham group received two-session/week sham stimulations in the first 4weeks and then active intervention for the following 4weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention [Texte imprimé et/ou numérique] / Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur . - p.1279-1294. Langues : Anglais (eng) in Autism > 26-5 (July 2022) . - p.1279-1294 Mots-clés : Autism Spectrum Disorder/therapy  Child  Double-Blind Method  Humans  Single-Blind Method  Temporal Lobe  Transcranial Magnetic Stimulation  Treatment Outcome  autism spectrum disorder  children and adolescents  intervention  posterior superior temporal sulcus  theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8weeks. Those in the sham group received two-session/week sham stimulations in the first 4weeks and then active intervention for the following 4weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

A lack of efficacy of continuous theta burst stimulation over the left dorsolateral prefrontal cortex in autism: A double blind randomized sham-controlled trial / Hsing-Chang NI in Autism Research, 16-6 (June 2023)  

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Regional brain volume differences between males with and without autism spectrum disorder are highly age-dependent / Hsiang-Yuan LIN in Molecular Autism, (May 2015)  

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Theta Burst Stimulation in Autism / Hsing-Chang NI

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White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities / Chun-Hung YEH in Molecular Autism, 13 (2022)  

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