Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study / Daniel S. MESSINGER in Molecular Autism, (June 2015)  

Public ISBD [article]  inMolecular Autism > (June 2015) . - p.1-12 Titre : Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study Type de document : Texte imprimé et/ou numérique Auteurs : Daniel S. MESSINGER, Auteur ; Gregory S. YOUNG, Auteur ; Sara Jane WEBB, Auteur ; Sally OZONOFF, Auteur ; Susan E. BRYSON, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Tony CHARMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Rebecca LANDA, Auteur ; Charles A. NELSON, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur Article en page(s) : p.1-12 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The increased male prevalence of autism spectrum disorder (ASD) may be mirrored by the early emergence of sex differences in ASD symptoms and cognitive functioning. The female protective effect hypothesis posits that ASD recurrence and symptoms will be higher among relatives of female probands. This study examined sex differences and sex of proband differences in ASD outcome and in the development of ASD symptoms and cognitive functioning among the high-risk younger siblings of ASD probands and low-risk children. En ligne : http://dx.doi.org/10.1186/s13229-015-0027-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study [Texte imprimé et/ou numérique] / Daniel S. MESSINGER, Auteur ; Gregory S. YOUNG, Auteur ; Sara Jane WEBB, Auteur ; Sally OZONOFF, Auteur ; Susan E. BRYSON, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Tony CHARMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Rebecca LANDA, Auteur ; Charles A. NELSON, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.1-12. Langues : Anglais (eng) in Molecular Autism > (June 2015) . - p.1-12 Index. décimale : PER Périodiques Résumé : The increased male prevalence of autism spectrum disorder (ASD) may be mirrored by the early emergence of sex differences in ASD symptoms and cognitive functioning. The female protective effect hypothesis posits that ASD recurrence and symptoms will be higher among relatives of female probands. This study examined sex differences and sex of proband differences in ASD outcome and in the development of ASD symptoms and cognitive functioning among the high-risk younger siblings of ASD probands and low-risk children. En ligne : http://dx.doi.org/10.1186/s13229-015-0027-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Language Differences at 12 Months in Infants Who Develop Autism Spectrum Disorder / DeWayne C. LAZENBY in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.899-909 Titre : Language Differences at 12 Months in Infants Who Develop Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : DeWayne C. LAZENBY, Auteur ; Georgios D. SIDERIDIS, Auteur ; Noelle HUNTINGTON, Auteur ; Matthew PRANTE, Auteur ; Philip S. DALE, Auteur ; Suzanne CURTIN, Auteur ; Lisa HENKEL, Auteur ; Jana M. IVERSON, Auteur ; Leslie J. CARVER, Auteur ; Karen DOBKINS, Auteur ; Natacha AKSHOOMOFF, Auteur ; Daina M. TAGAVI, Auteur ; Charles A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.899-909 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Expressive/receptive vocabulary  Item response theory  Infant-sibling  MacArthur-Bates Communicative Developmental Inventories (CDI) Index. décimale : PER Périodiques Résumé : Little is known about early language development in infants who later develop autism spectrum disorder (ASD). We analyzed prospective data from 346 infants, some of whom were at high risk for developing ASD, to determine if language differences could be detected at 12 months of age in the infants who later were diagnosed with ASD. Analyses revealed lower receptive and expressive language scores in infants who later were diagnosed with ASD. Controlling for overall ability to understand and produce single words, a Rasch analysis indicated that infants who later developed ASD had a higher degree of statistically unexpected word understanding and production. At 12 months of age, quantitative and qualitative language patterns distinguished infants who later developed ASD from those who did not. En ligne : http://dx.doi.org/10.1007/s10803-015-2632-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 [article] Language Differences at 12 Months in Infants Who Develop Autism Spectrum Disorder [Texte imprimé et/ou numérique] / DeWayne C. LAZENBY, Auteur ; Georgios D. SIDERIDIS, Auteur ; Noelle HUNTINGTON, Auteur ; Matthew PRANTE, Auteur ; Philip S. DALE, Auteur ; Suzanne CURTIN, Auteur ; Lisa HENKEL, Auteur ; Jana M. IVERSON, Auteur ; Leslie J. CARVER, Auteur ; Karen DOBKINS, Auteur ; Natacha AKSHOOMOFF, Auteur ; Daina M. TAGAVI, Auteur ; Charles A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.899-909. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.899-909 Mots-clés : Autism spectrum disorder (ASD)  Expressive/receptive vocabulary  Item response theory  Infant-sibling  MacArthur-Bates Communicative Developmental Inventories (CDI) Index. décimale : PER Périodiques Résumé : Little is known about early language development in infants who later develop autism spectrum disorder (ASD). We analyzed prospective data from 346 infants, some of whom were at high risk for developing ASD, to determine if language differences could be detected at 12 months of age in the infants who later were diagnosed with ASD. Analyses revealed lower receptive and expressive language scores in infants who later were diagnosed with ASD. Controlling for overall ability to understand and produce single words, a Rasch analysis indicated that infants who later developed ASD had a higher degree of statistically unexpected word understanding and production. At 12 months of age, quantitative and qualitative language patterns distinguished infants who later developed ASD from those who did not. En ligne : http://dx.doi.org/10.1007/s10803-015-2632-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281

Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study / Tony CHARMAN in Autism Research, 10-1 (January 2017)  

Public ISBD [article]  inAutism Research > 10-1 (January 2017) . - p.169-178 Titre : Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study Type de document : Texte imprimé et/ou numérique Auteurs : Tony CHARMAN, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Emily J. H. JONES, Auteur ; Rebecca LANDA, Auteur ; Suzanne MACARI, Auteur ; Daniel S. MESSINGER, Auteur ; Charles A. NELSON, Auteur ; Sally OZONOFF, Auteur ; Celine A. SAULNIER, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Sara Jane WEBB, Auteur ; Nurit YIRMIYA, Auteur ; Lonnie ZWAIGENBAUM, Auteur Article en page(s) : p.169-178 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  broader autism phenotype  developmental outcomes  high risk siblings  adaptive functioning Index. décimale : PER Périodiques Résumé : We characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n?=?859), and low-risk controls with no family history of ASD (n?=?473). We report outcomes at age 3 years using the Mullen Scales of Early Learning, the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview—Revised (ADI-R) and adaptive functioning on the Vineland Adaptive Behavior Scales. Around 11% of high-risk siblings had mild-to-moderate levels of developmental delay, a rate higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. Thirty percent of high-risk siblings had elevated scores on the ADOS, double the rate seen in the low-risk controls. High-risk siblings also had higher parent reported levels of ASD symptoms on the ADI-R and lower adaptive functioning on the Vineland. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures but not mild-to-moderate language delay. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. These findings are evidence for early emerging characteristics related to the “broader autism phenotype” (BAP) previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not have an ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes. En ligne : http://dx.doi.org/10.1002/aur.1669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study [Texte imprimé et/ou numérique] / Tony CHARMAN, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Emily J. H. JONES, Auteur ; Rebecca LANDA, Auteur ; Suzanne MACARI, Auteur ; Daniel S. MESSINGER, Auteur ; Charles A. NELSON, Auteur ; Sally OZONOFF, Auteur ; Celine A. SAULNIER, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Sara Jane WEBB, Auteur ; Nurit YIRMIYA, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.169-178. Langues : Anglais (eng) in Autism Research > 10-1 (January 2017) . - p.169-178 Mots-clés : autism spectrum disorder  broader autism phenotype  developmental outcomes  high risk siblings  adaptive functioning Index. décimale : PER Périodiques Résumé : We characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n?=?859), and low-risk controls with no family history of ASD (n?=?473). We report outcomes at age 3 years using the Mullen Scales of Early Learning, the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview—Revised (ADI-R) and adaptive functioning on the Vineland Adaptive Behavior Scales. Around 11% of high-risk siblings had mild-to-moderate levels of developmental delay, a rate higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. Thirty percent of high-risk siblings had elevated scores on the ADOS, double the rate seen in the low-risk controls. High-risk siblings also had higher parent reported levels of ASD symptoms on the ADI-R and lower adaptive functioning on the Vineland. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures but not mild-to-moderate language delay. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. These findings are evidence for early emerging characteristics related to the “broader autism phenotype” (BAP) previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not have an ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes. En ligne : http://dx.doi.org/10.1002/aur.1669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

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