ASD symptoms in toddlers and preschoolers: An examination of sex differences / Rosmary ROS-DEMARIZE in Autism Research, 13-1 (January 2020)  

Public ISBD [article]  inAutism Research > 13-1 (January 2020) . - p.157-166 Titre : ASD symptoms in toddlers and preschoolers: An examination of sex differences Type de document : texte imprimé Auteurs : Rosmary ROS-DEMARIZE, Auteur ; Catherine BRADLEY, Auteur ; Stephen M. KANNE, Auteur ; Zachary WARREN, Auteur ; Andrea BOAN, Auteur ; Clara M. LAJONCHERE, Auteur ; Justine PARK, Auteur ; Laura A. CARPENTER, Auteur Article en page(s) : p.157-166 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  restricted repetitive behaviors  screening measures  sex differences  social communication deficits Index. décimale : PER Périodiques Résumé : Although considerable work has documented higher prevalence rates of autism spectrum disorder (ASD) in boys, fewer studies have focused on sex differences within samples of young children at-risk for ASD. This study examined sex differences in ASD symptom domains and ASD screening outcomes among toddlers (18-35 months) and preschoolers (36-72 months) with ASD-related concerns. Participants included 480 children between 18 and 72 months evaluated by university-based ASD specialty clinics. Results revealed significant sex differences in severity of social communication (SC) deficits across age groups. Within the toddler group, girls diagnosed with ASD displayed greater SC deficits according to standardized observation and clinician severity ratings. Within the preschool group, girls diagnosed with ASD were rated by parents as having more severe SC deficits, but these differences were not corroborated by standardized observations or clinician ratings. No sex differences emerged for severity of restricted repetitive behaviors (RRBs) for either age group. Across the entire referred sample, boys and girls did not differ in terms of scores on commonly used screening instruments. Importantly, results suggest that two of the most commonly used ASD screeners (i.e., Modified-Checklist for Autism in Toddlers-Revised with Follow-up and Social Communication Questionnaire ) may underidentify RRBs in toddler and preschool-aged girls as screening scores were only influenced by severity of SC deficits. Greater SC deficits in young girls with ASD along with its impact on screening status suggests greater attention be placed on the under-identification of ASD in girls as well as current screening measures' ability to tap into the topography of ASD symptoms across genders. Autism Res 2020, 13: 157-166. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In this study, we found that young girls diagnosed with autism spectrum disorder tend to have greater social communication deficits than young boys and that these differences vary by age. Specifically, toddler-aged girls receive higher clinician ratings of social communication deficits when compared to boys, while preschool-aged girls receive higher parent ratings of social communication deficits. For girls, current screening tools seem to be more highly influenced by severity of social communication deficits than by restricted repetitive behaviors. En ligne : http://dx.doi.org/10.1002/aur.2241 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] ASD symptoms in toddlers and preschoolers: An examination of sex differences [texte imprimé] / Rosmary ROS-DEMARIZE, Auteur ; Catherine BRADLEY, Auteur ; Stephen M. KANNE, Auteur ; Zachary WARREN, Auteur ; Andrea BOAN, Auteur ; Clara M. LAJONCHERE, Auteur ; Justine PARK, Auteur ; Laura A. CARPENTER, Auteur . - p.157-166. Langues : Anglais (eng) in Autism Research > 13-1 (January 2020) . - p.157-166 Mots-clés : autism spectrum disorder  restricted repetitive behaviors  screening measures  sex differences  social communication deficits Index. décimale : PER Périodiques Résumé : Although considerable work has documented higher prevalence rates of autism spectrum disorder (ASD) in boys, fewer studies have focused on sex differences within samples of young children at-risk for ASD. This study examined sex differences in ASD symptom domains and ASD screening outcomes among toddlers (18-35 months) and preschoolers (36-72 months) with ASD-related concerns. Participants included 480 children between 18 and 72 months evaluated by university-based ASD specialty clinics. Results revealed significant sex differences in severity of social communication (SC) deficits across age groups. Within the toddler group, girls diagnosed with ASD displayed greater SC deficits according to standardized observation and clinician severity ratings. Within the preschool group, girls diagnosed with ASD were rated by parents as having more severe SC deficits, but these differences were not corroborated by standardized observations or clinician ratings. No sex differences emerged for severity of restricted repetitive behaviors (RRBs) for either age group. Across the entire referred sample, boys and girls did not differ in terms of scores on commonly used screening instruments. Importantly, results suggest that two of the most commonly used ASD screeners (i.e., Modified-Checklist for Autism in Toddlers-Revised with Follow-up and Social Communication Questionnaire ) may underidentify RRBs in toddler and preschool-aged girls as screening scores were only influenced by severity of SC deficits. Greater SC deficits in young girls with ASD along with its impact on screening status suggests greater attention be placed on the under-identification of ASD in girls as well as current screening measures' ability to tap into the topography of ASD symptoms across genders. Autism Res 2020, 13: 157-166. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In this study, we found that young girls diagnosed with autism spectrum disorder tend to have greater social communication deficits than young boys and that these differences vary by age. Specifically, toddler-aged girls receive higher clinician ratings of social communication deficits when compared to boys, while preschool-aged girls receive higher parent ratings of social communication deficits. For girls, current screening tools seem to be more highly influenced by severity of social communication deficits than by restricted repetitive behaviors. En ligne : http://dx.doi.org/10.1002/aur.2241 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Head Circumferences in Twins With and Without Autism Spectrum Disorders / Wendy FROEHLICH in Journal of Autism and Developmental Disorders, 43-9 (September 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2026-2037 Titre : Head Circumferences in Twins With and Without Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Wendy FROEHLICH, Auteur ; Sue C. CLEVELAND, Auteur ; Andrea TORRES, Auteur ; Jennifer M. PHILLIPS, Auteur ; Brianne COHEN, Auteur ; Tiffany TORIGOE, Auteur ; Janet MILLER, Auteur ; Angie FEDELE, Auteur ; Jack COLLINS, Auteur ; Karen SMITH, Auteur ; Linda J. LOTSPEICH, Auteur ; Lisa A. CROEN, Auteur ; Sally OZONOFF, Auteur ; Clara M. LAJONCHERE, Auteur ; Judith K. GRETHER, Auteur ; Joachim F. HALLMAYER, Auteur Article en page(s) : p.2026-2037 Langues : Anglais (eng) Mots-clés : Macrocephaly  Head circumference  Twins  Endophenotype  Genetics Index. décimale : PER Périodiques Résumé : To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4–18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs. En ligne : http://dx.doi.org/10.1007/s10803-012-1751-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Head Circumferences in Twins With and Without Autism Spectrum Disorders [texte imprimé] / Wendy FROEHLICH, Auteur ; Sue C. CLEVELAND, Auteur ; Andrea TORRES, Auteur ; Jennifer M. PHILLIPS, Auteur ; Brianne COHEN, Auteur ; Tiffany TORIGOE, Auteur ; Janet MILLER, Auteur ; Angie FEDELE, Auteur ; Jack COLLINS, Auteur ; Karen SMITH, Auteur ; Linda J. LOTSPEICH, Auteur ; Lisa A. CROEN, Auteur ; Sally OZONOFF, Auteur ; Clara M. LAJONCHERE, Auteur ; Judith K. GRETHER, Auteur ; Joachim F. HALLMAYER, Auteur . - p.2026-2037. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2026-2037 Mots-clés : Macrocephaly  Head circumference  Twins  Endophenotype  Genetics Index. décimale : PER Périodiques Résumé : To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4–18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs. En ligne : http://dx.doi.org/10.1007/s10803-012-1751-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Offering to Share: How to Put Heads Together in Autism Neuroimaging / Matthew K. BELMONTE in Journal of Autism and Developmental Disorders, 38-1 (January 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.2-13 Titre : Offering to Share: How to Put Heads Together in Autism Neuroimaging Type de document : texte imprimé Auteurs : Matthew K. BELMONTE, Auteur ; Anders M. DALE, Auteur ; Christos DAVATZIKOS, Auteur ; Guido GERIG, Auteur ; Martha R. HERBERT, Auteur ; Robert T. SCHULTZ, Auteur ; Janet E. LAINHART, Auteur ; Declan G.M. MURPHY, Auteur ; Thomas A. ZEFFIRO, Auteur ; Susan LEVI-PEARL, Auteur ; Clara M. LAJONCHERE, Auteur ; Diane C. CHUGANI, Auteur ; Rita M. CANTOR, Auteur ; Elizabeth H. AYLWARD, Auteur ; Allan L. REISS, Auteur ; Joseph PIVEN, Auteur ; Nancy J. MINSHEW, Auteur ; Eric COURCHESNE, Auteur ; David G. AMARAL, Auteur ; John C. MAZZIOTTA, Auteur ; Alan C. EVANS, Auteur ; Stephen R. DAGER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Sophia A. COLAMARINO, Auteur Année de publication : 2008 Article en page(s) : p.2-13 Langues : Anglais (eng) Mots-clés : Imaging MRI PET Morphometry Segmentation Data-sharing Index. décimale : PER Périodiques Résumé : Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including multispectral structural and diffusion-tensor imaging and optional extensions, provides for the collection of prospective, confound-free normative data, and extends sharing and collaborative development not only to data but to the analytical tools and methods applied to these data. A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on. En ligne : http://dx.doi.org/10.1007/s10803-006-0352-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315 [article] Offering to Share: How to Put Heads Together in Autism Neuroimaging [texte imprimé] / Matthew K. BELMONTE, Auteur ; Anders M. DALE, Auteur ; Christos DAVATZIKOS, Auteur ; Guido GERIG, Auteur ; Martha R. HERBERT, Auteur ; Robert T. SCHULTZ, Auteur ; Janet E. LAINHART, Auteur ; Declan G.M. MURPHY, Auteur ; Thomas A. ZEFFIRO, Auteur ; Susan LEVI-PEARL, Auteur ; Clara M. LAJONCHERE, Auteur ; Diane C. CHUGANI, Auteur ; Rita M. CANTOR, Auteur ; Elizabeth H. AYLWARD, Auteur ; Allan L. REISS, Auteur ; Joseph PIVEN, Auteur ; Nancy J. MINSHEW, Auteur ; Eric COURCHESNE, Auteur ; David G. AMARAL, Auteur ; John C. MAZZIOTTA, Auteur ; Alan C. EVANS, Auteur ; Stephen R. DAGER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Sophia A. COLAMARINO, Auteur . - 2008 . - p.2-13. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.2-13 Mots-clés : Imaging MRI PET Morphometry Segmentation Data-sharing Index. décimale : PER Périodiques Résumé : Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including multispectral structural and diffusion-tensor imaging and optional extensions, provides for the collection of prospective, confound-free normative data, and extends sharing and collaborative development not only to data but to the analytical tools and methods applied to these data. A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on. En ligne : http://dx.doi.org/10.1007/s10803-006-0352-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315

Strategies for Disseminating Information on Biomedical Research on Autism to Hispanic Parents / Clara M. LAJONCHERE in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1038-1050 Titre : Strategies for Disseminating Information on Biomedical Research on Autism to Hispanic Parents Type de document : texte imprimé Auteurs : Clara M. LAJONCHERE, Auteur ; Barbara Y. WHEELER, Auteur ; Thomas W. VALENTE, Auteur ; Cary KREUTZER, Auteur ; Aron MUNSON, Auteur ; Shrikanth NARAYANAN, Auteur ; Abe KAZEMZADEH, Auteur ; Roxana CRUZ, Auteur ; Irene MARTINEZ, Auteur ; Sheree M. SCHRAGER, Auteur ; Lisa SCHWEITZER, Auteur ; Tara CHKLOVSKI, Auteur ; Darryl HWANG, Auteur Article en page(s) : p.1038-1050 Langues : Anglais (eng) Mots-clés : Biomedical research on Autism  Hispanic/Latino  Health literacy  Racial disparities Index. décimale : PER Périodiques Résumé : Low income Hispanic families experience multiple barriers to accessing evidence-based information on Autism Spectrum Disorders (ASD). This study utilized a mixed-strategy intervention to create access to information in published bio-medical research articles on ASD by distilling the content into parent-friendly English- and Spanish-language ASD Science Briefs and presenting them to participants using two socially-oriented dissemination methods. There was a main effect for short-term knowledge gains associated with the Science Briefs but no effect for the dissemination method. After 5 months, participants reported utilizing the information learned and 90 % wanted to read more Science Briefs. These preliminary findings highlight the potential benefits of distilling biomedical research articles on ASD into parent-friendly educational products for currently underserved Hispanic parents. En ligne : http://dx.doi.org/10.1007/s10803-015-2649-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 [article] Strategies for Disseminating Information on Biomedical Research on Autism to Hispanic Parents [texte imprimé] / Clara M. LAJONCHERE, Auteur ; Barbara Y. WHEELER, Auteur ; Thomas W. VALENTE, Auteur ; Cary KREUTZER, Auteur ; Aron MUNSON, Auteur ; Shrikanth NARAYANAN, Auteur ; Abe KAZEMZADEH, Auteur ; Roxana CRUZ, Auteur ; Irene MARTINEZ, Auteur ; Sheree M. SCHRAGER, Auteur ; Lisa SCHWEITZER, Auteur ; Tara CHKLOVSKI, Auteur ; Darryl HWANG, Auteur . - p.1038-1050. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1038-1050 Mots-clés : Biomedical research on Autism  Hispanic/Latino  Health literacy  Racial disparities Index. décimale : PER Périodiques Résumé : Low income Hispanic families experience multiple barriers to accessing evidence-based information on Autism Spectrum Disorders (ASD). This study utilized a mixed-strategy intervention to create access to information in published bio-medical research articles on ASD by distilling the content into parent-friendly English- and Spanish-language ASD Science Briefs and presenting them to participants using two socially-oriented dissemination methods. There was a main effect for short-term knowledge gains associated with the Science Briefs but no effect for the dissemination method. After 5 months, participants reported utilizing the information learned and 90 % wanted to read more Science Briefs. These preliminary findings highlight the potential benefits of distilling biomedical research articles on ASD into parent-friendly educational products for currently underserved Hispanic parents. En ligne : http://dx.doi.org/10.1007/s10803-015-2649-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281

When Are We Sure? Predictors of Clinician Certainty in the Diagnosis of Autism Spectrum Disorder / Christina G. MCDONNELL in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1391-1401 Titre : When Are We Sure? Predictors of Clinician Certainty in the Diagnosis of Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Christina G. MCDONNELL, Auteur ; Catherine BRADLEY, Auteur ; Stephen M. KANNE, Auteur ; Clara M. LAJONCHERE, Auteur ; Zachary WARREN, Auteur ; Laura A. CARPENTER, Auteur Article en page(s) : p.1391-1401 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Diagnostic certainty  Differential diagnosis Index. décimale : PER Périodiques Résumé : Differential diagnosis of autism spectrum disorder (ASD) is challenging, and uncertainty regarding a child's diagnosis may result in under-identification or prolonged diagnostic pathways. The current study examined diagnostic certainty, or how sure clinicians were that their diagnosis was accurate, among 478 toddler and preschool-aged children referred for possible ASD to academic medical specialty clinics. Overall, 60 percent of diagnoses were made with complete certainty. Clinicians were more certain when positively identifying ASD than ruling it out. Children presenting with a moderate (vs high or low) level of observable ASD symptoms were less likely to have a certain diagnosis. Further, clinicians rated less diagnostic certainty for older children, those with public insurance, and those with higher IQ and adaptive behavior abilities. En ligne : https://dx.doi.org/10.1007/s10803-018-3831-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] When Are We Sure? Predictors of Clinician Certainty in the Diagnosis of Autism Spectrum Disorder [texte imprimé] / Christina G. MCDONNELL, Auteur ; Catherine BRADLEY, Auteur ; Stephen M. KANNE, Auteur ; Clara M. LAJONCHERE, Auteur ; Zachary WARREN, Auteur ; Laura A. CARPENTER, Auteur . - p.1391-1401. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1391-1401 Mots-clés : Autism spectrum disorder  Diagnostic certainty  Differential diagnosis Index. décimale : PER Périodiques Résumé : Differential diagnosis of autism spectrum disorder (ASD) is challenging, and uncertainty regarding a child's diagnosis may result in under-identification or prolonged diagnostic pathways. The current study examined diagnostic certainty, or how sure clinicians were that their diagnosis was accurate, among 478 toddler and preschool-aged children referred for possible ASD to academic medical specialty clinics. Overall, 60 percent of diagnoses were made with complete certainty. Clinicians were more certain when positively identifying ASD than ruling it out. Children presenting with a moderate (vs high or low) level of observable ASD symptoms were less likely to have a certain diagnosis. Further, clinicians rated less diagnostic certainty for older children, those with public insurance, and those with higher IQ and adaptive behavior abilities. En ligne : https://dx.doi.org/10.1007/s10803-018-3831-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

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