Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome / Mirko ULJAREVIĆ in Journal of Autism and Developmental Disorders, 48-11 (November 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3958-3964 Titre : Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome Type de document : texte imprimé Auteurs : Mirko ULJAREVIĆ, Auteur ; Izelle LABUSCHAGNE, Auteur ; Rebecca BOBIN, Auteur ; Anna ATKINSON, Auteur ; Darren R. HOCKING, Auteur Article en page(s) : p.3958-3964 Langues : Anglais (eng) Mots-clés : Anxiety  Autism spectrum disorder  Intolerance of uncertainty  Sensory hyper-sensitivity  Williams syndrome Index. décimale : PER Périodiques Résumé : This study explored the interrelationship between intolerance of uncertainty, sensory hyper-sensitivity and anxiety in Williams syndrome (WS). Thirty-two parents or guardians of individuals with WS (Mage = 24.76 years, SD = 7.55) were included. Associations between anxiety, intolerance of uncertainty, sensory hyper-sensitivity, and ASD symptoms were assessed. Linear regression analysis revealed that intolerance of uncertainty and sensory hyper-sensitivity were unique independent predictors of anxiety, while social communication score was not. There was evidence of a mediating effect of sensory hyper-sensitivity on the relationship between intolerance of uncertainty and anxiety. These findings bear strong resemblance to the pattern seen in ASD and emphasize the need for development of anxiety interventions that attempt to reduce negative beliefs about unpredictable situations in WS. En ligne : http://dx.doi.org/10.1007/s10803-018-3631-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome [texte imprimé] / Mirko ULJAREVIĆ, Auteur ; Izelle LABUSCHAGNE, Auteur ; Rebecca BOBIN, Auteur ; Anna ATKINSON, Auteur ; Darren R. HOCKING, Auteur . - p.3958-3964. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3958-3964 Mots-clés : Anxiety  Autism spectrum disorder  Intolerance of uncertainty  Sensory hyper-sensitivity  Williams syndrome Index. décimale : PER Périodiques Résumé : This study explored the interrelationship between intolerance of uncertainty, sensory hyper-sensitivity and anxiety in Williams syndrome (WS). Thirty-two parents or guardians of individuals with WS (Mage = 24.76 years, SD = 7.55) were included. Associations between anxiety, intolerance of uncertainty, sensory hyper-sensitivity, and ASD symptoms were assessed. Linear regression analysis revealed that intolerance of uncertainty and sensory hyper-sensitivity were unique independent predictors of anxiety, while social communication score was not. There was evidence of a mediating effect of sensory hyper-sensitivity on the relationship between intolerance of uncertainty and anxiety. These findings bear strong resemblance to the pattern seen in ASD and emphasize the need for development of anxiety interventions that attempt to reduce negative beliefs about unpredictable situations in WS. En ligne : http://dx.doi.org/10.1007/s10803-018-3631-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Delineating Visual Habituation Profiles in Preschoolers with Neurofibromatosis Type 1 and Autism Spectrum Disorder: A Cross-Syndrome Study / Darren R. HOCKING in Journal of Autism and Developmental Disorders, 54-5 (May 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-5 (May 2024) . - p.1998-2011 Titre : Delineating Visual Habituation Profiles in Preschoolers with Neurofibromatosis Type 1 and Autism Spectrum Disorder: A Cross-Syndrome Study Type de document : texte imprimé Auteurs : Darren R. HOCKING, Auteur ; Xiaoyun SUN, Auteur ; Kristina M. HAEBICH, Auteur ; Hayley DARKE, Auteur ; Kathryn N. NORTH, Auteur ; Giacomo VIVANTI, Auteur ; Jonathan M. PAYNE, Auteur Article en page(s) : p.1998-2011 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Atypical habituation to repetitive information has been commonly reported in Autism Spectrum Disorder (ASD) but it is not yet clear whether similar abnormalities are present in Neurofibromatosis Type 1 (NF1). We employed a cross-syndrome design using a novel eye tracking paradigm to measure habituation in preschoolers with NF1, children with idiopathic ASD and typically developing (TD) children. Eye movements were recorded to examine fixation duration to simultaneously presented repeating and novel stimuli. Children with NF1 showed a bias for longer look durations to repeating stimuli at the expense of novel stimuli, and slower habituation in NF1 was associated with elevated ASD traits. These findings could indicate aberrant modulation of bottom-up attentional networks that interact with the emergence of ASD phenotypes. En ligne : https://doi.org/10.1007/s10803-023-05913-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530 [article] Delineating Visual Habituation Profiles in Preschoolers with Neurofibromatosis Type 1 and Autism Spectrum Disorder: A Cross-Syndrome Study [texte imprimé] / Darren R. HOCKING, Auteur ; Xiaoyun SUN, Auteur ; Kristina M. HAEBICH, Auteur ; Hayley DARKE, Auteur ; Kathryn N. NORTH, Auteur ; Giacomo VIVANTI, Auteur ; Jonathan M. PAYNE, Auteur . - p.1998-2011. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-5 (May 2024) . - p.1998-2011 Index. décimale : PER Périodiques Résumé : Atypical habituation to repetitive information has been commonly reported in Autism Spectrum Disorder (ASD) but it is not yet clear whether similar abnormalities are present in Neurofibromatosis Type 1 (NF1). We employed a cross-syndrome design using a novel eye tracking paradigm to measure habituation in preschoolers with NF1, children with idiopathic ASD and typically developing (TD) children. Eye movements were recorded to examine fixation duration to simultaneously presented repeating and novel stimuli. Children with NF1 showed a bias for longer look durations to repeating stimuli at the expense of novel stimuli, and slower habituation in NF1 was associated with elevated ASD traits. These findings could indicate aberrant modulation of bottom-up attentional networks that interact with the emergence of ASD phenotypes. En ligne : https://doi.org/10.1007/s10803-023-05913-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530

Social affiliation motives modulate spontaneous learning in Williams syndrome but not in autism / Giacomo VIVANTI in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 40p. Titre : Social affiliation motives modulate spontaneous learning in Williams syndrome but not in autism Type de document : texte imprimé Auteurs : Giacomo VIVANTI, Auteur ; Darren R. HOCKING, Auteur ; Peter FANNING, Auteur ; Cheryl DISSANAYAKE, Auteur Article en page(s) : 40p. Langues : Anglais (eng) Mots-clés : Attention  Autistic Disorder/psychology  Child, Preschool  Female  Humans  Learning  Male  Williams Syndrome/psychology  Autism  Imitation  Social cognition  Social learning  Williams syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with autism spectrum disorder (ASD) and those with Williams syndrome (WS) have difficulties with learning, though the nature of these remains unclear. METHODS: In this study, we used novel eye-tracking and behavioral paradigms to measure how 36 preschoolers with ASD and 21 age- and IQ-matched peers with WS attend to and learn novel behaviors (1) from the outcomes of their own actions (non-social learning), (2) through imitation of others' actions (social learning), and across situations in which imitative learning served either an instrumental function or fulfilled social affiliation motives. RESULTS: The two groups demonstrated similar abilities to learn from the consequences of their own actions and to imitate new actions that were instrumental to the achievement of a tangible goal. Children with WS, unlike those with ASD, increased their attention and imitative learning performance when the model acted in a socially engaging manner. CONCLUSIONS: Learning abnormalities in ASD appear to be linked to the social rather than instrumental dimensions of learning. En ligne : http://dx.doi.org/10.1186/s13229-016-0101-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Social affiliation motives modulate spontaneous learning in Williams syndrome but not in autism [texte imprimé] / Giacomo VIVANTI, Auteur ; Darren R. HOCKING, Auteur ; Peter FANNING, Auteur ; Cheryl DISSANAYAKE, Auteur . - 40p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 40p. Mots-clés : Attention  Autistic Disorder/psychology  Child, Preschool  Female  Humans  Learning  Male  Williams Syndrome/psychology  Autism  Imitation  Social cognition  Social learning  Williams syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with autism spectrum disorder (ASD) and those with Williams syndrome (WS) have difficulties with learning, though the nature of these remains unclear. METHODS: In this study, we used novel eye-tracking and behavioral paradigms to measure how 36 preschoolers with ASD and 21 age- and IQ-matched peers with WS attend to and learn novel behaviors (1) from the outcomes of their own actions (non-social learning), (2) through imitation of others' actions (social learning), and across situations in which imitative learning served either an instrumental function or fulfilled social affiliation motives. RESULTS: The two groups demonstrated similar abilities to learn from the consequences of their own actions and to imitate new actions that were instrumental to the achievement of a tangible goal. Children with WS, unlike those with ASD, increased their attention and imitative learning performance when the model acted in a socially engaging manner. CONCLUSIONS: Learning abnormalities in ASD appear to be linked to the social rather than instrumental dimensions of learning. En ligne : http://dx.doi.org/10.1186/s13229-016-0101-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Social Attention, Joint Attention and Sustained Attention in Autism Spectrum Disorder and Williams Syndrome: Convergences and Divergences / Giacomo VIVANTI in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1866-1877 Titre : Social Attention, Joint Attention and Sustained Attention in Autism Spectrum Disorder and Williams Syndrome: Convergences and Divergences Type de document : texte imprimé Auteurs : Giacomo VIVANTI, Auteur ; Peter A.J. FANNING, Auteur ; Darren R. HOCKING, Auteur ; Stephanie SIEVERS, Auteur ; Cheryl DISSANAYAKE, Auteur Article en page(s) : p.1866-1877 Langues : Anglais (eng) Mots-clés : Autism  Williams syndrome  Attention  Social attention  Joint attention Index. décimale : PER Périodiques Résumé : There is limited knowledge on shared and syndrome-specific attentional profiles in autism spectrum disorder (ASD) and Williams syndrome (WS). Using eye-tracking, we examined attentional profiles of 35 preschoolers with ASD, 22 preschoolers with WS and 20 typically developing children across social and non-social dimensions of attention. Children with ASD and those with WS presented with overlapping deficits in spontaneous visual engagement with the target of others’ attention and in sustained attention. Children with ASD showed syndrome-specific abnormalities in monitoring and following a person’s referential gaze, as well as a lack of preferential attention to social stimuli. Children with ASD and WS present with shared as well as syndrome-specific abnormalities across social and non-social dimensions of attention. En ligne : http://dx.doi.org/10.1007/s10803-017-3106-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Social Attention, Joint Attention and Sustained Attention in Autism Spectrum Disorder and Williams Syndrome: Convergences and Divergences [texte imprimé] / Giacomo VIVANTI, Auteur ; Peter A.J. FANNING, Auteur ; Darren R. HOCKING, Auteur ; Stephanie SIEVERS, Auteur ; Cheryl DISSANAYAKE, Auteur . - p.1866-1877. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1866-1877 Mots-clés : Autism  Williams syndrome  Attention  Social attention  Joint attention Index. décimale : PER Périodiques Résumé : There is limited knowledge on shared and syndrome-specific attentional profiles in autism spectrum disorder (ASD) and Williams syndrome (WS). Using eye-tracking, we examined attentional profiles of 35 preschoolers with ASD, 22 preschoolers with WS and 20 typically developing children across social and non-social dimensions of attention. Children with ASD and those with WS presented with overlapping deficits in spontaneous visual engagement with the target of others’ attention and in sustained attention. Children with ASD showed syndrome-specific abnormalities in monitoring and following a person’s referential gaze, as well as a lack of preferential attention to social stimuli. Children with ASD and WS present with shared as well as syndrome-specific abnormalities across social and non-social dimensions of attention. En ligne : http://dx.doi.org/10.1007/s10803-017-3106-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

The cognitive neuropsychological phenotype of carriers of the FMR1 premutation / Jim GRIGSBY in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.28 Titre : The cognitive neuropsychological phenotype of carriers of the FMR1 premutation Type de document : texte imprimé Auteurs : Jim GRIGSBY, Auteur ; Kim CORNISH, Auteur ; Darren R. HOCKING, Auteur ; Claudine KRAAN, Auteur ; John M. OLICHNEY, Auteur ; Susan M. RIVERA, Auteur ; Andrea SCHNEIDER, Auteur ; Stephanie SHERMAN, Auteur ; Jing-Yu WANG, Auteur ; Jin-Chen YANG, Auteur Article en page(s) : p.28 Langues : Anglais (eng) Mots-clés : Cognition disorders  Executive function  Fmr1  Fxtas  Fragile X  Fragile X premutation  Fragile X-associated tremor/ataxia syndrome Index. décimale : PER Périodiques Résumé : The fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder affecting a subset of carriers of the FMR1 (fragile X mental retardation 1) premutation. Penetrance and expression appear to be significantly higher in males than females. Although the most obvious aspect of the phenotype is the movement disorder that gives FXTAS its name, the disorder is also accompanied by progressive cognitive impairment. In this review, we address the cognitive neuropsychological and neurophysiological phenotype for males and females with FXTAS, and for male and female unaffected carriers. Despite differences in penetrance and expression, the cognitive features of the disorder appear similar for both genders, with impairment of executive functioning, working memory, and information processing the most prominent. Deficits in these functional systems may be largely responsible for impairment on other measures, including tests of general intelligence and declarative learning. FXTAS is to a large extent a white matter disease, and the cognitive phenotypes observed are consistent with what some have described as white matter dementia, in contrast to the impaired cortical functioning more characteristic of Alzheimer's disease and related disorders. Although some degree of impaired executive functioning appears to be ubiquitous among persons with FXTAS, the data suggest that only a subset of unaffected carriers of the premutation - both female and male - demonstrate such deficits, which typically are mild. The best-studied phenotype is that of males with FXTAS. The manifestations of cognitive impairment among asymptomatic male carriers, and among women with and without FXTAS, are less well understood, but have come under increased scrutiny. En ligne : http://dx.doi.org/10.1186/1866-1955-6-28 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 [article] The cognitive neuropsychological phenotype of carriers of the FMR1 premutation [texte imprimé] / Jim GRIGSBY, Auteur ; Kim CORNISH, Auteur ; Darren R. HOCKING, Auteur ; Claudine KRAAN, Auteur ; John M. OLICHNEY, Auteur ; Susan M. RIVERA, Auteur ; Andrea SCHNEIDER, Auteur ; Stephanie SHERMAN, Auteur ; Jing-Yu WANG, Auteur ; Jin-Chen YANG, Auteur . - p.28. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.28 Mots-clés : Cognition disorders  Executive function  Fmr1  Fxtas  Fragile X  Fragile X premutation  Fragile X-associated tremor/ataxia syndrome Index. décimale : PER Périodiques Résumé : The fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder affecting a subset of carriers of the FMR1 (fragile X mental retardation 1) premutation. Penetrance and expression appear to be significantly higher in males than females. Although the most obvious aspect of the phenotype is the movement disorder that gives FXTAS its name, the disorder is also accompanied by progressive cognitive impairment. In this review, we address the cognitive neuropsychological and neurophysiological phenotype for males and females with FXTAS, and for male and female unaffected carriers. Despite differences in penetrance and expression, the cognitive features of the disorder appear similar for both genders, with impairment of executive functioning, working memory, and information processing the most prominent. Deficits in these functional systems may be largely responsible for impairment on other measures, including tests of general intelligence and declarative learning. FXTAS is to a large extent a white matter disease, and the cognitive phenotypes observed are consistent with what some have described as white matter dementia, in contrast to the impaired cortical functioning more characteristic of Alzheimer's disease and related disorders. Although some degree of impaired executive functioning appears to be ubiquitous among persons with FXTAS, the data suggest that only a subset of unaffected carriers of the premutation - both female and male - demonstrate such deficits, which typically are mild. The best-studied phenotype is that of males with FXTAS. The manifestations of cognitive impairment among asymptomatic male carriers, and among women with and without FXTAS, are less well understood, but have come under increased scrutiny. En ligne : http://dx.doi.org/10.1186/1866-1955-6-28 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346

The Interplay Between Anxiety and Social Functioning in Williams Syndrome / Deborah M. RIBY in Journal of Autism and Developmental Disorders, 44-5 (May 2014)  

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Verbal labels increase the salience of novel objects for preschoolers with typical development and Williams syndrome, but not in autism / Giacomo VIVANTI in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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