Dynamics of depression symptoms in adolescents during three types of psychotherapy and post-treatment follow-up / Madison AITKEN in Journal of Child Psychology and Psychiatry, 66-11 (November 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-11 (November 2025) . - p.1675-1687 Titre : Dynamics of depression symptoms in adolescents during three types of psychotherapy and post-treatment follow-up Type de document : texte imprimé Auteurs : Madison AITKEN, Auteur ; Sharon NEUFELD, Auteur ; Clement MA, Auteur ; IMPACT CONSORTIUM, Auteur ; Ian M. GOODYER, Auteur Article en page(s) : p.1675-1687 Langues : Anglais (eng) Mots-clés : Depression  intervention  psychotherapy  adolescence  symptomatology Index. décimale : PER Périodiques Résumé : Background According to the network theory of mental disorders, psychopathology emerges from symptoms that causally influence one another and create interconnections and feedback loops that maintain atypical mental states. Analysis of symptom networks during and following psychotherapy may provide clues to some of the mechanisms through which change occurs. Youth with depression are an important population in which to better understand psychotherapy mechanisms because current evidence-based interventions for this population show only modest effects. Methods Participants were adolescents with major depressive disorder (N?=?465; ages 11?17; 75% female) in a randomized controlled trial comparing cognitive behavioral therapy, short-term psychoanalytical psychotherapy, and brief psychosocial intervention (IMPACT, ISRCTN83033550). Eleven self-reported depression symptoms were used to compute two longitudinal networks: (1) treatment phase, using baseline, 6 and 12?weeks data; and (2) follow-up phase, using 36, 52, and 86?weeks data. Results During the treatment phase, all depression symptoms were interconnected. Symptoms of insomnia and fatigue showed the highest outstrength centrality (ability to predict other symptoms over time). In contrast, few symptoms were interconnected during the post-treatment phase except worthlessness, which had the highest outstrength centrality. Allowing network parameters to differ across the three treatment types improved model fit during the treatment phase and revealed that symptoms with the highest outstrength centrality varied by treatment type. Conclusions Individual symptoms may make key contributions to subsequent depressive psychopathology in adolescents. Longitudinal network analysis reveals that insomnia and fatigue predict other symptoms, allowing for consideration of specific mechanisms associated with depression treatment. The findings further suggest that negative cognitions about the self may emerge as a central putative cognitive vulnerability in those with a history of depression. Our exploratory findings also suggest that the three therapies (cognitive behavioral therapy, short-term psychoanalytical psychotherapy, and brief psychosocial intervention) may have achieved equifinality in part through different mechanisms. En ligne : https://doi.org/10.1111/jcpp.14175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Dynamics of depression symptoms in adolescents during three types of psychotherapy and post-treatment follow-up [texte imprimé] / Madison AITKEN, Auteur ; Sharon NEUFELD, Auteur ; Clement MA, Auteur ; IMPACT CONSORTIUM, Auteur ; Ian M. GOODYER, Auteur . - p.1675-1687. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-11 (November 2025) . - p.1675-1687 Mots-clés : Depression  intervention  psychotherapy  adolescence  symptomatology Index. décimale : PER Périodiques Résumé : Background According to the network theory of mental disorders, psychopathology emerges from symptoms that causally influence one another and create interconnections and feedback loops that maintain atypical mental states. Analysis of symptom networks during and following psychotherapy may provide clues to some of the mechanisms through which change occurs. Youth with depression are an important population in which to better understand psychotherapy mechanisms because current evidence-based interventions for this population show only modest effects. Methods Participants were adolescents with major depressive disorder (N?=?465; ages 11?17; 75% female) in a randomized controlled trial comparing cognitive behavioral therapy, short-term psychoanalytical psychotherapy, and brief psychosocial intervention (IMPACT, ISRCTN83033550). Eleven self-reported depression symptoms were used to compute two longitudinal networks: (1) treatment phase, using baseline, 6 and 12?weeks data; and (2) follow-up phase, using 36, 52, and 86?weeks data. Results During the treatment phase, all depression symptoms were interconnected. Symptoms of insomnia and fatigue showed the highest outstrength centrality (ability to predict other symptoms over time). In contrast, few symptoms were interconnected during the post-treatment phase except worthlessness, which had the highest outstrength centrality. Allowing network parameters to differ across the three treatment types improved model fit during the treatment phase and revealed that symptoms with the highest outstrength centrality varied by treatment type. Conclusions Individual symptoms may make key contributions to subsequent depressive psychopathology in adolescents. Longitudinal network analysis reveals that insomnia and fatigue predict other symptoms, allowing for consideration of specific mechanisms associated with depression treatment. The findings further suggest that negative cognitions about the self may emerge as a central putative cognitive vulnerability in those with a history of depression. Our exploratory findings also suggest that the three therapies (cognitive behavioral therapy, short-term psychoanalytical psychotherapy, and brief psychosocial intervention) may have achieved equifinality in part through different mechanisms. En ligne : https://doi.org/10.1111/jcpp.14175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children / Karson T.F. KUNG in Journal of Child Psychology and Psychiatry, 57-12 (December 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-12 (December 2016) . - p.1455-1462 Titre : No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children Type de document : texte imprimé Auteurs : Karson T.F. KUNG, Auteur ; Debra SPENCER, Auteur ; Vickie PASTERSKI, Auteur ; Sharon NEUFELD, Auteur ; Vivette GLOVER, Auteur ; Thomas G. O'CONNOR, Auteur ; Peter C. HINDMARSH, Auteur ; Ieuan A. HUGHES, Auteur ; Carlo L. ACERINI, Auteur ; Melissa HINES, Auteur Article en page(s) : p.1455-1462 Langues : Anglais (eng) Mots-clés : Congenital adrenal hyperplasia  fetal testosterone  prenatal testosterone exposure  autism  autistic traits  extreme male brain Index. décimale : PER Périodiques Résumé : Background There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis. Methods A parent-report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4–11 years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3–5 years. Results Findings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample. Conclusions These studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits. En ligne : http://dx.doi.org/10.1111/jcpp.12602 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children [texte imprimé] / Karson T.F. KUNG, Auteur ; Debra SPENCER, Auteur ; Vickie PASTERSKI, Auteur ; Sharon NEUFELD, Auteur ; Vivette GLOVER, Auteur ; Thomas G. O'CONNOR, Auteur ; Peter C. HINDMARSH, Auteur ; Ieuan A. HUGHES, Auteur ; Carlo L. ACERINI, Auteur ; Melissa HINES, Auteur . - p.1455-1462. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-12 (December 2016) . - p.1455-1462 Mots-clés : Congenital adrenal hyperplasia  fetal testosterone  prenatal testosterone exposure  autism  autistic traits  extreme male brain Index. décimale : PER Périodiques Résumé : Background There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis. Methods A parent-report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4–11 years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3–5 years. Results Findings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample. Conclusions These studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits. En ligne : http://dx.doi.org/10.1111/jcpp.12602 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Poor family functioning mediates the link between childhood adversity and adolescent nonsuicidal self-injury / M. CASSELS in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.881-887 Titre : Poor family functioning mediates the link between childhood adversity and adolescent nonsuicidal self-injury Type de document : texte imprimé Auteurs : M. CASSELS, Auteur ; Anne-Laura VAN HARMELEN, Auteur ; Sharon NEUFELD, Auteur ; Ian M. GOODYER, Auteur ; Peter B. JONES, Auteur ; Paul WILKINSON, Auteur Article en page(s) : p.881-887 Langues : Anglais (eng) Mots-clés : Family functioning  adolescence  adversity  self-harm  self-injury Index. décimale : PER Périodiques Résumé : BACKGROUND: Non-suicidal self-injury (NSSI) is a common harmful behavior during adolescence. Exposure to childhood family adversity (CFA) is associated with subsequent emergence of NSSI during adolescence. However, the pathways through which this early environmental risk may operate are not clear. AIMS: We tested four alternative hypotheses to explain the association between CFA and adolescent-onset NSSI. METHODS: A community sample of n = 933 fourteen year olds with no history of NSSI were followed up for 3 years. RESULTS: Poor family functioning at age 14 mediated the association between CFA before age 5 and subsequent onset of NSSI between 14 and 17 years. CONCLUSIONS: The findings support the cumulative suboptimal environmental hazards (proximal family relationships as a mediator) hypothesis. Improving the family environment at age 14 may mitigate the effects of CFA on adolescent onset of NSSI. En ligne : http://dx.doi.org/10.1111/jcpp.12866 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Poor family functioning mediates the link between childhood adversity and adolescent nonsuicidal self-injury [texte imprimé] / M. CASSELS, Auteur ; Anne-Laura VAN HARMELEN, Auteur ; Sharon NEUFELD, Auteur ; Ian M. GOODYER, Auteur ; Peter B. JONES, Auteur ; Paul WILKINSON, Auteur . - p.881-887. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.881-887 Mots-clés : Family functioning  adolescence  adversity  self-harm  self-injury Index. décimale : PER Périodiques Résumé : BACKGROUND: Non-suicidal self-injury (NSSI) is a common harmful behavior during adolescence. Exposure to childhood family adversity (CFA) is associated with subsequent emergence of NSSI during adolescence. However, the pathways through which this early environmental risk may operate are not clear. AIMS: We tested four alternative hypotheses to explain the association between CFA and adolescent-onset NSSI. METHODS: A community sample of n = 933 fourteen year olds with no history of NSSI were followed up for 3 years. RESULTS: Poor family functioning at age 14 mediated the association between CFA before age 5 and subsequent onset of NSSI between 14 and 17 years. CONCLUSIONS: The findings support the cumulative suboptimal environmental hazards (proximal family relationships as a mediator) hypothesis. Improving the family environment at age 14 may mitigate the effects of CFA on adolescent onset of NSSI. En ligne : http://dx.doi.org/10.1111/jcpp.12866 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Trajectories of depression symptom change during and following treatment in adolescents with unipolar major depression / Sian Emma DAVIES in Journal of Child Psychology and Psychiatry, 61-5 (May 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.565-574 Titre : Trajectories of depression symptom change during and following treatment in adolescents with unipolar major depression Type de document : texte imprimé Auteurs : Sian Emma DAVIES, Auteur ; Sharon NEUFELD, Auteur ; Eleonore VAN SPRANG, Auteur ; Lizanne SCHWEREN, Auteur ; Rogier KEIVIT, Auteur ; Peter FONAGY, Auteur ; Bernadka DUBICKA, Auteur ; Raphael KELVIN, Auteur ; Nick MIDGLEY, Auteur ; Shirley REYNOLDS, Auteur ; Mary TARGET, Auteur ; Paul WILKINSON, Auteur ; Anne-Laura VAN HARMELEN, Auteur ; Ian M. GOODYER, Auteur Article en page(s) : p.565-574 Langues : Anglais (eng) Mots-clés : Depression  longitudinal studies  outcome  therapy Index. décimale : PER Périodiques Résumé : OBJECTIVE: To classify a cohort of depressed adolescents recruited to the UK IMPACT trial, according to trajectories of symptom change. We examined for predictors and compared the data-driven categories of patients with a priori operational definitions of treatment response. METHOD: Secondary data analysis using growth mixture modelling (GMM). Missing data were imputed. Trajectories of self-reported depressive symptoms were plotted using scores taken at six nominal time points over 86 weeks from randomisation in all 465 patients. RESULTS: A piecewise GMM categorised patients into two classes with initially similar and subsequently distinct trajectories. Both groups had a significant decline in depressive symptoms over the first 18 weeks. Eighty-four per cent (84.1%, n = 391) of patients were classed as 'continued-improvers' with symptoms reducing over the duration of the study. A further class of 15.9% (n = 74) of patients were termed 'halted-improvers' with higher baseline depression scores, faster early recovery but no further improvement after 18 weeks. Presence of baseline comorbidity somewhat increased membership to the halted-improvers class (OR = 1.40, CI: 1.00-1.96). By end of study, compared with classes, a clinical remission cut-off score (/=50%) indexing treatment response misclassified 15% and 31% of cases, respectively. CONCLUSIONS: A fast reduction in depressive symptoms in the first few weeks of treatment may not indicate a good prognosis. Halted improvement is only seen after 18 weeks of treatment. Longitudinal modelling may improve the precision of revealing differential responses to treatment. Improvement in depressive symptoms may be somewhat better in the year after treatment than previously considered. En ligne : http://dx.doi.org/10.1111/jcpp.13145 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Trajectories of depression symptom change during and following treatment in adolescents with unipolar major depression [texte imprimé] / Sian Emma DAVIES, Auteur ; Sharon NEUFELD, Auteur ; Eleonore VAN SPRANG, Auteur ; Lizanne SCHWEREN, Auteur ; Rogier KEIVIT, Auteur ; Peter FONAGY, Auteur ; Bernadka DUBICKA, Auteur ; Raphael KELVIN, Auteur ; Nick MIDGLEY, Auteur ; Shirley REYNOLDS, Auteur ; Mary TARGET, Auteur ; Paul WILKINSON, Auteur ; Anne-Laura VAN HARMELEN, Auteur ; Ian M. GOODYER, Auteur . - p.565-574. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.565-574 Mots-clés : Depression  longitudinal studies  outcome  therapy Index. décimale : PER Périodiques Résumé : OBJECTIVE: To classify a cohort of depressed adolescents recruited to the UK IMPACT trial, according to trajectories of symptom change. We examined for predictors and compared the data-driven categories of patients with a priori operational definitions of treatment response. METHOD: Secondary data analysis using growth mixture modelling (GMM). Missing data were imputed. Trajectories of self-reported depressive symptoms were plotted using scores taken at six nominal time points over 86 weeks from randomisation in all 465 patients. RESULTS: A piecewise GMM categorised patients into two classes with initially similar and subsequently distinct trajectories. Both groups had a significant decline in depressive symptoms over the first 18 weeks. Eighty-four per cent (84.1%, n = 391) of patients were classed as 'continued-improvers' with symptoms reducing over the duration of the study. A further class of 15.9% (n = 74) of patients were termed 'halted-improvers' with higher baseline depression scores, faster early recovery but no further improvement after 18 weeks. Presence of baseline comorbidity somewhat increased membership to the halted-improvers class (OR = 1.40, CI: 1.00-1.96). By end of study, compared with classes, a clinical remission cut-off score (/=50%) indexing treatment response misclassified 15% and 31% of cases, respectively. CONCLUSIONS: A fast reduction in depressive symptoms in the first few weeks of treatment may not indicate a good prognosis. Halted improvement is only seen after 18 weeks of treatment. Longitudinal modelling may improve the precision of revealing differential responses to treatment. Improvement in depressive symptoms may be somewhat better in the year after treatment than previously considered. En ligne : http://dx.doi.org/10.1111/jcpp.13145 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

---

1 (1 - 4 / 4) Par page : 25 50 100 200